PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30909145-9 2019 Furthermore, in vitro studies showed a synergistic effect of testosterone and estradiol on GDF-15 secretion, and demonstrated that testosterone association with estradiol decreased GDF-15 secretion through androgen receptor/estrogen receptor-mediated pathways. Estradiol 161-170 androgen receptor Homo sapiens 206-223 31684907-5 2019 RESULTS: Here we demonstrated, in estrogen receptor alpha (ERalpha)-positive breast cancer cells, an androgen-dependent mechanism through which ligand-activated androgen receptor (AR) decreases estradiol-induced cyclin D1 protein, mRNA and gene promoter activity. Estradiol 194-203 androgen receptor Homo sapiens 161-178 31684907-5 2019 RESULTS: Here we demonstrated, in estrogen receptor alpha (ERalpha)-positive breast cancer cells, an androgen-dependent mechanism through which ligand-activated androgen receptor (AR) decreases estradiol-induced cyclin D1 protein, mRNA and gene promoter activity. Estradiol 194-203 androgen receptor Homo sapiens 180-182 31096185-1 2019 Evidence has been accumulating that, in men, some of the biological actions traditionally attributed to testosterone acting via the androgen receptor may in fact be dependent on its aromatization to estradiol (E2). Estradiol 199-208 androgen receptor Homo sapiens 132-149 31096185-1 2019 Evidence has been accumulating that, in men, some of the biological actions traditionally attributed to testosterone acting via the androgen receptor may in fact be dependent on its aromatization to estradiol (E2). Estradiol 210-212 androgen receptor Homo sapiens 132-149 32349931-2 2020 Eur Urol 2020;78:e2-3: Is It Always Correct to Continue Androgen Receptor Signaling Inhibitors in the COVID-19 Era? Estradiol 17-19 androgen receptor Homo sapiens 56-73 31289138-8 2019 Serum and glucocorticoid-regulated kinase 3 (SGK3) and cAMP-Dependent Protein Kinase Inhibitor beta (PKIB), were confirmed to be regulated by 4AD and shown to be mediated by AR; crucially re-exposure to estradiol suppressed expression of these genes. Estradiol 203-212 androgen receptor Homo sapiens 174-176 25536295-0 2015 Wild-type and specific mutant androgen receptor mediates transcription via 17beta-estradiol in sex hormone-sensitive cancer cells. Estradiol 75-91 androgen receptor Homo sapiens 30-47 31151151-2 2019 The androgen receptor (AR) was reported to support estradiol-mediated ER activity in an in vitro system. Estradiol 51-60 androgen receptor Homo sapiens 4-21 31151151-2 2019 The androgen receptor (AR) was reported to support estradiol-mediated ER activity in an in vitro system. Estradiol 51-60 androgen receptor Homo sapiens 23-25 30058741-0 2018 17beta-Estradiol inhibits testosterone-induced cell proliferation in HepG2 by modulating the relative ratios of 3 estrogen receptor isoforms to the androgen receptor. Estradiol 0-16 androgen receptor Homo sapiens 148-165 26015225-11 2015 17beta-estradiol (E2) up-regulates SOX4 expression in the absence of androgen through the formation of a protein complex between ERbeta and AR. Estradiol 0-16 androgen receptor Homo sapiens 140-142 30254080-4 2019 AR-positive lines were further evaluated by exposure to estrogen (17beta-Estradiol) and the synthetic progestin D-Norgestrel. Estradiol 66-82 androgen receptor Homo sapiens 0-2 27565181-3 2016 Here, a novel global examination of AR chromatin binding found that estradiol induced AR binding at unique sites compared with dihydrotestosterone (DHT). Estradiol 68-77 androgen receptor Homo sapiens 36-38 27565181-3 2016 Here, a novel global examination of AR chromatin binding found that estradiol induced AR binding at unique sites compared with dihydrotestosterone (DHT). Estradiol 68-77 androgen receptor Homo sapiens 86-88 27565181-5 2016 Furthermore, AR inhibition reduced baseline and estradiol-mediated proliferation in multiple ER+/AR+ breast cancer cell lines, and synergized with tamoxifen and fulvestrant. Estradiol 48-57 androgen receptor Homo sapiens 13-15 27565181-5 2016 Furthermore, AR inhibition reduced baseline and estradiol-mediated proliferation in multiple ER+/AR+ breast cancer cell lines, and synergized with tamoxifen and fulvestrant. Estradiol 48-57 androgen receptor Homo sapiens 97-99 20173016-7 2010 RESULTS: Several polymorphisms in SHBG, ESR2, AR, CYP19A1, and LHB were significantly associated with circulating levels of SHBG, LH, total, free, and bioavailable testosterone and estradiol, the LH x testosterone product, and indices of insulin sensitivity. Estradiol 181-190 androgen receptor Homo sapiens 46-48 21765438-3 2011 First, we observed that androgen receptor (AR) mRNA was more highly expressed in PZsc than TZsc when the cells were treated with dihydrotestosterone (DHT) and beta-oestradiol (E2) (P<0.05). Estradiol 176-178 androgen receptor Homo sapiens 24-41 21765438-3 2011 First, we observed that androgen receptor (AR) mRNA was more highly expressed in PZsc than TZsc when the cells were treated with dihydrotestosterone (DHT) and beta-oestradiol (E2) (P<0.05). Estradiol 176-178 androgen receptor Homo sapiens 43-45 18551363-6 2008 CONCLUSIONS: The inflammatory-like changes manifested by adhesion fibroblasts enhance the anabolic hormones receptor expression (ER-alpha, ER-beta, PRL, and A-R), when exposed to estradiol. Estradiol 179-188 androgen receptor Homo sapiens 157-160 19615976-4 2009 By blocking androgen receptor, JNK phosphorylation was reduced and 17beta-Estradiol treatment had no effect on it. Estradiol 67-83 androgen receptor Homo sapiens 12-29 19638585-5 2009 Consistent with a role for AR in breast cancer outcome, AR potently inhibited (ER(alpha))transactivation activity and 17beta-estradiol-stimulated growth of breast cancer cells. Estradiol 118-134 androgen receptor Homo sapiens 56-58 19638585-9 2009 We conclude that, by binding to a subset of EREs, the AR can prevent activation of target genes that mediate the stimulatory effects of 17beta-estradiol on breast cancer cells. Estradiol 136-152 androgen receptor Homo sapiens 54-56 17486077-4 2007 Treatment of the human prostate or mammary cancer cells (LNCaP or MCF-7, respectively) with nanomolar concentrations of this peptide inhibits the androgen- or estradiol-induced association between the AR or the ER and Src the Src/Erk pathway activation, cyclin D1 expression and DNA synthesis, without interfering in the receptor-dependent transcriptional activity. Estradiol 159-168 androgen receptor Homo sapiens 201-203 17989318-10 2007 Molecular modeling also indicated that 17-hydroexemestane interacted with ERalpha and AR through selective recognition motifs employed by 17beta-estradiol and R1881, respectively. Estradiol 138-154 androgen receptor Homo sapiens 86-88 17602621-11 2007 17beta-Estradiol and progesterone were found to be specific activators only for the genomic signaling pathway of AR. Estradiol 0-16 androgen receptor Homo sapiens 113-115 17875736-2 2007 We found that 17beta-estradiol (E(2)) is able to markedly up-regulate insulin-like growth factor (IGF)-I receptor (IGF-IR) mRNA and protein expression in both AR-positive (LNCaP cells) and AR-negative (PC-3 cells) prostate cancer cells. Estradiol 14-30 androgen receptor Homo sapiens 159-161 17875736-2 2007 We found that 17beta-estradiol (E(2)) is able to markedly up-regulate insulin-like growth factor (IGF)-I receptor (IGF-IR) mRNA and protein expression in both AR-positive (LNCaP cells) and AR-negative (PC-3 cells) prostate cancer cells. Estradiol 14-30 androgen receptor Homo sapiens 189-191 17503469-0 2007 Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cells. Estradiol 77-81 androgen receptor Homo sapiens 0-17 17503469-11 2007 CONCLUSIONS: These findings support involvement of both AR and ERbeta in mediating DHEA-, DHT-, and E(2)-induced PSA expression in prostate cancer cells. Estradiol 100-104 androgen receptor Homo sapiens 56-58 17223690-2 2007 Interaction of wild-type AR LBD with the random phage display peptide D11FxxLF was observed with dihydrotestosterone (DHT), testosterone, R1881, estradiol, spironolactone, progesterone, and cortisol resulting in distinct dose dependency (EC50) values for each ligand and correlating well with the reported rank order potency of these agonists. Estradiol 145-154 androgen receptor Homo sapiens 25-27 17011702-0 2007 A naturally occurring mutation in the human androgen receptor of a subject with complete androgen insensitivity confers binding and transactivation by estradiol. Estradiol 151-160 androgen receptor Homo sapiens 44-61 17054461-10 2006 With respect to men without AR mutations, subjects with AR mutations have lower ejaculate volume, higher testosterone levels, higher oestradiol levels, and higher androgen sensitivity index. Estradiol 133-143 androgen receptor Homo sapiens 56-58 16166329-7 2005 Ligand-dependent activation of the AR in human T47D and MCF-7 breast cancer cells resulted in inhibition of estradiol-stimulated cell proliferation and a reduction in the capacity of the ER to induce expression of the PR. Estradiol 108-117 androgen receptor Homo sapiens 35-37 16802247-7 2006 The AR and ER protein arrays showed affinities for fluorescence labelled testosterone and estradiol that were similar to those of literatures (0.65 vs. 0.89 nM, 5.96 vs. 10.3 nM, respectively). Estradiol 90-99 androgen receptor Homo sapiens 4-6 11673900-6 2001 As expected, AR-mediated responses were also elicited by high concentrations of the steroids progesterone, 17beta-estradiol, d-aldosterone, and dexamethasone, with observed EC50 values 10 to 350,000 times higher than that for R1881. Estradiol 107-123 androgen receptor Homo sapiens 13-15 15580310-4 2005 Here, we determined that 17beta-estradiol (E(2)) activated WOX1, p53 and ERK in COS7 fibroblasts, primary lung epithelial cells, and androgen receptor (AR)-negative prostate DU145 cells, but not in estrogen receptor (ER)-positive breast MCF7 cells. Estradiol 25-41 androgen receptor Homo sapiens 133-150 15580310-4 2005 Here, we determined that 17beta-estradiol (E(2)) activated WOX1, p53 and ERK in COS7 fibroblasts, primary lung epithelial cells, and androgen receptor (AR)-negative prostate DU145 cells, but not in estrogen receptor (ER)-positive breast MCF7 cells. Estradiol 25-41 androgen receptor Homo sapiens 152-154 15638871-10 2005 In humans, we found AR expression was significantly down-regulated by exogenous treatment with testosterone in F2M (31 +/- 13%, compared with control) or oestradiol in M2F (22 +/- 5%) but was significantly up-regulated by endogenous testosterone in BMT (128 +/- 17%). Estradiol 154-164 androgen receptor Homo sapiens 20-22 15544494-2 2004 The biological functions of these and other steroid hormones are mediated by a family of closely related steroid hormone receptors (SHRs), with the androgen receptor (AR) mediating the effects of testosterone and related androgens, and the classical estrogen receptor (ERalpha) mediating the effects of estradiol. Estradiol 303-312 androgen receptor Homo sapiens 148-165 15544494-2 2004 The biological functions of these and other steroid hormones are mediated by a family of closely related steroid hormone receptors (SHRs), with the androgen receptor (AR) mediating the effects of testosterone and related androgens, and the classical estrogen receptor (ERalpha) mediating the effects of estradiol. Estradiol 303-312 androgen receptor Homo sapiens 167-169 12499384-0 2003 Isolation and characterization of androgen receptor mutant, AR(M749L), with hypersensitivity to 17-beta estradiol treatment. Estradiol 96-113 androgen receptor Homo sapiens 34-51 12499384-0 2003 Isolation and characterization of androgen receptor mutant, AR(M749L), with hypersensitivity to 17-beta estradiol treatment. Estradiol 96-113 androgen receptor Homo sapiens 60-62 12499384-1 2003 Estrogens, primarily 17beta-estradiol (E(2)), may play important roles in male physiology via the androgen receptor (AR). Estradiol 21-37 androgen receptor Homo sapiens 98-115 12499384-1 2003 Estrogens, primarily 17beta-estradiol (E(2)), may play important roles in male physiology via the androgen receptor (AR). Estradiol 21-37 androgen receptor Homo sapiens 117-119 12499384-2 2003 It has already been shown that E(2) modulates AR function in LNCaP prostate cancer cells and xenograft CWR22 prostate cancer tissues. Estradiol 31-35 androgen receptor Homo sapiens 46-48 12054912-5 2002 Therefore, the aim of this study was to determine in whole DU-145 human prostate cells the effect of EFAs and their metabolites on the binding and affinity of the estrogen receptor (ER) and androgen receptor (AR) to estradiol (E(2)) and testosterone (T), respectively. Estradiol 216-225 androgen receptor Homo sapiens 190-207 12054912-5 2002 Therefore, the aim of this study was to determine in whole DU-145 human prostate cells the effect of EFAs and their metabolites on the binding and affinity of the estrogen receptor (ER) and androgen receptor (AR) to estradiol (E(2)) and testosterone (T), respectively. Estradiol 216-225 androgen receptor Homo sapiens 209-211 15161534-8 2004 RESULTS: Growth of LNCaPas-AR was inhibited significantly (P < 0.05) compared with that of LNCaP and LNCaPNeo at 1 nmol/L R1881, 10 nmol/L 17beta-estradiol, and 1 nmol/L progesterone, respectively. Estradiol 142-158 androgen receptor Homo sapiens 27-29 12941814-12 2003 In addition, activation of a common tumor-derived AR allele by 17 beta-estradiol and progesterone was inhibited through ectopic expression of cyclin D1. Estradiol 63-80 androgen receptor Homo sapiens 50-52 12656669-5 2003 Cell line-specific regulation of androgen receptor, estrogen receptor-alpha (ERalpha), RARalpha, RARgamma and VDR expression was observed after estradiol treatment. Estradiol 144-153 androgen receptor Homo sapiens 33-50 12068007-0 2002 Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation. Estradiol 85-101 androgen receptor Homo sapiens 39-56 12068007-0 2002 Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation. Estradiol 85-101 androgen receptor Homo sapiens 110-127 11397870-15 2001 Because androgens can antagonize E(2) action, enhanced endometrial AR expression induced by APs could play a role in the antiproliferative, "antiestrogenic" effects of APs in primates. Estradiol 33-37 androgen receptor Homo sapiens 67-69 11501969-6 2001 Characterization of the functional relationship between the AR and these coregulators indicated that ARA70 and ARA55 could enhance the androgenic effects of 17beta-estradiol (E2) and hydroxyflutamide (HF), an antiandrogen commonly used in the treatment of prostate cancer. Estradiol 157-173 androgen receptor Homo sapiens 60-62 11501969-6 2001 Characterization of the functional relationship between the AR and these coregulators indicated that ARA70 and ARA55 could enhance the androgenic effects of 17beta-estradiol (E2) and hydroxyflutamide (HF), an antiandrogen commonly used in the treatment of prostate cancer. Estradiol 175-177 androgen receptor Homo sapiens 60-62 12083956-11 2001 ARA70 enhanced receptor activation by both androgen and estradiol, whereas ARA160 augmented only androgen-induced AR activity. Estradiol 56-65 androgen receptor Homo sapiens 0-2 11155740-3 2000 Our previous reports suggest that ARA70 can enhance the androgenic activity of 17 beta-estradiol (E2) and antiandrogens toward AR. Estradiol 79-96 androgen receptor Homo sapiens 34-36 10987273-5 2000 beta-Catenin also increased AR transcriptional activation by androstenedione and estradiol and diminished the antagonism of bicalutamide. Estradiol 81-90 androgen receptor Homo sapiens 28-30 11032808-1 2000 Treatment of human prostate carcinoma-derived LNCaP cells with androgen or oestradiol triggers simultaneous association of androgen receptor and oestradiol receptor beta with Src, activates the Src/Raf-1/Erk-2 pathway and stimulates cell proliferation. Estradiol 75-85 androgen receptor Homo sapiens 123-140 9749837-6 1998 In fibroblasts, known to contain an estrogen receptor, estradiol treatment (5 x 10(-7) M) also increases the AR immunostaining. Estradiol 55-64 androgen receptor Homo sapiens 109-111 10405524-2 1999 Our previous reports have suggested that the cofactor ARA70 can confer the androgenic effect from 17 beta-estradiol (E2) and antiandrogen to AR. Estradiol 98-115 androgen receptor Homo sapiens 54-56 10334909-4 1999 Androgen receptor ligands (such as dihydrotestosterone and beta-estradiol) stimulate receptor expression and phosphorylation and, as a result, they act as agonists or partial agonists. Estradiol 59-73 androgen receptor Homo sapiens 0-17 10075738-5 1999 Transient transfection assay in prostate cancer DU145 cells further demonstrates that ARA55 can enhance AR transcriptional activity in the presence of 1 nM dihydrotestosterone or its antagonists such as 100 nM 17beta-estradiol or 1 microM hydroxyflutamide. Estradiol 210-226 androgen receptor Homo sapiens 86-88 1472451-15 1992 Estrogen treatment with 10 nM 17 beta-estradiol for 3 days reduced the AR level only by 25%. Estradiol 33-47 androgen receptor Homo sapiens 71-73 9033395-5 1997 Use of the Thr-868-Ala mutated AR(LBD) in the assay resulted not only in a clear AR TAD-LBD interaction in the presence of R1881 and DHT but also in the presence of E2, Pg, and R5020, corresponding to the alteration in ligand specificity induced by the mutation. Estradiol 165-167 androgen receptor Homo sapiens 31-33 8912473-4 1996 Some AR mutations in prostate cancer show broadened ligand specificity, such that the transcription-factor activity of the AR can be stimulated not just by dihydrotestosterone (DHT) but also by estradiol and other androgen metabolites that have a low affinity for the AR. Estradiol 194-203 androgen receptor Homo sapiens 5-7 8912473-4 1996 Some AR mutations in prostate cancer show broadened ligand specificity, such that the transcription-factor activity of the AR can be stimulated not just by dihydrotestosterone (DHT) but also by estradiol and other androgen metabolites that have a low affinity for the AR. Estradiol 194-203 androgen receptor Homo sapiens 123-125 8912473-4 1996 Some AR mutations in prostate cancer show broadened ligand specificity, such that the transcription-factor activity of the AR can be stimulated not just by dihydrotestosterone (DHT) but also by estradiol and other androgen metabolites that have a low affinity for the AR. Estradiol 194-203 androgen receptor Homo sapiens 123-125 8530589-0 1995 Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol. Estradiol 97-106 androgen receptor Homo sapiens 14-31 8496305-5 1993 Androgen receptor blockade was confirmed by significant increases in 24-h mean LH concentrations and in total 17 beta-estradiol and free testosterone levels in the serum. Estradiol 110-127 androgen receptor Homo sapiens 0-17 9180843-5 1997 Other mutations, in the ligand binding domain, modify the AR specificity resulting in its activation by weak androgens or even antiandrogens, progestagens or estradiol. Estradiol 158-167 androgen receptor Homo sapiens 58-60 8828509-4 1996 In agreement with the aberrant ligand specificity of the mutated androgen receptor in LNCaP cells, stimulation of lipid accumulation was also apparent after treatment with progesterone and estradiol. Estradiol 189-198 androgen receptor Homo sapiens 65-82 11725052-0 1995 Effects of Estradiol and Testosterone on the Synthesis, Expression and Degradation of Androgen Receptor in Human Uterine Endometrial Fibroblasts. Estradiol 11-20 androgen receptor Homo sapiens 86-103 11725052-2 1995 17beta-Estradiol (E) induced the expressions of androgen receptor (AR) mRNA, and predominantly increased the level of testosterone-binding sites (TBS) in uterine endometrial fibroblasts. Estradiol 0-16 androgen receptor Homo sapiens 48-65 11725052-2 1995 17beta-Estradiol (E) induced the expressions of androgen receptor (AR) mRNA, and predominantly increased the level of testosterone-binding sites (TBS) in uterine endometrial fibroblasts. Estradiol 0-16 androgen receptor Homo sapiens 67-69 1428232-3 1992 Dexamethasone (Dex), Organon 2058 (Org 2058), dihydrotestosterone (DHT), and all-trans-retinoic acid (RA) down-regulated AR mRNA levels in T-47D (ER+, PR+) cells 6 hr after treatment, whereas oestradiol (E2) had no effect. Estradiol 192-202 androgen receptor Homo sapiens 121-123 1668832-6 1991 Steroid-binding competition assays using in vitro synthesized ARs showed that LNCaP AR had a higher affinity than normal AR for progestins, 17 beta-estradiol, and hydroxyflutamide. Estradiol 140-157 androgen receptor Homo sapiens 62-64 1668832-6 1991 Steroid-binding competition assays using in vitro synthesized ARs showed that LNCaP AR had a higher affinity than normal AR for progestins, 17 beta-estradiol, and hydroxyflutamide. Estradiol 140-157 androgen receptor Homo sapiens 84-86 34121684-13 2021 Addition of FCX in the presence of estradiol, testosterone, and dehydroepiandrosterone, LNCaP cells markedly caused a dose-dependent increase in cell proliferation indicating the compound activity to be facilitated through androgen receptor pathway. Estradiol 35-44 androgen receptor Homo sapiens 223-240 2728128-3 1989 The androgen receptor shows considerable cross binding activity with progesterone and estradiol but not with the glucocorticoid triamcinolone acetonide. Estradiol 86-95 androgen receptor Homo sapiens 4-21 3263955-8 1988 The affinity of steroids for the androgen receptor decreased in the order of: R1881 (relative binding affinity: 100.0) greater than dihydrotestosterone (67.7) greater than progesterone (29.4) greater than testosterone (23.8) greater than estradiol (4.3) greater than triamcinolone acetonide (less than 0.1). Estradiol 238-247 androgen receptor Homo sapiens 33-50 3402389-0 1988 Mediation by the androgen receptor of the stimulatory and antiandrogenic actions of 17 beta-estradiol on the growth of androgen-sensitive Shionogi mammary carcinoma cells in culture. Estradiol 84-101 androgen receptor Homo sapiens 17-34 3569146-7 1987 Cytosol competition studies demonstrated that the androgen receptor in MCF-7 cells possesses an approximately 125-fold lower affinity for estradiol than for DHT. Estradiol 138-147 androgen receptor Homo sapiens 50-67 3569146-11 1987 The estradiol-mediated reduction in androgen receptor content was dose dependent; a 50% reduction in androgen receptor number was observed after 6 days of treatment with 2.6 X 10(-11) M estradiol. Estradiol 4-13 androgen receptor Homo sapiens 36-53 3569146-11 1987 The estradiol-mediated reduction in androgen receptor content was dose dependent; a 50% reduction in androgen receptor number was observed after 6 days of treatment with 2.6 X 10(-11) M estradiol. Estradiol 4-13 androgen receptor Homo sapiens 101-118 3569146-11 1987 The estradiol-mediated reduction in androgen receptor content was dose dependent; a 50% reduction in androgen receptor number was observed after 6 days of treatment with 2.6 X 10(-11) M estradiol. Estradiol 186-195 androgen receptor Homo sapiens 36-53 3569146-11 1987 The estradiol-mediated reduction in androgen receptor content was dose dependent; a 50% reduction in androgen receptor number was observed after 6 days of treatment with 2.6 X 10(-11) M estradiol. Estradiol 186-195 androgen receptor Homo sapiens 101-118 3569146-12 1987 Additional experiments revealed that MCF-7 cells exhibited a time-dependent increase in androgen receptor content when estradiol was withdrawn; continued estradiol treatment prevented this rise in receptor content. Estradiol 119-128 androgen receptor Homo sapiens 88-105 3569146-12 1987 Additional experiments revealed that MCF-7 cells exhibited a time-dependent increase in androgen receptor content when estradiol was withdrawn; continued estradiol treatment prevented this rise in receptor content. Estradiol 154-163 androgen receptor Homo sapiens 88-105 3569146-13 1987 Moreover, androgen receptor levels began to decrease from the point when the ethanol vehicle added to the medium was replaced with 2.6 nM estradiol. Estradiol 138-147 androgen receptor Homo sapiens 10-27 3762019-9 1986 Binding affinities of all other steroids to the androgen receptor were markedly lower and showed the following order of potency: estrogens (estradiol, ethinyl estradiol, diethylstilbestrol) greater than glucocorticoids as well as aromatase inhibitors and potassium canrenoate. Estradiol 140-149 androgen receptor Homo sapiens 48-65