PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3041262-2 1988 17 beta-Estradiol, which is required for tumorigenesis of the cell line in the nude mouse and which stimulates proliferation in vitro, was able to significantly induce IGF-I secretion at 10(-13) M, with maximal induction at 10(-11) M. Under optimal conditions IGF-I could be induced 4-fold after 4 days. Estradiol 0-17 insulin like growth factor 1 Homo sapiens 260-265 3251671-2 1988 The cohort concentrations of Insulin-like Growth Factor-1 (IGF1) were significantly correlated with serum IGF1 and dominant follicles contained significantly higher concentrations of IGF1 and oestradiol (E2) than their cohorts. Estradiol 192-202 insulin like growth factor 1 Homo sapiens 29-57 3251671-2 1988 The cohort concentrations of Insulin-like Growth Factor-1 (IGF1) were significantly correlated with serum IGF1 and dominant follicles contained significantly higher concentrations of IGF1 and oestradiol (E2) than their cohorts. Estradiol 192-202 insulin like growth factor 1 Homo sapiens 59-63 3264254-5 1988 Time-course studies indicated that the effects were detectable at 12 h, and continued to increase up to 48 h. The conversion of added dehydroepiandrosterone sulfate (DHEAS) to E2 was stimulated by CT and TPA and inhibited by IGF-I in a concentration-dependent manner. Estradiol 176-178 insulin like growth factor 1 Homo sapiens 225-230 4040964-0 1985 Physiologic testosterone or estradiol induction of puberty increases plasma somatomedin-C. Estradiol 28-37 insulin like growth factor 1 Homo sapiens 76-89 2430786-0 1987 Gonadotropins and estradiol stimulate immunoreactive insulin-like growth factor-I production by porcine granulosa cells in vitro. Estradiol 18-27 insulin like growth factor 1 Homo sapiens 53-81 3732135-1 1986 Estradiol amplified synergistically the dose- and time-dependent stimulatory actions of human somatomedin-C on progesterone biosynthesis by cultured swine granulosa cells. Estradiol 0-9 insulin like growth factor 1 Homo sapiens 94-107 3009492-2 1986 Proliferation of these cells was also stimulated by IGF-I and II when added to RPMI 1640 medium, fortified with selenium, hydrocortisone, transferrin, and beta-estradiol. Estradiol 155-169 insulin like growth factor 1 Homo sapiens 52-57 32565805-13 2020 Additionally, estradiol-17beta suppressed MCF-7 cell apoptosis, stimulated cell proliferation and cell migration, and increased RCC2, IGF1, and TWIST1 expression. Estradiol 14-30 insulin like growth factor 1 Homo sapiens 134-138 4040752-1 1985 Isolated swine granulosa cells incubated in chemically defined medium in vitro responded to synthetically pure human somatomedin C/IGF-I in a dose and time-dependent fashion with increased pregnenolone, progesterone and estradiol biosynthesis. Estradiol 220-229 insulin like growth factor 1 Homo sapiens 117-130 4040752-1 1985 Isolated swine granulosa cells incubated in chemically defined medium in vitro responded to synthetically pure human somatomedin C/IGF-I in a dose and time-dependent fashion with increased pregnenolone, progesterone and estradiol biosynthesis. Estradiol 220-229 insulin like growth factor 1 Homo sapiens 131-136 4040752-4 1985 The ability of somatomedin C/IGF-I to stimulate estradiol production on the one hand, and to act synergistically with estradiol to stimulate progesterone biosynthesis on the other hand, suggests a unique intrafollicular mechanism for amplifying progestin biosynthetic capacity in granulosa cells. Estradiol 48-57 insulin like growth factor 1 Homo sapiens 15-28 4040752-4 1985 The ability of somatomedin C/IGF-I to stimulate estradiol production on the one hand, and to act synergistically with estradiol to stimulate progesterone biosynthesis on the other hand, suggests a unique intrafollicular mechanism for amplifying progestin biosynthetic capacity in granulosa cells. Estradiol 48-57 insulin like growth factor 1 Homo sapiens 29-34 33826978-6 2021 Also, in granulosa cells collected in spring and fall, IGF1 alone and FSH alone increased (P < 0.05) estradiol production by severalfold, and a combination of FSH and IGF1 increased (P < 0.05) estradiol production above either FSH or IGF1 treatment alone. Estradiol 101-110 insulin like growth factor 1 Homo sapiens 55-59 33826978-6 2021 Also, in granulosa cells collected in spring and fall, IGF1 alone and FSH alone increased (P < 0.05) estradiol production by severalfold, and a combination of FSH and IGF1 increased (P < 0.05) estradiol production above either FSH or IGF1 treatment alone. Estradiol 193-202 insulin like growth factor 1 Homo sapiens 55-59 33826978-6 2021 Also, in granulosa cells collected in spring and fall, IGF1 alone and FSH alone increased (P < 0.05) estradiol production by severalfold, and a combination of FSH and IGF1 increased (P < 0.05) estradiol production above either FSH or IGF1 treatment alone. Estradiol 193-202 insulin like growth factor 1 Homo sapiens 167-171 33826978-6 2021 Also, in granulosa cells collected in spring and fall, IGF1 alone and FSH alone increased (P < 0.05) estradiol production by severalfold, and a combination of FSH and IGF1 increased (P < 0.05) estradiol production above either FSH or IGF1 treatment alone. Estradiol 193-202 insulin like growth factor 1 Homo sapiens 167-171 33826978-8 2021 In contrast, EGF decreased (P < 0.05) FSH plus IGF1-induced estradiol production by over 80% in granulosa cells of both spring and fall collected ovaries. Estradiol 60-69 insulin like growth factor 1 Homo sapiens 47-51 31175966-2 2019 There are accumulating evidence for the interaction of IGF-1 and 17beta-estradiol systems. Estradiol 65-81 insulin like growth factor 1 Homo sapiens 55-60 25164606-9 2015 During weight gain, when pubertal development and growth are resumed there is an additional independent positive association between the markers and IGF-1 and oestradiol. Estradiol 159-169 insulin like growth factor 1 Homo sapiens 149-154 29846284-10 2018 Insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) were also up-regulated after chronic ST-1435 and E2 exposure, suggesting the involvement of IGF-1 signaling as the potential underlined regulatory pathway transducing ST-1435 effect. Estradiol 114-116 insulin like growth factor 1 Homo sapiens 0-28 29846284-10 2018 Insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) were also up-regulated after chronic ST-1435 and E2 exposure, suggesting the involvement of IGF-1 signaling as the potential underlined regulatory pathway transducing ST-1435 effect. Estradiol 114-116 insulin like growth factor 1 Homo sapiens 30-35 29846284-10 2018 Insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) were also up-regulated after chronic ST-1435 and E2 exposure, suggesting the involvement of IGF-1 signaling as the potential underlined regulatory pathway transducing ST-1435 effect. Estradiol 114-116 insulin like growth factor 1 Homo sapiens 41-46 29149058-14 2017 Furthermore, the effect of GH/IGF-1 could be mediated by, or be overlapped with that of other hormones, such as estradiol and testosterone. Estradiol 112-121 insulin like growth factor 1 Homo sapiens 30-35 28211546-5 2017 We utilized our established 3D in vitro model to characterize the effects of DHEA, prolactin, 17beta-estradiol on insulin-growth factor-1 and -2 (IGF-1, -2) signaling and metabolic function in primary corneal fibroblasts from healthy controls (HCFs) and KC patients (HKCs). Estradiol 94-110 insulin like growth factor 1 Homo sapiens 146-151 29857825-0 2018 Effects of estradiol and progesterone on secretion of epidermal growth factor and insulin-like growth factor-1 in cultured yak endometrial epithelial cells. Estradiol 11-20 insulin like growth factor 1 Homo sapiens 82-110 27760898-4 2017 The cytoplasmic membrane-impermeable bovine serum albumin-conjugated estradiol (BSA-E2) at 1 nM, an equimolar concentration at which 17beta-estradiol (E2) exerts anti-proliferative effects, did not inhibit IGF-1-induced lactotroph proliferation. Estradiol 69-78 insulin like growth factor 1 Homo sapiens 206-211 24469035-5 2015 Estradiol-treated MCF7 cells stably expressing PR-B exhibited enhanced ER Ser167 phosphorylation and recruitment of ER, PR and the proline-, glutamate- and leucine-rich protein 1 (PELP1) to an estrogen response element in the CTSD distal promoter; this complex co-immunoprecipitated with IGF1 receptor (IGFR1) in whole-cell lysates. Estradiol 0-9 insulin like growth factor 1 Homo sapiens 288-292 24801047-8 2014 Among women in the strata (above median split) of IGF-1 (>25 nmol/l) or GH (>0.80 mlU/l), we observed that an increase in salivary 17beta-estradiol was associated with a higher odds for having higher percent mammographic density (>28.5%). Estradiol 137-153 insulin like growth factor 1 Homo sapiens 50-55 24801047-9 2014 The odds ratios (ORs) per standard deviation increase in 17beta-estradiol were 1.81 [95% confidence interval (CI) 1.08-3.03] in the high IGF-1 stratum and 2.08 (95% CI 1.10-3.94) in the high GH stratum. Estradiol 57-73 insulin like growth factor 1 Homo sapiens 137-142 24801047-10 2014 Furthermore, women in these strata of growth factors (above median) who had an overall average 17beta-estradiol above median (>16.8 pmol/l) had higher ORs for having higher percent mammographic density (>28.5%): IGF-1 4.13 (95 % CI 1.33-12.83) and GH 4.17 (95 % CI 1.41-12.28). Estradiol 95-111 insulin like growth factor 1 Homo sapiens 218-223 24347426-4 2014 OBJECTIVE: To assess the effects of 17beta-estradiol (E2) and raloxifene on bioactive IGF1. Estradiol 36-52 insulin like growth factor 1 Homo sapiens 86-90 25165472-2 2014 Our results showed significant positive correlations between circulating testosterone and insulin growth factor-1 (IGF-1) with knee flexion, knee extension, one-repetition maximum (1-RM), and peak oxygen consumption (VO2 peak), while no correlation was observed with estradiol. Estradiol 267-276 insulin like growth factor 1 Homo sapiens 115-120 24664559-4 2014 Fibroblast growth factor 9 stimulated (P < 0.05) IGF-I-induced estradiol production in the presence of FSH and testosterone. Estradiol 66-75 insulin like growth factor 1 Homo sapiens 52-57 24188698-8 2014 A strong positive correlation was recorded between intra-follicular IGF-1 and oestradiol. Estradiol 78-88 insulin like growth factor 1 Homo sapiens 68-73 23073341-3 2013 IGF-I and b-insulin induced testosterone and 17beta-estradiol production in carp ovarian theca and granulosa cells in short-term coincubation and this induction was significantly inhibited by Wortmannin and LY294002, two mechanistically different specific inhibitors of PI3 kinase. Estradiol 45-61 insulin like growth factor 1 Homo sapiens 0-5 23785020-6 2013 During GH treatment, IGF-I increased [(median (IQR)] 166 (162-235) vs. 702 (572-875) mug/L, p < 0.001) together with oestradiol [(mean +- SD) 78 +- 23 vs. 111 +- 30 pm, p = 0.019], and the oestradiol/testosterone ratio (p = 0.003). Estradiol 192-202 insulin like growth factor 1 Homo sapiens 21-26 23785020-10 2013 GH/IGF-I activity was positively associated with serum oestradiol, suggesting that GH/IGF-I stimulates aromatase activity in vivo. Estradiol 55-65 insulin like growth factor 1 Homo sapiens 3-8 23785020-10 2013 GH/IGF-I activity was positively associated with serum oestradiol, suggesting that GH/IGF-I stimulates aromatase activity in vivo. Estradiol 55-65 insulin like growth factor 1 Homo sapiens 86-91 22108915-1 2012 OBJECTIVE: To evaluate the effects of oral estradiol and transdermal 17beta-estradiol on serum concentrations of IGF1 and its binding proteins in women with hypopituitarism. Estradiol 43-52 insulin like growth factor 1 Homo sapiens 113-117 23011535-6 2012 However, an epidemiological study has also shown that endogenous estradiol level is an independent risk factor for colon cancer, positively associated with colon cancer after normalizing insulin, IGF-1. Estradiol 65-74 insulin like growth factor 1 Homo sapiens 196-201 21541704-2 2012 We performed microarray analysis on MCF-7 breast cancer cells treated with estradiol (E2) or IGF-I for 3 or 24 h. IGF-I regulated mRNA of five to tenfold more genes than E2, and many genes were co-regulated by both ligands. Estradiol 75-84 insulin like growth factor 1 Homo sapiens 114-119 22621285-0 2012 Relationship between the neuroprotective effects of insulin-like growth factor-1 and 17beta-oestradiol in human neuroblasts. Estradiol 85-102 insulin like growth factor 1 Homo sapiens 52-80 22447628-7 2012 rhChem (10 or 100 ng/ml) significantly decreased insulin-like growth factor-1 (IGF-1) (10(-8) M)-induced secretion of progesterone and estradiol (as determined by radioimmunoassay) but did not affect basal-or FSH (10(-8) M)-induced steroid secretion in hGCs and KGN cells. Estradiol 135-144 insulin like growth factor 1 Homo sapiens 49-77 22447628-7 2012 rhChem (10 or 100 ng/ml) significantly decreased insulin-like growth factor-1 (IGF-1) (10(-8) M)-induced secretion of progesterone and estradiol (as determined by radioimmunoassay) but did not affect basal-or FSH (10(-8) M)-induced steroid secretion in hGCs and KGN cells. Estradiol 135-144 insulin like growth factor 1 Homo sapiens 79-84 22108915-1 2012 OBJECTIVE: To evaluate the effects of oral estradiol and transdermal 17beta-estradiol on serum concentrations of IGF1 and its binding proteins in women with hypopituitarism. Estradiol 69-85 insulin like growth factor 1 Homo sapiens 113-117 23788886-0 2012 Alterations of insulin-like growth factor I (IGF-I) and estradiol serum levels in chronic hepatitis C. AIM OF THE STUDY: Deregulation of insulin-like growth factor I (IGF-I) production and decreased hepatic estrogen levels were associated with development of hepatocellular carcinoma (HCC) in hepatitis C virus (HCV) infected cirrhotic patients. Estradiol 56-65 insulin like growth factor 1 Homo sapiens 167-172 21721462-9 2011 CONCLUSION: The administration of transdermal 17beta-estradiol combined with oral medroxyprogesterone increases the IGF-I bioavailability. Estradiol 46-62 insulin like growth factor 1 Homo sapiens 116-121 22201898-4 2012 Elucidating the relationship between insulin resistance associated with aging in females, and the cross-talk between estradiol, insulin, and insulin-like growth factor (IGF-1) signaling pathways, will lead to a more complete understanding of the mechanism underlying estradiol-mediated neuroprotection. Estradiol 267-276 insulin like growth factor 1 Homo sapiens 169-174 22168360-8 2011 CONCLUSIONS: The study demonstrates that PAX2 activation by estradiol is selectively achieved in breast cancer cells of the luminal subtype, via ERalpha, and identifies IGF-1 as a negative regulator of PAX2 activity in these cells. Estradiol 60-69 insulin like growth factor 1 Homo sapiens 169-174 21735688-0 2011 [Influence of estradiol administration mode on plasma insulin-like growth factor-I (IGF-I) and its binding proteins 1 and 3 concentration in postmenopausal women treated with norethisterone acetate]. Estradiol 14-23 insulin like growth factor 1 Homo sapiens 54-82 21735688-1 2011 AIM: The aim of the present work was to assess the influence of estradiol administration mode on the plasma IGF-I, IGFBP-1, IGFBP-3 levels in postmenopausal women treated with norethisterone acetate. Estradiol 64-73 insulin like growth factor 1 Homo sapiens 108-113 21735688-0 2011 [Influence of estradiol administration mode on plasma insulin-like growth factor-I (IGF-I) and its binding proteins 1 and 3 concentration in postmenopausal women treated with norethisterone acetate]. Estradiol 14-23 insulin like growth factor 1 Homo sapiens 84-89 20726112-9 2010 Progesterone and estradiol accumulation was significantly (P < 0.05) greater in presence of FGF and IGF-I than TGF-alpha + TGF-beta1. Estradiol 17-26 insulin like growth factor 1 Homo sapiens 103-108 22286784-18 2011 CONCLUSION: Estradiol plasma level is correlated to circulating IGF-I, albeit the relation seems to be biphasic. Estradiol 12-21 insulin like growth factor 1 Homo sapiens 64-69 20890664-3 2011 As estradiol action requires IGF-I, direct inhibition of IGF-I action theoretically might be an efficacious alternative to tamoxifen. Estradiol 3-12 insulin like growth factor 1 Homo sapiens 29-34 20890664-3 2011 As estradiol action requires IGF-I, direct inhibition of IGF-I action theoretically might be an efficacious alternative to tamoxifen. Estradiol 3-12 insulin like growth factor 1 Homo sapiens 57-62 20444909-10 2010 Mean IGF-I concentration was reduced significantly with high-dose tamoxifen (P<0.01) and estradiol valerate treatment (P<0.05), whereas mean SHBG levels rose with both (P<0.01). Estradiol 92-110 insulin like growth factor 1 Homo sapiens 5-10 19897011-2 2010 In intact follicles, IGF-I and b-insulin stimulated testosterone and 17beta-estradiol production in vitro. Estradiol 69-85 insulin like growth factor 1 Homo sapiens 21-26 20379950-6 2010 Finally, 17beta-estradiol significantly induces both mRNA and protein expression of RIGF1 in human preadipose cells via ER and thus reinforces the signaling pathway of the proliferative factor, IGF1. Estradiol 9-25 insulin like growth factor 1 Homo sapiens 85-89 19897011-5 2010 HCG-stimulated 17beta-estradiol production, however, was significantly increased by IGF-I and b-insulin. Estradiol 15-31 insulin like growth factor 1 Homo sapiens 84-89 19897011-8 2010 Our results thus indicate that IGF-I and b-insulin alone can stimulate testosterone and 17beta-estradiol production in vitellogenic follicles of C. carpio by stimulating aromatase activity and P450arom gene expression. Estradiol 88-104 insulin like growth factor 1 Homo sapiens 31-36 18676717-1 2008 We previously showed that a combined trenbolone acetate (TBA)/estradiol-17beta (E2) implant significantly increases IGF-I mRNA levels in the LM of feedlot steers by 28 d after implantation. Estradiol 62-78 insulin like growth factor 1 Homo sapiens 116-121 18852162-8 2009 These findings suggest that E(2)-induced proliferation of endometrial carcinoma cells is mediated by the MAPK3/1 pathway via autocrine stimulation of IGF1. Estradiol 28-32 insulin like growth factor 1 Homo sapiens 150-154 18498055-6 2010 In our patient, endogenous estradiol levels have a significant influence on IGF-I levels. Estradiol 27-36 insulin like growth factor 1 Homo sapiens 76-81 19428444-5 2009 This regimen of estradiol treatment involves classical intracellular estrogen receptors, transactivation of IGF-1 receptors and stimulation of the ERK/MAPK signaling pathway, which in turn maintains CREB activity in the ischemic CA1. Estradiol 16-25 insulin like growth factor 1 Homo sapiens 108-113 19176313-10 2009 Follicular-fluid concentration of free IGF1 was lower for cleaved oocytes (P<0.001) and >8 cell embryos (P<0.05), and oestradiol was lower (P<0.05) for >8 cell embryos. Estradiol 127-137 insulin like growth factor 1 Homo sapiens 39-43 16866317-10 2006 Third, fat-rich diets depress secretion of insulin and IGF-1, which directly or indirectly affects LH, oestradiol and progesterone secretion and follicle development. Estradiol 103-113 insulin like growth factor 1 Homo sapiens 55-60 18082739-8 2008 Estradiol production was significantly stimulated by both GH (72 hours) and IGF-I (24 and 72 hours) and that of P only by IGF-I (72 hours). Estradiol 0-9 insulin like growth factor 1 Homo sapiens 76-81 17953960-8 2008 Effects of GH and insulin-like growth factor 1 (IGF-1) on progesterone and estradiol production were examined in the presence or absence of human chorionic gonadotropin (hCG) in human luteinized granulosa cells. Estradiol 75-84 insulin like growth factor 1 Homo sapiens 48-53 17953960-12 2008 Estradiol production was increased by IGF-1 and GH. Estradiol 0-9 insulin like growth factor 1 Homo sapiens 38-43 18193094-5 2008 17beta-Estradiol (E2) induced the gene expression of c-Myc and IGF-1 and increased the binding of ERalpha to the AP1 site of the promoters of c-Myc and IGF-1. Estradiol 0-16 insulin like growth factor 1 Homo sapiens 63-68 18193094-5 2008 17beta-Estradiol (E2) induced the gene expression of c-Myc and IGF-1 and increased the binding of ERalpha to the AP1 site of the promoters of c-Myc and IGF-1. Estradiol 0-16 insulin like growth factor 1 Homo sapiens 152-157 18473910-10 2008 The relationship between insulin resistance states associated with aging in females, and the cross-talk between estradiol and proteins includes in the IRS-1/PI3-k/Akt and IGF-1-IR signalling pathways, will lead to a more complete understanding of the precise mechanism underlying estradiol-mediated neuroprotection. Estradiol 112-121 insulin like growth factor 1 Homo sapiens 171-176 17872375-7 2007 Treatment with E(2) or raloxifene increased both IGF-I and cyclooxygenase (COX)-2 mRNA expression in HUVECs, whereas they attenuated the serum-induced increase of these genes in HASMCs. Estradiol 15-19 insulin like growth factor 1 Homo sapiens 49-54 17872375-8 2007 Treatment by E(2) and raloxifene induced recruitment of coactivator complex and histone acetylation at both the IGF-I and COX-2 gene promoter in HUVECs. Estradiol 13-17 insulin like growth factor 1 Homo sapiens 112-117 17872375-9 2007 In contrast, in HASMCs, E(2), and raloxifene attenuated the serum-induced recruitment of coactivator complexes and histone acetylation at both the IGF-I and COX-2 gene promoters. Estradiol 24-28 insulin like growth factor 1 Homo sapiens 147-152 17458902-1 2007 Induction of 17beta-estradiol (E2) and insulin-like growth factor-I (IGF-I) has been detected in breast carcinoma, however the interaction between E2 and IGF-I in the proliferation of breast carcinoma cells is still unclear. Estradiol 13-29 insulin like growth factor 1 Homo sapiens 154-159 17492948-2 2007 Previous studies in postmenopausal women have shown a differential effect between transdermal 17beta-oestradiol and oral ethynyl-oestradiol on GH and IGF-1 concentrations. Estradiol 94-111 insulin like growth factor 1 Homo sapiens 150-155 17492948-3 2007 This secondary analysis, based on a large randomized trial, aimed to estimate the effect of the route of administration of 17beta-oestradiol in combined hormone replacement therapy with progesterone on IGF-1 and IGFBP-3 levels. Estradiol 123-140 insulin like growth factor 1 Homo sapiens 202-207 17289850-7 2007 Estradiol enhanced the effect of IGF-I on IGFBP-2 levels, and this was associated with increased phosphorylation of IGFR1. Estradiol 0-9 insulin like growth factor 1 Homo sapiens 33-38 17320084-7 2007 IGF-I increased testosterone and estradiol-17beta production by ovarian fragments but decreased production of 17,20beta-dihydroxy-4-pregnen-3-one, a precursor to the MIH, which was below detection levels. Estradiol 33-49 insulin like growth factor 1 Homo sapiens 0-5 17484513-15 2007 CONCLUSIONS: Low-dose oral estradiol reduces plasma levels of IGF-I and increases IGFBP-1 and SHBG concentrations, while GH is unchanged. Estradiol 27-36 insulin like growth factor 1 Homo sapiens 62-67 18612048-4 2008 The release of IGF1 was significantly increased by 17beta-estradiol (10 nM). Estradiol 51-67 insulin like growth factor 1 Homo sapiens 15-19 18202196-8 2008 ER or IGF1-R antagonists inhibited the proliferative effect of serum readmission, cyst fluid, 17beta-estradiol, and IGF1. Estradiol 94-110 insulin like growth factor 1 Homo sapiens 6-10 18637482-11 2008 Additional effects include activation of the PI-3-kinase and mTOR pathways through estradiol-induced binding of ERalpha to the IGF-1 and EGF receptors. Estradiol 83-92 insulin like growth factor 1 Homo sapiens 127-132 17504916-10 2007 However, it increased progesterone secretion (P < 0.05) by about twofold and oestradiol production (P < 0.05) by about 1.6-fold in response to insulin-like growth factor-I (IGF-I) (10(-8) M). Estradiol 80-90 insulin like growth factor 1 Homo sapiens 149-177 17504916-10 2007 However, it increased progesterone secretion (P < 0.05) by about twofold and oestradiol production (P < 0.05) by about 1.6-fold in response to insulin-like growth factor-I (IGF-I) (10(-8) M). Estradiol 80-90 insulin like growth factor 1 Homo sapiens 179-184 17138646-9 2007 These findings support a model whereby estradiol acts via the classical estrogen receptors and IGF-I receptors, which converge on activation of ERK/MAPK signaling and CREB to promote neuronal survival in the face of global ischemia. Estradiol 39-48 insulin like growth factor 1 Homo sapiens 95-100 16821205-23 2005 CONCLUSIONS: 17b-estradiol may be as important contributor to insulin-like growth factor-I (IGF-I) plasma level as age in hypoestrogenic, hypogonadotropic women. Estradiol 13-26 insulin like growth factor 1 Homo sapiens 62-90 16213990-8 2005 In addition, free IGF-I concentrations in FFL were positively correlated (P < 0.01) with FFL estradiol, progesterone, androstenedione, estradiol:progesterone ratio, total IGF-I and total IGF-II. Estradiol 96-105 insulin like growth factor 1 Homo sapiens 18-23 16213990-8 2005 In addition, free IGF-I concentrations in FFL were positively correlated (P < 0.01) with FFL estradiol, progesterone, androstenedione, estradiol:progesterone ratio, total IGF-I and total IGF-II. Estradiol 138-147 insulin like growth factor 1 Homo sapiens 18-23 16322546-16 2005 We suggest that these actions of leptin on the IGF system decrease the bioavailability of IGF-I, resulting in decreased oestradiol production. Estradiol 120-130 insulin like growth factor 1 Homo sapiens 90-95 16821205-23 2005 CONCLUSIONS: 17b-estradiol may be as important contributor to insulin-like growth factor-I (IGF-I) plasma level as age in hypoestrogenic, hypogonadotropic women. Estradiol 13-26 insulin like growth factor 1 Homo sapiens 92-97 16091478-8 2005 Patients taking ethinyl estradiol had lower age-adjusted IGF-I sd scores and required almost twice the GH dose to achieve an IGF-I sd score that remained lower than patients with normal gonadal function and patients receiving transdermal estradiol. Estradiol 24-33 insulin like growth factor 1 Homo sapiens 57-62 16091478-8 2005 Patients taking ethinyl estradiol had lower age-adjusted IGF-I sd scores and required almost twice the GH dose to achieve an IGF-I sd score that remained lower than patients with normal gonadal function and patients receiving transdermal estradiol. Estradiol 24-33 insulin like growth factor 1 Homo sapiens 125-130 15762036-0 2004 Effects of 17beta-estradiol, tamoxifen and raloxifene on the protein and mRNA expression of interleukin-6, transforming growth factor-beta1 and insulin-like growth factor-1 in primary human osteoblast cultures. Estradiol 11-27 insulin like growth factor 1 Homo sapiens 144-172 16024245-10 2005 Additional effects include activation of PI-3 kinase and mTOR pathways through estradiol induced binding of ER alpha to the IGF-1 and EGF receptors. Estradiol 79-88 insulin like growth factor 1 Homo sapiens 124-129 16113100-11 2005 Additional effects include activation of the PI3-K and mTOR pathways through estradiol-induced binding of ERalpha to the IGF-I and epidermal growth factor receptors. Estradiol 77-86 insulin like growth factor 1 Homo sapiens 121-126 15713723-0 2005 Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I/IGFBP-1 concentrations. Estradiol 17-26 insulin like growth factor 1 Homo sapiens 41-69 15713723-0 2005 Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I/IGFBP-1 concentrations. Estradiol 17-26 insulin like growth factor 1 Homo sapiens 71-76 15713723-0 2005 Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I/IGFBP-1 concentrations. Estradiol 17-26 insulin like growth factor 1 Homo sapiens 124-129 15713723-1 2005 The present study tests the clinical postulate that elevated testosterone (Te) and estradiol (E2) concentrations modulate the effects of constant iv infusion of saline vs. recombinant human IGF-I on free IGF-I, IGF binding protein (IGFBP)-1, and dimeric IGF-I/IGFBP-1 concentrations in healthy aging adults. Estradiol 83-92 insulin like growth factor 1 Homo sapiens 190-195 15713723-1 2005 The present study tests the clinical postulate that elevated testosterone (Te) and estradiol (E2) concentrations modulate the effects of constant iv infusion of saline vs. recombinant human IGF-I on free IGF-I, IGF binding protein (IGFBP)-1, and dimeric IGF-I/IGFBP-1 concentrations in healthy aging adults. Estradiol 83-92 insulin like growth factor 1 Homo sapiens 204-209 15713723-1 2005 The present study tests the clinical postulate that elevated testosterone (Te) and estradiol (E2) concentrations modulate the effects of constant iv infusion of saline vs. recombinant human IGF-I on free IGF-I, IGF binding protein (IGFBP)-1, and dimeric IGF-I/IGFBP-1 concentrations in healthy aging adults. Estradiol 83-92 insulin like growth factor 1 Homo sapiens 204-209 15817823-1 2005 The actions of oestradiol in the brain involve interaction with growth factors, such as insulin-like growth factor-I (IGF-I). Estradiol 15-25 insulin like growth factor 1 Homo sapiens 88-116 15817823-1 2005 The actions of oestradiol in the brain involve interaction with growth factors, such as insulin-like growth factor-I (IGF-I). Estradiol 15-25 insulin like growth factor 1 Homo sapiens 118-123 15371274-6 2005 FSH (1 ng/ ml) and IGF-I (30 ng/ml) stimulated 17beta-estradiol (E2) production in human GCs, respectively. Estradiol 47-63 insulin like growth factor 1 Homo sapiens 19-24 15579776-11 2004 However, the IGF-I increment in response to GH decreased after oral 17beta-estradiol (P < 0.05), whereas it was unchanged after testosterone administration. Estradiol 68-84 insulin like growth factor 1 Homo sapiens 13-18 15762036-4 2004 Gene expression of IGF-I increased following 24 or 30 h incubation with 10(-8) M 17beta-estradiol and 30 h incubation with raloxifene. Estradiol 81-97 insulin like growth factor 1 Homo sapiens 19-24 15762036-8 2004 On the other hand, an increase in IGF-I synthesis induced by raloxifene and estradiol could mediate, in part, the effects of these compounds on bone. Estradiol 76-85 insulin like growth factor 1 Homo sapiens 34-39 15641264-10 2004 Estradiol levels of girls and testosterone levels of boys differed significantly between stages, and in both sexes, serum IGF-1 levels and IGF-1/IGFBP-3 ratios were significantly correlated with sex steroid levels. Estradiol 0-9 insulin like growth factor 1 Homo sapiens 139-144 15140868-5 2004 17beta-Estradiol up-regulates epidermal growth factor (EGF) receptor, but down-regulates p53 protein in leiomyoma cells, whereas progesterone augments EGF and Bcl-2 protein, but inhibits insulin-like growth factor (IGF-I) and tumour necrosis factor (TNFalpha). Estradiol 0-16 insulin like growth factor 1 Homo sapiens 215-220 15240605-8 2004 For each 1.0 pg/ml (3.5 pmol/liter) increase in free testosterone, IGF-I increased 19 ng/ml (2.5 nmol/liter), controlling for estradiol, body mass index, and GH pulse parameters (r(2) = 0.64). Estradiol 126-135 insulin like growth factor 1 Homo sapiens 67-72 15126563-2 2004 In this study, we hypothesize that low concentration of genistein mimics the action of 17beta-estradiol in stimulation of MCF-7 cell growth by enhancement of IGF-I signaling pathway. Estradiol 87-103 insulin like growth factor 1 Homo sapiens 158-163 15001627-7 2004 In summary, compared with Pl, E(2) supplementation in postmenopausal women: 1) amplifies endogenously driven GH secretory-burst mass; 2) initiates rapid onset of GHRH-stimulated GH release; and 3) potentiates IGF-I-dependent suppression of unstimulated GH concentrations. Estradiol 30-34 insulin like growth factor 1 Homo sapiens 209-214 12821935-1 2003 In breast cancer cells, 17-beta-estradiol (E2) upregulates the expression of insulin receptor substrate 1 (IRS-1), a molecule transmitting insulin-like growth factor-I (IGF-I) signals through the PI-3K/Akt survival pathways. Estradiol 24-41 insulin like growth factor 1 Homo sapiens 139-167 16146053-7 2004 There are significant positive correlations between IGF-1 and testosterone, IGF-1 and estradiol serum concentrations as well as between IGF-1 serum concentration, BMI and sum of skin folds thicknesses. Estradiol 86-95 insulin like growth factor 1 Homo sapiens 52-57 15032275-10 2004 For all three growth factors an additive effect was seen in combination with estradiol, which was greatest for IGF-I. Estradiol 77-86 insulin like growth factor 1 Homo sapiens 111-116 14557438-7 2003 Oral estradiol reduced baseline (P < 0.05) and GH stimulated (P < 0.05) IGF-I levels, and GH stimulated IGF-binding protein-3 (IGFBP-3) levels (P < 0.05). Estradiol 5-14 insulin like growth factor 1 Homo sapiens 78-83 12927315-8 2003 CONCLUSIONS: The association of cyproterone acetate to oral estradiol determines a significant reduction of IGF-I levels and an increase of SHBG; nevertheless, it does not seem to influence the serum levels of the IGF-I binding proteins. Estradiol 60-69 insulin like growth factor 1 Homo sapiens 108-113 12908822-5 2003 The results showed that the extracellular levels of free IGF-1 locally in the breast were doubled in the luteal phase, when estradiol and progesterone levels were elevated, compared with the follicular phase. Estradiol 124-133 insulin like growth factor 1 Homo sapiens 57-62 12821935-1 2003 In breast cancer cells, 17-beta-estradiol (E2) upregulates the expression of insulin receptor substrate 1 (IRS-1), a molecule transmitting insulin-like growth factor-I (IGF-I) signals through the PI-3K/Akt survival pathways. Estradiol 24-41 insulin like growth factor 1 Homo sapiens 169-174 12361468-4 2002 The results showed that addition of IGF-I stimulated progesterone production (150%, P < 0.01), oestradiol production (65%, P < 0.05) and bcl-2 gene expression (approximately 200%, P < 0.05), but decreased apoptosis (P < 0.05). Estradiol 98-108 insulin like growth factor 1 Homo sapiens 36-41 12773957-4 2003 Transdermal administration of 17beta oestradiol resulted in a slight increase in serum IGF-I but no change in mean 24h GH levels. Estradiol 30-47 insulin like growth factor 1 Homo sapiens 87-92 12414853-11 2002 There was a positive correlation between changes in IGF-I and changes in weight, body fat determined by DXA, and estradiol for both groups. Estradiol 113-122 insulin like growth factor 1 Homo sapiens 52-57 12034517-12 2002 CONCLUSION: Oral estradiol sequentially combined with dydrogesterone, a non-androgenic progestogen, induced positive changes of some cardiovascular (HDL-C) and breast (SHBG and IGF-I) metabolic markers. Estradiol 17-26 insulin like growth factor 1 Homo sapiens 177-182 11337496-9 2001 Thus the ability of estradiol to antagonize the insulin-induced increase in p21 gene expression, with consequent activation of cyclin E-Cdk2, is a central component of the synergistic stimulation of breast epithelial cell proliferation induced by simultaneous activation of the estrogen and insulin/IGF-I signaling pathways. Estradiol 20-29 insulin like growth factor 1 Homo sapiens 299-304 11924572-0 2002 Human osteoblasts" proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. Estradiol 57-73 insulin like growth factor 1 Homo sapiens 133-161 11924572-7 2002 In TE85 cells, strain increased medium concentrations of insulin-like growth factor (IGF) II but not IGF-I, whereas 17beta-estradiol increased medium concentrations of IGF-I but not IGF-II. Estradiol 116-132 insulin like growth factor 1 Homo sapiens 168-173 11924572-8 2002 Neutralizing monoclonal antibody (MNAb) to IGF-I (3 microg/ml) blocked the effects of 17beta-estradiol and exogenous truncated IGF-I (tIGF-I; 50 ng/ml) but not those of strain or tIGF-II (50 ng/ml). Estradiol 86-102 insulin like growth factor 1 Homo sapiens 43-48 11953083-1 2002 OBJECTIVE: To assess the effects of leptin on follicle-stimulating hormone (FSH) and insulin-like growth factor-I (IGF-I) induced production of estradiol (E(2))-17beta and progesterone (P) in cultured human luteinized granulosa cell (GC). Estradiol 144-153 insulin like growth factor 1 Homo sapiens 85-113 11953083-1 2002 OBJECTIVE: To assess the effects of leptin on follicle-stimulating hormone (FSH) and insulin-like growth factor-I (IGF-I) induced production of estradiol (E(2))-17beta and progesterone (P) in cultured human luteinized granulosa cell (GC). Estradiol 144-153 insulin like growth factor 1 Homo sapiens 115-120 11836333-7 2002 Statistical comparisons revealed that E2 repletion increased the mean (+/- SEM) serum E2 concentration to 222 +/- 26 pg/ml from 16 +/- 1.7 pg/ml during placebo (P < 0.001) and suppressed the serum LH by 48% (P = 0.0033), serum FSH by 64% (P < 0.001), and serum IGF-I by 44% (P = 0.021). Estradiol 38-40 insulin like growth factor 1 Homo sapiens 267-272 11739462-10 2001 E2 supplementation increased the (mean +/- SEM) serum E2 concentration from 43 +/- 1.8 (control) to 121 +/- 4 pg/ml (E2) (158 +/- 6.6 to 440 +/- 15 pmol/liter; P < 0.001), lowered the 0800 h (preinfusion) serum IGF-I concentration from 127 +/- 7.7 to 73 +/- 3.6 microg/liter (P < 0.01), and amplified spontaneous pulsatile GH production from 7.5 +/- 1.1 to 13 +/- 2.3 microg/liter per 6 h (P = 0.020). Estradiol 0-2 insulin like growth factor 1 Homo sapiens 214-219 11376126-4 2001 Oestradiol induced expression of IRS-1 results in enhanced tyrosine phosphorylation of IRS-1 after IGF-1 stimulation, followed by enhanced mitogen activated protein kinase, phosphoinositide 3" kinase, and Akt activation. Estradiol 0-10 insulin like growth factor 1 Homo sapiens 99-104 11443179-9 2001 Estrogen administration increased the serum estradiol concentration from 12 +/- 1 to 245 +/- 35 pg/mL [42 +/- 4 to 920 +/- 110 pmol/L] (P < 10(-4)); decreased serum concentrations of LH (P = 0.018), FSH (P < 10(-4)), and insulin-like growth factor-I (P = 0.003); and elevated the fasting (6-h mean) serum GH concentration from 0.41 +/- 0.07 to 0.87 +/- 0.27 (P = 0.011). Estradiol 44-53 insulin like growth factor 1 Homo sapiens 227-255 14666173-0 2001 Different action of ovine GH on porcine theca and granulosa cells proliferation and insulin-like growth factors I- and II-stimulated estradiol production. Estradiol 133-142 insulin like growth factor 1 Homo sapiens 84-121 11376126-5 2001 Oestradiol can also potentiate the effect of IGF-1 on the expression of cyclin D1 and cyclin E, and on the phosphorylation of the retinoblastoma protein (RB). Estradiol 0-10 insulin like growth factor 1 Homo sapiens 45-50 11207198-10 2001 Coincubation of 17beta-estradiol and an antibody against insulin-like growth factor I (IGF I) led to neutralization of ESC-mediated EEC proliferation. Estradiol 16-32 insulin like growth factor 1 Homo sapiens 57-85 11430712-2 2001 UNLABELLED: Timing of 17beta-estradiol (E2) administration in relation to that of GH could influence the "first pass effect" of E2 on hepatic IGF-I secretion. Estradiol 22-38 insulin like growth factor 1 Homo sapiens 142-147 11207198-10 2001 Coincubation of 17beta-estradiol and an antibody against insulin-like growth factor I (IGF I) led to neutralization of ESC-mediated EEC proliferation. Estradiol 16-32 insulin like growth factor 1 Homo sapiens 87-92 11207198-11 2001 This work provides evidence that the effect of 17beta-estradiol on human EEC proliferation may be mediated at least in part through ESC-secreted IGF I. Estradiol 47-63 insulin like growth factor 1 Homo sapiens 145-150 10653980-2 2000 Treatment of cells with 40 ng/ml IGF-I resulted in a 60% decrease in ER-alpha protein concentration by 3 h, and the amount of ER-alpha remained suppressed for 24 h. A multiple-dose ligand-binding assay demonstrated that the decrease in ER-alpha protein corresponded to a similar decrease of 50% in estradiol-binding sites with no effect on the binding affinity of ER-alpha. Estradiol 298-307 insulin like growth factor 1 Homo sapiens 33-38 11155090-10 2000 Multiple regression analysis revealed an age-and BMI- independent association between oestradiol and IGF-1. Estradiol 86-96 insulin like growth factor 1 Homo sapiens 101-106 10634425-0 2000 A switch from oral (2 mg/day) to transdermal (50 microg/day) 17beta-estradiol therapy increases serum insulin-like growth factor-I levels in recombinant human growth hormone (GH)-substituted women with GH deficiency. Estradiol 61-77 insulin like growth factor 1 Homo sapiens 102-130 10065335-8 1999 We consistently find chronic oestradiol treatment of transplant recipients inhibits arteriosclerosis by attenuating both IGF-I expression and the immune response, particularly major histocompatibility complex class II expression. Estradiol 29-39 insulin like growth factor 1 Homo sapiens 121-126 10634425-10 2000 Further investigation should be undertaken to answer the question whether the increase in serum IGF-I levels is due to lower serum levels of estradiol or to differences in the mode of administration of estradiol. Estradiol 141-150 insulin like growth factor 1 Homo sapiens 96-101 10634425-10 2000 Further investigation should be undertaken to answer the question whether the increase in serum IGF-I levels is due to lower serum levels of estradiol or to differences in the mode of administration of estradiol. Estradiol 202-211 insulin like growth factor 1 Homo sapiens 96-101 10399774-13 1999 Estrogen administration suppressed peripheral markers of the IGF system, as evidenced by a negative correlation between plasma concentration of estradiol and IGF-1 (r = -0.93, P < 0.03), and a trend for a similar relationship between plasma levels of estradiol and IGFBP-3 (r = -0.86, P = 0.06). Estradiol 144-153 insulin like growth factor 1 Homo sapiens 158-163 10421796-8 1999 A single addition of leptin (1 ng/ml) or a combination of leptin (1 ng/ml), FSH (100 ng/ml), and IGF-I (100 ng/ml) gave rise to an increase in each parameter of oestrogen-producing activity measured, i.e. P450arom mRNA level, P450arom protein level, aromatase specific activity, and the oestradiol concentration in the culture supernatant. Estradiol 287-297 insulin like growth factor 1 Homo sapiens 97-102 10404809-2 1999 It has been suggested that oral and transdermal 17beta-estradiol (E2) may have different effects on serum insulin-like growth factor I (IGF-I), a potent bone-forming growth factor. Estradiol 48-64 insulin like growth factor 1 Homo sapiens 106-134 10404809-2 1999 It has been suggested that oral and transdermal 17beta-estradiol (E2) may have different effects on serum insulin-like growth factor I (IGF-I), a potent bone-forming growth factor. Estradiol 48-64 insulin like growth factor 1 Homo sapiens 136-141 10084597-7 1999 In cultured GC, leptin had no effect on estradiol production, alone or in the presence of FSH, but caused a concentration-related inhibition of the insulin-like growth factor I (IGF-I) augmentation of FSH-stimulated estradiol production. Estradiol 216-225 insulin like growth factor 1 Homo sapiens 148-176 10084597-7 1999 In cultured GC, leptin had no effect on estradiol production, alone or in the presence of FSH, but caused a concentration-related inhibition of the insulin-like growth factor I (IGF-I) augmentation of FSH-stimulated estradiol production. Estradiol 216-225 insulin like growth factor 1 Homo sapiens 178-183 9844353-4 1998 RESULTS: Within each group, IGF-I levels were gender-independent while showed age-related variations with positive association with pubertal stage--peaking up in pubertal stage IV--(DS: r = 0.6, NS: r = 0.4, both p < 0.0001) and testosterone (DS: r = 0.6, NS: r = 0.5, p < 0.001) or estradiol (DS: r = 0.6, NS: r = 0.5, p < 0.001) levels. Estradiol 289-298 insulin like growth factor 1 Homo sapiens 28-33 9798135-1 1998 The objective of this study was to determine the influence of transdermal estradiol administration on insulin-like growth factor I (IGF-I) serum level in a series larger than those published to date. Estradiol 74-83 insulin like growth factor 1 Homo sapiens 102-130 9798135-1 1998 The objective of this study was to determine the influence of transdermal estradiol administration on insulin-like growth factor I (IGF-I) serum level in a series larger than those published to date. Estradiol 74-83 insulin like growth factor 1 Homo sapiens 132-137 9798135-6 1998 Transdermal estradiol seems to induce a bimodal effect on IGF-I serum levels, depending on IGF-I basal values. Estradiol 12-21 insulin like growth factor 1 Homo sapiens 58-63 9798135-6 1998 Transdermal estradiol seems to induce a bimodal effect on IGF-I serum levels, depending on IGF-I basal values. Estradiol 12-21 insulin like growth factor 1 Homo sapiens 91-96 9795373-5 1998 IGF-I (10 ng/ml or more) inhibited androstenedione and PGF secretion, stimulated testosterone, estradiol, OT and cAMP production, but did not influence progesterone, IGFBP-3 or PGE output in these conditions. Estradiol 95-104 insulin like growth factor 1 Homo sapiens 0-5 9798135-0 1998 Insulin-like growth factor I (IGF-I) serum level modifications during transdermal estradiol treatment in postmenopausal women: a possible bimodal effect depending on basal IGF-I values. Estradiol 82-91 insulin like growth factor 1 Homo sapiens 0-28 9798135-0 1998 Insulin-like growth factor I (IGF-I) serum level modifications during transdermal estradiol treatment in postmenopausal women: a possible bimodal effect depending on basal IGF-I values. Estradiol 82-91 insulin like growth factor 1 Homo sapiens 30-35 9626134-11 1998 Estradiol replacement significantly increased both serum IGF-I and IGFBP-3 through adolescence, even in IGF-I-supplemented animals. Estradiol 0-9 insulin like growth factor 1 Homo sapiens 57-62 9626134-11 1998 Estradiol replacement significantly increased both serum IGF-I and IGFBP-3 through adolescence, even in IGF-I-supplemented animals. Estradiol 0-9 insulin like growth factor 1 Homo sapiens 104-109 9626134-12 1998 However, with the transition from adolescence, estradiol suppressed serum IGF-I secretion, yet continued to increase IGFBP-3 in young adult and fully adult females. Estradiol 47-56 insulin like growth factor 1 Homo sapiens 74-79 9626134-18 1998 Replacement with estradiol significantly elevated serum GH in adolescent and adult females, particularly in females supplemented with IGF-I. Estradiol 17-26 insulin like growth factor 1 Homo sapiens 134-139 9626134-21 1998 However, estradiol replacement restored the response to GHRH in these adult, IGF-I-supplemented females. Estradiol 9-18 insulin like growth factor 1 Homo sapiens 77-82 9626134-24 1998 Furthermore, IGF-I has a greater suppressive effect on GH secretion with advancing age, an effect reversed by estradiol replacement. Estradiol 110-119 insulin like growth factor 1 Homo sapiens 13-18 10990135-3 1998 Moreover, physiological regulation of the GH-IGF-I axis is evident within the follicular phase of the normal human menstrual cycle, wherein mean serum GH and plasma IGF-I concentrations rise concurrently with increased oestradiol secretion in the preovulatory phase. Estradiol 219-229 insulin like growth factor 1 Homo sapiens 45-50 9654167-3 1998 RESULTS: IGF-I alone resulted in a significant dose-dependent increase in medium estradiol (E2) (p<0.05) and progesterone (P) (p<0.001) and suppression of IGF-binding protein-1 (IGFBP-1) (p<0.001), without any increase in [3H]-thymidine incorporation (P=0.10). Estradiol 81-90 insulin like growth factor 1 Homo sapiens 9-14 9610425-3 1998 These circumstances urged us to perform this pilot study using a non-invasive method that involved the application of 17 beta-estradiol as it is known that estradiol enhances expression of insulin-like growth factor-I (IGF-I) which can promote growth in breast tissue. Estradiol 118-135 insulin like growth factor 1 Homo sapiens 189-217 9610425-3 1998 These circumstances urged us to perform this pilot study using a non-invasive method that involved the application of 17 beta-estradiol as it is known that estradiol enhances expression of insulin-like growth factor-I (IGF-I) which can promote growth in breast tissue. Estradiol 118-135 insulin like growth factor 1 Homo sapiens 219-224 9610425-3 1998 These circumstances urged us to perform this pilot study using a non-invasive method that involved the application of 17 beta-estradiol as it is known that estradiol enhances expression of insulin-like growth factor-I (IGF-I) which can promote growth in breast tissue. Estradiol 126-135 insulin like growth factor 1 Homo sapiens 189-217 9071977-1 1997 The interaction between GH and IGF-I in modulating oestradiol biosynthetic capacity was examined in cultured porcine granulosa cells. Estradiol 51-61 insulin like growth factor 1 Homo sapiens 31-36 9610425-3 1998 These circumstances urged us to perform this pilot study using a non-invasive method that involved the application of 17 beta-estradiol as it is known that estradiol enhances expression of insulin-like growth factor-I (IGF-I) which can promote growth in breast tissue. Estradiol 126-135 insulin like growth factor 1 Homo sapiens 219-224 9215289-16 1997 The mean serum IGF-I concentration also decreased significantly from 116 +/- 17 to 93 +/- 15 micrograms/L (saline vs. E2 infusion, respectively; P < 0.05). Estradiol 118-120 insulin like growth factor 1 Homo sapiens 15-20 9571602-10 1998 This hypothesis is further supported by the finding of a correlation between plasma levels of IGF-I and estradiol but not progesterone in individual patients at different times during the menstrual cycle. Estradiol 104-113 insulin like growth factor 1 Homo sapiens 94-99 9405735-5 1998 As assessed by a quantitative reverse transcriptase-polymerase chain reaction method, treatment of hFOB/ER9 cells with 17beta-estradiol (E2) increased steady state levels of IGF-I mRNA in a time- and dose- dependent fashion with a maximal increase of 319% +/- 33% (P < 0.01) of control occurring after treatment with 10(-7) M E2 for 48 hours. Estradiol 119-135 insulin like growth factor 1 Homo sapiens 174-179 9264503-13 1997 CONCLUSIONS: In vivo estradiol treatment abolishes both IGF-I mitogenic effects and IGF-I protein expression in the vascular wall, which may be causally related to the inhibitory effect of estradiol on transplant arteriosclerosis. Estradiol 21-30 insulin like growth factor 1 Homo sapiens 56-61 9264503-13 1997 CONCLUSIONS: In vivo estradiol treatment abolishes both IGF-I mitogenic effects and IGF-I protein expression in the vascular wall, which may be causally related to the inhibitory effect of estradiol on transplant arteriosclerosis. Estradiol 21-30 insulin like growth factor 1 Homo sapiens 84-89 9264503-13 1997 CONCLUSIONS: In vivo estradiol treatment abolishes both IGF-I mitogenic effects and IGF-I protein expression in the vascular wall, which may be causally related to the inhibitory effect of estradiol on transplant arteriosclerosis. Estradiol 189-198 insulin like growth factor 1 Homo sapiens 56-61 9264503-13 1997 CONCLUSIONS: In vivo estradiol treatment abolishes both IGF-I mitogenic effects and IGF-I protein expression in the vascular wall, which may be causally related to the inhibitory effect of estradiol on transplant arteriosclerosis. Estradiol 189-198 insulin like growth factor 1 Homo sapiens 84-89 9140076-5 1997 In the presence of IGF-I or insulin, the induction of progesterone receptor mRNA by oestradiol was considerably attenuated in MCF-7 cells, showing that the enhanced down-regulation of OR mRNA levels influenced the expression of oestrogen-regulated genes. Estradiol 84-94 insulin like growth factor 1 Homo sapiens 19-24 9056422-5 1997 All MCF-7/IGF-IR clones responded to the synergistic action of 1 nM estradiol (E2) and small amounts of IGF-I (up to 0.8 ng/ml). Estradiol 68-77 insulin like growth factor 1 Homo sapiens 10-15 9071977-5 1997 In contrast, concurrent treatment with IGF-I produced a 4.3-fold increase (26 vs 112 ng/ 2 x 10(6) cells per 24 h, P < 0.001) in oestradiol accumulation. Estradiol 132-142 insulin like growth factor 1 Homo sapiens 39-44 9071977-6 1997 GH amplified IGF-I-induced oestradiol production in a dose (minimal dose requirement of 0.3 ng/ml)- and time (minimal time requirement of 24-48 h)-dependent manner. Estradiol 27-37 insulin like growth factor 1 Homo sapiens 13-18 9071977-7 1997 Studies on the site(s) of action indicated that GH exerts its amplifying effects on IGF-I-induced oestradiol production both proximal and distal to cAMP generation. Estradiol 98-108 insulin like growth factor 1 Homo sapiens 84-89 9071977-8 1997 As the specificity study and the inhibitory study indicated, GH amplification of IGF-I-induced oestradiol production is a process involving gene transcription and/or translation and the synergism is not solely specific to IGF-I as IGF-II-induced oestradiol production was also amplified in the presence of GH. Estradiol 95-105 insulin like growth factor 1 Homo sapiens 81-86 9071977-8 1997 As the specificity study and the inhibitory study indicated, GH amplification of IGF-I-induced oestradiol production is a process involving gene transcription and/or translation and the synergism is not solely specific to IGF-I as IGF-II-induced oestradiol production was also amplified in the presence of GH. Estradiol 246-256 insulin like growth factor 1 Homo sapiens 81-86 8603578-6 1996 On the other hand, tamoxifen, similar to estradiol, increased IGF-I-stimulated tyrosine phosphorylation of cellular substrates. Estradiol 41-50 insulin like growth factor 1 Homo sapiens 62-67 8869589-9 1996 IGFBP-4 proteolyzed in the conditioned medium from cells treated with PTH and 17 beta-estradiol was less effective at inhibiting IGF-I-stimulated [3H]thymidine incorporation into DNA compared with that proteolyzed in the conditioned medium from PTH-treated cells. Estradiol 78-95 insulin like growth factor 1 Homo sapiens 129-134 8742122-1 1996 Evidence that oestrogen is involved in the regulation of the somatotrophic axis in adult humans is provided by the observations that mean growth hormone (GH) levels are higher in women than men, that the fall in GH and insulin-like growth factor-1 (IGF-1) with aging are correlated to oestradiol levels and that oestrogen increases the GH responses to provocative stimuli. Estradiol 285-295 insulin like growth factor 1 Homo sapiens 249-254 8742122-5 1996 Transdermal administration of 17 beta-oestradiol resulted in a slight increase in serum IGF-1 but no change in mean 24-hour GH levels. Estradiol 30-48 insulin like growth factor 1 Homo sapiens 88-93 7698287-14 1995 The similarities between TSP, TGF beta and IGF-I, in terms of their distribution and regulation by 17 beta estradiol treatment, may indicate a role for TSP in modulating bone cell proliferation and function through interaction with local growth factors. Estradiol 99-116 insulin like growth factor 1 Homo sapiens 43-48 7587167-3 1995 However, species differences exist with regard to insulin and IGF-I effects on granulosa cell estradiol production. Estradiol 94-103 insulin like growth factor 1 Homo sapiens 62-67 7750475-0 1995 Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol. Estradiol 137-146 insulin like growth factor 1 Homo sapiens 14-42 7750475-0 1995 Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol. Estradiol 137-146 insulin like growth factor 1 Homo sapiens 44-49 7750475-9 1995 IGF-I stimulates Ishikawa cell proliferation, but at low concentrations, and this stimulation is largely dependent on the presence of estradiol. Estradiol 134-143 insulin like growth factor 1 Homo sapiens 0-5 8552446-6 1995 IGF-I produced no increase in progesterone accumulation but increased estradiol accumulation 5.6-fold compared with cells treated with vehicle. Estradiol 70-79 insulin like growth factor 1 Homo sapiens 0-5 8552446-7 1995 The combination of GH and FSH produced an 0.83-fold increase in estradiol accumulation, whereas the combination of IGF-I and FSH resulted in a 2.9-fold increase in estradiol accumulation above FSH alone. Estradiol 164-173 insulin like growth factor 1 Homo sapiens 115-120 8520621-0 1995 Relationship between serum estradiol concentration and IGF-I, IGF-II and IGF-binding proteins in patients with premature ovarian failure on short-term estradiol therapy. Estradiol 27-36 insulin like growth factor 1 Homo sapiens 55-60 7947343-3 1994 In osteoblasts, oestradiol stimulates the production of IGF-I which appears to act as an autocrine growth factor. Estradiol 16-26 insulin like growth factor 1 Homo sapiens 56-61 8788308-14 1995 Estradiol and androstenedione, but not testosterone, may also be stimulators of IGF-I output. Estradiol 0-9 insulin like growth factor 1 Homo sapiens 80-85 8788308-10 1995 Blockade of estradiol (but not of testosterone) in the medium by specific antisera (1 or 10%) significantly reduced IGF-I output. Estradiol 12-21 insulin like growth factor 1 Homo sapiens 116-121 7810645-3 1994 The inclusion of 17 beta-estradiol (10(-11) to 10(-9) M) in the culture medium increased multilayer depths, increased labeling for IGF-I, IGF-II, and TGF-beta 1, and resulted in earlier detection of TGF-beta 1 label. Estradiol 17-34 insulin like growth factor 1 Homo sapiens 131-136 7947343-4 1994 In uterine tissue, oestradiol increases the synthesis of IGF-I in the stroma which then modulates the proliferation of epithelial cells although there is also evidence that oestradiol can modulate the sensitivity of uterine epithelial cells to IGFs. Estradiol 19-29 insulin like growth factor 1 Homo sapiens 57-62 7947343-4 1994 In uterine tissue, oestradiol increases the synthesis of IGF-I in the stroma which then modulates the proliferation of epithelial cells although there is also evidence that oestradiol can modulate the sensitivity of uterine epithelial cells to IGFs. Estradiol 173-183 insulin like growth factor 1 Homo sapiens 57-62 7515764-2 1994 This result is consistent with prior reports indicating that the uterotrophic effects of estradiol are mediated at least in part by estradiol-stimulated uterine IGF-I gene expression. Estradiol 89-98 insulin like growth factor 1 Homo sapiens 161-166 7522591-6 1994 In tightly bound but not weakly associated cells, IGF-1 stimulated estradiol production. Estradiol 67-76 insulin like growth factor 1 Homo sapiens 50-55 7515764-7 1994 The uterotrophic toxicity of chronic estradiol or tamoxifen treatment may be causally related to both the inhibition of uterine IGFBP-3 expression and the stimulation of uterine IGF-I expression by these compounds. Estradiol 37-46 insulin like growth factor 1 Homo sapiens 178-183 7515764-2 1994 This result is consistent with prior reports indicating that the uterotrophic effects of estradiol are mediated at least in part by estradiol-stimulated uterine IGF-I gene expression. Estradiol 132-141 insulin like growth factor 1 Homo sapiens 161-166 8191926-8 1994 Both IGF-I binding capacity and release decreased either with increases in cell number or after treatment with 17 beta-estradiol (17 beta E2) and parathyroid hormone (PTH). Estradiol 111-128 insulin like growth factor 1 Homo sapiens 5-10 8175988-7 1994 In contrast, insulin produced only a small increase of estradiol in response to IGF-I. Estradiol 55-64 insulin like growth factor 1 Homo sapiens 80-85 7522203-2 1994 IGFBP-1 abolished IGF-I-stimulated estradiol production by luteinizing granulosa cells in a dose-dependent manner with a 50% inhibitory concentration (IC50) of 0.27 nM. Estradiol 35-44 insulin like growth factor 1 Homo sapiens 18-23 8187298-7 1994 RESULTS: The treatment caused a decrease in the LH and FSH responses to GnRH test and plasma oestradiol, which resulted in decreased urinary GH excretion, plasma IGF-I levels, height velocity and bone age maturation. Estradiol 93-103 insulin like growth factor 1 Homo sapiens 162-167 7508947-7 1994 Estradiol was high in fluid from invasive malignant cysts of postmenopausal women and correlated with IGF-I in the cyst fluid. Estradiol 0-9 insulin like growth factor 1 Homo sapiens 102-107 7690723-5 1993 AFP purified from either term cord blood or midtrimester amniotic fluid dose-dependently inhibited estradiol production stimulated by the combination of FSH and insulin-like growth factor-I. Estradiol 99-108 insulin like growth factor 1 Homo sapiens 161-189 8195346-0 1994 Exogenous steroids and the control of oestradiol secretion by human granulosa-lutein cells by follicle stimulating hormone and insulin-like growth factor-I. Estradiol 38-48 insulin like growth factor 1 Homo sapiens 127-155 8195346-5 1994 In the second part of this study we examined the control of granulosa-lutein oestradiol secretion by follicle stimulating hormone (FSH) and insulin-like growth factor-I (IGF-I) in the presence and absence of exogenous androstenedione (10(-6) M). Estradiol 77-87 insulin like growth factor 1 Homo sapiens 140-168 8195346-5 1994 In the second part of this study we examined the control of granulosa-lutein oestradiol secretion by follicle stimulating hormone (FSH) and insulin-like growth factor-I (IGF-I) in the presence and absence of exogenous androstenedione (10(-6) M). Estradiol 77-87 insulin like growth factor 1 Homo sapiens 170-175 8252747-5 1993 Serum GHBP levels were negatively (r = -0.67; P < 0.01) and IGF-I levels were positively related (r = 0.69; P < 0.01) to serum oestradiol concentrations. Estradiol 133-143 insulin like growth factor 1 Homo sapiens 63-68 7507128-1 1993 Oestradiol is important in the growth of uterine leiomyomata and may act primarily or secondarily through mediators such as growth factors, including the insulin-like growth factors (IGF-I and IGF-II), mitogenic peptides. Estradiol 0-10 insulin like growth factor 1 Homo sapiens 183-188 7507128-15 1993 These data support the hypothesis that IGF-I, but not IGF-II, may be a mediator of oestradiol action in the growth of uterine leiomyomata, and that IGFBPs may further modulate, by an autocrine or paracrine mechanism, IGF-I action in this tissue. Estradiol 83-93 insulin like growth factor 1 Homo sapiens 39-44 8286688-3 1993 Rising estradiol levels transiently increase growth hormone (GH) concentrations, which in turn leads to increases in insulin-like growth factor (IGF)-I, insulin resistance, and physiological hyper-insulinemia. Estradiol 7-16 insulin like growth factor 1 Homo sapiens 117-151 8435211-1 1993 Insulin-like growth factors I and II (IGF-I and IGF-II) are potent mitogens for some human breast cancer cell lines, and expression of IGF-II mRNA in the oestrogen receptor-positive (ER+) and oestradiol (E2) stimulated human breast cancer cell line T47D is increased by E2, suggesting a role for IGF-II in the mitogenic response to E2. Estradiol 192-202 insulin like growth factor 1 Homo sapiens 0-36 7506561-2 1993 In this study, we examined oestradiol (E2) regulation of IGF-I and IGF binding proteins (IGFBP) in an oestrogen-responsive ovarian cancer cell line, PE04. Estradiol 27-37 insulin like growth factor 1 Homo sapiens 57-62 8435211-1 1993 Insulin-like growth factors I and II (IGF-I and IGF-II) are potent mitogens for some human breast cancer cell lines, and expression of IGF-II mRNA in the oestrogen receptor-positive (ER+) and oestradiol (E2) stimulated human breast cancer cell line T47D is increased by E2, suggesting a role for IGF-II in the mitogenic response to E2. Estradiol 192-202 insulin like growth factor 1 Homo sapiens 38-43 8012064-9 1993 Estradiol increased the Ka of the EGF receptor approximately 2-fold (p < 0.01) and increased the number of receptors/cell for IGF-1 approximately 50% (p < 0.01). Estradiol 0-9 insulin like growth factor 1 Homo sapiens 129-134 1284489-2 1992 Both IGFBP-1 and IGFBP-3 produced a dose-related inhibition of IGF-I-stimulated oestradiol accumulation in granulosa cell-conditioned medium with complete reversal of the effects of IGF-I in the presence of a molar excess of binding protein. Estradiol 80-90 insulin like growth factor 1 Homo sapiens 63-68 1562524-13 1992 The results suggest a cooperative interaction of oestradiol and IGF-I. Estradiol 49-59 insulin like growth factor 1 Homo sapiens 64-69 1280287-0 1992 Transdermal 17 beta-estradiol combined with oral progestogen increases plasma levels of insulin-like growth factor-I in postmenopausal women. Estradiol 12-29 insulin like growth factor 1 Homo sapiens 88-116 1280287-6 1992 In postmenopausal women transdermal estradiol administration restored the circulating E2 levels to the early follicular range and increased the IGF-I levels (from 76.4 +/- 9.2 micrograms/l to 141.8 +/- 20.8 micrograms/l; p less than 0.01). Estradiol 36-45 insulin like growth factor 1 Homo sapiens 144-149 1280287-9 1992 These results suggest that cyclic replacement therapy with transdermal 17 beta-estradiol in combination with chlormadinone acetate given orally increase the plasma levels of IGF-I in postmenopausal women. Estradiol 71-88 insulin like growth factor 1 Homo sapiens 174-179 1562524-0 1992 Oestradiol treatment increases the sensitivity of MCF-7 cells for the growth stimulatory effect of IGF-I. Estradiol 0-10 insulin like growth factor 1 Homo sapiens 99-104 1634015-4 1992 The combination of IGF-I and albumin, however, produced a marked (704%) synergistic stimulation of estradiol 17 beta-hydroxysteroid dehydrogenase activity. Estradiol 99-108 insulin like growth factor 1 Homo sapiens 19-24 1562524-14 1992 It is concluded that growth stimulation of MCF-7 cells by long term treatment with oestradiol may be mediated through autocrine secretion of IGF-I. Estradiol 83-93 insulin like growth factor 1 Homo sapiens 141-146 1806564-1 1991 There is evidence that insulin-like growth factor I (IGF-I) is a potent regulator of oestradiol synthesis by human granulosa and luteal cells; however, the question of whether IGF-I regulates progesterone synthesis by these cell types has yet to be answered. Estradiol 85-95 insulin like growth factor 1 Homo sapiens 23-51 1842568-5 1991 The higher the initial DHEA-S and E2 concentration of the gymnasts, the higher were the IGF-I basal levels. Estradiol 34-36 insulin like growth factor 1 Homo sapiens 88-93 1806564-1 1991 There is evidence that insulin-like growth factor I (IGF-I) is a potent regulator of oestradiol synthesis by human granulosa and luteal cells; however, the question of whether IGF-I regulates progesterone synthesis by these cell types has yet to be answered. Estradiol 85-95 insulin like growth factor 1 Homo sapiens 53-58 1910243-4 1991 It was found that in granulosa cells from follicles of natural cycles, FSH as well as IGF-I significantly stimulated progesterone and estradiol production in a majority of the experiments. Estradiol 134-143 insulin like growth factor 1 Homo sapiens 86-91 1843144-6 1991 A reverse correlation was established between concentrations of IGF-1 and total estradiol. Estradiol 80-89 insulin like growth factor 1 Homo sapiens 64-69 2040851-7 1991 If IGF-I and IGF-II act to stimulate E2DH reductive activity in breast tumours then such a mechanism could account for the increased concentrations of oestradiol detected in breast tumours. Estradiol 151-161 insulin like growth factor 1 Homo sapiens 3-8 1905506-3 1991 Furthermore, IGF-I alone and in combination with FSH or LH enhanced estradiol and progesterone production. Estradiol 68-77 insulin like growth factor 1 Homo sapiens 13-18 34183565-6 2021 Significant changes were detected in hepatic proteins with oral estradiol: TBG and SHBG levels increased (15.29 +- 3.87 vs 20.84 +- 5.49 mug/mL, P < 0.001; 61.85 +- 33.6 vs 121.4 +- 49.36 nmol/L, P < 0.001; respectively), whereas IGF-1 levels decreased (152 +- 38.91 vs 96 +- 17.59 ng/mL; P < 0.001). Estradiol 64-73 insulin like growth factor 1 Homo sapiens 230-235 2242341-0 1990 Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture. Estradiol 35-44 insulin like growth factor 1 Homo sapiens 56-84 33588025-11 2021 In humans, long-term exposure to estradiol and leptin can alter endometrial homeostasis through the NEAT1-miR-204-5p-Igf1 axis and favor carcinogenic pathways, which provide mechanistic insight into the obesity-associated endometrial cancer. Estradiol 33-42 insulin like growth factor 1 Homo sapiens 117-121