PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1860872-6	1991	The phosphorylation occurred at a similar dose of PMA as that which induced desensitization (half-maximal at approximately 300 nM, maximal at 500 nM to 1 microM), could be reproduced by pretreatment with the PKC activators DiC8 or phorbol 12,13-dibutyrate (PDBu), and could be blocked by the PKC inhibitors sphingosine or H-7.	1,2-dioctanoylglycerol	223-227	proline rich transmembrane protein 2	Homo sapiens	208-211	
9525478-6	1998	Simultaneous addition of di-C8 and ionomycin, however, caused a significant increase in the expression of the 15/7 epitope and cell adhesion, suggesting synergy between elevating [Ca++]i and stimulating PKC in beta1 integrin activation.	1,2-dioctanoylglycerol	25-30	proline rich transmembrane protein 2	Homo sapiens	203-206	
8964090-9	1996	Furthermore, acute exposure of K562 cells to known protein kinase C (PKC) activators, phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoylglycerol (DiC8), curtailed serotonin uptake by these cells.	1,2-dioctanoylglycerol	128-153	proline rich transmembrane protein 2	Homo sapiens	51-67	
8964090-9	1996	Furthermore, acute exposure of K562 cells to known protein kinase C (PKC) activators, phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoylglycerol (DiC8), curtailed serotonin uptake by these cells.	1,2-dioctanoylglycerol	128-153	proline rich transmembrane protein 2	Homo sapiens	69-72	
8430818-7	1993	In contrast, treatment with either TNF (1,000 U/ml for 15 min) or 1,2-dioctanoylglycerol (4 x 10(-5) M for 5 min), a diacylglycerol that activates PKC, resulted in translocation of fluorescence to the cell periphery; fine, punctate PKC-associated fluorescence was localized to the margins of cells.	1,2-dioctanoylglycerol	66-88	proline rich transmembrane protein 2	Homo sapiens	147-150	
8430818-7	1993	In contrast, treatment with either TNF (1,000 U/ml for 15 min) or 1,2-dioctanoylglycerol (4 x 10(-5) M for 5 min), a diacylglycerol that activates PKC, resulted in translocation of fluorescence to the cell periphery; fine, punctate PKC-associated fluorescence was localized to the margins of cells.	1,2-dioctanoylglycerol	66-88	proline rich transmembrane protein 2	Homo sapiens	232-235	
11447027-4	2001	Contraction of LES and ESO induced by the PKC agonist 1,2-dioctanoylglycerol (DG) was unaffected by MLCK inhibitors.	1,2-dioctanoylglycerol	54-76	proline rich transmembrane protein 2	Homo sapiens	42-45	
8786383-3	1996	PKC was activated by: (a) exposure of cultures to 10 nM 12-o-tetradecanoyl phorbol 13-acetate (TPA); (b) microinjection of 1 mM dioctanoylglycerol (diC8) directly into perikaryal of motor neurons;(c) addition of 10 microM diC8 to culture medium.	1,2-dioctanoylglycerol	148-152	proline rich transmembrane protein 2	Homo sapiens	0-3	
8786383-3	1996	PKC was activated by: (a) exposure of cultures to 10 nM 12-o-tetradecanoyl phorbol 13-acetate (TPA); (b) microinjection of 1 mM dioctanoylglycerol (diC8) directly into perikaryal of motor neurons;(c) addition of 10 microM diC8 to culture medium.	1,2-dioctanoylglycerol	222-226	proline rich transmembrane protein 2	Homo sapiens	0-3	
1335820-2	1992	We have tested the hypothesis that PKC modulates Ca2+ channel activity in hippocampal neurons by conducting a detailed comparison of the effects of the diacylglycerols, diC8 and OAG, with those of the phorbol ester, PDBu, on whole-cell and single-channel Ca2+ currents.	1,2-dioctanoylglycerol	169-173	proline rich transmembrane protein 2	Homo sapiens	35-38	
1370499-9	1992	Moreover, 1,2-dioctanoylglycerol, mezerein, and 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol, which are nonphorbol activators of PKC, also promoted actin assembly.	1,2-dioctanoylglycerol	10-32	proline rich transmembrane protein 2	Homo sapiens	143-146	
1846746-3	1991	4 beta-phorbol 12-myristate 13-acetate (PMA) and 1,2-dioctanoyl-sn-glycerol, which directly activate PKC, stimulated the synthesis of PAF.	1,2-dioctanoylglycerol	49-75	proline rich transmembrane protein 2	Homo sapiens	101-104	
3169138-5	1988	Since PK-C in SH-SY5Y cells was activated by both TPA and DiC8 it is suggested that the activation of PK-C alone is not sufficient to induce differentiation in SH-SY5Y cells.	1,2-dioctanoylglycerol	58-62	proline rich transmembrane protein 2	Homo sapiens	6-10