PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32370059-6 2020 Only patients in the MCP-1-high group had a significantly altered cytokine profile in the FF, and had a significantly higher serum estradiol level (p = 0.002) and a significantly lower number of oocytes recovered (p = 0.01) compared to the MCP-1-low and the control group. Estradiol 131-140 C-C motif chemokine ligand 2 Homo sapiens 21-26 29934505-3 2018 Here we examined the levels of CCL2 in 4 breast cancer cell lines along with 57 human breast cancer specimens and found them significantly increased with presence of 17beta-estradiol (E2) in estrogen receptor (ER)-positive breast cancer cells, while anti-estrogen treatment weakened this enhancement. Estradiol 166-182 C-C motif chemokine ligand 2 Homo sapiens 31-35 31760088-4 2020 Exposure of MCF-7 cells to 17ss-estradiol stimulated cell proliferation and the expression of pro-metastatic and pro-invasive elements such as claudin-1, matrix metalloproteinase 9 (MMP9), and the CC chemokine ligand 2 (CCL2). Estradiol 32-41 C-C motif chemokine ligand 2 Homo sapiens 197-218 31760088-4 2020 Exposure of MCF-7 cells to 17ss-estradiol stimulated cell proliferation and the expression of pro-metastatic and pro-invasive elements such as claudin-1, matrix metalloproteinase 9 (MMP9), and the CC chemokine ligand 2 (CCL2). Estradiol 32-41 C-C motif chemokine ligand 2 Homo sapiens 220-224 21829352-7 2011 Conversely, females administered high doses of estradiol had a >=10-fold lower induction of TNF-alpha and CCL2 in the lungs and increased rates of survival as compared with females that had either low or no estradiol. Estradiol 47-56 C-C motif chemokine ligand 2 Homo sapiens 109-113 25901081-10 2015 In a zebrafish model, macrophages increased cancer cell dissemination via CCL2 and CCL5 in the presence of estradiol, which was inhibited with anti-CCL2 and anti-CCL5 treatment. Estradiol 107-116 C-C motif chemokine ligand 2 Homo sapiens 148-152 22381103-0 2012 Effects of 17beta-estradiol on the release of monocyte chemotactic protein-1 and MAPK activity in monocytes stimulated with peritoneal fluid from endometriosis patients. Estradiol 11-27 C-C motif chemokine ligand 2 Homo sapiens 46-76 25340263-6 2015 Ten nmol/l 17beta-estradiol increased RAGE and monocyte chemoattractant protein-1 (MCP-1) gene and protein expression in human umbilical vein endothelial cells (HUVECs), both of which were blocked by 10 nmol/l bazedoxifene. Estradiol 11-27 C-C motif chemokine ligand 2 Homo sapiens 47-81 25340263-6 2015 Ten nmol/l 17beta-estradiol increased RAGE and monocyte chemoattractant protein-1 (MCP-1) gene and protein expression in human umbilical vein endothelial cells (HUVECs), both of which were blocked by 10 nmol/l bazedoxifene. Estradiol 11-27 C-C motif chemokine ligand 2 Homo sapiens 83-88 22523336-8 2012 In a separate clinical trial, the direct adverse effects of lowering testosterone and raising estradiol on MCP1 were substantiated in vivo. Estradiol 94-103 C-C motif chemokine ligand 2 Homo sapiens 107-111 21685244-7 2011 The combination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with 17beta-estradiol can promote the invasion of ESCs via suppressing CD82 expression and stimulating CCL2 secretion and CCR2 expression, and the enhanced interaction of CCL2-CCR2 recruits more macrophages into the ectopic milieu in a paracrine manner, which further downregulates CD82 expression in the ectopic ESCs. Estradiol 67-83 C-C motif chemokine ligand 2 Homo sapiens 165-169 21685244-7 2011 The combination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with 17beta-estradiol can promote the invasion of ESCs via suppressing CD82 expression and stimulating CCL2 secretion and CCR2 expression, and the enhanced interaction of CCL2-CCR2 recruits more macrophages into the ectopic milieu in a paracrine manner, which further downregulates CD82 expression in the ectopic ESCs. Estradiol 67-83 C-C motif chemokine ligand 2 Homo sapiens 233-237 18347511-8 2008 CONCLUSION: An increase in adiponectin level due to a decrease in estradiol results in a reduction in monocyte chemotactic protein-1 level in postmenopausal women, suggesting that adiponectin may be associated with a protective role against insulin resistance and atherosclerosis, which occur in the postmenopausal stage. Estradiol 66-75 C-C motif chemokine ligand 2 Homo sapiens 102-132 19933497-5 2010 The effects of estradiol (5 x 10(- 8) mol/L), progesterone (10(-7) mol/L), or both on MCP-1 messenger RNA (mRNA) and protein levels were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis and enzyme-linked immunosorbent serologic assay (ELISA), respectively. Estradiol 15-24 C-C motif chemokine ligand 2 Homo sapiens 86-91 16543969-5 2006 17beta-dihydroequilenin and 17beta-estradiol at a concentration of 1 microM reduced IL-1alpha-induced up regulation of IL-6, IL-8 and MCP-1 close to control levels. Estradiol 28-44 C-C motif chemokine ligand 2 Homo sapiens 134-139 12123781-0 2002 Female gender, menstrual cycle and estradiol affect plasma levels of monocyte chemotactic protein-1 (MCP-1) in humans. Estradiol 35-44 C-C motif chemokine ligand 2 Homo sapiens 69-99 12787135-0 2003 17Beta-estradiol inhibits MCP-1 production in human keratinocytes. Estradiol 0-16 C-C motif chemokine ligand 2 Homo sapiens 26-31 12787135-4 2003 We examined in vitro effects of 17beta-estradiol (E2) on MCP-1 production by human keratinocytes. Estradiol 32-48 C-C motif chemokine ligand 2 Homo sapiens 57-62 12204776-0 2002 17Beta-estradiol inhibits the adhesion of leukocytes in TNF-alpha stimulated human endothelial cells by blocking IL-8 and MCP-1 secretion, but not its transcription. Estradiol 0-16 C-C motif chemokine ligand 2 Homo sapiens 122-127 12123781-0 2002 Female gender, menstrual cycle and estradiol affect plasma levels of monocyte chemotactic protein-1 (MCP-1) in humans. Estradiol 35-44 C-C motif chemokine ligand 2 Homo sapiens 101-106 11872210-0 2002 Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells. Estradiol 0-9 C-C motif chemokine ligand 2 Homo sapiens 25-30 12082363-8 2002 However, MPA antagonized the E(2)-induced significant reduction of MCP-1 synthesis, with the difference between both progestins being significant (p < 0.01). Estradiol 29-33 C-C motif chemokine ligand 2 Homo sapiens 67-72 11872210-11 2002 On the other hand, in HCAEC, estradiol induced a 30% decrease in mRNA expression and resulted in dose-dependent inhibition of MCP-1 production as detected by ELISA. Estradiol 29-38 C-C motif chemokine ligand 2 Homo sapiens 126-131 11861035-0 2002 The effect of 17 beta-estradiol on MCP-1 serum levels in postmenopausal women. Estradiol 14-31 C-C motif chemokine ligand 2 Homo sapiens 35-40 10377035-5 1999 We investigated the regulation of MCP-1 expression in human endometrial stromal cells by estradiol 17beta (E2) and progestins. Estradiol 89-98 C-C motif chemokine ligand 2 Homo sapiens 34-39 11449089-14 2001 Estradiol also inhibited the MCP-1 protein production in a concentration-dependent manner (p < 0.05). Estradiol 0-9 C-C motif chemokine ligand 2 Homo sapiens 29-34 10871649-3 2000 To elucidate the mechanisms involved in the regulation of MCP-1 expression in eutopic endometrial cells, we studied the effects of ovarian hormones and found that oestradiol (10(-9) and 10(-8) mol/l) markedly increased MCP-1 mRNA steady-state levels and protein secretion by endometrial cells in response to interleukin-1beta (IL-1beta) (0.1 ng/ml). Estradiol 163-173 C-C motif chemokine ligand 2 Homo sapiens 58-63 10871649-4 2000 The IL-1beta-induced MCP-1 expression was even higher following pretreatment of cells with both oestradiol (10(-9) mol/l) and progesterone (5x10(-8) mol/l). Estradiol 96-106 C-C motif chemokine ligand 2 Homo sapiens 21-26 10690908-4 2000 In the present study we report that estradiol (E2) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1-induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid (mRNA) synthesis, whereas progesterone had no significant effects. Estradiol 36-45 C-C motif chemokine ligand 2 Homo sapiens 183-213 10690908-4 2000 In the present study we report that estradiol (E2) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1-induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid (mRNA) synthesis, whereas progesterone had no significant effects. Estradiol 36-45 C-C motif chemokine ligand 2 Homo sapiens 215-220 8781708-0 1996 Physiological concentration of 17 beta-estradiol inhibits chemotaxis of human monocytes in response to monocyte chemotactic protein 1. Estradiol 31-48 C-C motif chemokine ligand 2 Homo sapiens 103-133 8781708-4 1996 We investigated the effect of 17 beta-estradiol on the migration of human monocytes in response to MCP-1, using a modified Boyden chamber. Estradiol 30-47 C-C motif chemokine ligand 2 Homo sapiens 99-104 8781708-5 1996 A physiological concentration of 17 beta-estradiol (10(12) - 10(4)M) inhibited the migration of monocytes exposed to MCP-1. Estradiol 33-50 C-C motif chemokine ligand 2 Homo sapiens 117-122 8781708-6 1996 Two estrogen receptor antagonists, tamoxifen and clomiphene, each restored monocyte chemotaxis to MCP-1 to control level, even in the presence of 17 beta-estradiol, suggesting that estrogen receptors are related to the effect of 17 beta-estradiol. Estradiol 229-246 C-C motif chemokine ligand 2 Homo sapiens 98-103 8781708-8 1996 These findings suggest that inhibition of the chemotactic response of monocytes exposed to MCP-1 may be one mechanism for the anti-atherogenic effect of 17 beta-estradiol. Estradiol 153-170 C-C motif chemokine ligand 2 Homo sapiens 91-96