PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1318210-5 1992 The neutral endopeptidase inhibitor phosphoramidon (1 microM) increased the potency of ANF-(5-27) in both epithelium-intact and epithelium-denuded guinea-pig tracheal rings. phosphoramidon 36-50 natriuretic peptide A Rattus norvegicus 87-90 10334507-3 1999 The cGMP formation stimulated by ANP in LLC-PK1 cells was significantly decreased by pre-treatment of the peptide with rat renal brush-border membranes, and the inactivation of ANP was inhibited by neutral endopeptidase inhibitors, phosphoramidon and S-thiorphan. phosphoramidon 232-246 natriuretic peptide A Rattus norvegicus 177-180 10334507-5 1999 In addition, phosphoramidon potentiated the natriuresis with a low dose (7.5 pmol min(-1) kg(-1)) of ANP but not of BNP in rats. phosphoramidon 13-27 natriuretic peptide A Rattus norvegicus 101-104 8355566-14 1993 It is concluded that the antihypertensive action of SCH 32615 and low doses of phosphoramidon can be attributed to the inhibition of NEP which may presumably cause an accumulation of ANF. phosphoramidon 79-93 natriuretic peptide A Rattus norvegicus 183-186 1318210-6 1992 In contrast, removal of the epithelium from rat trachea, or pretreatment with phosphoramidon (1 microM) decreased relaxant responsiveness to ANF-(5-27). phosphoramidon 78-92 natriuretic peptide A Rattus norvegicus 141-144 2548762-2 1989 Relative to baseline values in rats with remnant kidneys, phosphoramidon led to elevations of plasma ANP levels and concomitant increases in urinary sodium excretion, fractional excretion of sodium, glomerular filtration rate, filtration fraction, and urinary cyclic GMP excretion. phosphoramidon 58-72 natriuretic peptide A Rattus norvegicus 101-104 2966343-2 1988 Cleavage at this site represents the major ANF degradative activity in rat kidney, and is inhibited by the known metalloendoprotease inhibitors, thiorphan, phosphoramidon and zincov with IC50 values in the nanomolar range. phosphoramidon 156-170 natriuretic peptide A Rattus norvegicus 43-46