PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22306083-2	2012	17beta-Estradiol (E2) in primary rat pachytene spermatocytes (PS) binds estrogen receptor alpha (ESR1) and GPER to activate EGFR/ERK/c-Jun pathway leading to up regulation of proapoptotic factor bax.	Estradiol	0-16	epidermal growth factor receptor	Rattus norvegicus	124-128	
31648182-5	2020	Moreover, 17beta-estradiol and HB-EGF treatments restored hippocampal EGFR activation and alleviated downstream autophagy process and neuronal loss in OVX rats.	Estradiol	10-26	epidermal growth factor receptor	Rattus norvegicus	70-74	
1313194-4	1992	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), which exhibits a broad spectrum of antiestrogenic effects in the female rat uterus, inhibited the 17 beta-estradiol-induced increase in uterine wet weights, cytosolic and nuclear ER and PR levels, peroxidase activity, and EGF receptor binding activity.	Estradiol	145-159	epidermal growth factor receptor	Rattus norvegicus	266-278	
1949047-2	1991	Treatment of the animals with 17 beta-estradiol (0.33 mumol/kg X 2) caused an increase in uterine cytosolic and nuclear estrogen and progesterone receptor levels, uterine peroxidase activity, uterine wet weights and uterine epidermal growth factor (EGF) receptor binding activity and steady state EGF receptor mRNA levels.	Estradiol	30-47	epidermal growth factor receptor	Rattus norvegicus	224-262	
1949047-2	1991	Treatment of the animals with 17 beta-estradiol (0.33 mumol/kg X 2) caused an increase in uterine cytosolic and nuclear estrogen and progesterone receptor levels, uterine peroxidase activity, uterine wet weights and uterine epidermal growth factor (EGF) receptor binding activity and steady state EGF receptor mRNA levels.	Estradiol	30-47	epidermal growth factor receptor	Rattus norvegicus	297-309	
2289633-0	1990	2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17 beta-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression.	Estradiol	53-67	epidermal growth factor receptor	Rattus norvegicus	101-133	
2289633-1	1990	Treatment of immature female Sprague-Dawley rats with 17 beta-estradiol (5 micrograms/animal) resulted in an increase in uterine epidermal growth factor (EGF) receptor binding activity.	Estradiol	54-71	epidermal growth factor receptor	Rattus norvegicus	129-167	
2289633-2	1990	Moreover, in a separate study it was also shown that 17 beta-estradiol increased steady-state levels of rat uterine EGF receptor mRNA as determined by Northern analysis.	Estradiol	53-70	epidermal growth factor receptor	Rattus norvegicus	116-128	
2289633-4	1990	Cotreatment of the animals with both TCDD (16 nmol/kg) and 17 beta-estradiol (5 micrograms/rat) gave results which showed that TCDD significantly inhibited the estrogen-induced increases in rat uterine EGF receptor binding activity and EGF receptor mRNA levels.	Estradiol	59-76	epidermal growth factor receptor	Rattus norvegicus	202-214	
2289633-4	1990	Cotreatment of the animals with both TCDD (16 nmol/kg) and 17 beta-estradiol (5 micrograms/rat) gave results which showed that TCDD significantly inhibited the estrogen-induced increases in rat uterine EGF receptor binding activity and EGF receptor mRNA levels.	Estradiol	59-76	epidermal growth factor receptor	Rattus norvegicus	236-248	
22332115-2	2011	17beta-estradiol activates Sertoli cell proliferation in immature rats by a mechanism that involves the translocation of the estrogen receptors ESR1 and ESR2 to the plasma membrane, phosphorylation of epidermal growth factor receptor and activation of mitogen-activated protein kinase 3/1.	Estradiol	0-16	epidermal growth factor receptor	Rattus norvegicus	201-233