PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10478842-0 1999 Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Estradiol 53-69 aryl hydrocarbon receptor Homo sapiens 84-109 10922479-2 2000 T47D human breast cancer cells express a functional estrogen receptor alpha (ERalpha) and AhR, and treatment of these cells with 17beta-estradiol (E2) or TCDD resulted in a rapid proteasome-dependent decrease in immunoreactive ERalpha and AhR proteins (>60-80%), respectively. Estradiol 129-145 aryl hydrocarbon receptor Homo sapiens 90-93 10922479-2 2000 T47D human breast cancer cells express a functional estrogen receptor alpha (ERalpha) and AhR, and treatment of these cells with 17beta-estradiol (E2) or TCDD resulted in a rapid proteasome-dependent decrease in immunoreactive ERalpha and AhR proteins (>60-80%), respectively. Estradiol 129-145 aryl hydrocarbon receptor Homo sapiens 239-242 10619402-1 1999 To determine the molecular mechanisms underlying the "cross talk" between the activity of 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD), which binds to arylhydrocarbon receptor (AHR) and estradiol (E2)-liganded estrogen receptor (ER), we first examined the initial step of estrogen action, ligand binding to ER. Estradiol 185-194 aryl hydrocarbon receptor Homo sapiens 176-179 30010799-8 2019 Among those genes affected by site and estradiol treatment were three aryl hydrocarbon receptor (AHR) isoforms, suggesting that developmental estrogen signaling might program sensitivity to AHR ligands later in life. Estradiol 39-48 aryl hydrocarbon receptor Homo sapiens 70-95 9934858-5 1999 In contrast, both compounds inhibited 17beta-estradiol (E2)-induced cell proliferation and transactivation in MCF-7/T47D cells and uterine responses in B6C3F1 mice; surprisingly inhibition of E2-induced reporter gene activity was not observed in T47D cells transfected with pCKB, and this was observed as a cell-specific response with other AhR agonists. Estradiol 38-54 aryl hydrocarbon receptor Homo sapiens 341-344 8631852-8 1996 Reciprocally, estradiol treatment blocked TCDD-induced accumulation of CYP1A1 mRNA and AhR-mediated activation of the CYP1A1 promoter. Estradiol 14-23 aryl hydrocarbon receptor Homo sapiens 87-90 7685553-6 1993 The results of this study support the role for the Ah receptor in mediating the inhibition of the 17 beta-estradiol-induced secretion of the 52-kDa protein in MCF-7 cells and also points out the utility of this technique as a bioassay for this class of compounds. Estradiol 98-115 aryl hydrocarbon receptor Homo sapiens 51-62 34498192-6 2022 A battery of in vitro bioassays detected high estrogenicity, androgenicity, and AhR-mediated activity (viz., in treated wastewater) in the concentrations 24.2 ng/L, 62.2 ng/L, and 0.98 ng/L of 17beta-estradiol, dihydrotestosterone and 2,3,7,8-TCDD equivalents, respectively. Estradiol 193-209 aryl hydrocarbon receptor Homo sapiens 80-83 31698960-7 2020 This study showed that both classic ESR1 and GPER1 were involved in the inhibitory effect of both PAH mixtures on E2 secretion and confirmed that expression of P450arom could be downregulated through the aryl hydrocarbon receptor and additionally through the ESR2. Estradiol 114-116 aryl hydrocarbon receptor Homo sapiens 204-229 7494865-4 1995 Molecular biology studies show that TCDD inhibited 17 beta-estradiol-induced cathepsin D gene expression by targeted interaction of the nuclear Ah receptor with imperfect dioxin responsive elements strategically located within the estrogen receptor-Sp1 enhancer sequence of this gene. Estradiol 51-68 aryl hydrocarbon receptor Homo sapiens 144-155 30010799-8 2019 Among those genes affected by site and estradiol treatment were three aryl hydrocarbon receptor (AHR) isoforms, suggesting that developmental estrogen signaling might program sensitivity to AHR ligands later in life. Estradiol 39-48 aryl hydrocarbon receptor Homo sapiens 97-100 30010799-8 2019 Among those genes affected by site and estradiol treatment were three aryl hydrocarbon receptor (AHR) isoforms, suggesting that developmental estrogen signaling might program sensitivity to AHR ligands later in life. Estradiol 39-48 aryl hydrocarbon receptor Homo sapiens 190-193 19901195-5 2010 Of specific interest was the observation, that in the absence of ER, 4OHT can induce the expression of AHR target genes involved in estradiol metabolism, cellular proliferation, and metastasis in cellular models of breast cancer. Estradiol 132-141 aryl hydrocarbon receptor Homo sapiens 103-106 28962316-3 2014 The present study investigated TCDD"s impact on the transcriptional cross-talk between AhR and ERalpha and its modulation by 17beta-estradiol (E2) in the human hepatoma cell line HepG2, which is AhR-responsive but ERalpha-negative. Estradiol 125-141 aryl hydrocarbon receptor Homo sapiens 195-198 24299737-4 2014 Basal and TCDD-, 17beta-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERalpha, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHR((ko)) and MDA-MB-231 AHR(ko) cells. Estradiol 17-33 aryl hydrocarbon receptor Homo sapiens 79-82 24299737-4 2014 Basal and TCDD-, 17beta-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERalpha, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHR((ko)) and MDA-MB-231 AHR(ko) cells. Estradiol 17-33 aryl hydrocarbon receptor Homo sapiens 191-194 24299737-4 2014 Basal and TCDD-, 17beta-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERalpha, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHR((ko)) and MDA-MB-231 AHR(ko) cells. Estradiol 17-33 aryl hydrocarbon receptor Homo sapiens 191-194 20804740-1 2010 Induction of the breast cancer resistance protein (BCRP/ABCG2) expression has been found in various tissues and cell-types after exposure to chemicals including 17beta-estradiol, rosiglitazone, imatinib, as well as aryl hydrocarbon receptor (AhR) activators such as 2,3,7,8-tetrachlorodibenzodioxin, 3-methylcholanthrene (3MC), and omeprazole. Estradiol 161-177 aryl hydrocarbon receptor Homo sapiens 242-245 23855798-6 2013 17beta-estradiol (E2) reduced basal and TCDD-induced AhR activity only in ERalpha-positive cells. Estradiol 0-16 aryl hydrocarbon receptor Homo sapiens 53-56 22345291-8 2012 When AhR was knocked down by small interfering RNA, the suppressive effect of icaritin on estradiol-stimulated breast cancer cell growth and gene expression was abolished, and ERalpha protein stability was partially restored. Estradiol 90-99 aryl hydrocarbon receptor Homo sapiens 5-8 19604390-8 2009 RESULTS: MCF10AT1 cells continuously exposed to 17-beta-estradiol (E2) developed sub-lines that show AhR overexpression with the characteristic phenotype of increased proliferation, and distinct resistance to apoptosis. Estradiol 48-65 aryl hydrocarbon receptor Homo sapiens 101-104 16675542-4 2006 The mechanism of inhibitory AhR-ERalpha/Sp1 cross talk was further investigated by chromatin immunoprecipitation (ChIP), and the results show that ERalpha/Sp1 and the AhR are constitutively bound to the CAD gene promoter and only minor changes are observed after treatment with 17beta-estradiol, TCDD, or their combination. Estradiol 278-294 aryl hydrocarbon receptor Homo sapiens 28-31 18691609-7 2008 Co-treatment experiments with TCDD and CoCl(2), to induce hypoxia, or TCDD and 17-beta-estradiol (E2) indicated crosstalk between AhR and Hif or ER, in agreement with other experimental models. Estradiol 79-96 aryl hydrocarbon receptor Homo sapiens 130-133 16675542-4 2006 The mechanism of inhibitory AhR-ERalpha/Sp1 cross talk was further investigated by chromatin immunoprecipitation (ChIP), and the results show that ERalpha/Sp1 and the AhR are constitutively bound to the CAD gene promoter and only minor changes are observed after treatment with 17beta-estradiol, TCDD, or their combination. Estradiol 278-294 aryl hydrocarbon receptor Homo sapiens 167-170 12970067-1 2003 Cytochrome P450 (CYP)1A1 and CYP1B1, which are under the regulatory control of the aryl hydrocarbon (Ah) receptor (AhR), catalyze the metabolic activation of numerous procarcinogens and the hydroxylation of 17beta-estradiol (E2) at the C-2 and C-4 positions, respectively. Estradiol 207-223 aryl hydrocarbon receptor Homo sapiens 83-113 15026081-4 2004 Ten nanomolar dihydrotestosterone (DHT) and 17 beta-estradiol (E2) induced transactivation in LNCaP cells transfected with pPB or pARR(3); however, inhibitory AhR-AR crosstalk was observed only with the latter construct. Estradiol 44-61 aryl hydrocarbon receptor Homo sapiens 159-162 15026081-4 2004 Ten nanomolar dihydrotestosterone (DHT) and 17 beta-estradiol (E2) induced transactivation in LNCaP cells transfected with pPB or pARR(3); however, inhibitory AhR-AR crosstalk was observed only with the latter construct. Estradiol 63-65 aryl hydrocarbon receptor Homo sapiens 159-162 12970067-1 2003 Cytochrome P450 (CYP)1A1 and CYP1B1, which are under the regulatory control of the aryl hydrocarbon (Ah) receptor (AhR), catalyze the metabolic activation of numerous procarcinogens and the hydroxylation of 17beta-estradiol (E2) at the C-2 and C-4 positions, respectively. Estradiol 207-223 aryl hydrocarbon receptor Homo sapiens 115-118 12612060-1 2003 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other aryl hydrocarbon receptor (AhR) ligands suppress 17beta-estradiol (E)-induced responses in the rodent uterus and mammary tumors and in human breast cancer cells. Estradiol 102-118 aryl hydrocarbon receptor Homo sapiens 53-78 12612060-1 2003 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other aryl hydrocarbon receptor (AhR) ligands suppress 17beta-estradiol (E)-induced responses in the rodent uterus and mammary tumors and in human breast cancer cells. Estradiol 102-118 aryl hydrocarbon receptor Homo sapiens 80-83 12485607-5 2002 The three hAhR TAD subdomains inhibited the 17beta-estradiol-induced estrogen-response element-mediated reporter-gene transactivation. Estradiol 51-60 aryl hydrocarbon receptor Homo sapiens 10-14 12485607-6 2002 Cotransfection of hAhR with the ligand-binding domain (LBD) of ERalpha also squelched TCDD-dependent DRE-driven reporter-gene activity in the presence of 17beta-estradiol. Estradiol 154-170 aryl hydrocarbon receptor Homo sapiens 18-22 11165043-1 2001 17beta-estradiol (E2) induces cathepsin D gene expression in MCF-7 human breast cancer cells and this response is inhibited by aryl hydrocarbon receptor (AhR) agonists, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Estradiol 18-20 aryl hydrocarbon receptor Homo sapiens 127-152 11165043-0 2001 Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Estradiol 61-77 aryl hydrocarbon receptor Homo sapiens 92-117 11165043-1 2001 17beta-estradiol (E2) induces cathepsin D gene expression in MCF-7 human breast cancer cells and this response is inhibited by aryl hydrocarbon receptor (AhR) agonists, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Estradiol 0-16 aryl hydrocarbon receptor Homo sapiens 127-152 11165043-1 2001 17beta-estradiol (E2) induces cathepsin D gene expression in MCF-7 human breast cancer cells and this response is inhibited by aryl hydrocarbon receptor (AhR) agonists, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Estradiol 0-16 aryl hydrocarbon receptor Homo sapiens 154-157 11179685-1 2001 Aryl hydrocarbon receptor (AhR) agonists inhibit 17beta-estradiol (E2) induced growth of MCF-7 human breast cancer cells in vitro and rodent mammary tumor growth in vivo. Estradiol 49-65 aryl hydrocarbon receptor Homo sapiens 0-25 11179685-1 2001 Aryl hydrocarbon receptor (AhR) agonists inhibit 17beta-estradiol (E2) induced growth of MCF-7 human breast cancer cells in vitro and rodent mammary tumor growth in vivo. Estradiol 49-65 aryl hydrocarbon receptor Homo sapiens 27-30 11179685-1 2001 Aryl hydrocarbon receptor (AhR) agonists inhibit 17beta-estradiol (E2) induced growth of MCF-7 human breast cancer cells in vitro and rodent mammary tumor growth in vivo. Estradiol 67-69 aryl hydrocarbon receptor Homo sapiens 0-25 11179685-1 2001 Aryl hydrocarbon receptor (AhR) agonists inhibit 17beta-estradiol (E2) induced growth of MCF-7 human breast cancer cells in vitro and rodent mammary tumor growth in vivo. Estradiol 67-69 aryl hydrocarbon receptor Homo sapiens 27-30 11165043-1 2001 17beta-estradiol (E2) induces cathepsin D gene expression in MCF-7 human breast cancer cells and this response is inhibited by aryl hydrocarbon receptor (AhR) agonists, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Estradiol 18-20 aryl hydrocarbon receptor Homo sapiens 154-157