PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29312637-6 2017 Moreover, we are the first to show that Notch regulates by suppressing JunB synthesis and that the negative effect of Notch is partially reversed by treatment with the JunB activator TPA (12-O-tetradeca-noylphorbol-13-acetate). Tetradecanoylphorbol Acetate 183-186 jun B proto-oncogene Mus musculus 71-75 1708123-2 1991 JunB expression is modulated by a wide variety of extracellular stimuli, such as serum, growth factors, phorbol esters (TPA) and activators of protein kinase A (PKA). Tetradecanoylphorbol Acetate 120-123 jun B proto-oncogene Mus musculus 0-4 1708123-4 1991 Here we show that the junB promoter is activated by serum, TPA, and activated PKA. Tetradecanoylphorbol Acetate 59-62 jun B proto-oncogene Mus musculus 22-26 7818761-1 1995 This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain. Tetradecanoylphorbol Acetate 102-138 jun B proto-oncogene Mus musculus 180-184 7818761-1 1995 This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain. Tetradecanoylphorbol Acetate 140-143 jun B proto-oncogene Mus musculus 180-184 2504580-6 1989 Contrary to c-jun and junB transcription, which are strongly stimulated by serum or TPA treatment of quiescent 3T3 cells, junD transcription is not significantly stimulated in these conditions. Tetradecanoylphorbol Acetate 84-87 jun B proto-oncogene Mus musculus 22-26 29312637-6 2017 Moreover, we are the first to show that Notch regulates by suppressing JunB synthesis and that the negative effect of Notch is partially reversed by treatment with the JunB activator TPA (12-O-tetradeca-noylphorbol-13-acetate). Tetradecanoylphorbol Acetate 183-186 jun B proto-oncogene Mus musculus 168-172 29312637-6 2017 Moreover, we are the first to show that Notch regulates by suppressing JunB synthesis and that the negative effect of Notch is partially reversed by treatment with the JunB activator TPA (12-O-tetradeca-noylphorbol-13-acetate). Tetradecanoylphorbol Acetate 188-225 jun B proto-oncogene Mus musculus 71-75 29312637-6 2017 Moreover, we are the first to show that Notch regulates by suppressing JunB synthesis and that the negative effect of Notch is partially reversed by treatment with the JunB activator TPA (12-O-tetradeca-noylphorbol-13-acetate). Tetradecanoylphorbol Acetate 188-225 jun B proto-oncogene Mus musculus 168-172 15520189-6 2004 Expression levels of activator protein-1 family members (c-jun, junB, junD, and c-fos) and transforming growth factor (TGF)-alpha were significantly lower in TPA-treated Smad3(-/-) skin, cultured keratinocytes, and papillomas, as compared with Smad3(+/+) controls. Tetradecanoylphorbol Acetate 158-161 jun B proto-oncogene Mus musculus 64-68 16365389-4 2006 Furthermore, tissue-specific junB knockout mice respond to 12-O-tetradecanoyl-phorbol-13-acetate, a potent AP-1 activator, with markedly increased and sustained epidermal RAE-1epsilon expression. Tetradecanoylphorbol Acetate 59-96 jun B proto-oncogene Mus musculus 29-33 20232358-3 2010 TPA significantly increased c-jun, jun B, c-fos, fra-1, and fra-2 and decreased jun D within 3-6 h after treatment. Tetradecanoylphorbol Acetate 0-3 jun B proto-oncogene Mus musculus 35-40 20232358-4 2010 AP-1:DNA binding reached a maximum 2.5-fold induction over controls 4 h after TPA treatment and antibodies to jun B, jun D, and fra-2 in the EMSA binding reaction resulted in supershifts in both acetone- and TPA-treated mice 1-6 h after treatment. Tetradecanoylphorbol Acetate 208-211 jun B proto-oncogene Mus musculus 110-115 20232358-8 2010 While sham animals treated with either acetone or TPA contained jun B, jun D, and fra-2 proteins in the AP-1:DNA complex by supershift analysis, fra-2 was no longer seen in adx DER animals. Tetradecanoylphorbol Acetate 50-53 jun B proto-oncogene Mus musculus 64-69 18641637-1 2008 Mice that lack JunB in epidermal cells are born with normal skin; however, keratinocytes hyperproliferate in vitro and on TPA treatment in vivo. Tetradecanoylphorbol Acetate 122-125 jun B proto-oncogene Mus musculus 15-19 7675040-4 1995 We found that IL-1 + TPA-treated cells contain significantly higher Jun B protein levels than cells treated with TPA alone. Tetradecanoylphorbol Acetate 21-24 jun B proto-oncogene Mus musculus 68-73 9270030-8 1997 Supershift electrophoresis mobility shift assay revealed that Jun B and c-Jun were absent from the AP-1/DNA complex following TNF-alpha but present following TPA treatment. Tetradecanoylphorbol Acetate 158-161 jun B proto-oncogene Mus musculus 62-67 12640676-9 2003 Additionally, some TPA-induced genes, such as Sprr1A, Saa3, JunB, Il4ralpha, Gp38, RalGDS and Slpi exhibit high basal level in advanced stages of skin carcinogenesis, suggesting that at least a subgroup of the identified TPA-regulated genes may contribute to tumour progression and metastasis. Tetradecanoylphorbol Acetate 19-22 jun B proto-oncogene Mus musculus 60-64 7675040-9 1995 Thus, the stimulation of AP-1-mediated gene expression by IL-1 in EL4 cells is due to the promotion of Jun B protein accumulation that, in turn, facilitates Jun B heterodimerization with TPA-induced Fra-1 protein, thereby forming an active AP-1 complex. Tetradecanoylphorbol Acetate 187-190 jun B proto-oncogene Mus musculus 103-108 8314805-2 1993 We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells. Tetradecanoylphorbol Acetate 157-193 jun B proto-oncogene Mus musculus 45-49 8392062-2 1993 J774 cells responded to either phorbol 12-myristate 13-acetate (PMA) or LPS by the transient increase in the expression levels of c-jun and junB mRNA, but not of junD mRNA. Tetradecanoylphorbol Acetate 31-62 jun B proto-oncogene Mus musculus 140-144 8392062-2 1993 J774 cells responded to either phorbol 12-myristate 13-acetate (PMA) or LPS by the transient increase in the expression levels of c-jun and junB mRNA, but not of junD mRNA. Tetradecanoylphorbol Acetate 64-67 jun B proto-oncogene Mus musculus 140-144 8392062-8 1993 JunB in nuclear fraction appears to specifically bind to 12-O-tetradecanoylphorbol-13-acetate-response element (TRE), since preincubation of nuclear extracts with anti-JunB serum reduced the amount of TRE-binding proteins and since the amount of JunB, but not of c-Jun or JunD, immunoprecipitated from TRE-cross-linked nuclear proteins increased in response to LPS. Tetradecanoylphorbol Acetate 57-93 jun B proto-oncogene Mus musculus 0-4 8392062-8 1993 JunB in nuclear fraction appears to specifically bind to 12-O-tetradecanoylphorbol-13-acetate-response element (TRE), since preincubation of nuclear extracts with anti-JunB serum reduced the amount of TRE-binding proteins and since the amount of JunB, but not of c-Jun or JunD, immunoprecipitated from TRE-cross-linked nuclear proteins increased in response to LPS. Tetradecanoylphorbol Acetate 57-93 jun B proto-oncogene Mus musculus 168-172 8392062-8 1993 JunB in nuclear fraction appears to specifically bind to 12-O-tetradecanoylphorbol-13-acetate-response element (TRE), since preincubation of nuclear extracts with anti-JunB serum reduced the amount of TRE-binding proteins and since the amount of JunB, but not of c-Jun or JunD, immunoprecipitated from TRE-cross-linked nuclear proteins increased in response to LPS. Tetradecanoylphorbol Acetate 57-93 jun B proto-oncogene Mus musculus 168-172 8314805-2 1993 We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells. Tetradecanoylphorbol Acetate 157-193 jun B proto-oncogene Mus musculus 113-117 8314805-2 1993 We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells. Tetradecanoylphorbol Acetate 195-198 jun B proto-oncogene Mus musculus 45-49 8314805-2 1993 We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells. Tetradecanoylphorbol Acetate 195-198 jun B proto-oncogene Mus musculus 113-117 8426742-8 1993 The serum induction of c-fos and junD as well as the serum and TPA (12-O-tetradecanoylphorbol-13-acetate) induction of junB and egr-1 are almost completely abolished. Tetradecanoylphorbol Acetate 63-66 jun B proto-oncogene Mus musculus 119-123 8426742-8 1993 The serum induction of c-fos and junD as well as the serum and TPA (12-O-tetradecanoylphorbol-13-acetate) induction of junB and egr-1 are almost completely abolished. Tetradecanoylphorbol Acetate 68-104 jun B proto-oncogene Mus musculus 119-123 1281302-4 1992 Transcriptional activation of the c-jun, junB and c-fos genes following TPA/serum induction was unaffected and efficient transactivation of AP-1 reporter constructs was demonstrated in these cells. Tetradecanoylphorbol Acetate 72-75 jun B proto-oncogene Mus musculus 41-45 1417179-8 1992 The tumor-promoting phorbol ester (phorbol 12-myristate 13-acetate [PMA]), known to induce jun and fos gene expression, caused increases in jun-B and fos-B that preceded the decrease in albumin mRNA levels at 24 hours. Tetradecanoylphorbol Acetate 35-66 jun B proto-oncogene Mus musculus 140-145 1417179-8 1992 The tumor-promoting phorbol ester (phorbol 12-myristate 13-acetate [PMA]), known to induce jun and fos gene expression, caused increases in jun-B and fos-B that preceded the decrease in albumin mRNA levels at 24 hours. Tetradecanoylphorbol Acetate 68-71 jun B proto-oncogene Mus musculus 140-145