PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26714634-9	2015	LPS interaction with TLR4 activates downstream mitogen-activated protein kinase and nuclear factor-kappaB signalling pathways and subsequently causes inflammatory mediator production.	lps	0-3	toll-like receptor 4	Rattus norvegicus	21-25	
26714634-8	2015	LPS, zymosan and poly(I:C) all down-regulated TLR4 messenger RNA (mRNA) and up-regulated TLR2 mRNA at 6 and 24 h. In spite of their inability to elaborate pro-inflammatory mediator output, the nominally microglia-free astrocytes (>99 % purity) also showed similar behaviours to those of microglia, as well as changes in TLR3 gene expression.	lps	0-3	toll-like receptor 4	Rattus norvegicus	46-50	
22685683-11	2012	Preconditioning of newborn rats with LPS increased TLR4, Caspase-9 and -3 levels, but failed to affect basal expression of HSP60, Bax, and Bcl-2.	lps	37-40	toll-like receptor 4	Rattus norvegicus	51-55	
33551748-10	2020	In conclusion, this study provides a basis for future research to better understand the molecular mechanism underlying LPS pre-conditioning /TLR4 pre-activation and its functional role in offering cytoprotective response in neuronal environment.	lps	119-122	toll-like receptor 4	Rattus norvegicus	141-145	
16631199-2	2006	Toll-Like receptor 4 (TLR-4) has been implicated as the proximal transmembrane receptor for the LPS/CD 14 complex during the activation of lipopolysacharide (LPS)-induced sepsis.	lps	96-99	toll-like receptor 4	Rattus norvegicus	0-20	
16631199-2	2006	Toll-Like receptor 4 (TLR-4) has been implicated as the proximal transmembrane receptor for the LPS/CD 14 complex during the activation of lipopolysacharide (LPS)-induced sepsis.	lps	96-99	toll-like receptor 4	Rattus norvegicus	22-27	
16631199-2	2006	Toll-Like receptor 4 (TLR-4) has been implicated as the proximal transmembrane receptor for the LPS/CD 14 complex during the activation of lipopolysacharide (LPS)-induced sepsis.	lps	158-161	toll-like receptor 4	Rattus norvegicus	0-20	
16631199-2	2006	Toll-Like receptor 4 (TLR-4) has been implicated as the proximal transmembrane receptor for the LPS/CD 14 complex during the activation of lipopolysacharide (LPS)-induced sepsis.	lps	158-161	toll-like receptor 4	Rattus norvegicus	22-27	
16631199-3	2006	It is our hypothesis that TLR-4 is present on lung pericytes and is up-regulated in response to LPS.	lps	96-99	toll-like receptor 4	Rattus norvegicus	26-31	
16631199-8	2006	An increase in the mRNA was observed in CD-14, TLR-2, and TLR-4 in the presence of increasing LPS 4 h after treatment.	lps	94-97	toll-like receptor 4	Rattus norvegicus	58-63	
16631199-10	2006	CONCLUSIONS: The up-regulation of TLR-4 in the presence of increasing LPS suggests its importance in pericyte LPS-induced activation.	lps	70-73	toll-like receptor 4	Rattus norvegicus	34-39	
16631199-10	2006	CONCLUSIONS: The up-regulation of TLR-4 in the presence of increasing LPS suggests its importance in pericyte LPS-induced activation.	lps	110-113	toll-like receptor 4	Rattus norvegicus	34-39	
16631199-11	2006	Pericyte TLR-4 recognition of LPS could play a role in capillary leak seen in sepsis.	lps	30-33	toll-like receptor 4	Rattus norvegicus	9-14	
30610044-3	2018	This study was conducted to investigate whether BMSCs could alleviate the inflammation reaction in lipopolysaccaride (LPS)-induced acute kidney injury (septic-AKI) of rats via inhibition of toll-like receptors (TLR4)-nuclear factor-kappa B (NF-kappaB) signaling pathway.	lps	118-121	toll-like receptor 4	Rattus norvegicus	211-239	
30610044-6	2018	Results showed that LPS treatment caused the increases of the concentration of blood urea nitrogen (BUN) and serum creatinine (SCr), accompanied by tissue injury and the up-regulation of TLR4 and NF-kappaB, that was its key downstream signaling molecule, in both mRNA and protein level.	lps	20-23	toll-like receptor 4	Rattus norvegicus	187-191