PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33481370-4 2020 Leptin and Peroxisome Proliferator-Activated Receptor gamma(PPARgamma) are involved in carbohydrate metabolism and reproduction function regulation. Carbohydrates 87-99 peroxisome proliferator activated receptor gamma Homo sapiens 11-59 33481370-4 2020 Leptin and Peroxisome Proliferator-Activated Receptor gamma(PPARgamma) are involved in carbohydrate metabolism and reproduction function regulation. Carbohydrates 87-99 peroxisome proliferator activated receptor gamma Homo sapiens 60-69 31392349-0 2020 Lipophagy mediated carbohydrate-induced changes of lipid metabolism via oxidative stress, endoplasmic reticulum (ER) stress and ChREBP/PPARgamma pathways. Carbohydrates 19-31 peroxisome proliferator activated receptor gamma Homo sapiens 135-144 31392349-9 2020 Our study provided innovative evidence for the direct relationship between carbohydrate and lipid metabolism via ChREBP/PPARgamma pathway. Carbohydrates 75-87 peroxisome proliferator activated receptor gamma Homo sapiens 120-129 32190036-2 2020 Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that are involved in carbohydrate and fatty-acid metabolism and have also been associated with DR. Three PPAR isoforms are known: PPARG, PPARA, and PPARD. Carbohydrates 95-107 peroxisome proliferator activated receptor gamma Homo sapiens 204-209 30702076-1 2018 The aim of this study was to determine the role of Pro12Ala polymorphism of the PPAR-gamma gene, associated with lipid and carbohydrate metabolism, in the genesis of gestational weight gain (GWG). Carbohydrates 123-135 peroxisome proliferator activated receptor gamma Homo sapiens 80-90 31240708-8 2020 The expression of PPAR gamma was high in the presence of sucrose and galactose, possibly of adipogenic cocktail in enhancing the expression rather than the effect of carbohydrate. Carbohydrates 166-178 peroxisome proliferator activated receptor gamma Homo sapiens 18-28 30458368-5 2019 At the same time, the existing data demonstrate that organotin compounds (OTCs) induces aberrant expression of PPARgamma-targeted genes, resulting in altered of adipokine, glucose transporter, proinflammatory cytokines levels, and lipid and carbohydrate metabolism. Carbohydrates 241-253 peroxisome proliferator activated receptor gamma Homo sapiens 111-120 30702076-11 2018 The modified transcriptional activity of PPAR-gamma gene, associated with lipid and carbohydrate metabolism, has a direct effect on the weight gain during pregnancy. Carbohydrates 84-96 peroxisome proliferator activated receptor gamma Homo sapiens 41-51 28651828-9 2018 CONCLUSION: Hypocaloric diet reduces UCP3 expression in individuals with obesity and the UCP3, PLIN1 and PPARG2 expression correlate positively with carbohydrate oxidation and negatively with lipid oxidation. Carbohydrates 149-161 peroxisome proliferator activated receptor gamma Homo sapiens 105-111 26018229-4 2016 PPAR includes three isoforms: PPAR-alpha, PPAR- beta and PPAR- gamma, all of which are exerting critical influences on the maintenance of the metabolism of saccharides, lipids and proteins. Carbohydrates 156-167 peroxisome proliferator activated receptor gamma Homo sapiens 57-68 28947679-3 2017 Peroxisome proliferator activator receptorgamma (PPARgamma) is a key player in carbohydrate metabolism. Carbohydrates 79-91 peroxisome proliferator activated receptor gamma Homo sapiens 0-47 28947679-3 2017 Peroxisome proliferator activator receptorgamma (PPARgamma) is a key player in carbohydrate metabolism. Carbohydrates 79-91 peroxisome proliferator activated receptor gamma Homo sapiens 49-58 27916646-2 2017 All three PPAR isotypes, PPARalpha, PPARbeta/delta, and PPARgamma, are activated by a variety of molecules, including fatty acids, eicosanoids and phospholipids, and regulate a spectrum of genes involved in development, lipid and carbohydrate metabolism, inflammation, and proliferation and differentiation of many cell types in different tissues. Carbohydrates 230-242 peroxisome proliferator activated receptor gamma Homo sapiens 56-65 29203734-2 2017 Activation of receptor PPAR-gamma regulates carbohydrate and lipid metabolism, immune and inflammatory responses in heart tissues. Carbohydrates 44-56 peroxisome proliferator activated receptor gamma Homo sapiens 23-33 27197753-1 2016 Peroxisome proliferator-activated receptor gamma (PPARgamma) is a critical regulator of carbohydrate and lipid metabolism, adipocyte differentiation and inflammatory response. Carbohydrates 88-100 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 27197753-1 2016 Peroxisome proliferator-activated receptor gamma (PPARgamma) is a critical regulator of carbohydrate and lipid metabolism, adipocyte differentiation and inflammatory response. Carbohydrates 88-100 peroxisome proliferator activated receptor gamma Homo sapiens 50-59 24497707-1 2013 BACKGROUND: Peroxisome proliferator activator receptor gamma (PPARgamma) is a nuclear transcription factor regulating multiple genes involved in cell growth, differentiation, carbohydrate and lipid metabolism and energy production. Carbohydrates 175-187 peroxisome proliferator activated receptor gamma Homo sapiens 12-60 26322090-1 2015 INTRODUCTION: Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcription factor of the nuclear receptor superfamily that is involved in lipid and carbohydrate metabolism as well as inflammation; thereby it participates in metabolic diseases including diabetes. Carbohydrates 184-196 peroxisome proliferator activated receptor gamma Homo sapiens 14-62 26322090-1 2015 INTRODUCTION: Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcription factor of the nuclear receptor superfamily that is involved in lipid and carbohydrate metabolism as well as inflammation; thereby it participates in metabolic diseases including diabetes. Carbohydrates 184-196 peroxisome proliferator activated receptor gamma Homo sapiens 64-73 24379269-5 2013 PPARgamma are transcriptional factors belonging to the ligand-activated nuclear receptor superfamily which directly regulate the expression of a large number of genes involved in adipocyte differentiation, lipid and carbohydrate metabolism as well as adipokine synthesis; thereby they are implicated in various metabolic disorders, including obesity, insulin resistance, dyslipidemia, and hypertension. Carbohydrates 216-228 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 23891824-3 2013 Peroxisome proliferator-activated receptor PPARalpha and PPARgamma are members of a family of nuclear receptors involved in the metabolism of lipids and carbohydrates, adipogenesis and sensitivity to insulin. Carbohydrates 153-166 peroxisome proliferator activated receptor gamma Homo sapiens 57-66 24464185-1 2014 Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear hormone receptor that regulates a number of genes involved in lipid and carbohydrate metabolism. Carbohydrates 146-158 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 24464185-1 2014 Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear hormone receptor that regulates a number of genes involved in lipid and carbohydrate metabolism. Carbohydrates 146-158 peroxisome proliferator activated receptor gamma Homo sapiens 50-59 24374061-3 2014 Peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor and ligand-dependent transcription factor, regulates pathways of inflammation, lipid and carbohydrate metabolism, antioxidant defences and mitochondrial biogenesis. Carbohydrates 170-182 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 24374061-3 2014 Peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor and ligand-dependent transcription factor, regulates pathways of inflammation, lipid and carbohydrate metabolism, antioxidant defences and mitochondrial biogenesis. Carbohydrates 170-182 peroxisome proliferator activated receptor gamma Homo sapiens 50-59 24779289-0 2014 Effects of the C161T polymorphism in the gene of peroxisome proliferators activated receptor gamma on changes of plasma lipid and apolipoprotein ratios induced by a high carbohydrate diet in a healthy Chinese Han young population. Carbohydrates 170-182 peroxisome proliferator activated receptor gamma Homo sapiens 49-98 24497707-1 2013 BACKGROUND: Peroxisome proliferator activator receptor gamma (PPARgamma) is a nuclear transcription factor regulating multiple genes involved in cell growth, differentiation, carbohydrate and lipid metabolism and energy production. Carbohydrates 175-187 peroxisome proliferator activated receptor gamma Homo sapiens 62-71 22122458-1 2012 Peroxisome Proliferator-Activated Receptor gamma (PPARgamma), originally described as a transcription factor for genes of carbohydrate and lipid metabolism, has been more recently studied in the context of cardiovascular pathophysiology. Carbohydrates 122-134 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 23569420-1 2013 The PPARgamma nuclear receptor regulates the expression of genes involved in lipid and carbohydrate metabolism, and it has protective effects in some patients with type 2 diabetes. Carbohydrates 87-99 peroxisome proliferator activated receptor gamma Homo sapiens 4-13 23176218-4 2013 PPARgamma plays an important role in regulating carbohydrate and lipid metabolism, and ligands for PPARgamma can improve insulin sensitivity and reduce triglyceride levels. Carbohydrates 48-60 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 23176218-4 2013 PPARgamma plays an important role in regulating carbohydrate and lipid metabolism, and ligands for PPARgamma can improve insulin sensitivity and reduce triglyceride levels. Carbohydrates 48-60 peroxisome proliferator activated receptor gamma Homo sapiens 99-108 22528626-8 2013 Greater obesity risk was also found in inactive or high carbohydrate intake subjects with the Ala12 allele of PPARG2 gene. Carbohydrates 56-68 peroxisome proliferator activated receptor gamma Homo sapiens 110-116 22122458-1 2012 Peroxisome Proliferator-Activated Receptor gamma (PPARgamma), originally described as a transcription factor for genes of carbohydrate and lipid metabolism, has been more recently studied in the context of cardiovascular pathophysiology. Carbohydrates 122-134 peroxisome proliferator activated receptor gamma Homo sapiens 50-59 21533120-6 2011 Many genes involved in lipid, carbohydrate, xenobiotic and cholesterol metabolism, as well as inflammation and immunity, were regulated by both PPARgamma and PPARalpha/gamma agonists in at least a number of human hepatocyte populations and/or HepaRG cells. Carbohydrates 30-42 peroxisome proliferator activated receptor gamma Homo sapiens 144-153 22731403-3 2012 Peroxisome proliferator-activated receptors (PPARs), which have three isoforms: PPAR-alpha, PPAR-gamma, and PPAR-delta, are key regulators of adipogenesis, lipid and carbohydrate metabolism, and are potential drug targets for treating metabolic syndrome. Carbohydrates 166-178 peroxisome proliferator activated receptor gamma Homo sapiens 92-102 23077903-6 2012 While PPARalpha mediates the hypolipemiant actions of fibrates, PPARgamma is the receptor for thiazolidinediones (glitazones) reccomended in type 2 diabetes treatment; by binding to PPARgamma, glitazones modulates transcription of genes involved in lipid and carbohydrate metabolism. Carbohydrates 259-271 peroxisome proliferator activated receptor gamma Homo sapiens 64-73 23077903-6 2012 While PPARalpha mediates the hypolipemiant actions of fibrates, PPARgamma is the receptor for thiazolidinediones (glitazones) reccomended in type 2 diabetes treatment; by binding to PPARgamma, glitazones modulates transcription of genes involved in lipid and carbohydrate metabolism. Carbohydrates 259-271 peroxisome proliferator activated receptor gamma Homo sapiens 182-191 21911496-8 2011 Using rosiglitazone as a model PPARgamma agonist, which decreased TNFalpha-induced high mannose N-glycan expression, we demonstrate a role for these carbohydrate residues in THP-1 rolling and adhesion that is independent of endothelial surface adhesion molecule expression (ICAM-1 and E-selectin). Carbohydrates 149-161 peroxisome proliferator activated receptor gamma Homo sapiens 31-40 20409934-8 2008 It is known that PPAR-gamma plays a role in the regulation of multiple genes affecting carbohydrate and lipid metabolism; however, the clinical significance of this remains to be established. Carbohydrates 87-99 peroxisome proliferator activated receptor gamma Homo sapiens 17-27 21687509-2 2011 By binding to peroxisome proliferator-activated receptor gamma (PPARgamma) they modulate transcription of genes of carbohydrate and lipid metabolism. Carbohydrates 115-127 peroxisome proliferator activated receptor gamma Homo sapiens 14-62 21687509-2 2011 By binding to peroxisome proliferator-activated receptor gamma (PPARgamma) they modulate transcription of genes of carbohydrate and lipid metabolism. Carbohydrates 115-127 peroxisome proliferator activated receptor gamma Homo sapiens 64-73 21666962-4 2011 They compose the nuclear receptor superfamily and there are in three isoforms (PPARalpha,PPARbeta/delta and PPARgamma), which play an important role in the regulation of the metabolism of carbohydrates, lipids and proteins. Carbohydrates 188-201 peroxisome proliferator activated receptor gamma Homo sapiens 108-117 20158092-1 2010 Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a ligand-activated transcription factor regulating gene expression involved in the fatty acids, lipoprotein and carbohydrate metabolism and inflammation. Carbohydrates 176-188 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 20158092-1 2010 Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a ligand-activated transcription factor regulating gene expression involved in the fatty acids, lipoprotein and carbohydrate metabolism and inflammation. Carbohydrates 176-188 peroxisome proliferator activated receptor gamma Homo sapiens 50-59 18818299-1 2009 Peroxisome proliferator-activated receptor (PPAR) gamma is a nuclear receptor that coordinates carbohydrate and lipid metabolism, and is a therapeutic target for type 2 diabetes. Carbohydrates 95-107 peroxisome proliferator activated receptor gamma Homo sapiens 0-55 20158101-3 2010 Recently, PPARgamma activity has been shown to influence the gene expression involved in carbohydrate and lipid metabolism. Carbohydrates 89-101 peroxisome proliferator activated receptor gamma Homo sapiens 10-19 19172745-1 2008 The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) has important roles in adipogenesis and immune response as well as roles in both lipid and carbohydrate metabolism. Carbohydrates 173-185 peroxisome proliferator activated receptor gamma Homo sapiens 71-80 18159845-1 2007 INTRODUCTION: The peroxisome proliferator-activated receptor gamma (PPARgamma), a transcriptor factor, regulates immunological and metabolic processes, which are important for carbohydrate and lipid metabolism. Carbohydrates 176-188 peroxisome proliferator activated receptor gamma Homo sapiens 18-66 18159845-1 2007 INTRODUCTION: The peroxisome proliferator-activated receptor gamma (PPARgamma), a transcriptor factor, regulates immunological and metabolic processes, which are important for carbohydrate and lipid metabolism. Carbohydrates 176-188 peroxisome proliferator activated receptor gamma Homo sapiens 68-77 16968414-5 2006 PPARs, and in particular PPARalpha and PPARgamma, are well known for their critical role in the regulation of energy homeostasis by controlling expression of a variety of genes involved in lipid and carbohydrate metabolism. Carbohydrates 199-211 peroxisome proliferator activated receptor gamma Homo sapiens 39-48 16154710-9 2006 PPAR-gamma influences the gene expression involved in carbohydrate metabolism. Carbohydrates 54-66 peroxisome proliferator activated receptor gamma Homo sapiens 0-10 15673477-2 2005 The role of PPAR gamma in macronutrient metabolism has received particular attention, for three main reasons: first, it is the target of the thiazolidinediones (TZDs), a novel class of insulin sensitisers widely used to treat type 2 diabetes; second, it plays a central role in adipogenesis; and third, it appears to be primarily involved in regulating lipid metabolism with predominantly secondary effects on carbohydrate metabolism, a notion in keeping with the currently in vogue "lipocentric" view of diabetes. Carbohydrates 410-422 peroxisome proliferator activated receptor gamma Homo sapiens 12-22 15617852-11 2005 PPAR-gamma influences the gene expression involved in carbohydrate metabolism, and pioglitazone and rosiglitazone, ligands for PPAR-gamma, improve insulin resistance in diabetic patients. Carbohydrates 54-66 peroxisome proliferator activated receptor gamma Homo sapiens 0-10 16511590-2 2006 However, studies on the action and structure of the 3 human PPAR isotypes (PPARalpha, PPARdelta, and PPARgamma) suggest that these moieties are intimately involved in nutrient sensing and the regulation of carbohydrate and lipid metabolism. Carbohydrates 206-218 peroxisome proliferator activated receptor gamma Homo sapiens 101-110 16511590-6 2006 This Review will focus on the role of PPARgamma in human physiology, with specific reference to clinical pharmacological studies, and analysis of PPARG gene variants in the abnormal lipid and carbohydrate metabolism of the metabolic syndrome. Carbohydrates 192-204 peroxisome proliferator activated receptor gamma Homo sapiens 146-151 15868121-6 2005 PPARgamma is a nuclear receptor that influences the expression of multiple genes involved in carbohydrate and lipid metabolism and is an attractive therapeutic target for the prevention and control of insulin resistance, type 2 diabetes and atherosclerosis. Carbohydrates 93-105 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 15940190-1 2005 AIM: To elucidate associations of polymorphic markers of PPAR, PPARG2, IRS1, IRS2 genes with disturbances of carbohydrate metabolism in patients with hypertension and excessive weight. Carbohydrates 109-121 peroxisome proliferator activated receptor gamma Homo sapiens 63-69 12829631-9 2003 These results are consistent with the putative roles of PPAR-gamma(1) and PPAR-gamma(2) in carbohydrate metabolism and energy homeostasis, respectively. Carbohydrates 91-103 peroxisome proliferator activated receptor gamma Homo sapiens 74-86 11395869-7 2001 A new approach to the treatment of type 2 diabetes are thiasolinediones, insulin-sensitizing substances, the molecular basis of their action being via activation of PPAR gamma-nuclear receptors with subsequent change in expression of genes participating in carbohydrate and lipid metabolism. Carbohydrates 257-269 peroxisome proliferator activated receptor gamma Homo sapiens 165-175 11965833-3 2000 Thiazolidinediones, pharmacological ligands for PPAR gamma, can modulate the expression of genes influencing carbohydrate and lipid metabolism. Carbohydrates 109-121 peroxisome proliferator activated receptor gamma Homo sapiens 48-58 10591673-1 1999 The peroxisome proliferator-activated receptor gamma (PPARgamma) gene has been implicated in morbid obesity and is important to lipid and carbohydrate metabolism. Carbohydrates 138-150 peroxisome proliferator activated receptor gamma Homo sapiens 4-52 10591673-1 1999 The peroxisome proliferator-activated receptor gamma (PPARgamma) gene has been implicated in morbid obesity and is important to lipid and carbohydrate metabolism. Carbohydrates 138-150 peroxisome proliferator activated receptor gamma Homo sapiens 54-63