PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30518737-6	2019	Thus, the expression levels of Clock, being upregulated by forskolin and BMP-7, were functionally linked to estradiol production and progesterone suppression by human granulosa cells.	Estradiol	108-117	clock circadian regulator	Homo sapiens	31-36	
30518737-4	2019	Knockdown of Clock gene by siRNA resulted in a significant reduction of estradiol production by inhibiting P450arom expression, while it induced a significant increase of progesterone production by upregulating 3betaHSD in KGN cells treated with forskolin.	Estradiol	72-81	clock circadian regulator	Homo sapiens	13-18	
29577261-10	2018	Clock genes and especially BMAL1 showed an important role in fertility, whereas oestradiol and androgens exhibited tissue-specific effects on clock gene expression.	Estradiol	80-90	clock circadian regulator	Homo sapiens	142-147	
21819971-3	2011	Per2 siRNA treatment did not stimulate the production of estradiol and expression of P450arom, whereas Clock siRNA treatment inhibited the production of estradiol and expression of P450arom mRNA.	Estradiol	153-162	clock circadian regulator	Homo sapiens	103-108