PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1860872-6 1991 The phosphorylation occurred at a similar dose of PMA as that which induced desensitization (half-maximal at approximately 300 nM, maximal at 500 nM to 1 microM), could be reproduced by pretreatment with the PKC activators DiC8 or phorbol 12,13-dibutyrate (PDBu), and could be blocked by the PKC inhibitors sphingosine or H-7. 1,2-dioctanoylglycerol 223-227 proline rich transmembrane protein 2 Homo sapiens 208-211 9525478-6 1998 Simultaneous addition of di-C8 and ionomycin, however, caused a significant increase in the expression of the 15/7 epitope and cell adhesion, suggesting synergy between elevating [Ca++]i and stimulating PKC in beta1 integrin activation. 1,2-dioctanoylglycerol 25-30 proline rich transmembrane protein 2 Homo sapiens 203-206 8964090-9 1996 Furthermore, acute exposure of K562 cells to known protein kinase C (PKC) activators, phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoylglycerol (DiC8), curtailed serotonin uptake by these cells. 1,2-dioctanoylglycerol 128-153 proline rich transmembrane protein 2 Homo sapiens 51-67 8964090-9 1996 Furthermore, acute exposure of K562 cells to known protein kinase C (PKC) activators, phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoylglycerol (DiC8), curtailed serotonin uptake by these cells. 1,2-dioctanoylglycerol 128-153 proline rich transmembrane protein 2 Homo sapiens 69-72 8430818-7 1993 In contrast, treatment with either TNF (1,000 U/ml for 15 min) or 1,2-dioctanoylglycerol (4 x 10(-5) M for 5 min), a diacylglycerol that activates PKC, resulted in translocation of fluorescence to the cell periphery; fine, punctate PKC-associated fluorescence was localized to the margins of cells. 1,2-dioctanoylglycerol 66-88 proline rich transmembrane protein 2 Homo sapiens 147-150 8430818-7 1993 In contrast, treatment with either TNF (1,000 U/ml for 15 min) or 1,2-dioctanoylglycerol (4 x 10(-5) M for 5 min), a diacylglycerol that activates PKC, resulted in translocation of fluorescence to the cell periphery; fine, punctate PKC-associated fluorescence was localized to the margins of cells. 1,2-dioctanoylglycerol 66-88 proline rich transmembrane protein 2 Homo sapiens 232-235 11447027-4 2001 Contraction of LES and ESO induced by the PKC agonist 1,2-dioctanoylglycerol (DG) was unaffected by MLCK inhibitors. 1,2-dioctanoylglycerol 54-76 proline rich transmembrane protein 2 Homo sapiens 42-45 8786383-3 1996 PKC was activated by: (a) exposure of cultures to 10 nM 12-o-tetradecanoyl phorbol 13-acetate (TPA); (b) microinjection of 1 mM dioctanoylglycerol (diC8) directly into perikaryal of motor neurons;(c) addition of 10 microM diC8 to culture medium. 1,2-dioctanoylglycerol 148-152 proline rich transmembrane protein 2 Homo sapiens 0-3 8786383-3 1996 PKC was activated by: (a) exposure of cultures to 10 nM 12-o-tetradecanoyl phorbol 13-acetate (TPA); (b) microinjection of 1 mM dioctanoylglycerol (diC8) directly into perikaryal of motor neurons;(c) addition of 10 microM diC8 to culture medium. 1,2-dioctanoylglycerol 222-226 proline rich transmembrane protein 2 Homo sapiens 0-3 1335820-2 1992 We have tested the hypothesis that PKC modulates Ca2+ channel activity in hippocampal neurons by conducting a detailed comparison of the effects of the diacylglycerols, diC8 and OAG, with those of the phorbol ester, PDBu, on whole-cell and single-channel Ca2+ currents. 1,2-dioctanoylglycerol 169-173 proline rich transmembrane protein 2 Homo sapiens 35-38 1370499-9 1992 Moreover, 1,2-dioctanoylglycerol, mezerein, and 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol, which are nonphorbol activators of PKC, also promoted actin assembly. 1,2-dioctanoylglycerol 10-32 proline rich transmembrane protein 2 Homo sapiens 143-146 1846746-3 1991 4 beta-phorbol 12-myristate 13-acetate (PMA) and 1,2-dioctanoyl-sn-glycerol, which directly activate PKC, stimulated the synthesis of PAF. 1,2-dioctanoylglycerol 49-75 proline rich transmembrane protein 2 Homo sapiens 101-104 3169138-5 1988 Since PK-C in SH-SY5Y cells was activated by both TPA and DiC8 it is suggested that the activation of PK-C alone is not sufficient to induce differentiation in SH-SY5Y cells. 1,2-dioctanoylglycerol 58-62 proline rich transmembrane protein 2 Homo sapiens 6-10