PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8979148-3	1996	Estradiol, for example, has been reported to regulate TNF, IL-6, IL-1 and JE expression.	Estradiol	0-9	interleukin 1 complex	Mus musculus	65-69	
10768707-7	2000	The depressed proinflammatory cytokine (IL-1 and IL-6) release seen in splenic and peritoneal macrophages was restored in the 17beta-estradiol-treated hemorrhage group.	Estradiol	133-142	interleukin 1 complex	Mus musculus	40-44	
1319175-2	1992	Maximal expression of Ia antigen and release of interleukin 1 (IL1) were observed during the first week of pregnancy (implantation), when the highest peak of estradiol was produced.	Estradiol	158-167	interleukin 1 complex	Mus musculus	22-66	
8393776-5	1993	In line with this finding, addition of 17 beta-estradiol to calvaria cell cultures followed by withdrawal of the steroid caused an increase in the amount of IL-6 produced in response to the subsequent stimulation of these cultures with IL-1 or PTH compared to that in cultures that had never been treated with estradiol; when the inactive isomer 17 alpha-estradiol was used, no change in IL-6 production was observed.	Estradiol	39-56	interleukin 1 complex	Mus musculus	236-240	
8393776-5	1993	In line with this finding, addition of 17 beta-estradiol to calvaria cell cultures followed by withdrawal of the steroid caused an increase in the amount of IL-6 produced in response to the subsequent stimulation of these cultures with IL-1 or PTH compared to that in cultures that had never been treated with estradiol; when the inactive isomer 17 alpha-estradiol was used, no change in IL-6 production was observed.	Estradiol	47-56	interleukin 1 complex	Mus musculus	236-240	
8318028-6	1993	Estradiol and progesterone reduced both spontaneous and IL-1-induced cartilage degradation in vitro.	Estradiol	0-9	interleukin 1 complex	Mus musculus	56-60	
1541679-3	1992	Addition of 17 beta-estradiol in the cultures exerted a dose-dependent inhibition of IL-1-, TNF-, and IL-1 + TNF-induced production of bioassayable IL-6.	Estradiol	12-29	interleukin 1 complex	Mus musculus	85-89	
1541679-3	1992	Addition of 17 beta-estradiol in the cultures exerted a dose-dependent inhibition of IL-1-, TNF-, and IL-1 + TNF-induced production of bioassayable IL-6.	Estradiol	12-29	interleukin 1 complex	Mus musculus	102-106	
27148737-0	2016	Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway.	Estradiol	0-9	interleukin 1 complex	Mus musculus	106-110