PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19407217-4 2009 We found that PKA activation using 50 micromol/l forskolin and 5 mmol/l 3-isobutyl-1-methylxanthine stimulated BK channels in cell-attached patches and the catalytic subunit of PKA (200 U/ml) had a similar effect in excised inside-out patches. 1-Methyl-3-isobutylxanthine 72-99 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 14-17 25539776-3 2015 We tried to inhibit the TREK-1 current by activating protein kinase A (PKA) with a mixture of forskolin and isobutyl-methylxanthine (IBMX). 1-Methyl-3-isobutylxanthine 108-131 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 53-69 25539776-3 2015 We tried to inhibit the TREK-1 current by activating protein kinase A (PKA) with a mixture of forskolin and isobutyl-methylxanthine (IBMX). 1-Methyl-3-isobutylxanthine 108-131 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 71-74 25539776-3 2015 We tried to inhibit the TREK-1 current by activating protein kinase A (PKA) with a mixture of forskolin and isobutyl-methylxanthine (IBMX). 1-Methyl-3-isobutylxanthine 133-137 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 53-69 25539776-3 2015 We tried to inhibit the TREK-1 current by activating protein kinase A (PKA) with a mixture of forskolin and isobutyl-methylxanthine (IBMX). 1-Methyl-3-isobutylxanthine 133-137 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 71-74 22770428-7 2012 Inhibition of cAMP-dependent protein kinase [also known as protein kinase A (PKA)] by H89 mimicked the effect of ACPD, and the mGluR agonist had its actions reversed by artificially sustaining cAMP through the PDE (phosphodiesterase) inhibitor IBMX (isobutylmethylxanthine) or the cAMP mimetic dbcAMP (dibutyryl cAMP). 1-Methyl-3-isobutylxanthine 250-272 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 59-75 22770428-7 2012 Inhibition of cAMP-dependent protein kinase [also known as protein kinase A (PKA)] by H89 mimicked the effect of ACPD, and the mGluR agonist had its actions reversed by artificially sustaining cAMP through the PDE (phosphodiesterase) inhibitor IBMX (isobutylmethylxanthine) or the cAMP mimetic dbcAMP (dibutyryl cAMP). 1-Methyl-3-isobutylxanthine 250-272 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 77-80 22933300-10 2012 The beta-adrenergic receptor antagonist propranolol or the PKA inhibitor H-89 completely blocked isoproterenol + IBMX-induced increase on surface NKCC2, while propranolol or H-89 alone had no effect. 1-Methyl-3-isobutylxanthine 113-117 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 59-62 22916194-6 2012 The inhibition of both PTP and phosphorylation of PKA substrates by SACH could be restored by addition of cAMP analog dibutyryl-cAMP (dbcAMP) and phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX). 1-Methyl-3-isobutylxanthine 174-201 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 50-53 22916194-6 2012 The inhibition of both PTP and phosphorylation of PKA substrates by SACH could be restored by addition of cAMP analog dibutyryl-cAMP (dbcAMP) and phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX). 1-Methyl-3-isobutylxanthine 203-207 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 50-53 15485496-2 2004 3-Isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor, and forskolin increased the amplitude of evoked inhibitory postsynaptic currents (eIPSCs) in a sensitive manner to protein kinase A (PKA) inhibition (with KT-5720). 1-Methyl-3-isobutylxanthine 0-27 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 182-198 15485496-2 2004 3-Isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor, and forskolin increased the amplitude of evoked inhibitory postsynaptic currents (eIPSCs) in a sensitive manner to protein kinase A (PKA) inhibition (with KT-5720). 1-Methyl-3-isobutylxanthine 0-27 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 200-203 15485496-2 2004 3-Isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor, and forskolin increased the amplitude of evoked inhibitory postsynaptic currents (eIPSCs) in a sensitive manner to protein kinase A (PKA) inhibition (with KT-5720). 1-Methyl-3-isobutylxanthine 29-33 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 182-198 15485496-2 2004 3-Isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor, and forskolin increased the amplitude of evoked inhibitory postsynaptic currents (eIPSCs) in a sensitive manner to protein kinase A (PKA) inhibition (with KT-5720). 1-Methyl-3-isobutylxanthine 29-33 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 200-203 14688288-7 2004 In attempts to identify this PKA-independent mechanism, we found that the newly developed cAMP analog 8CPT-2Me-cAMP, which selectively activates the cAMP-dependent guanine nucleotide exchange factor (cAMP-GEF) pathway, mimicked the protective effects of IBMX and forskolin, suggesting that the cAMP-GEF pathway is involved. 1-Methyl-3-isobutylxanthine 254-258 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 29-32 9299372-5 1997 PKA activators such as forskolin (FSK), isobutylmethylxanthine, dibutyryl cAMP and isoproterenol, significantly activated Raf-1 and MAP kinases with a peak at 2 and 8 min, respectively, followed by an increase in protein synthesis in cardiac myocytes. 1-Methyl-3-isobutylxanthine 40-62 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 0-3 12755590-4 2003 Inhibition or augmentation of cyclic AMP and/or protein kinase A (PKA) by Rp-Ado-3N,5N-cyclic monophosphorothioate triethylamine salt or 3-isobutyl-1-methylxanthine had no effect on allyl alcohol-induced cell death. 1-Methyl-3-isobutylxanthine 137-164 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 48-64 12755590-4 2003 Inhibition or augmentation of cyclic AMP and/or protein kinase A (PKA) by Rp-Ado-3N,5N-cyclic monophosphorothioate triethylamine salt or 3-isobutyl-1-methylxanthine had no effect on allyl alcohol-induced cell death. 1-Methyl-3-isobutylxanthine 137-164 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 66-69 9054858-6 1997 Similar synergistic activation of MAP kinases was observed when other protein kinase A-activating agents such as forskolin, dibutyryl cAMP, and isobutyl-methylxanthine were used with a protein kinase C-activating agent at the same time. 1-Methyl-3-isobutylxanthine 144-167 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 70-86 9236220-4 1997 PKA was induced by perfusing oocytes with a cocktail that contained forskolin, chlorophenylthio-cAMP, dibutyryl-cAMP, and 3-isobutyl-1-methylxanthine. 1-Methyl-3-isobutylxanthine 122-149 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 0-3 9834339-7 1997 Agents that activate PKA at different stages of the PKA activation pathway, including 3-isobutyl-1-methylxanthine (IBMX), forskolin, and cholera toxin, inhibited EGF-induced migration. 1-Methyl-3-isobutylxanthine 86-113 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 21-24 9834339-7 1997 Agents that activate PKA at different stages of the PKA activation pathway, including 3-isobutyl-1-methylxanthine (IBMX), forskolin, and cholera toxin, inhibited EGF-induced migration. 1-Methyl-3-isobutylxanthine 86-113 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 52-55 9834339-7 1997 Agents that activate PKA at different stages of the PKA activation pathway, including 3-isobutyl-1-methylxanthine (IBMX), forskolin, and cholera toxin, inhibited EGF-induced migration. 1-Methyl-3-isobutylxanthine 115-119 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 21-24 9834339-7 1997 Agents that activate PKA at different stages of the PKA activation pathway, including 3-isobutyl-1-methylxanthine (IBMX), forskolin, and cholera toxin, inhibited EGF-induced migration. 1-Methyl-3-isobutylxanthine 115-119 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 52-55