PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24903198-13 2014 In the patient population prolactin levels were inversely associated with age, smoking status, waist circumference, total cholesterol, triglyceride and low-density lipoprotein (LDL) and positively associated with high-density lipoprotein, estradiol, total testosterone, dehydroepiandrosterone sulfate, 17-hydroxyprogesterone and cortisol levels. Estradiol 239-248 prolactin Homo sapiens 26-35 29708436-0 2018 PROLACTIN LEVELS DO NOT RISE AMONG TRANSGENDER WOMEN TREATED WITH ESTRADIOL AND SPIRONOLACTONE. Estradiol 66-75 prolactin Homo sapiens 0-9 26921057-6 2016 The estradiol level correlated negatively with serum prolactin level both in the treatment group and the control group at the end of the 8th week and the 4th week respectively. Estradiol 4-13 prolactin Homo sapiens 53-62 26691151-3 2016 We found that GH3 cell lines stably expressing Luc under control of the ERE-mutated hPRL promoter (ERE-Mut) displayed a dramatically reduced transcriptional response to 17beta-estradiol (E2) treatment compared with cells expressing Luc from the wild-type (WT) ERE hPRL-Luc promoter (ERE-WT). Estradiol 169-185 prolactin Homo sapiens 84-88 26753478-4 2015 RESULTS: They found a correlation between serum PRL concentration and result of M. Hamilton depression scale (R = 0.21; p = 0.005) and a between serum PRL concentration and serum 17beta-estradiol concentration (R = 0.21; p = 0.003). Estradiol 179-195 prolactin Homo sapiens 151-154 25993525-4 2015 We therefore investigated the contribution of central PRL/PRLR signaling to the control of estradiol-induced surges of LH and PRL and pulsatile LH secretion under basal and hyperprolactinemic conditions. Estradiol 91-100 prolactin Homo sapiens 54-57 24903198-14 2014 In multiple regression analyses, prolactin was inversely associated with LDL and positively associated with estradiol, 17-hydroxyprogesterone and cortisol after correcting for age, BMI and smoking status in patients with PCOS. Estradiol 108-117 prolactin Homo sapiens 33-42 20929122-7 2010 Besides, the level of PRL was positively correlated with LH and E2 levels in patients. Estradiol 64-66 prolactin Homo sapiens 22-25 24888527-6 2014 Moreover, prolactin was negatively correlated with estradiol and testosterone in the group of all male subjects and the male patients. Estradiol 51-60 prolactin Homo sapiens 10-19 20601496-4 2010 Several recent studies indicated that PRL action in vivo may be influenced by the hormonal milieu, e.g. other growth factors such as 17beta-oestradiol (E(2)). Estradiol 133-150 prolactin Homo sapiens 38-41 23973924-3 2013 In addition, the role of 17beta-estradiol as a possible modulator of LPS-induced PRL cell proliferation was further investigated. Estradiol 25-41 prolactin Homo sapiens 81-84 23397510-12 2013 In all 74 individuals, prolactin correlated inversely with age (p < 0.0001) and directly with serum estradiol (p = 0.018). Estradiol 103-112 prolactin Homo sapiens 23-32 23581407-5 2013 It was found that in the presence of estradiol, prolactin inhibits prolidase activity and its down-stream signaling proteins: HIF-1alpha, mTOR, AKT and MAPK p-38, while in the absence of estradiol, an opposite effect was observed. Estradiol 37-46 prolactin Homo sapiens 48-57 23581407-5 2013 It was found that in the presence of estradiol, prolactin inhibits prolidase activity and its down-stream signaling proteins: HIF-1alpha, mTOR, AKT and MAPK p-38, while in the absence of estradiol, an opposite effect was observed. Estradiol 187-196 prolactin Homo sapiens 48-57 18089703-1 2008 BACKGROUND: Estradiol (E(2)) stimulates GH and prolactin secretion and suppresses FSH secretion in postmenopausal women. Estradiol 12-21 prolactin Homo sapiens 47-56 20568397-11 2010 RESULTS: Patients with hyperprolactinemia and regular menstrual cycle presented low biological activity of prolactin and normal serum FSH, LH and estradiol levels. Estradiol 146-155 prolactin Homo sapiens 28-37 19664636-8 2009 Prepartum estradiol levels were significantly elevated during the lowered prolactin treatment and estradiol was significantly lowered postpartum with the elevated prolactin treatment. Estradiol 10-19 prolactin Homo sapiens 74-83 19326843-0 2009 [Effect of estradiol on Ca2+ release from intracellular stores in porcine oocytes stimulated by prolactin, theophylline, or guanosine triphosphate]. Estradiol 11-20 prolactin Homo sapiens 96-105 19326843-1 2009 The interaction between prolactin and theophylline as well as between prolactin and guanosine triphosphate during Ca2+ release from intracellular stores of estradiol-treated porcine oocytes isolated from the ovary at the stage of follicular growth were studied using fluorescent Ca(2+)-sensitive probe chlortetracycline. Estradiol 156-165 prolactin Homo sapiens 70-79 19326843-3 2009 Conversely, Ca2+ release from intracellular stores increased only after the combined exposure to prolactin and theophylline in the the presence of estradiol. Estradiol 147-156 prolactin Homo sapiens 97-106 19326843-5 2009 Protein kinase C regulated Ca2+ release from intracellular stores after the combined exposure to prolactin and theophylline only in the presence of estradiol; while the activation of protein kinase C required no estradiol during the combined exposure to prolactin and guanosine triphosphate. Estradiol 148-157 prolactin Homo sapiens 97-106 19326843-6 2009 The data obtained indicate the effect of estradiol on Ca2+ release from intracellular stores after the combined exposure to prolactin and theophylline, while no such effect was observed after the combined exposure to prolactin and guanosine triphosphate. Estradiol 41-50 prolactin Homo sapiens 124-133 18843963-5 2008 CONCLUSIONS: During controlled ovarian stimulation, prolactin secretion is not affected by Gn but may be stimulated by estradiol. Estradiol 119-128 prolactin Homo sapiens 52-61 18089703-1 2008 BACKGROUND: Estradiol (E(2)) stimulates GH and prolactin secretion and suppresses FSH secretion in postmenopausal women. Estradiol 23-27 prolactin Homo sapiens 47-56 18006630-1 2008 Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl). Estradiol 161-170 prolactin Homo sapiens 216-220 18006630-2 2008 We found that estradiol induced a reproducible 1.8-fold activation of the hPrl gene promoter, using pituitary GH3 cells stably transfected with a 5000-bp hPrl promoter fragment linked to luciferase reporter gene. Estradiol 14-23 prolactin Homo sapiens 74-78 18006630-2 2008 We found that estradiol induced a reproducible 1.8-fold activation of the hPrl gene promoter, using pituitary GH3 cells stably transfected with a 5000-bp hPrl promoter fragment linked to luciferase reporter gene. Estradiol 14-23 prolactin Homo sapiens 154-158 18006630-8 2008 When cells were treated with both estradiol and TNFalpha, we observed synergistic activation of the hPrl promoter, which was mediated by the -1189-bp ERE. Estradiol 34-43 prolactin Homo sapiens 100-104 16690806-3 2006 Treatment of human endometrial stromal cells with hormones (estradiol and medroxyprogesterone acetate) plus dibutyryl cAMP (H+dbcAMP) for 48 h increased expression of IGFBP1, PRL, TIMP3, CNR1, and DCN but not LAMB1, as measured by real-time PCR. Estradiol 60-69 prolactin Homo sapiens 175-178 17438530-3 2007 We have shown that PRL stimulates activating protein-1 (AP-1) activity in breast cancer cells, and can cooperate with estradiol in this pathway. Estradiol 118-127 prolactin Homo sapiens 19-22 17110010-8 2007 Finally, a significant and positive correlation was found between the prolactin and estradiol levels in the paranoid subgroup alone. Estradiol 84-93 prolactin Homo sapiens 70-79 17110010-9 2007 Thus, it appears that low estradiol levels are associated with low prolactin levels, alleged hyperdopaminergic tone and psychotic breakdown in paranoid schizophrenia. Estradiol 26-35 prolactin Homo sapiens 67-76 17054466-13 2006 It is suggested that oestradiol stimulates the secretion of PRL in women by acting through oestrogen receptors. Estradiol 21-31 prolactin Homo sapiens 60-63 15829128-6 2005 We hypothesize that the exogenous testosterone was aromatized to oestradiol, which stimulated the release of PRL by the anterior pituitary. Estradiol 65-75 prolactin Homo sapiens 109-112 15134429-5 2004 DP and NC had comparable levels of reproductive hormones, with the exception of elevated prolactin levels, which increased, as did thyroid-stimulating hormone levels, in response to estradiol treatment. Estradiol 182-191 prolactin Homo sapiens 89-98 14575729-1 2004 OBJECTIVE: To investigate the relationship between sex hormones (estradiol, testosterone, androstendione, DHEA-S) and prolactin on one hand and musculo-skeletal pain and psychological distress on the other during the menopausal transition. Estradiol 65-74 prolactin Homo sapiens 118-127 11397894-6 2001 Coincubation with estradiol resulted in enhanced fetal PRL response to PrRP, and GH release was only increased in the presence of estradiol. Estradiol 18-27 prolactin Homo sapiens 55-58 12824819-0 2003 Ethanol and estradiol modulate alternative splicing of dopamine D2 receptor messenger RNA and abolish the inhibitory action of bromocriptine on prolactin release from the pituitary gland. Estradiol 12-21 prolactin Homo sapiens 144-153 11726571-0 2001 Plasma prolactin/oestradiol ratio at 38 weeks gestation predicts the duration of lactational amenorrhoea. Estradiol 17-27 prolactin Homo sapiens 7-16 12392686-6 2002 In winter-acclimatized male carp, where the pituitary PRL level is low, 17beta-estradiol treatment increased PRL but not GK immunoreactivity. Estradiol 72-88 prolactin Homo sapiens 54-57 12392686-6 2002 In winter-acclimatized male carp, where the pituitary PRL level is low, 17beta-estradiol treatment increased PRL but not GK immunoreactivity. Estradiol 72-88 prolactin Homo sapiens 109-112 11935401-5 2002 Oestradiol and testosterone can stimulate rapid release of prolactin selectively from type II lactotrophs characterised by small round vesicles. Estradiol 0-10 prolactin Homo sapiens 59-68 11935401-12 2002 Both oestradiol and glucocorticoids therefore influence the secretion of prolactin by novel direct and indirect mechanisms, in addition to their much better understood effects on transcription via classical intracellular steroid receptors. Estradiol 5-15 prolactin Homo sapiens 73-82 11396264-1 2001 In a 34-year-old woman with primary subfertility, a strongly increased serum concentration of prolactin was found in combination with normal levels of oestradiol, which is an indication for the presence of prolactin forms without clinical effect. Estradiol 151-161 prolactin Homo sapiens 206-215 11335865-8 2000 (3) The mean level of the serum prolactin in the group of patients without gynecomastia (n = 53) was significantly higher than that in the normal group (n = 35), but there was no significant difference in blood luteinizing hormone, follicle-stimulating hormone, testosterone (T), estradiol (E(2)) or T/E(2) ratio between the groups. Estradiol 280-289 prolactin Homo sapiens 32-41 11278160-7 2001 The differential response of adding 50mcg versus 100mcg estradiol on the types of symptom affected may be related to the estrogen effect on LH and prolactin. Estradiol 56-65 prolactin Homo sapiens 147-156 10476911-4 1999 As in primary cultures of endometrial stromal cells, treatment of N5 cells with progesterone and estradiol alone or in combination with prostaglandin E2 stimulated the synthesis and release of prolactin. Estradiol 97-106 prolactin Homo sapiens 193-202 10476911-5 1999 Transient transfection of the N5 cells with an expression vector containing - 2927/ + 66 bp of the decidual prolactin promoter coupled to a luciferase reporter gene resulted in a 20 to 25-fold increase in luciferase activity, a magnitude similar to that which occurs in primary cultures of endometrial stromal cells decidualized in vitro by treatment with progesterone and estradiol. Estradiol 373-382 prolactin Homo sapiens 108-117 9238678-12 1996 Addition of 50 microM dibutyryl cAMP to stromal cells treated with MPA and oestradiol only partially reversed the suppression of decidualization and prolactin release by RA. Estradiol 75-85 prolactin Homo sapiens 149-158 10979048-3 1996 On the other hand, hyperinsulinaemia and disorders in GH, PRL and cortisol release were associated with lower levels of reverse triiodothyronine, gonadotropins, testosterone, 17-corticoids and SHBG and higher levels of triiodothyronine, estradiol, 17-hydroxycorticoids and IGF-I. Estradiol 237-246 prolactin Homo sapiens 58-61 9986923-7 1999 These results indicate that melatonin may affect the daily secretion of prolactin in ewes during the breeding season, and suggest that the variable response of prolactin to the melatonin signal in intact and ovariectomized ewes relates to the interaction between both ovarian steroids - estradiol and progesterone - and the prolactin-releasing factor. Estradiol 287-296 prolactin Homo sapiens 160-169 9986923-7 1999 These results indicate that melatonin may affect the daily secretion of prolactin in ewes during the breeding season, and suggest that the variable response of prolactin to the melatonin signal in intact and ovariectomized ewes relates to the interaction between both ovarian steroids - estradiol and progesterone - and the prolactin-releasing factor. Estradiol 287-296 prolactin Homo sapiens 160-169 9231238-0 1997 The circulating concentrations of FSH, LH and prolactin in the oestradiol-implanted ovariectomized ewe treated with caffeine. Estradiol 63-73 prolactin Homo sapiens 46-55 9239689-3 1996 Human PRL caused a dose-dependent decrease in hFSH-induced 17 beta-oestradiol production, even when cells were cultured in the presence of a cAMP analogue (8-Br-cAMP). Estradiol 59-77 prolactin Homo sapiens 6-9 7890253-0 1995 Effect of acute ethanol ingestion on prolactin in menopausal women using estradiol replacement. Estradiol 73-82 prolactin Homo sapiens 37-46 7890253-9 1995 In menopausal women using transdermal estradiol, acute ethanol ingestion is associated with an increase in serum prolactin. Estradiol 38-47 prolactin Homo sapiens 113-122 1352703-8 1992 Basal and post-stimulation prolactin levels were correlated with estradiol levels. Estradiol 65-74 prolactin Homo sapiens 27-36 7506205-10 1994 These results indicate that there are synergistic effects among PGE2, estradiol, and MPA, resulting in acceleration of endometrial stromal cell differentiation and enhanced PRL expression. Estradiol 70-79 prolactin Homo sapiens 173-176 1534540-4 1992 This rapid effect of estradiol also enhanced PRL mRNA, but did not affect other species of mRNA encoding for proenkephalin, D2 receptor mRNA, or hexosaminidase-A. Estradiol 21-30 prolactin Homo sapiens 45-48 1525456-8 1992 RESULTS: Higher serum prolactin was associated with both higher estradiol levels and use of LA but did not have any effects on fertilization rate, embryo quality, or occurrence of pregnancy. Estradiol 64-73 prolactin Homo sapiens 22-31 1534990-3 1992 Incubation of stromal cells with a mixture of estradiol, medroxyprogesterone acetate and relaxin, at a concentration reported to yield maximal stimulation of PRL production, resulted in changes from elongated to rounder cells, approx. Estradiol 46-55 prolactin Homo sapiens 158-161 8000909-2 1994 We have recently shown that PRL was able to bind to a protein of high molecular weight in plasma obtained from estradiol treated ovariectomized females rats. Estradiol 111-120 prolactin Homo sapiens 28-31 1294377-3 1992 The FF PRL concentration was correlated positively with plasma PRL and highest estradiol levels during the stimulatory cycle. Estradiol 79-88 prolactin Homo sapiens 7-10 2286281-16 1990 These results indicated that the pulsatility and circadian secretion of prolactin were preserved during pregnancy and puerperium and also suggested that prolactin secretion during pregnancy, delivery and puerperium was regulated by at least 3 factors: estradiol, dopamine and LH-hCG. Estradiol 252-261 prolactin Homo sapiens 72-81 2147816-0 1990 Comparison of norethindrone and medroxyprogesterone acetate with natural progesterone and estradiol in stimulating prolactin production from cultured endometrial stromal cells. Estradiol 90-99 prolactin Homo sapiens 115-124 1752603-4 1991 PRL levels in the hMG cycle increased according to estradiol levels. Estradiol 51-60 prolactin Homo sapiens 0-3 2286281-16 1990 These results indicated that the pulsatility and circadian secretion of prolactin were preserved during pregnancy and puerperium and also suggested that prolactin secretion during pregnancy, delivery and puerperium was regulated by at least 3 factors: estradiol, dopamine and LH-hCG. Estradiol 252-261 prolactin Homo sapiens 153-162 2125674-3 1990 The mean values of gonadotrophins and estradiol were characteristic of hypogonadotropic hypogonadism when the concentration of prolactin was higher than 4000 mIU/l. Estradiol 38-47 prolactin Homo sapiens 127-136 2209924-9 1990 An increase in prolactin secretion was found after the tissues were treated with a combination of 10(-8)M estradiol and 10(-6)M progesterone or 10(-6)M progesterone alone. Estradiol 106-115 prolactin Homo sapiens 15-24 2209924-17 1990 Mixed cultures of the decidual tissues and villi showed that the prolactin secretion rate increased in all groups treated with/without estradiol and/or progesterone. Estradiol 135-144 prolactin Homo sapiens 65-74 2383926-0 1990 Prolactin secretion in women during the oestradiol-induced luteinizing hormone surge with or without progesterone. Estradiol 40-50 prolactin Homo sapiens 0-9 6787487-0 1981 Feedback effects of estradiol and progesterone upon gonadotropin and prolactin release. Estradiol 20-29 prolactin Homo sapiens 69-78 2327450-10 1990 Estradiol induced a sustained increase in prolactin production even after withdrawal of steroids. Estradiol 0-9 prolactin Homo sapiens 42-51 2305604-7 1990 The results indicate that prolactin synthesis in the endometrium is regulated directly by progesterone, and indirectly by estradiol. Estradiol 122-131 prolactin Homo sapiens 26-35 6787487-1 1981 The relationship between estradiol- and progesterone-mediated gonadotropin release and steroid-induced changes in prolactin levels was investigated in an improved human experimental model. Estradiol 25-34 prolactin Homo sapiens 114-123 34438820-8 2021 PRL was negatively correlated with T in both sexes and with P4 and E2 in female geese. Estradiol 67-69 prolactin Homo sapiens 0-3 34738596-9 2021 Further, higher levels of LH and LH/FSH ratio and lower estradiol levels were observed in patients with normal prolactin levels. Estradiol 56-65 prolactin Homo sapiens 111-120 2689208-8 1989 A high PRL concentration inhibits gonadoliberin formation, LH secretion; testosterone concentration and especially dihydrotestosterone concentration decrease (or do not change) with an elevation of estradiol level that on the whole results in feminization. Estradiol 198-207 prolactin Homo sapiens 7-10 2589434-6 1989 We conclude that estradiol selectively augments the amplitude of episodic prolactin pulsatility, amplifies ultradian rhythms, and increases the mass of prolactin released per secretory burst. Estradiol 17-26 prolactin Homo sapiens 74-83 2589434-6 1989 We conclude that estradiol selectively augments the amplitude of episodic prolactin pulsatility, amplifies ultradian rhythms, and increases the mass of prolactin released per secretory burst. Estradiol 17-26 prolactin Homo sapiens 152-161 2756161-2 1989 On clinical studies, we investigated change of serum prolactin level during the menstrual cycle and relationship to other hormones (LH, FSH, estradiol, progesterone). Estradiol 141-150 prolactin Homo sapiens 53-62 2595862-2 1989 The findings demonstrated the increased levels of prolactin (249.09 +/- 39.6 mu/U/ml), significantly exceeding the normal (132.6 +/- 32.4 mu/U/ml), a tendency towards a decrease in the levels of FSH and testosterone (up to 7.01 +/- 0.70 nmol/l versus 12.57 +/- 0.39 nmol/l in health) and manifest elevation of estradiol levels (up to 634.71 +/- 29.16 nmol/l versus 205.02 +/- 18.60 nmol/l), as well as its ratio to the testosterone levels. Estradiol 310-319 prolactin Homo sapiens 50-59 2744187-0 1989 Prolactin suppression by bromocriptine stimulates aromatization of testosterone to estradiol in women. Estradiol 83-92 prolactin Homo sapiens 0-9 2756161-4 1989 We conclude that change of prolactin level during the menstrual cycle is related with change of estradiol level. Estradiol 96-105 prolactin Homo sapiens 27-36 3207131-1 1988 We evaluated the effect of preovulatory concentrations of estradiol on the 24-hour profile of prolactin secretion in women with regular menstrual cycles. Estradiol 58-67 prolactin Homo sapiens 94-103 3207131-6 1988 These results suggest in women with regular menstrual cycles: (1) that estrogen administration that achieves slightly greater than preovulatory estradiol concentrations can stimulate prolactin release, (2) that estradiol may elevate prolactin by increasing its pulsatile secretion, (3) that estradiol does not alter the diurnal pattern of prolactin secretion, (4) that estradiol concentrations just above preovulatory levels can be associated with markedly elevated prolactin concentrations. Estradiol 144-153 prolactin Homo sapiens 183-192 3207131-6 1988 These results suggest in women with regular menstrual cycles: (1) that estrogen administration that achieves slightly greater than preovulatory estradiol concentrations can stimulate prolactin release, (2) that estradiol may elevate prolactin by increasing its pulsatile secretion, (3) that estradiol does not alter the diurnal pattern of prolactin secretion, (4) that estradiol concentrations just above preovulatory levels can be associated with markedly elevated prolactin concentrations. Estradiol 211-220 prolactin Homo sapiens 183-192 3207131-6 1988 These results suggest in women with regular menstrual cycles: (1) that estrogen administration that achieves slightly greater than preovulatory estradiol concentrations can stimulate prolactin release, (2) that estradiol may elevate prolactin by increasing its pulsatile secretion, (3) that estradiol does not alter the diurnal pattern of prolactin secretion, (4) that estradiol concentrations just above preovulatory levels can be associated with markedly elevated prolactin concentrations. Estradiol 211-220 prolactin Homo sapiens 233-242 3207131-6 1988 These results suggest in women with regular menstrual cycles: (1) that estrogen administration that achieves slightly greater than preovulatory estradiol concentrations can stimulate prolactin release, (2) that estradiol may elevate prolactin by increasing its pulsatile secretion, (3) that estradiol does not alter the diurnal pattern of prolactin secretion, (4) that estradiol concentrations just above preovulatory levels can be associated with markedly elevated prolactin concentrations. Estradiol 211-220 prolactin Homo sapiens 233-242 3207131-6 1988 These results suggest in women with regular menstrual cycles: (1) that estrogen administration that achieves slightly greater than preovulatory estradiol concentrations can stimulate prolactin release, (2) that estradiol may elevate prolactin by increasing its pulsatile secretion, (3) that estradiol does not alter the diurnal pattern of prolactin secretion, (4) that estradiol concentrations just above preovulatory levels can be associated with markedly elevated prolactin concentrations. Estradiol 211-220 prolactin Homo sapiens 233-242 3089848-10 1986 The pattern of serum prolactin levels in the patients with transient hyperprolactinemia was almost synchronized with that of serum estradiol levels. Estradiol 131-140 prolactin Homo sapiens 21-30 3139336-6 1988 In the FSH cycles without an LH surge, PRL levels increased as long as FSH administration was continued and showed a significant positive correlation with the increasing serum oestradiol levels (r = 0.77). Estradiol 176-186 prolactin Homo sapiens 39-42 3102546-12 1987 Along with the rise of estradiol levels an increase of sex hormone-binding globulin and PRL levels occurred. Estradiol 23-32 prolactin Homo sapiens 88-91 3171320-0 1988 Human follicular fluid: prolactin is biologically active and ovum fertilization correlates with estradiol concentration. Estradiol 96-105 prolactin Homo sapiens 24-33 3416226-5 1988 Pre-exposure of granulosa cell cultures to estradiol increased the subsequent stimulatory effect of prolactin on lipoprotein utilization. Estradiol 43-52 prolactin Homo sapiens 100-109 3618680-3 1987 Since tamoxifen citrate administration also suppressed prolactin levels, it was suggested that a low but sustained serum level of estradiol and consequently continuous estrogenic stimulation may be an important causative factor in the development of hyperprolactinemic anovulation. Estradiol 130-139 prolactin Homo sapiens 55-64 3089848-14 1986 After the administration of estradiol benzoate (100 micrograms/kg), serum estradiol levels increased markedly, serum prolactin levels increased with the similar change in serum estradiol levels, and serum prolactin levels in the patients with transient hyperprolactinemia were significantly higher compared to those of the controls (p less than 0.01 approximately 0.005). Estradiol 28-37 prolactin Homo sapiens 117-126 3089848-14 1986 After the administration of estradiol benzoate (100 micrograms/kg), serum estradiol levels increased markedly, serum prolactin levels increased with the similar change in serum estradiol levels, and serum prolactin levels in the patients with transient hyperprolactinemia were significantly higher compared to those of the controls (p less than 0.01 approximately 0.005). Estradiol 28-37 prolactin Homo sapiens 205-214 3002762-7 1986 The evolution of PRL and oPL receptors was determined during pregnancy and lactation and at different periods after an estradiol and progesterone treatment, which provokes growth of the mammary gland and milk secretion. Estradiol 119-128 prolactin Homo sapiens 17-20 3958122-7 1986 These observations confirm the impairment of LH pulsatility in hyperprolactinemia and demonstrate that normalization of PRL levels by surgery can restore LH pulsatile secretion in certain women as early as the eighth day after operation in the absence of a significant change in serum E2 levels. Estradiol 285-287 prolactin Homo sapiens 120-123 3002762-11 1986 Injections of large doses of estradiol and progesterone to nonpregnant ewes were able to reproduce effectively the pattern of PRL receptors observed during pregnancy, but had no effect on oPL receptor levels. Estradiol 29-38 prolactin Homo sapiens 126-129 2987289-6 1985 Physiological concentrations of 17 beta-estradiol or dihydrotestosterone increased the cellular capacity of hPRL binding. Estradiol 32-49 prolactin Homo sapiens 108-112 4034850-5 1985 However, in the post-menopausal women treated with estrogen (intramuscular 17-beta-estradiol), the opiate antagonist was able to lower plasma PRL concentrations. Estradiol 75-92 prolactin Homo sapiens 142-145 4034335-3 1985 Results showed that between the 28th-40th week there is an increase in the prolactin level of the umbilical arterial and venous blood with a parallel increase in the cortisol level of umbilical arterial blood and a fall in the progesterone level of umbilical arterial and venous blood which between the 36th and 40th week results in a rise of the oestradiol/progesterone quotient. Estradiol 347-357 prolactin Homo sapiens 75-84 3932176-11 1985 In all cases tested (n = 4), preincubation of the tumor cells with estradiol (10(-8) M) modified the inhibition of PRL release induced by bromocriptine with a half-inhibitory concentration displaced from 3 X 10(-11) M (control) to 3 X 10(-10) M (estradiol). Estradiol 67-76 prolactin Homo sapiens 115-118 3932176-11 1985 In all cases tested (n = 4), preincubation of the tumor cells with estradiol (10(-8) M) modified the inhibition of PRL release induced by bromocriptine with a half-inhibitory concentration displaced from 3 X 10(-11) M (control) to 3 X 10(-10) M (estradiol). Estradiol 246-255 prolactin Homo sapiens 115-118 3964791-4 1985 In the luteal phase women, the number of PRL pulses was significantly (P less than 0.001) greater during naloxone than during saline infusion (3.4 vs. 1.6 pulses/8 h), and a positive linear correlation was found between the integrated PRL response to naloxone and the levels of circulating estradiol (r = 0.62) and progesterone (r = 0.95). Estradiol 290-299 prolactin Homo sapiens 41-44 6434684-6 1984 After pituitary glands were preincubated for 20 h in medium containing oestradiol-17 beta, the basal release of prolactin was enhanced as was the response to TRH. Estradiol 71-89 prolactin Homo sapiens 112-121 6481291-3 1984 When prolactin was added along with hCG in four of six corpora lutea, however, progesterone production significantly increased and in three of six corpora lutea oestradiol production was increased above that induced by hCG alone. Estradiol 161-171 prolactin Homo sapiens 5-14 6863485-3 1983 These transitory elevations in hPRL to 27-70 ng/ml lasted only one to three days and coincided with the preovulatory estradiol peak. Estradiol 117-126 prolactin Homo sapiens 31-35 6736849-3 1984 Combined treatment with oestradiol and progesterone induced physiological development of the lobuloalveolar structure of the mammary gland in the presence of prolactin. Estradiol 24-34 prolactin Homo sapiens 158-167 6736849-6 1984 The interaction of oestradiol-17 beta with prolactin appears to be a main trigger for mammary gland development. Estradiol 19-37 prolactin Homo sapiens 43-52 6431636-7 1984 There was a significant positive correlation between cord prolactin and estradiol-17 beta levels in full-term infants. Estradiol 72-89 prolactin Homo sapiens 58-67 6424977-0 1984 Changes in plasma levels of prolactin, in relation to those of FSH, oestradiol, androstenedione and progesterone around the preovulatory surge of LH in women. Estradiol 68-78 prolactin Homo sapiens 28-37 6424977-5 1984 In 10 women oestradiol, androstenedione and prolactin were measured 8 hourly around the pre-ovulatory surge of LH beginning at 0800 h. Prolactin showed a sustained increase in levels beginning at the start of and lasting for the duration of the pre-ovulatory LH surge; oestradiol levels did not rise around this time, and declined by 24 h after the onset of the LH surge. Estradiol 12-22 prolactin Homo sapiens 135-144 6424977-5 1984 In 10 women oestradiol, androstenedione and prolactin were measured 8 hourly around the pre-ovulatory surge of LH beginning at 0800 h. Prolactin showed a sustained increase in levels beginning at the start of and lasting for the duration of the pre-ovulatory LH surge; oestradiol levels did not rise around this time, and declined by 24 h after the onset of the LH surge. Estradiol 269-279 prolactin Homo sapiens 135-144 6700897-4 1984 Amniotic fluid prolactin levels correlate significantly with maternal plasma concentrations of estradiol and estrone. Estradiol 95-104 prolactin Homo sapiens 15-24 6695548-2 1984 The increase in serum Prl was strictly related to testosterone aromatization to oestradiol, since anti-oestrogen compounds were effective in reducing (clomiphene) or abolishing (tamoxifen) the enhanced Prl secretion. Estradiol 80-90 prolactin Homo sapiens 22-25 6695548-2 1984 The increase in serum Prl was strictly related to testosterone aromatization to oestradiol, since anti-oestrogen compounds were effective in reducing (clomiphene) or abolishing (tamoxifen) the enhanced Prl secretion. Estradiol 80-90 prolactin Homo sapiens 202-205 6838618-1 1983 The ability of 2-Hydroxyestradiol, a catecholestrogen, and 17 beta Estradiol to interact with the dopamine inhibition of prolactin and with dopamine receptors has been tested on dispersed human prolactin-secreting cells obtained from ten pituitary adenomas. Estradiol 59-76 prolactin Homo sapiens 121-130 6575400-1 1983 Increasing concentrations of estradiol (E2) ranging from 0.01 to 10 nM were found to inhibit partially but significantly the lactogenic effect of ovine prolactin (oPRL) on alpha-lactalbumin production in primate mammary tissues maintained in organ culture for 9 days. Estradiol 29-38 prolactin Homo sapiens 152-161 6203986-4 1983 The authors believe that this increased secretion of prolactin in patients with prostatic cancer is related to a decrease in the testosterone: oestradiol ratio. Estradiol 143-153 prolactin Homo sapiens 53-62 6833935-3 1983 However, in two out of five corpora lutea, higher concentrations of prolactin (100 and 1000 ng/ml) significantly reduced the oestradiol-17 beta production induced by human chorionic gonadotrophin (hCG; 10 i.u./ml); lower doses of prolactin had little effect. Estradiol 125-143 prolactin Homo sapiens 68-77 6834334-1 1983 The current experiment was designed to investigate whether changes in prolactin concentrations might be involved in the seasonal change in responsiveness of the hypothalamic-pituitary axis to the negative feedback effects of oestradiol in the ewe. Estradiol 225-235 prolactin Homo sapiens 70-79 7172459-0 1982 Hydrotestolactone lowers serum oestradiol and PRL levels in normal men: evidence of a role of oestradiol in prl secretion. Estradiol 94-104 prolactin Homo sapiens 108-111 6404046-1 1983 Estradurin (a polymer of 17-beta-oestradiol) has an inhibitory effect on the synthesis/secretion of PRL. Estradiol 25-43 prolactin Homo sapiens 100-103 6404046-5 1983 A stimulatory effect of 17-beta-oestradiol (0.01 micrograms/ml) on the synthesis/secretion of PRL was suggested by the tissue from one post-pregnancy pituitary. Estradiol 24-42 prolactin Homo sapiens 94-97 7076799-0 1982 Prolactin directly inhibits basal as well as gonadotropin-stimulated secretion of progesterone and 17 beta-estradiol in the human ovary. Estradiol 99-116 prolactin Homo sapiens 0-9 7076799-3 1982 Ovine PRL (0.1-10 IU/ml) directly suppressed progesterone and 17 beta-estradiol secretion by human ovaries. Estradiol 62-79 prolactin Homo sapiens 6-9 7067928-5 1982 Estradiol treatment for corresponding periods resulted in prolactin synthesis representing 94 +/- 5, 144 +/- 11 and 270 +/- 22% of controls and prolactin mRNA levels representing 115 +/- 7, 160 +/- 7 and 322 +/- 22% of controls. Estradiol 0-9 prolactin Homo sapiens 58-67 7067928-5 1982 Estradiol treatment for corresponding periods resulted in prolactin synthesis representing 94 +/- 5, 144 +/- 11 and 270 +/- 22% of controls and prolactin mRNA levels representing 115 +/- 7, 160 +/- 7 and 322 +/- 22% of controls. Estradiol 0-9 prolactin Homo sapiens 144-153 6798066-1 1982 The effects of tamoxifen and 17 beta-estradiol on the levels of FSH, PRL, and pregnancy zone protein were compared in two groups of postmenopausal women. Estradiol 29-46 prolactin Homo sapiens 69-72 6798066-6 1982 The decreases in PRL after 1 and 3 months of treatment with tamoxifen were 36% and 71%, and 19% and 31% after treatment with estradiol. Estradiol 125-134 prolactin Homo sapiens 17-20 7053988-0 1982 Estradiol inhibits prolactin induced alpha-lactalbumin production in normal primate mammary tissue in vitro. Estradiol 0-9 prolactin Homo sapiens 19-28 7053988-1 1982 The effect of estradiol on prolactin induced alpha-lactalbumin production in normal primate mammary tissue was studied by maintaining tissues in organ culture with or without various combinations of oPRL and 17 beta-estradiol. Estradiol 14-23 prolactin Homo sapiens 27-36 7053988-4 1982 By 9 days in culture estradiol (10(-11) M) caused a mean 31% inhibition of prolactin-induced alpha-lactalbumin; with estradiol (10(-8) M) the inhibition was 40%. Estradiol 21-30 prolactin Homo sapiens 75-84 7172459-1 1982 The effect on serum PRL levels of lowering serum oestradiol (E2) concentration by short-term administration of an aromatase activity inhibitor, hydrotestolactone (HT), was studied in six healthy male subjects. Estradiol 49-59 prolactin Homo sapiens 20-23 7172459-1 1982 The effect on serum PRL levels of lowering serum oestradiol (E2) concentration by short-term administration of an aromatase activity inhibitor, hydrotestolactone (HT), was studied in six healthy male subjects. Estradiol 61-63 prolactin Homo sapiens 20-23 7319468-6 1981 The results point towards a prolactin secretory hypersensitivity for oestradiol in patients with cyclical mastalgia. Estradiol 69-79 prolactin Homo sapiens 28-37 6116372-5 1981 Incubation of prolactin-secreting adenomas with oestradiol for as long as 24 days produced no change in hormone secretion. Estradiol 48-58 prolactin Homo sapiens 14-23 7319468-5 1981 A significant positive correlation between oestradiol and prolactin was found in patients and normals, but with larger prolactin levels in patients. Estradiol 43-53 prolactin Homo sapiens 58-67 7319468-5 1981 A significant positive correlation between oestradiol and prolactin was found in patients and normals, but with larger prolactin levels in patients. Estradiol 43-53 prolactin Homo sapiens 119-128 6113354-6 1981 This study demonstrated a heterogeneity of serum prolactin responses to acute oestradiol administration in women with prolactinomas. Estradiol 78-88 prolactin Homo sapiens 49-58 6796300-8 1981 In non-nursing puerperal women treated with bromocriptine, exogenous oestradiol caused a significant rise in plasma prolactin. Estradiol 69-79 prolactin Homo sapiens 116-125 6796300-11 1981 In nursing and in non-nursing women treated with bromocriptine prolactin responses to TRH were increased after oestradiol challenge. Estradiol 111-121 prolactin Homo sapiens 63-72 6788948-6 1981 Serum prolactin rose by about 50%, 48 h after the serum oestradiol peak, then declined during the mid-luteal phase before rising at the end of the cycle. Estradiol 56-66 prolactin Homo sapiens 6-15 6784423-3 1981 Furthermore, the relationship between changes in prolactin and oestradiol-17 beta levels during the normal menstrual cycle and in the climacteric was studied. Estradiol 63-81 prolactin Homo sapiens 49-58 6784423-8 1981 The levels of plasma prolactin during the ovulatory and the luteal phase in the cycle were significantly (P less than 0.02) higher than that of the follicular phase, and a positive correlation between changes in plasma concentration of oestradiol-17 beta and prolactin was found. Estradiol 236-254 prolactin Homo sapiens 21-30 6784423-8 1981 The levels of plasma prolactin during the ovulatory and the luteal phase in the cycle were significantly (P less than 0.02) higher than that of the follicular phase, and a positive correlation between changes in plasma concentration of oestradiol-17 beta and prolactin was found. Estradiol 236-254 prolactin Homo sapiens 259-268 6784423-9 1981 Also in post-menopausal women a relationship between plasma concentration of prolactin and oestradiol-17 beta was seen. Estradiol 91-109 prolactin Homo sapiens 77-86 7472275-3 1981 Acute administration (within 36 h) of 17 beta-estradiol, but not 17 alpha-estradiol, suppressed both spontaneous and prolactin-stimulated progesterone production. Estradiol 38-55 prolactin Homo sapiens 117-126 598012-4 1977 In this study serum oestradiol correlates with prolactin in the girls, but not in the boys. Estradiol 20-30 prolactin Homo sapiens 47-56 7015779-8 1981 In hyperprolactinemic anovulatory syndrome, a negative correlation between estradiol and PRL levels was found. Estradiol 75-84 prolactin Homo sapiens 89-92 7202836-8 1981 During the 1-h incubation, estradiol (1.0 ng/ml) increased prolactin content in the medium, although no newly synthesized prolactin appeared in the medium or the cells. Estradiol 27-36 prolactin Homo sapiens 59-68 7202836-9 1981 During the 4-h incubation period significantly more labelled prolactin was released into the medium in the presence of estradiol (1.0 ng/ml) than in the control. Estradiol 119-128 prolactin Homo sapiens 61-70 6448002-0 1980 Stable prolactin level after enhanced estradiol production following dehydroepiandrosterone sulfate. Estradiol 38-47 prolactin Homo sapiens 7-16 488431-6 1979 Moreover, the high levels of intrafollicular prolactin were associated with a marked reduction in FSH accumulation and low levels of estradiol in antral fluid. Estradiol 133-142 prolactin Homo sapiens 45-54 6779473-4 1980 The serum concentration of prolactin was unchanged in patients receiving 2 mg oestradiol-17 beta plus 1 mg oestriol but increased in patients receiving 4 mg oestradiol-17 beta plus 2 mg oestriol or 50 micrograms ethinyl-oestradiol, thus indicating dose-dependence for natural human oestrogens. Estradiol 78-96 prolactin Homo sapiens 27-36 6779473-4 1980 The serum concentration of prolactin was unchanged in patients receiving 2 mg oestradiol-17 beta plus 1 mg oestriol but increased in patients receiving 4 mg oestradiol-17 beta plus 2 mg oestriol or 50 micrograms ethinyl-oestradiol, thus indicating dose-dependence for natural human oestrogens. Estradiol 157-175 prolactin Homo sapiens 27-36 7430914-5 1980 While prolactin markedly proliferated and anti-prolactin serum significantly inhibited the mucosal weight, oestradiol, TRH and perphenazine dramatically depressed proliferation of the mucosa, suggesting that prolactin secretion was inhibited. Estradiol 107-117 prolactin Homo sapiens 47-56 7430914-5 1980 While prolactin markedly proliferated and anti-prolactin serum significantly inhibited the mucosal weight, oestradiol, TRH and perphenazine dramatically depressed proliferation of the mucosa, suggesting that prolactin secretion was inhibited. Estradiol 107-117 prolactin Homo sapiens 47-56 6247023-4 1980 Treatment of male rats with estradiol valerate induced hepatic hPrl receptors, but only in the presence of an intact pituitary. Estradiol 28-37 prolactin Homo sapiens 63-67 113144-6 1979 The basal level of PRL in the whole series was more closely related to the level of serum oestradiol (r = 0.778, P less than 0.001) than to that of serum progesterone (r = 0.442, P less than 0.05). Estradiol 90-100 prolactin Homo sapiens 19-22 121700-0 1979 [Role of 17-beta-estradiol in the synthesis and secretion of prolactin]. Estradiol 9-26 prolactin Homo sapiens 61-70 121700-3 1979 The data suggest that 17-beta-estradiol doesn"t increase the number of TRH receptors on pituitary cell surface, but stimulates prolactin synthesis. Estradiol 22-39 prolactin Homo sapiens 127-136 489915-5 1979 In two patients, who had never received estrogen treatment prior to this study, estradiol induced a significant elevation of serum prolactin levels within 24 h and levels remained higher than basal values for the rest of the estrogen treatment period. Estradiol 80-89 prolactin Homo sapiens 131-140 122427-0 1978 The relationship of changes in serum estradiol and progesterone during the menstrual cycle to the thyrotropin and prolactin responses to thyrotropin-releasing hormone. Estradiol 37-46 prolactin Homo sapiens 114-123 418418-0 1978 Prolactin secretion from clonal pituitary cells following incubation with estradiol, progesterone, thyrotrophin releasing hormone and dopamine. Estradiol 74-83 prolactin Homo sapiens 0-9 558225-7 1977 The overall pattern of serum prolactin during the menstrual cycle resembles that reported for circulating 17beta-estradiol. Estradiol 106-122 prolactin Homo sapiens 29-38 1101600-5 1975 Administration of oestradiol-17beta caused marked increase in plasma PRL levels during menstrual cycle. Estradiol 18-35 prolactin Homo sapiens 69-72 1009676-5 1976 A direct relationship between oestradiol and prolactin levels was noted, although there was no correlation between prolactin on the one hand and FSH, LH and progesterone on the other. Estradiol 30-40 prolactin Homo sapiens 45-54 984083-2 1976 Circulating PRL levels in response to intravenous infusion of 17 beta-estradiol (E2), at a rate of 50 mug per hour for 4 hours, were studied in 10 subjects, and a chronic administration of ethinyl estradiol (EE) at a dose of 400 mug per day, for 1 week, was evaluated in five hypogonadal subjects. Estradiol 62-79 prolactin Homo sapiens 12-15 33488290-7 2021 CSE concentrations at 0.01% and 0.025% increased the prolactin expression levels after treatment with E2 and MPA, whereas 0.1% and 0.25% CSE concentrations suppressed prolactin. Estradiol 102-104 prolactin Homo sapiens 53-62 4211473-0 1973 [Influence of estradiol-17 beta and progesterone during induction by prolactin and growth hormone of lobulo-alveolar differentiation of mammary tissue of the pregnant ewe: study in organotypic culture]. Estradiol 14-31 prolactin Homo sapiens 69-78 4771991-0 1973 Prolactin and progesterone effect on specific estradiol binding in uterine and mammary tissues in vitro. Estradiol 46-55 prolactin Homo sapiens 0-9 5007980-1 1972 The secretion of prolactin as affected by milking, oestradiol administration and onset of parturition. Estradiol 51-61 prolactin Homo sapiens 17-26 33605905-8 2021 Prolactin correlated positively with E2 (r = 0.296, P = 0.037), and TAC (r = 0.336, P = 0.011) in women with BCa. Estradiol 37-39 prolactin Homo sapiens 0-9 33426414-9 2020 Prior to the treatment, significant negative correlation between PRL and E2 (r = -0.386, p = 0.007), PRL and progesterone (r = -0.420, p = 0.003) was detected. Estradiol 73-75 prolactin Homo sapiens 65-68 33241169-1 2020 Estrogen (17beta-estradiol or E2) is a crucial regulator of the synthesis and secretion of pituitary reproductive hormones luteinizing hormone, follicle-stimulating hormone, and prolactin. Estradiol 10-26 prolactin Homo sapiens 178-187 33241169-1 2020 Estrogen (17beta-estradiol or E2) is a crucial regulator of the synthesis and secretion of pituitary reproductive hormones luteinizing hormone, follicle-stimulating hormone, and prolactin. Estradiol 30-32 prolactin Homo sapiens 178-187 33081268-9 2020 In conclusion, elevated secretion of COR and PRL in infertile women impairs the menstrual cycle by decreasing the pre-ovulatory LH peak and E2 and postovulatory E2 levels that affect the endometrial growth, and consequently reduce the chances to conceive. Estradiol 140-142 prolactin Homo sapiens 45-48 33081268-9 2020 In conclusion, elevated secretion of COR and PRL in infertile women impairs the menstrual cycle by decreasing the pre-ovulatory LH peak and E2 and postovulatory E2 levels that affect the endometrial growth, and consequently reduce the chances to conceive. Estradiol 161-163 prolactin Homo sapiens 45-48 32083234-9 2020 The increased proliferation induced by estradiol was enhanced after adding prolactin in both cell lines. Estradiol 39-48 prolactin Homo sapiens 75-84 32083234-11 2020 Long-term effects of serum prolactin on persistent proliferative endometrium in the presence of estradiol may induce abnormal proliferation of EG in hyperprolactinemic women. Estradiol 96-105 prolactin Homo sapiens 27-36 32736755-3 2020 From a neurologic perspective, the key hormone changes are those of the sex steroids, estradiol and progesterone, secreted first from the ovary and then from the placenta, the adrenal glucocorticoid cortisol, as well as the anterior pituitary peptide hormone prolactin and its pregnancy-specific homolog placental lactogen. Estradiol 86-95 prolactin Homo sapiens 259-268