PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19056636-2 2009 In cells, holocarboxylase synthetase (HCS) mediates covalent binding of biotin to histones; biotinylation of lysine-12 in histone H4 (K12BioH4) causes gene repression. k12bioh4 134-142 holocarboxylase synthetase Homo sapiens 10-36 19056636-2 2009 In cells, holocarboxylase synthetase (HCS) mediates covalent binding of biotin to histones; biotinylation of lysine-12 in histone H4 (K12BioH4) causes gene repression. k12bioh4 134-142 holocarboxylase synthetase Homo sapiens 38-41 19056636-6 2009 The nuclear translocation of HCS correlated with biotin concentrations in cell culture media; the relative enrichment of both HCS and K12BioH4 at SMVT promoter 1 (but not promoter 2) increased by 91% in cells cultured in medium containing 10 nmol/L biotin compared with 0.25 nmol/L biotin. k12bioh4 134-142 holocarboxylase synthetase Homo sapiens 29-32