PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17822058-9	2007	In this clone, the FRT-neo*-IRES-tPA gene was integrated at a transcription-active, DHFR-mediated, gene-amplifiable locus in the chromosomes.	Tetradecanoylphorbol Acetate	33-36	dihydrofolate reductase	Cricetulus griseus	84-88	
11389717-1	2001	4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus.	Tetradecanoylphorbol Acetate	0-37	dihydrofolate reductase	Cricetulus griseus	141-164	
11389717-1	2001	4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus.	Tetradecanoylphorbol Acetate	0-37	dihydrofolate reductase	Cricetulus griseus	166-170	
11389717-1	2001	4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus.	Tetradecanoylphorbol Acetate	39-42	dihydrofolate reductase	Cricetulus griseus	141-164	
11389717-1	2001	4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus.	Tetradecanoylphorbol Acetate	39-42	dihydrofolate reductase	Cricetulus griseus	166-170	
11389717-4	2001	TPA incubation increased the expression and activity of DHFR.	Tetradecanoylphorbol Acetate	0-3	dihydrofolate reductase	Cricetulus griseus	56-60	
11389717-13	2001	We conclude that one mechanism by which TPA enhances MTX resistance, mainly by gene amplification, is through an increase in Sp1 expression which leads to DHFR activation.	Tetradecanoylphorbol Acetate	40-43	dihydrofolate reductase	Cricetulus griseus	155-159