PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25372509-2 2014 The hydride reductions of a cis-2,6-disubstituted N-acylpiperidone, an N-acyltropinone, and tert-butylcyclohexanone by lithium aluminum hydride and by a bulky borohydride reagent were investigated computationally and compared to experiment. lithium aluminum hydride 119-143 suppressor of cytokine signaling 2 Homo sapiens 28-33 25372509-4 2014 In particular, we have calculated that a twist-boat conformation is relevant to the reactivity and facial selectivity of hydride reduction of cis-2,6-disubstituted N-acylpiperidones with a small hydride reagent (LiAlH4) but not with a bulky hydride (lithium triisopropylborohydride). lithium aluminum hydride 212-218 suppressor of cytokine signaling 2 Homo sapiens 142-147