PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34532767-1 2021 AIMS/HYPOTHESIS: The mammalian enzyme glucokinase (GK), expressed predominantly in liver and pancreas, plays an essential role in carbohydrate metabolism. Carbohydrates 130-142 glucokinase Homo sapiens 38-49 11498026-2 2001 When the diet is rich in carbohydrates, secreted insulin stimulates the expression of genes for enzymes involved in glucose utilization (glucokinase, L-type pyruvate kinase and lipogenic enzymes) and inhibits genes for enzymes involved in glucose production (phosphenolpyruvate carboxykinase). Carbohydrates 25-38 glucokinase Homo sapiens 137-148 10818272-2 2000 When a pellet diet containing 14% carbohydrate was given, most of the increased activity had a low affinity towards glucose (S0.5 = 19.5 mM) and resembled the mammalian glucokinase (Hexokinase IV or D) and the glucokinase-like activity previously observed in salmon liver. Carbohydrates 34-46 glucokinase Homo sapiens 169-180 10818272-2 2000 When a pellet diet containing 14% carbohydrate was given, most of the increased activity had a low affinity towards glucose (S0.5 = 19.5 mM) and resembled the mammalian glucokinase (Hexokinase IV or D) and the glucokinase-like activity previously observed in salmon liver. Carbohydrates 34-46 glucokinase Homo sapiens 210-221 10818272-5 2000 Perch with a very high hepatic glucokinase-like activity after eating the pellet diet had high activities of pyruvate kinase and glucose-6-phosphate dehydrogenase, indicating a high capacity of glycolysis and carbohydrate utilization. Carbohydrates 209-221 glucokinase Homo sapiens 31-42 7639682-2 1995 This study shows that, in hepatocytes incubated with 5 mM glucose as sole carbohydrate substrate, both glucokinase and its regulatory protein bind to the cell matrix by a Mg(2+)-dependent mechanism. Carbohydrates 74-86 glucokinase Homo sapiens 103-114 1502186-6 1992 The identification of mutations in glucokinase, a protein that plays an important role in hepatic and beta-cell glucose metabolism, indicates that early-onset non-insulin-dependent diabetes mellitus may be primarily a disorder of carbohydrate metabolism. Carbohydrates 230-242 glucokinase Homo sapiens 35-46 11833461-7 2001 In the liver, when the diet is rich in carbohydrates, insulin is secreted and stimulates the expression of genes involved in glucose utilization (glucokinase, L-pyruvate kinase, lipogenic enzymes) and inhibits genes involved in glucose production (phosphenolpyruvate carboxykinase). Carbohydrates 39-52 glucokinase Homo sapiens 146-157 34532767-1 2021 AIMS/HYPOTHESIS: The mammalian enzyme glucokinase (GK), expressed predominantly in liver and pancreas, plays an essential role in carbohydrate metabolism. Carbohydrates 130-142 glucokinase Homo sapiens 51-53 33352264-21 2021 Carbohydrate dysmetabolism was set for 57.6 % women with previously diagnosed GDM: 11 (7.0 %) were diagnosed with impaired fasting glycemia (IFG), 14 (8.9 %) with impaired glucose tolerance (IGT), type 2 Diabetes Mellitus (DM) was diagnosed for 58 (36.7 %), DM type 1 for 7 (4.4 %), MODY2 (maturity onset diabetes of the young) - 1 (0.6 %) patients. Carbohydrates 0-12 glucokinase Homo sapiens 283-288 3533069-7 1986 These data establish a physiological role for the glucokinase enzyme activity in avian carbohydrate metabolism and suggest that in contrast with the mammal, the particulate fraction is the more physiologically important enzyme. Carbohydrates 87-99 glucokinase Homo sapiens 50-61 6390088-3 1984 Refeeding with a high-carbohydrate diet restores glucokinase activity in islet extracts, blood insulin, and blood glucose. Carbohydrates 22-34 glucokinase Homo sapiens 49-60 32286938-3 2020 GK acts as promising drug target for the pharmacological treatment of patients with type 2 diabetes mellitus (T2DM) as it plays an important role in the control of carbohydrate metabolism. Carbohydrates 164-176 glucokinase Homo sapiens 0-2 24503189-6 2014 CONCLUSIONS: This novel mutation in the glucokinase gene led to atypical symptomatic exercise-induced hyperglycaemia that was responsive to low dose sulfonylurea with self-reported additional benefit after reduction of carbohydrate intake. Carbohydrates 219-231 glucokinase Homo sapiens 40-51 28850848-2 2018 However they conserved a "mammalian-type" nutritional regulation of glucokinase encoding gene and its enzymatic activity by dietary carbohydrates which remains puzzling regarding their dietary regime. Carbohydrates 132-145 glucokinase Homo sapiens 68-79 28850848-6 2018 Additionally, glycaemia and more particularly gck mRNA level and gck enzymatic activity prove that Kerguelen trout digest and metabolise dietary carbohydrates. Carbohydrates 145-158 glucokinase Homo sapiens 46-49 28850848-6 2018 Additionally, glycaemia and more particularly gck mRNA level and gck enzymatic activity prove that Kerguelen trout digest and metabolise dietary carbohydrates. Carbohydrates 145-158 glucokinase Homo sapiens 65-68 28850848-11 2018 As a conclusion, our findings may explain the evolutionary conservation of a "mammalian-type" nutritional regulation of gck by dietary carbohydrates in these carnivorous fish. Carbohydrates 135-148 glucokinase Homo sapiens 120-123 27174229-0 2016 Kinetic Basis of Carbohydrate-Mediated Inhibition of Human Glucokinase by the Glucokinase Regulatory Protein. Carbohydrates 17-29 glucokinase Homo sapiens 59-70 27174229-0 2016 Kinetic Basis of Carbohydrate-Mediated Inhibition of Human Glucokinase by the Glucokinase Regulatory Protein. Carbohydrates 17-29 glucokinase Homo sapiens 78-89 24728127-0 2014 Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure. Carbohydrates 103-115 glucokinase Homo sapiens 32-43 24728127-0 2014 Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure. Carbohydrates 103-115 glucokinase Homo sapiens 50-53 24728127-9 2014 CONCLUSIONS/INTERPRETATION: Common variation in GCK influences the rate of carbohydrate oxidation, 24 h energy expenditure and diabetes risk in Pima Indians. Carbohydrates 75-87 glucokinase Homo sapiens 48-51 23573289-1 2013 BACKGROUND: Glucokinase (GCK) plays an important role in the regulation of carbohydrate metabolism. Carbohydrates 75-87 glucokinase Homo sapiens 12-23 23573289-1 2013 BACKGROUND: Glucokinase (GCK) plays an important role in the regulation of carbohydrate metabolism. Carbohydrates 75-87 glucokinase Homo sapiens 25-28 24896238-4 2014 Indeed, the present review will describe the existence of the GK enzyme in different animal species that have naturally different levels of carbohydrate in their diets. Carbohydrates 140-152 glucokinase Homo sapiens 62-64 24896238-5 2014 Thus, some studies have been performed to analyse the nutritional regulation of the GK enzyme in humans and rodents (having high levels of dietary carbohydrates in their diets), in the chicken (moderate level of carbohydrates in its diet) and rainbow trout (no carbohydrate intake in its diet). Carbohydrates 147-160 glucokinase Homo sapiens 84-86 24896238-5 2014 Thus, some studies have been performed to analyse the nutritional regulation of the GK enzyme in humans and rodents (having high levels of dietary carbohydrates in their diets), in the chicken (moderate level of carbohydrates in its diet) and rainbow trout (no carbohydrate intake in its diet). Carbohydrates 212-225 glucokinase Homo sapiens 84-86 24896238-5 2014 Thus, some studies have been performed to analyse the nutritional regulation of the GK enzyme in humans and rodents (having high levels of dietary carbohydrates in their diets), in the chicken (moderate level of carbohydrates in its diet) and rainbow trout (no carbohydrate intake in its diet). Carbohydrates 147-159 glucokinase Homo sapiens 84-86 24896238-6 2014 All these data illustrate the nutritional importance of the GK enzyme irrespective of feeding habits, even in animals known to poorly use dietary carbohydrates (carnivorous species). Carbohydrates 146-159 glucokinase Homo sapiens 60-62 22289546-0 2011 The influence of dietary carbohydrate content on glycaemia in patients with glucokinase maturity-onset diabetes of the young. Carbohydrates 25-37 glucokinase Homo sapiens 76-87 22289546-7 2011 In patients with GCK MODY on high-carbohydrate diets, glucose levels were significantly higher, and more hyperglycaemic episodes occurred, compared with patients on low-carbohydrate diets. Carbohydrates 34-46 glucokinase Homo sapiens 17-20 22289546-7 2011 In patients with GCK MODY on high-carbohydrate diets, glucose levels were significantly higher, and more hyperglycaemic episodes occurred, compared with patients on low-carbohydrate diets. Carbohydrates 169-181 glucokinase Homo sapiens 17-20 22289546-8 2011 This short-term observational study suggested that diets with a modestly limited carbohydrate content may improve glycaemic control in patients with GCK MODY. Carbohydrates 82-94 glucokinase Homo sapiens 150-153 18780155-5 2009 Low glucokinase (GK) activity is reported to be a principal feature of feline hepatic carbohydrate metabolism but the molecular pathways that regulate GK activity are not known. Carbohydrates 86-98 glucokinase Homo sapiens 4-15 18780155-5 2009 Low glucokinase (GK) activity is reported to be a principal feature of feline hepatic carbohydrate metabolism but the molecular pathways that regulate GK activity are not known. Carbohydrates 86-98 glucokinase Homo sapiens 17-19