PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26925135-7	2016	Compared with the diabetes group, the content of inflammatory cytokines TNF-alpha, IL-8, ICAM and IL-1alpha was dramatically lower in the aminoguanidine group.	pimagedine	138-152	tumor necrosis factor	Rattus norvegicus	72-81	
29228430-8	2017	The application of AGEs inhibitor aminoguanidine significantly improved liver functions and lower TNF-alpha or IL-6 levels when compared to the model group (p<0.05 in all cases).	pimagedine	34-48	tumor necrosis factor	Rattus norvegicus	98-107	
26925135-10	2016	CONCLUSIONS: Aminoguanidine may have a good systemic effect on alleviating the pathological changes of skin tissue in diabetic rats, which may be attributed to the regulation of GSH-PX, TNF-alpha, IL-8, ICAM and IL-1alpha.	pimagedine	13-27	tumor necrosis factor	Rattus norvegicus	186-195	
15639000-7	2005	Aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, and ascorbic acid, an antioxidant, decreased IL-1beta, TNF-alpha contents and hyperglycaemia.	pimagedine	0-14	tumor necrosis factor	Rattus norvegicus	124-133	
15680278-7	2005	The results demonstrated that increases in plasma TNF-alpha and NO, and the vasohyporeactivity induced by lipopolysaccharide treatment were significantly inhibited by hyperbaric oxygen and aminoguanidine.	pimagedine	189-203	tumor necrosis factor	Rattus norvegicus	50-59	
10440132-8	1999	Treatment with aminoguanidine reduced the expression of TNF-alpha, inducible nitric oxide synthase and intraglomerular NO2-/NO3- production.	pimagedine	15-29	tumor necrosis factor	Rattus norvegicus	56-65	
11330554-0	2001	The effect of advanced glycation end-products and aminoguanidine on TNFalpha production by rat peritoneal macrophages.	pimagedine	50-64	tumor necrosis factor	Rattus norvegicus	68-76	
11330554-1	2001	OBJECTIVE: To evaluate the effect of advanced glycation end-products (AGEs) and the inhibitor of their formation, aminoguanidine, on tumor necrosis factor-alpha (TNFalpha) production (as a functional marker) by rat peritoneal macrophages (PMphi).	pimagedine	114-128	tumor necrosis factor	Rattus norvegicus	133-160	
11330554-1	2001	OBJECTIVE: To evaluate the effect of advanced glycation end-products (AGEs) and the inhibitor of their formation, aminoguanidine, on tumor necrosis factor-alpha (TNFalpha) production (as a functional marker) by rat peritoneal macrophages (PMphi).	pimagedine	114-128	tumor necrosis factor	Rattus norvegicus	162-170	
9648854-3	1998	The NOS inhibitors N-monomethylarginine, aminoguanidine, and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine.HCl prevented TNF-alpha/LPS-induced cell death and DNA fragmentation, suggesting that the TNF-alpha/LPS-induced cell death is mediated by iNOS-derived NO.	pimagedine	41-55	tumor necrosis factor	Rattus norvegicus	120-129	
9472897-9	1998	Coapplication of either aminoguanidine or dexamethasone with TNFalpha prevented dilatation of cerebral arterioles compared with TNFalpha alone (4+/-2% and 1+/-1% dilatation at 4 hours, respectively; P<.05).	pimagedine	24-38	tumor necrosis factor	Rattus norvegicus	128-136	
9472897-15	1998	Inhibition of TNFalpha-induced dilatation by aminoguanidine and dexamethasone suggests that the vasodilatation was due predominantly to expression of inducible NO synthase.	pimagedine	45-59	tumor necrosis factor	Rattus norvegicus	14-22