PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14736703-14 2004 We conclude that SUR1 deletion depolarizes the beta-cells and markedly elevates basal [Ca2+]i. Elevated [Ca2+]i in turn sensitizes the beta-cells to the secretory effects of ACh and IBMX. 1-Methyl-3-isobutylxanthine 182-186 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Mus musculus 17-21 14736703-9 2004 Pretreatment of perifused SUR1-/- islets with ACh or IBMX restored glucose stimulation of IR, an effect expectedly insensitive to diazoxide. 1-Methyl-3-isobutylxanthine 53-57 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Mus musculus 26-30