PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34510628-1 2021 N-acetylglutamate synthase deficiency (NAGSD, MIM #237310) is an autosomal recessive urea cycle disorder caused either by decreased expression of the NAGS gene or defective NAGS enzyme resulting in decreased production of N-acetylglutamate (NAG), an allosteric activator of carbamylphosphate synthetase 1 (CPS1). N-acetylglutamic acid 222-239 N-acetylglutamate synthase Homo sapiens 173-177 27934952-1 2016 N-acetylglutamate synthase (NAGS; E.C.2.3.1.1) catalyzes the formation of N-acetylglutamate (NAG) from acetyl coenzyme A and glutamate. N-acetylglutamic acid 0-17 N-acetylglutamate synthase Homo sapiens 28-32 30337552-1 2018 N-acetylglutamate synthase deficiency (NAGSD, MIM #237310) is an autosomal recessive disorder of the urea cycle that results from absent or decreased production of N-acetylglutamate (NAG) due to either decreased NAGS gene expression or defective NAGS enzyme. N-acetylglutamic acid 0-17 N-acetylglutamate synthase Homo sapiens 39-43 30337552-1 2018 N-acetylglutamate synthase deficiency (NAGSD, MIM #237310) is an autosomal recessive disorder of the urea cycle that results from absent or decreased production of N-acetylglutamate (NAG) due to either decreased NAGS gene expression or defective NAGS enzyme. N-acetylglutamic acid 0-17 N-acetylglutamate synthase Homo sapiens 212-216 27771289-1 2016 BACKGROUND: N-acetylglutamate synthase (NAGS) plays a key role in the removal of ammonia via the urea cycle by catalyzing the synthesis of N-acetylglutamate (NAG), the obligatory cofactor in the carbamyl phosphate synthetase 1 reaction. N-acetylglutamic acid 12-29 N-acetylglutamate synthase Homo sapiens 40-44 18801197-4 2008 NAG is produced enzymatically by N-acetylglutamate synthase (NAGS), which is also found in bacteria and plants as the first enzyme of arginine biosynthesis. N-acetylglutamic acid 0-3 N-acetylglutamate synthase Homo sapiens 33-59 25615976-1 2015 Structures of the catalytic N-acetyltransferase (NAT) domain of the bifunctional N-acetyl-L-glutamate synthase/kinase (NAGS/K) from Xylella fastidiosa bound to N-acetyl-L-glutamate (NAG) with and without an N-terminal His tag have been solved and refined at 1.7 and 1.4 A resolution, respectively. N-acetylglutamic acid 81-101 N-acetylglutamate synthase Homo sapiens 119-123 30780843-1 2012 Carglumic acid is a structural analog and the first registered synthetic form of the naturally occurring allosteric activator of the urea cycle, N-acetylglutamate (NAG), which is the product of the enzyme NAG synthase (NAGS). N-acetylglutamic acid 145-162 N-acetylglutamate synthase Homo sapiens 205-217 30780843-1 2012 Carglumic acid is a structural analog and the first registered synthetic form of the naturally occurring allosteric activator of the urea cycle, N-acetylglutamate (NAG), which is the product of the enzyme NAG synthase (NAGS). N-acetylglutamic acid 145-162 N-acetylglutamate synthase Homo sapiens 219-223 22383952-4 2012 N-acetylglutamate synthase (NAGS) produces a unique cofactor, N-acetylglutamate (NAG), that is essential for the catalytic function of the first and rate-limiting enzyme of ureagenesis, carbamyl phosphate synthetase 1 (CPS1). N-acetylglutamic acid 0-17 N-acetylglutamate synthase Homo sapiens 28-32 27570737-2 2016 Carbamoylphosphate synthetase 1 (CPS1), the first and rate-limiting enzyme of urea cycle, is activated by N-acetylglutamate (NAG), and thus N-acetylglutamate synthase (NAGS) is an essential part of the urea cycle. N-acetylglutamic acid 106-123 N-acetylglutamate synthase Homo sapiens 140-166 27570737-2 2016 Carbamoylphosphate synthetase 1 (CPS1), the first and rate-limiting enzyme of urea cycle, is activated by N-acetylglutamate (NAG), and thus N-acetylglutamate synthase (NAGS) is an essential part of the urea cycle. N-acetylglutamic acid 106-123 N-acetylglutamate synthase Homo sapiens 168-172 26068232-1 2015 N-acetylglutamate synthase (NAGS) catalyzes the production of N-acetylglutamate (NAG) from acetyl-CoA and L-glutamate. N-acetylglutamic acid 0-17 N-acetylglutamate synthase Homo sapiens 28-32 21941437-2 2011 The product of NAGS is N-acetylglutamate which is the absolutely required allosteric activator of the first urea cycle enzyme carbamoylphosphate synthetase 1. N-acetylglutamic acid 23-40 N-acetylglutamate synthase Homo sapiens 15-19 18801197-4 2008 NAG is produced enzymatically by N-acetylglutamate synthase (NAGS), which is also found in bacteria and plants as the first enzyme of arginine biosynthesis. N-acetylglutamic acid 0-3 N-acetylglutamate synthase Homo sapiens 61-65 15878741-1 2005 The mitochondrial enzyme N-acetylglutamate synthase (NAGS) produces N-acetylglutamate serving as an allosteric activator of carbamylphosphate synthetase 1, the first enzyme of the urea cycle. N-acetylglutamic acid 25-42 N-acetylglutamate synthase Homo sapiens 53-57 16321554-1 2006 N-Acetylglutamate synthase (NAGS, EC 2.3.1.1) is a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetylcoenzyme A. N-acetylglutamic acid 104-121 N-acetylglutamate synthase Homo sapiens 0-26 16321554-1 2006 N-Acetylglutamate synthase (NAGS, EC 2.3.1.1) is a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetylcoenzyme A. N-acetylglutamic acid 104-121 N-acetylglutamate synthase Homo sapiens 28-32 12633501-4 2003 In these species, NAG can be produced by two enzymic reactions: one catalysed by NAG synthase (NAGS) and the other by ornithine acetyltransferase (OAT). N-acetylglutamic acid 18-21 N-acetylglutamate synthase Homo sapiens 81-93 12633501-4 2003 In these species, NAG can be produced by two enzymic reactions: one catalysed by NAG synthase (NAGS) and the other by ornithine acetyltransferase (OAT). N-acetylglutamic acid 18-21 N-acetylglutamate synthase Homo sapiens 95-99 12633501-5 2003 In ureotelic species, NAG is produced exclusively by NAGS. N-acetylglutamic acid 22-25 N-acetylglutamate synthase Homo sapiens 53-57 12594532-1 2003 N-acetylglutamate synthase (NAGS) is a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate, an essential allosteric activator of carbamyl phosphate synthetase I, the first enzyme of the urea cycle. N-acetylglutamic acid 0-17 N-acetylglutamate synthase Homo sapiens 28-32 12447942-2 2002 Its activator, N-acetylglutamate, is synthesized from acetyl-CoA and glutamate in a reaction catalyzed by N-acetylglutamate synthase (NAGS). N-acetylglutamic acid 15-32 N-acetylglutamate synthase Homo sapiens 106-132 12447942-2 2002 Its activator, N-acetylglutamate, is synthesized from acetyl-CoA and glutamate in a reaction catalyzed by N-acetylglutamate synthase (NAGS). N-acetylglutamic acid 15-32 N-acetylglutamate synthase Homo sapiens 134-138