PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12771140-1 2003 Glucosylceramide-based glycosphingolipids have been previously demonstrated to regulate negatively the formation of inositol 1,4,5-trisphosphate by phospholipase C-gamma1. Inositol 1,4,5-Trisphosphate 116-144 phospholipase C gamma 1 Homo sapiens 148-170 12682243-7 2003 Finally, analogs that mimic the actions of diacylglycerol and inositol 1,4,5-triphosphate, the immediate products of PLCgamma-1 activity, restored integrin avidity modulation and IL-2 production by anergic T cells. Inositol 1,4,5-Trisphosphate 62-89 phospholipase C gamma 1 Homo sapiens 117-127 11956293-2 2002 Here we show that calcium/calcineurin-dependent activation of nuclear factor of activated T cells (NFAT) by Nef in Jurkat T cells requires the endoplasmic reticulum-resident inositol trisphosphate receptor (IP(3)R), but yet does not involve increase in phospholipase-C gamma 1 (PLC gamma 1)-catalyzed production of IP(3) or depletion of IP(3)-regulated intracellular calcium stores. Inositol 1,4,5-Trisphosphate 207-212 phospholipase C gamma 1 Homo sapiens 278-289 11956293-2 2002 Here we show that calcium/calcineurin-dependent activation of nuclear factor of activated T cells (NFAT) by Nef in Jurkat T cells requires the endoplasmic reticulum-resident inositol trisphosphate receptor (IP(3)R), but yet does not involve increase in phospholipase-C gamma 1 (PLC gamma 1)-catalyzed production of IP(3) or depletion of IP(3)-regulated intracellular calcium stores. Inositol 1,4,5-Trisphosphate 207-212 phospholipase C gamma 1 Homo sapiens 253-276 10419537-3 1999 Here we show that the increased chemotaxis correlates with increased activation of phospholipase C-gamma1 (PLC-gamma1), measured as inositol-1,4, 5-trisphosphate release. Inositol 1,4,5-Trisphosphate 132-161 phospholipase C gamma 1 Homo sapiens 83-105 11823862-1 2002 Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. Inositol 1,4,5-Trisphosphate 112-140 phospholipase C gamma 1 Homo sapiens 0-23 11048639-2 2000 IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-gamma1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. Inositol 1,4,5-Trisphosphate 0-3 phospholipase C gamma 1 Homo sapiens 155-165 10672930-1 1999 Phospholipase C-gamma1 (PLC-gamma1) is a lipase that hydrolyzes PIP2 to generate two second messengers, IP3 and DAG. Inositol 1,4,5-Trisphosphate 104-107 phospholipase C gamma 1 Homo sapiens 0-22 10672930-1 1999 Phospholipase C-gamma1 (PLC-gamma1) is a lipase that hydrolyzes PIP2 to generate two second messengers, IP3 and DAG. Inositol 1,4,5-Trisphosphate 104-107 phospholipase C gamma 1 Homo sapiens 24-34 11823862-1 2002 Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. Inositol 1,4,5-Trisphosphate 112-140 phospholipase C gamma 1 Homo sapiens 25-36 10700379-1 2000 Phospholipase C-gamma1 is a tightly regulated, multidomain protein that generates the second messengers inositol 1,4,5-trisphosphate and diacylglycerol. Inositol 1,4,5-Trisphosphate 104-132 phospholipase C gamma 1 Homo sapiens 0-22 10419537-3 1999 Here we show that the increased chemotaxis correlates with increased activation of phospholipase C-gamma1 (PLC-gamma1), measured as inositol-1,4, 5-trisphosphate release. Inositol 1,4,5-Trisphosphate 132-161 phospholipase C gamma 1 Homo sapiens 107-117 9293962-5 1997 The bradykinin-induced tyrosine phosphorylation of PLC-gamma1 was relatively transient and was associated with an increase in intracellular levels of IP3. Inositol 1,4,5-Trisphosphate 150-153 phospholipase C gamma 1 Homo sapiens 51-61 10100621-4 1999 This tyrosine phosphorylation of PLC-gamma1 caused the increment of the intracellular inositol triphosphate (IP3) levels in L6 myoblasts. Inositol 1,4,5-Trisphosphate 109-112 phospholipase C gamma 1 Homo sapiens 33-43 10373546-8 1999 Hence, when assayed under physiological conditions necessary to achieve a rapid biological response (Ca2+ mobilization and IP3 formation), both SH2 domains of PLC-gamma1 are essential to growth factor responsiveness. Inositol 1,4,5-Trisphosphate 123-126 phospholipase C gamma 1 Homo sapiens 159-169 7822789-5 1995 The substrate for PLC gamma 1, phosphatidylinositol 4,5-bisphosphate (PIP2), is hydrolyzed to the protein kinase C activator diacylglycerol and inositol 1,4,5-triphosphate (IP3), which promotes calcium release from the endoplasmic reticulum. Inositol 1,4,5-Trisphosphate 144-171 phospholipase C gamma 1 Homo sapiens 18-29 9226298-2 1997 This increase in [Ca2+]i is elicited by an increase in inositol 1,4,5-trisphosphate which is the consequence of tyrosine phosphorylation and activation of phospholipase C-gamma1 as well as protein tyrosine phosphatases. Inositol 1,4,5-Trisphosphate 55-83 phospholipase C gamma 1 Homo sapiens 155-177 7487955-5 1995 Tyrosine phosphorylation of PLC gamma 1 correlated with the time- and concentration-dependent decrease in the mass of membrane phosphatidylinositol 4,5-bisphosphate (PIP2) and the increase in the epithelial concentration of inositol 1,4,5-trisphosphate (IP3). Inositol 1,4,5-Trisphosphate 224-252 phospholipase C gamma 1 Homo sapiens 28-39 7487955-5 1995 Tyrosine phosphorylation of PLC gamma 1 correlated with the time- and concentration-dependent decrease in the mass of membrane phosphatidylinositol 4,5-bisphosphate (PIP2) and the increase in the epithelial concentration of inositol 1,4,5-trisphosphate (IP3). Inositol 1,4,5-Trisphosphate 254-257 phospholipase C gamma 1 Homo sapiens 28-39 7822789-5 1995 The substrate for PLC gamma 1, phosphatidylinositol 4,5-bisphosphate (PIP2), is hydrolyzed to the protein kinase C activator diacylglycerol and inositol 1,4,5-triphosphate (IP3), which promotes calcium release from the endoplasmic reticulum. Inositol 1,4,5-Trisphosphate 173-176 phospholipase C gamma 1 Homo sapiens 18-29 8034732-12 1994 These results demonstrate that Epo induces tyrosine phosphorylation and activation of PLC-gamma 1 to produce Ins-P3 and then it mobilizes calcium from intracellular stores. Inositol 1,4,5-Trisphosphate 109-115 phospholipase C gamma 1 Homo sapiens 86-97 8034732-8 1994 The activity of PLC-gamma 1 was also investigated using inositol 1,4,5-trisphosphate (Ins-P3) as an indicator. Inositol 1,4,5-Trisphosphate 56-84 phospholipase C gamma 1 Homo sapiens 16-27 8034732-8 1994 The activity of PLC-gamma 1 was also investigated using inositol 1,4,5-trisphosphate (Ins-P3) as an indicator. Inositol 1,4,5-Trisphosphate 86-92 phospholipase C gamma 1 Homo sapiens 16-27 33792909-8 2021 PLC releases Inositol-1,4,5-trisphosphate (IP3) causing IP3-receptor (IP3R) activation and Ca2+ flux from the endoplasmic reticulum into the cytosol, which stimulates Ca2+ -release-activated-channels (CRAC)-mediated Ca2+ influx. Inositol 1,4,5-Trisphosphate 43-46 phospholipase C gamma 1 Homo sapiens 0-3 8327490-11 1993 Thus, it is likely that the Fyn kinase or other protein-tyrosine kinases may be responsible for the early tyrosine phosphorylation of phospholipase C-gamma 1, which results in inositol 1,4,5-trisphosphate release and mobilization of intracellular Ca2+. Inositol 1,4,5-Trisphosphate 176-204 phospholipase C gamma 1 Homo sapiens 134-157 31953353-2 2020 In this study, to our knowledge, we uncover that ORP5L interacts physically with PLCgamma1 in T cells, extracts PIP2 from the plasma membrane via its ORD domain (OSBP-related domain), presents it to PLCgamma1 (enabling IP3 generation), and eventually maintains intracellular Ca2+ homeostasis. Inositol 1,4,5-Trisphosphate 219-222 phospholipase C gamma 1 Homo sapiens 81-90 31953353-2 2020 In this study, to our knowledge, we uncover that ORP5L interacts physically with PLCgamma1 in T cells, extracts PIP2 from the plasma membrane via its ORD domain (OSBP-related domain), presents it to PLCgamma1 (enabling IP3 generation), and eventually maintains intracellular Ca2+ homeostasis. Inositol 1,4,5-Trisphosphate 219-222 phospholipase C gamma 1 Homo sapiens 199-208 25916191-2 2015 In T cells, the Tec family kinase, interleukin-2-induced tyrosine kinase (ITK), phosphorylates PLCgamma1 at tyrosine 783 (Y783) leading to activation of phospholipase function and subsequent production of the second messengers inositol 1,4,5-trisphosphate and diacylglycerol. Inositol 1,4,5-Trisphosphate 227-255 phospholipase C gamma 1 Homo sapiens 95-104 27759161-3 2017 Phospholipase Cgamma (PLCgamma) 1 is an important signaling molecule that generates two second messengers, diacylglycerol and inositol 1,4,5-trisphosphate, that are important to mediate PKC activation and intracellular Ca2+ flux in many signaling pathways. Inositol 1,4,5-Trisphosphate 126-154 phospholipase C gamma 1 Homo sapiens 0-33 26588873-2 2016 PLCgamma1 functions as a signal transducer that converts an extracellular stimulus into intracellular signals by generating second messengers such as DAG and IP3. Inositol 1,4,5-Trisphosphate 158-161 phospholipase C gamma 1 Homo sapiens 0-9 26633375-0 2015 DAG/PKCdelta and IP3/Ca2+/CaMK IIbeta Operate in Parallel to Each Other in PLCgamma1-Driven Cell Proliferation and Migration of Human Gastric Adenocarcinoma Cells, through Akt/mTOR/S6 Pathway. Inositol 1,4,5-Trisphosphate 17-20 phospholipase C gamma 1 Homo sapiens 75-84 26633375-2 2015 However, whether DAG/PKCdelta and IP3/Ca(2+)/CaMK IIbeta axes are simultaneously involved in PLCgamma1-driven cell proliferation and migration of human gastric adenocarcinoma cells and the underlying mechanism are not elucidated. Inositol 1,4,5-Trisphosphate 34-37 phospholipase C gamma 1 Homo sapiens 93-102 26633375-6 2015 The data indicate that DAG/PKCdelta and IP3/Ca(2+)/CaMK IIbeta operate in parallel to each other in PLCgamma1-driven cell proliferation and migration of human gastric adenocarcinoma cells through Akt/mTOR/S6 pathway, with important implication for validating PLCgamma1 as a molecular biomarker in early gastric cancer diagnosis and disease surveillance. Inositol 1,4,5-Trisphosphate 40-43 phospholipase C gamma 1 Homo sapiens 100-109 19179337-8 2009 The recruitment of PLC-gamma1 to Nephrin activated PLC-gamma1, as detected by phosphorylation of PLC-gamma1 Tyr-783 and increase in inositol 1,4,5-trisphosphate level. Inositol 1,4,5-Trisphosphate 132-160 phospholipase C gamma 1 Homo sapiens 19-29 25252913-7 2014 Ectopic expression of the PLCgamma1-R707Q mutant in endothelial cells revealed reduced PLCgamma1-Y783 phosphorylation with concomitant increased c-RAF/MEK/ERK1/2 phosphorylation, increased IP3 amounts, and increased Ca(2+)-dependent calcineurin activation compared with ectopic expressed PLCgamma1-wild-type. Inositol 1,4,5-Trisphosphate 189-192 phospholipase C gamma 1 Homo sapiens 26-35 24866019-5 2014 Inositol 1,4,5-trisphosphate (IP3), generated by PLCgamma1 in response to pressure, sensitized IP3 receptors (IP3Rs) to Ca(2+) influx mediated by the mechanosensitive TRPC6 channel, synergistically increasing IP3R-mediated Ca(2+) release to activate TRPM4 currents, leading to smooth muscle depolarization and constriction of isolated cerebral arteries. Inositol 1,4,5-Trisphosphate 0-28 phospholipase C gamma 1 Homo sapiens 49-58 24866019-5 2014 Inositol 1,4,5-trisphosphate (IP3), generated by PLCgamma1 in response to pressure, sensitized IP3 receptors (IP3Rs) to Ca(2+) influx mediated by the mechanosensitive TRPC6 channel, synergistically increasing IP3R-mediated Ca(2+) release to activate TRPM4 currents, leading to smooth muscle depolarization and constriction of isolated cerebral arteries. Inositol 1,4,5-Trisphosphate 30-33 phospholipase C gamma 1 Homo sapiens 49-58 19179337-8 2009 The recruitment of PLC-gamma1 to Nephrin activated PLC-gamma1, as detected by phosphorylation of PLC-gamma1 Tyr-783 and increase in inositol 1,4,5-trisphosphate level. Inositol 1,4,5-Trisphosphate 132-160 phospholipase C gamma 1 Homo sapiens 51-61 19179337-8 2009 The recruitment of PLC-gamma1 to Nephrin activated PLC-gamma1, as detected by phosphorylation of PLC-gamma1 Tyr-783 and increase in inositol 1,4,5-trisphosphate level. Inositol 1,4,5-Trisphosphate 132-160 phospholipase C gamma 1 Homo sapiens 51-61 17531443-1 2007 Phospholipase C-gamma1 (PLC-gamma1), which generates two second messengers, namely, inositol-1, 4, 5-trisphosphate and diacylglycerol, is implicated in growth factor-mediated chemotaxis. Inositol 1,4,5-Trisphosphate 84-114 phospholipase C gamma 1 Homo sapiens 0-22 17531443-1 2007 Phospholipase C-gamma1 (PLC-gamma1), which generates two second messengers, namely, inositol-1, 4, 5-trisphosphate and diacylglycerol, is implicated in growth factor-mediated chemotaxis. Inositol 1,4,5-Trisphosphate 84-114 phospholipase C gamma 1 Homo sapiens 24-34