PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9540987-4	1998	Following treatment with these diols or 3-isobutyl-1-methylxanthine, melanin and tyrosinase activity are increased within S91 cells and NHEM; however, for cultured NHEM, the largest increases of melanin and tyrosinase occur in an extracellular particulate fraction, shown by electron microscopy to consist almost entirely of stage III and IV melanosomes.	1-Methyl-3-isobutylxanthine	40-67	tyrosinase	Mus musculus	81-91	
9540987-4	1998	Following treatment with these diols or 3-isobutyl-1-methylxanthine, melanin and tyrosinase activity are increased within S91 cells and NHEM; however, for cultured NHEM, the largest increases of melanin and tyrosinase occur in an extracellular particulate fraction, shown by electron microscopy to consist almost entirely of stage III and IV melanosomes.	1-Methyl-3-isobutylxanthine	40-67	tyrosinase	Mus musculus	207-217	
3134020-5	1988	The level of mouse tyrosinase mRNA was elevated after stimulation of Cloudman S-91 melanoma cells with melanotropin and isobutylmethylxanthine and the level of transcript reflected that of tyrosinase activity and melanin content in the cells.	1-Methyl-3-isobutylxanthine	120-142	tyrosinase	Mus musculus	19-29	
30476649-7	2019	Additionally we have found that (1a, 2b and 3f) compounds had a strong melanogenesis inhibition effect in isobutylmethylxanthine (IBMX)-treated murine melanoma B16F10 cells when tested at low and non cytotoxic dose (10-50 microM), by attenuating the melanin production, intracellular tyrosinase activity and tyrosinase expression.	1-Methyl-3-isobutylxanthine	106-128	tyrosinase	Mus musculus	284-294	
2438034-7	1987	Dibutyryl cAMP and 3-isobutyl-1-methylxanthine augmented tyrosinase activation by PGE1 without enhancing the inhibitory action of PGE1 on cell growth.	1-Methyl-3-isobutylxanthine	19-46	tyrosinase	Mus musculus	57-67	
6201140-5	1984	Melanotropin (melanocyte stimulating hormone), dibutyryl cyclic adenosine monophosphate, and isobutylmethylxanthine caused an increase in the abundance of newly synthesized tyrosinase that was directly proportional to the increase in enzyme activity.	1-Methyl-3-isobutylxanthine	93-115	tyrosinase	Mus musculus	173-183	
202603-1	1978	Incubation of cultured B-16 melanoma cells with 1-methyl-3-isobutyl xanthine (MIX) produced a sustained rise in intracellular adenosine 3",5"-cyclic monophosphate (cAMP) which preceded an increase in the specific activity of tyrosinase (EC 1.10.3.1).	1-Methyl-3-isobutylxanthine	48-76	tyrosinase	Mus musculus	225-235	
30476649-7	2019	Additionally we have found that (1a, 2b and 3f) compounds had a strong melanogenesis inhibition effect in isobutylmethylxanthine (IBMX)-treated murine melanoma B16F10 cells when tested at low and non cytotoxic dose (10-50 microM), by attenuating the melanin production, intracellular tyrosinase activity and tyrosinase expression.	1-Methyl-3-isobutylxanthine	106-128	tyrosinase	Mus musculus	308-318	
30476649-7	2019	Additionally we have found that (1a, 2b and 3f) compounds had a strong melanogenesis inhibition effect in isobutylmethylxanthine (IBMX)-treated murine melanoma B16F10 cells when tested at low and non cytotoxic dose (10-50 microM), by attenuating the melanin production, intracellular tyrosinase activity and tyrosinase expression.	1-Methyl-3-isobutylxanthine	130-134	tyrosinase	Mus musculus	284-294	
30476649-7	2019	Additionally we have found that (1a, 2b and 3f) compounds had a strong melanogenesis inhibition effect in isobutylmethylxanthine (IBMX)-treated murine melanoma B16F10 cells when tested at low and non cytotoxic dose (10-50 microM), by attenuating the melanin production, intracellular tyrosinase activity and tyrosinase expression.	1-Methyl-3-isobutylxanthine	130-134	tyrosinase	Mus musculus	308-318	
24632067-3	2014	Betulinic acid significantly attenuated 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production by inhibiting tyrosinase, tyrosinase related protein (TRP)-1, and TRP-2 expression through the modulation of their corresponding transcription factors, microphthalamia associated transcription factor (MITF) and cAMP response element binding protein (CREB), in B16F10 cells.	1-Methyl-3-isobutylxanthine	69-73	tyrosinase	Mus musculus	116-126	
30130471-3	2018	Quercetin-7-O-alpha-L-rhamnoside attenuated cellular tyrosinase activity and melanogenesis in alpha-MSH plus IBMX-stimulated B16F10 melanoma cells.	1-Methyl-3-isobutylxanthine	109-113	tyrosinase	Mus musculus	53-63	
30360412-0	2018	A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in alpha-MSH and IBMX-Induced B16F10 Melanoma Cells.	1-Methyl-3-isobutylxanthine	145-149	tyrosinase	Mus musculus	9-19	
24632067-3	2014	Betulinic acid significantly attenuated 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production by inhibiting tyrosinase, tyrosinase related protein (TRP)-1, and TRP-2 expression through the modulation of their corresponding transcription factors, microphthalamia associated transcription factor (MITF) and cAMP response element binding protein (CREB), in B16F10 cells.	1-Methyl-3-isobutylxanthine	40-67	tyrosinase	Mus musculus	116-126