PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33945801-1	2021	17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) and steroid sulfatase (STS) are involved in the synthesis of the most potent estrogen in the human body, estradiol (E2).	Estradiol	173-175	steroid sulfatase	Homo sapiens	61-78	
9873454-1	1998	A series of 17 alpha-derivatives of 17 beta-estradiol was synthesized and tested for their ability to inhibit the estrone-sulfatase activity transforming estrone sulfate to estrone.	Estradiol	36-53	steroid sulfatase	Homo sapiens	114-131	
29054710-1	2017	The female hormone 17 beta-estradiol (E2) is synthesized from estrone by steroid sulfatase (STS), and metabolized into 2-methoxyestradiol (2-ME), whereby the biological activity of the latter is substantially different from that of E2.	Estradiol	19-36	steroid sulfatase	Homo sapiens	73-90	
21782294-0	2011	Chemical synthesis and evaluation of 17alpha-alkylated derivatives of estradiol as inhibitors of steroid sulfatase.	Estradiol	70-79	steroid sulfatase	Homo sapiens	97-114	
20888390-1	2011	Aromatase, estrone sulfatase, and 17beta-hydroxysteroid dehydrogenase type 1 are involved in the key steps of 17beta-estradiol biosynthesis.	Estradiol	110-126	steroid sulfatase	Homo sapiens	11-28	
15823201-1	2005	BACKGROUND: The purpose of this study was to localize the expression of steroid sulfatase (STS) in cumulus cells and to determine the relationship between STS mRNA expression and the serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol and progesterone.	Estradiol	261-270	steroid sulfatase	Homo sapiens	72-89	
12413846-1	2002	Estrone sulfate (E1S) is an endogenous prodrug that delivers estrone and, subsequently, estradiol to the target cells following the hydrolysis by the enzyme estrone sulfatase which is active in various tissues including hormone dependent breast cancer cells.	Estradiol	88-97	steroid sulfatase	Homo sapiens	157-174	
33945801-1	2021	17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) and steroid sulfatase (STS) are involved in the synthesis of the most potent estrogen in the human body, estradiol (E2).	Estradiol	162-171	steroid sulfatase	Homo sapiens	61-78	
21925885-0	2011	Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives.	Estradiol	63-72	steroid sulfatase	Homo sapiens	14-31	
17481887-0	2007	Estradiol inhibits the estrone sulfatase activity in normal and cancerous human breast tissues.	Estradiol	0-9	steroid sulfatase	Homo sapiens	23-40	
8918978-10	1996	It is concluded that nomegestrol acetate in the hormone-dependent MCF-7 and T-47D breast cancer cells significantly inhibits the estrone sulfatase and 17beta-HSD activities which converts E1S to the biologically active estrogen estradiol.	Estradiol	228-237	steroid sulfatase	Homo sapiens	129-146