PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8979148-3 1996 Estradiol, for example, has been reported to regulate TNF, IL-6, IL-1 and JE expression. Estradiol 0-9 interleukin 1 complex Mus musculus 65-69 10768707-7 2000 The depressed proinflammatory cytokine (IL-1 and IL-6) release seen in splenic and peritoneal macrophages was restored in the 17beta-estradiol-treated hemorrhage group. Estradiol 133-142 interleukin 1 complex Mus musculus 40-44 1319175-2 1992 Maximal expression of Ia antigen and release of interleukin 1 (IL1) were observed during the first week of pregnancy (implantation), when the highest peak of estradiol was produced. Estradiol 158-167 interleukin 1 complex Mus musculus 22-66 8393776-5 1993 In line with this finding, addition of 17 beta-estradiol to calvaria cell cultures followed by withdrawal of the steroid caused an increase in the amount of IL-6 produced in response to the subsequent stimulation of these cultures with IL-1 or PTH compared to that in cultures that had never been treated with estradiol; when the inactive isomer 17 alpha-estradiol was used, no change in IL-6 production was observed. Estradiol 39-56 interleukin 1 complex Mus musculus 236-240 8393776-5 1993 In line with this finding, addition of 17 beta-estradiol to calvaria cell cultures followed by withdrawal of the steroid caused an increase in the amount of IL-6 produced in response to the subsequent stimulation of these cultures with IL-1 or PTH compared to that in cultures that had never been treated with estradiol; when the inactive isomer 17 alpha-estradiol was used, no change in IL-6 production was observed. Estradiol 47-56 interleukin 1 complex Mus musculus 236-240 8318028-6 1993 Estradiol and progesterone reduced both spontaneous and IL-1-induced cartilage degradation in vitro. Estradiol 0-9 interleukin 1 complex Mus musculus 56-60 1541679-3 1992 Addition of 17 beta-estradiol in the cultures exerted a dose-dependent inhibition of IL-1-, TNF-, and IL-1 + TNF-induced production of bioassayable IL-6. Estradiol 12-29 interleukin 1 complex Mus musculus 85-89 1541679-3 1992 Addition of 17 beta-estradiol in the cultures exerted a dose-dependent inhibition of IL-1-, TNF-, and IL-1 + TNF-induced production of bioassayable IL-6. Estradiol 12-29 interleukin 1 complex Mus musculus 102-106 27148737-0 2016 Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway. Estradiol 0-9 interleukin 1 complex Mus musculus 106-110