PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24269736-3 2014 This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid. Estradiol 53-55 proopiomelanocortin Homo sapiens 64-68 24573184-0 2014 Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsatile ACTH secretion and ACTH approximate entropy in unstressed older men and women. Estradiol 0-9 proopiomelanocortin Homo sapiens 92-96 24573184-2 2014 We postulated that testosterone (T) in men and estradiol (E2) in women govern unstressed cortisol-mediated negative feedback on ACTH secretion. Estradiol 47-56 proopiomelanocortin Homo sapiens 128-132 18308488-8 2009 The interval between the peaks of oestradiol and LH to ovulation was prolonged in the ACTH group compared to the C group (p<0.05), with a tendency towards an earlier decline of oestradiol in the ACTH group. Estradiol 34-44 proopiomelanocortin Homo sapiens 86-90 18308488-8 2009 The interval between the peaks of oestradiol and LH to ovulation was prolonged in the ACTH group compared to the C group (p<0.05), with a tendency towards an earlier decline of oestradiol in the ACTH group. Estradiol 180-190 proopiomelanocortin Homo sapiens 86-90 18308488-8 2009 The interval between the peaks of oestradiol and LH to ovulation was prolonged in the ACTH group compared to the C group (p<0.05), with a tendency towards an earlier decline of oestradiol in the ACTH group. Estradiol 180-190 proopiomelanocortin Homo sapiens 198-202 12072043-10 2002 Oestradiol also attenuated mental stress-induced increases in ACTH, cortisol and adrenaline, but did not influence either total body or forearm spillover of noradrenaline. Estradiol 0-10 proopiomelanocortin Homo sapiens 62-66 15673970-9 2005 Elevated plasma estradiol was apparently related to the increase in plasma ACTH and played a major role in excessive growth in this patient. Estradiol 16-25 proopiomelanocortin Homo sapiens 75-79 16648815-0 2006 ACTH-cortisol activity during the 17beta-estradiol and LH preovulatory surges of the menstrual cycle. Estradiol 34-50 proopiomelanocortin Homo sapiens 0-4 9824829-3 1998 Thus, the mean circadian level of melatonin, by determining the manner and rapidity of proopiomelanocortin (POMC) cleavage, would also determine the mean proopiomelanocortin (POMC) level, maintained in dynamic equilibrium as a result of the simultaneous influence of testosterone, estradiol and cortisol on the intensity of POMC mRNA synthesis. Estradiol 281-290 proopiomelanocortin Homo sapiens 154-173 12018035-3 2002 In general, estradiol and testosterone exert a stimulatory, progesterone an inhibitory effect on neuronal activities which are mediated by excitatory (e.g. glutamate, aspartate), and inhibitory amino acids (e.g. GABA) and neuropeptides (e.g. beta-endorphin), respectively. Estradiol 12-21 proopiomelanocortin Homo sapiens 242-256 10887750-1 2000 In order to elucidate the effect of stress on reproductive hormones, the present study was designed to investigate the effect of adrenocorticotropic hormone (ACTH) on the plasma levels of cortisol, progesterone, oestradiol-17 beta and prostaglandin F2 alpha metabolite in ovariectomized gilts. Estradiol 212-230 proopiomelanocortin Homo sapiens 129-156 10887750-1 2000 In order to elucidate the effect of stress on reproductive hormones, the present study was designed to investigate the effect of adrenocorticotropic hormone (ACTH) on the plasma levels of cortisol, progesterone, oestradiol-17 beta and prostaglandin F2 alpha metabolite in ovariectomized gilts. Estradiol 212-230 proopiomelanocortin Homo sapiens 158-162 10887750-9 2000 It can be concluded that the administration of ACTH to ovariectomized gilts, results in the elevation of cortisol, progesterone and prostaglandin F2 alpha metabolite but not of oestradiol-17 beta. Estradiol 177-195 proopiomelanocortin Homo sapiens 47-51 11451621-7 2001 A positive correlation was obtained between 17 beta-estradiol and ACTH (r=0.48), estradiol and cortisol (r=0.52) as well as estradiol and DHEA-S (r=0.60). Estradiol 44-61 proopiomelanocortin Homo sapiens 66-70 11451621-7 2001 A positive correlation was obtained between 17 beta-estradiol and ACTH (r=0.48), estradiol and cortisol (r=0.52) as well as estradiol and DHEA-S (r=0.60). Estradiol 52-61 proopiomelanocortin Homo sapiens 66-70 11415991-7 2001 Both the ACTH response, over time, and the area under the ACTH response curve were significantly higher in the E(2)-treated animals (P < 0.05). Estradiol 111-115 proopiomelanocortin Homo sapiens 9-13 11415991-7 2001 Both the ACTH response, over time, and the area under the ACTH response curve were significantly higher in the E(2)-treated animals (P < 0.05). Estradiol 111-115 proopiomelanocortin Homo sapiens 58-62 11341305-10 2001 However, a linear regression analysis revealed that the increase of ACTH in relation to cortisol depends on serum free testosterone in men (p=0.042) and on serum free 17 beta-estradiol (p<0.001) together with serum IL-6 in women (p=0.021). Estradiol 170-184 proopiomelanocortin Homo sapiens 68-72 10368794-12 1999 Serum estradiol, estrone, GH and plasma beta-endorphin levels significantly increased progressively for the three months of treatment, with higher levels for estrone and estradiol in subjects receiving estradiol alone or plus DHEAS. Estradiol 170-179 proopiomelanocortin Homo sapiens 40-54 10368794-12 1999 Serum estradiol, estrone, GH and plasma beta-endorphin levels significantly increased progressively for the three months of treatment, with higher levels for estrone and estradiol in subjects receiving estradiol alone or plus DHEAS. Estradiol 170-179 proopiomelanocortin Homo sapiens 40-54 10022424-5 1999 After supplementation with estradiol, the increases in both systolic and diastolic blood pressure in response to mental stress were reduced, and cortisol, ACTH, plasma epinephrine and norepinephrine, and total body norepinephrine spillover responses to stress were significantly attenuated (P < 0.05 in each case). Estradiol 27-36 proopiomelanocortin Homo sapiens 155-159 9824829-3 1998 Thus, the mean circadian level of melatonin, by determining the manner and rapidity of proopiomelanocortin (POMC) cleavage, would also determine the mean proopiomelanocortin (POMC) level, maintained in dynamic equilibrium as a result of the simultaneous influence of testosterone, estradiol and cortisol on the intensity of POMC mRNA synthesis. Estradiol 281-290 proopiomelanocortin Homo sapiens 175-179 9824829-3 1998 Thus, the mean circadian level of melatonin, by determining the manner and rapidity of proopiomelanocortin (POMC) cleavage, would also determine the mean proopiomelanocortin (POMC) level, maintained in dynamic equilibrium as a result of the simultaneous influence of testosterone, estradiol and cortisol on the intensity of POMC mRNA synthesis. Estradiol 281-290 proopiomelanocortin Homo sapiens 175-179 8855815-2 1996 The present study investigated how a short term elevation of estradiol levels affects ACTH, cortisol, norepinephrine, and heart rate responses to mental stress in healthy men. Estradiol 61-70 proopiomelanocortin Homo sapiens 86-90 9578512-3 1998 The effects of a sudden drop in estradiol levels on basal and CRH-stimulated levels of ACTH, cortisol, testosterone, androstenedione and 17-hydroxyprogesterone (17-OHP) were assessed in nine premenopausal women (44-48 years of age), before and after ovariectomy. Estradiol 32-41 proopiomelanocortin Homo sapiens 87-91 9408882-0 1997 Influence of estradiol and androstenedione on ACTH and cortisol secretion in the ovine fetus. Estradiol 13-22 proopiomelanocortin Homo sapiens 46-50 9002999-1 1997 Reported studies using the conventional pituitary cell culture technique suggest that beta-endorphin (B-EP) produced locally in the pituitary or reaching it from the hypothalamus acts in conjunction with estradiol (E2) to initiate and in conjunction with progesterone (P4) to terminate the midcycle surge of LH. Estradiol 204-213 proopiomelanocortin Homo sapiens 86-100 9002999-1 1997 Reported studies using the conventional pituitary cell culture technique suggest that beta-endorphin (B-EP) produced locally in the pituitary or reaching it from the hypothalamus acts in conjunction with estradiol (E2) to initiate and in conjunction with progesterone (P4) to terminate the midcycle surge of LH. Estradiol 204-213 proopiomelanocortin Homo sapiens 102-106 8855815-6 1996 However, the estradiol-treated subjects showed exaggerated peak ACTH (P < 0.001) and cortisol (P < 0.002) responses compared to the placebo group. Estradiol 13-22 proopiomelanocortin Homo sapiens 64-68 8093438-0 1993 Estradiol is selectively neurotoxic to hypothalamic beta-endorphin neurons. Estradiol 0-9 proopiomelanocortin Homo sapiens 52-66 7732806-9 1995 Furthermore, ACTH also significantly stimulated 17 beta-estradiol production. Estradiol 48-65 proopiomelanocortin Homo sapiens 13-17 8345057-4 1993 This is the first description of estradiol stimulation of cortisol production by cultured adrenal cells in ACTH-independent Cushing"s syndrome. Estradiol 33-42 proopiomelanocortin Homo sapiens 107-111 8218628-2 1993 In addition to its multiple physiological actions, we have shown that estradiol is also selectively cytotoxic to beta-endorphin neurons in the hypothalamic arcuate nucleus. Estradiol 70-79 proopiomelanocortin Homo sapiens 113-127 8218628-4 1993 The estradiol-induced loss of beta-endorphin neurons engenders a compensatory increment in mu opioid binding in the medial preoptic area rendering this region supersensitive to residual beta-endorphin or to other endogenous opioids. Estradiol 4-13 proopiomelanocortin Homo sapiens 30-44 8218628-4 1993 The estradiol-induced loss of beta-endorphin neurons engenders a compensatory increment in mu opioid binding in the medial preoptic area rendering this region supersensitive to residual beta-endorphin or to other endogenous opioids. Estradiol 4-13 proopiomelanocortin Homo sapiens 186-200 8300812-9 1993 Seven women with ovarian suppression (oestradiol concentration < 175 pmol/l by day 28) had consistently lower mean ACTH concentrations at all time points than the four remaining women who had oestradiol concentrations 222-880 pmol/l by day 28. Estradiol 38-48 proopiomelanocortin Homo sapiens 118-122 8093438-2 1993 Eight weeks after EV treatment, a 60% decrease in the total number of beta-endorphin-immunoreactive neurons was detected in the arcuate nucleus. Estradiol 18-20 proopiomelanocortin Homo sapiens 70-84 8093438-8 1993 The evidence indicates that the selective neurotoxic effect of estradiol on hypothalamic beta-endorphin neurons contributes to reproductive senescence, suggesting that steroids may participate in disruption of the biological functions that they normally facilitate. Estradiol 63-72 proopiomelanocortin Homo sapiens 89-103 2164934-6 1990 Transdermal estradiol raised serum estradiol levels, blunted the time to peak plasma concentration of LH to LHRH and produced a normal response to ACTH. Estradiol 12-21 proopiomelanocortin Homo sapiens 147-151 1369589-16 1992 Levels of POMC mRNA in the MBH were increased (p < 0.01) by both estradiol and progesterone as compared with the no steroid group. Estradiol 68-77 proopiomelanocortin Homo sapiens 10-14 1639959-15 1992 In conclusion, our data demonstrate that the release of IR-beta END from Ishikawa cells in culture is inhibited by estradiol and dexamethasone, suggesting that endometrial beta END is under estrogen and glucocorticoid regulation, as is the case with hypothalamic and pituitary POMC-derived peptides. Estradiol 115-124 proopiomelanocortin Homo sapiens 277-281 1756018-6 1991 Oestradiol and progesterone increase beta-endorphin concentrations in the luteal phase of the menstrual cycle, and this is followed by a rapid fall at menstruation. Estradiol 0-10 proopiomelanocortin Homo sapiens 37-51 1425446-0 1992 Vitamin E protects hypothalamic beta-endorphin neurons from estradiol neurotoxicity. Estradiol 60-69 proopiomelanocortin Homo sapiens 32-46 1425446-1 1992 Estradiol valerate (EV) treatment has been shown to result in the destruction of 60% of beta-endorphin neurons in the hypothalamic arcuate nucleus. Estradiol 0-18 proopiomelanocortin Homo sapiens 88-102 1425446-1 1992 Estradiol valerate (EV) treatment has been shown to result in the destruction of 60% of beta-endorphin neurons in the hypothalamic arcuate nucleus. Estradiol 20-22 proopiomelanocortin Homo sapiens 88-102 1688992-6 1990 Finally, circulating steroids regulate the hypothalamic POMC system with testosterone stimulating POMC gene expression whilst oestradiol and glucocorticoids induce an inhibitory control. Estradiol 126-136 proopiomelanocortin Homo sapiens 56-60 2848074-6 1988 In contrast to 1,25(OH)2D3, alpha-MSH at a concentration of 5 X 10(-7) M caused a sevenfold increase in intracellular cAMP after 12 min but only a modest increase (less than 20%) in melanocyte tyrosinase activity after 48 h. Incubation with beta-estradiol for 24 h caused a dose-dependent increase in tyrosinase activity. Estradiol 241-255 proopiomelanocortin Homo sapiens 28-37 3018717-1 1986 We have studied the possible function of the placental adrenocorticotrophic hormone-(ACTH-) like substance (PALS) in placental steroidogenesis by measuring oestradiol (E2) and progesterone (P4) in term human placental explants incubated with commercially available porcine ACTH I-39. Estradiol 156-166 proopiomelanocortin Homo sapiens 85-89 3026229-0 1986 [Adrenal reactivity to prolonged-action ACTH in hirsute women treated with 50 mg of cyproterone acetate combined with percutaneous estradiol]. Estradiol 131-140 proopiomelanocortin Homo sapiens 40-44 6288755-3 1982 After acute iv administration of estradiol (2 micrograms), beta-EP did not rise from previously low levels (less than 133 pg/ml) over the ensuing 3 h. After chronic estradiol replacement for 3 weeks, portal beta-EP was detectable in 2 of 4 ovariectomized monkeys, with peak values of 341 and 733 pg/ml, respectively. Estradiol 33-42 proopiomelanocortin Homo sapiens 59-66 2936246-4 1986 The amenorrhea group showed higher mean (+/- SE) resting levels of immunoreactive beta-endorphin (11.0 +/- 0.8 versus 8.3 +/- 0.6 pg/ml, p less than 0.05) and cortisol (274 +/- 35 versus 134 +/- 14 nmol/L, p less than 0.001) and lower mean resting levels of prolactin (2.4 +/- 0.3 versus 5.7 +/- 1.1 ng/ml, p less than 0.01), luteinizing hormone (4.0 +/- 0.7 versus 10.5 +/- 1.8 IU/L, p less than 0.01), and estradiol (0.09 +/- 0.01 versus 0.19 +/- 0.07 nmol/L, p less than 0.05) than the control group. Estradiol 408-417 proopiomelanocortin Homo sapiens 82-96 6098492-3 1984 The release of beta-endorphin from these hypothalamic neurons is influenced by gonadal steroids, maximal release being observed when both estradiol and progesterone are present. Estradiol 138-147 proopiomelanocortin Homo sapiens 15-29 6288755-3 1982 After acute iv administration of estradiol (2 micrograms), beta-EP did not rise from previously low levels (less than 133 pg/ml) over the ensuing 3 h. After chronic estradiol replacement for 3 weeks, portal beta-EP was detectable in 2 of 4 ovariectomized monkeys, with peak values of 341 and 733 pg/ml, respectively. Estradiol 33-42 proopiomelanocortin Homo sapiens 207-214 218416-0 1979 Response of plasma non-conjugated oestradiol to manipulated adrenal function by ACTH and dexamethasone. Estradiol 34-44 proopiomelanocortin Homo sapiens 80-84 6261922-5 1981 Most produce ACTH and all evaluated so far produce estradiol. Estradiol 51-60 proopiomelanocortin Homo sapiens 13-17 218416-4 1979 During the application of ACTH free oestradiol increased from 21.3 +/- 5.7 to 25.5 +/- 7.1 ng/ml (P less than 0.025) in the patients without dexamethasone. Estradiol 36-46 proopiomelanocortin Homo sapiens 26-30 218416-7 1979 The patients receiving dexamethasone exhibited during ACTH-infusion a rise of oestradiol from 3.8 +/- 1.9 to 7.8 +/- 3.1 ng/ml (P less than 0.001). Estradiol 78-88 proopiomelanocortin Homo sapiens 54-58 35343-5 1979 Leu-enkephalin, dopamine, prostaglandin E1 and E2 slightly reduced the release of ACTH induced by HY-CRF, but the inhibitory effect of these substances were not dose-related. Estradiol 47-49 proopiomelanocortin Homo sapiens 82-86 177438-5 1976 ACTH increased all plasma steroid levels except estradiol, whereas after dexamethasone, all sex hormone levels were significantly decreased. Estradiol 48-57 proopiomelanocortin Homo sapiens 0-4 191557-4 1977 The increase in ACTH release induced by hypothalamic extract of vasopressin was reduced by corticossterone, cortisol or progesterone but not by testosterone or oestradiol, but the increase in pituitary ACTH content was not affected by any of these steroids. Estradiol 160-170 proopiomelanocortin Homo sapiens 16-20 164093-2 1975 Response of oestradiol, oestrone, testosterone and cortisol to dexamethasone and ACTH administration. Estradiol 12-22 proopiomelanocortin Homo sapiens 81-85 4324509-0 1969 [Effect of testosterone, estradiol, progesterone, and their derivatives on the release of ACTH]. Estradiol 25-34 proopiomelanocortin Homo sapiens 90-94 13391521-0 1956 Antagonism of glucocorticoids and ACTH on estradiol 17beta induced uterine growth. Estradiol 42-58 proopiomelanocortin Homo sapiens 34-38 31827460-4 2019 It seemed that alteration of estradiol levels influenced ACTH and cortisol levels via some pathway. Estradiol 29-38 proopiomelanocortin Homo sapiens 57-61 27523914-5 2016 Biochemistry demonstrated corticotropin (ACTH)-independent CS (cortisol=1900ng/mL (n=50-250), ACTH<10pg/mL (n=20-46)) with estradiol and testosterone overproduction. Estradiol 126-135 proopiomelanocortin Homo sapiens 41-45