PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16926278-7	2006	All PDE5 constructs had similar affinities for 3-isobutyl-1-methylxanthine, sildenafil, tadalafil, and UK-122764, but mutants containing a complete GAF-B had 7- to 18-fold higher affinity for vardenafil-based compounds compared with those lacking a complete GAF-B.	1-Methyl-3-isobutylxanthine	47-74	phosphodiesterase 5A	Homo sapiens	4-8	
15210993-5	2004	The nonselective inhibitor 3-isobutyl-1-methylxanthine (IBMX) binds to a similar subpocket in the active sites of PDE4, PDE5, and PDE9 and has a common pattern of the binding.	1-Methyl-3-isobutylxanthine	27-54	phosphodiesterase 5A	Homo sapiens	120-124	
15357833-4	2004	Here we report that long-term application of hypergravity (up to 5 g for 24 h) stimulated cGMP efflux in cultured melanocytes and in non-metastatic melanoma cells in the presence of 0.1 mM 3-isobutyl-1-methylxanthine (IBMX), a non-selective phosphodiesterase (PDE) inhibitor.	1-Methyl-3-isobutylxanthine	189-216	phosphodiesterase 5A	Homo sapiens	260-263	
15210993-5	2004	The nonselective inhibitor 3-isobutyl-1-methylxanthine (IBMX) binds to a similar subpocket in the active sites of PDE4, PDE5, and PDE9 and has a common pattern of the binding.	1-Methyl-3-isobutylxanthine	56-60	phosphodiesterase 5A	Homo sapiens	120-124	
11388700-11	2001	However, compared with corpus cavernosum PDE5, the platelet enzyme exhibited higher sensitivity to dipyridamole and IBMX (IC50 0.46 and 1.8 uM, respectively).	1-Methyl-3-isobutylxanthine	116-120	phosphodiesterase 5A	Homo sapiens	41-45	
10574925-6	1999	The catalytic fragment and full-length PDE5 have similar IC(50) values for the inhibitors 3-isobutyl-1-methylxanthine (20 microM) and sildenafil (Viagra(TM))(4 nM).	1-Methyl-3-isobutylxanthine	90-117	phosphodiesterase 5A	Homo sapiens	39-43