PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7762602-7	1995	EC monolayers exposed to TNF-alpha showed increased cAMP levels when exposed to 3-isobutyl-1-methylxanthine, a nonspecific CNPDE inhibitor.	1-Methyl-3-isobutylxanthine	80-107	tumor necrosis factor	Bos taurus	25-34	
1655042-6	1991	Agents which increase cAMP, (e.g., forskolin and isobutylmethylxanthine) blocked the induction of PAI-1 synthesis by PMA, LPS, TGF beta and TNF alpha suggesting that induction may occur by lowering cAMP.	1-Methyl-3-isobutylxanthine	49-71	tumor necrosis factor	Bos taurus	140-149	
2173454-11	1990	Agents that may increase cAMP levels in PMN (PTX, DBcAMP, forskolin, isobutyl methylxanthine, and terbutaline) significantly attenuate TNF-induced PMN chemiluminescence (p less than 0.05).	1-Methyl-3-isobutylxanthine	69-92	tumor necrosis factor	Bos taurus	135-138	
17469134-10	2007	OSM and TNF induced a 6-fold increase in (342)FFGV-G2, which was abrogated by forskolin and IBMX (by >80%).	1-Methyl-3-isobutylxanthine	92-96	tumor necrosis factor	Bos taurus	8-11	
17469134-11	2007	OSM and TNF stimulated MMP expression as visualized by zymography, and MMP expression was dose-dependently inhibited by forskolin and IBMX.	1-Methyl-3-isobutylxanthine	134-138	tumor necrosis factor	Bos taurus	8-11