PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8241020-2 1993 By Northern analysis, preproGRP mRNA was stimulated by 4 beta-phorbol 12-myristate 13 alpha-acetate (PMA) in a concentration- and time-dependent manner in these cells. Tetradecanoylphorbol Acetate 101-104 gastrin releasing peptide Homo sapiens 22-31 10542109-4 1999 Further, we demonstrate that gastrin-releasing peptide, which activates a Gq-coupled GRP receptor, isoproterenol, which activates a Gs-coupled beta-adrenergic receptor, calcium ionophores, and phorbol 12-myristate 13-acetate, a stimulator of protein kinase C, can mediate increases in luciferase expression in the presence of forskolin but not in its absence. Tetradecanoylphorbol Acetate 193-224 gastrin releasing peptide Homo sapiens 29-54 8241020-3 1993 In cell line NCI-H209, the addition of 10(-6) M PMA increased a 0.9-kb mRNA after 8 h. An inactive phorbol ester, 4 alpha-PMA, had little effect on preproGRP mRNA. Tetradecanoylphorbol Acetate 48-51 gastrin releasing peptide Homo sapiens 148-157 2849413-4 1988 Pretreatment with phorbol 12-myristate 13-acetate (PMA) for 20 min inhibited the ability of [Tyr4]bombesin to induce phosphatidylinositol (PtdIns) turnover and to increase intracellular free Ca2+ ([Ca2+]i). Tetradecanoylphorbol Acetate 18-49 gastrin releasing peptide Homo sapiens 98-106 1321770-4 1992 Pretreatment of MCF-7 cells with TPA caused attenuation of both these BN-induced responses. Tetradecanoylphorbol Acetate 33-36 gastrin releasing peptide Homo sapiens 70-72 1321770-6 1992 Furthermore, putative down-regulation of PKC by prolonged TPA pretreatment also reversed the inhibitory action of TPA and enhanced BN-induced phosphoinositide hydrolysis. Tetradecanoylphorbol Acetate 58-61 gastrin releasing peptide Homo sapiens 131-133 1321770-7 1992 TPA also inhibited BN-induced increases in cytosolic Ca2+ concentration ([Ca2+]i) and caused a dose-dependent inhibition of epidermal growth factor (EGF) binding in MCF-7 cells. Tetradecanoylphorbol Acetate 0-3 gastrin releasing peptide Homo sapiens 19-21 2849413-4 1988 Pretreatment with phorbol 12-myristate 13-acetate (PMA) for 20 min inhibited the ability of [Tyr4]bombesin to induce phosphatidylinositol (PtdIns) turnover and to increase intracellular free Ca2+ ([Ca2+]i). Tetradecanoylphorbol Acetate 51-54 gastrin releasing peptide Homo sapiens 98-106 2849413-5 1988 Pretreatment with PMA for 48 h attenuated the ability of subsequently added PMA to decrease the response to [Tyr4]bombesin. Tetradecanoylphorbol Acetate 18-21 gastrin releasing peptide Homo sapiens 114-122 2849413-5 1988 Pretreatment with PMA for 48 h attenuated the ability of subsequently added PMA to decrease the response to [Tyr4]bombesin. Tetradecanoylphorbol Acetate 76-79 gastrin releasing peptide Homo sapiens 114-122 3558493-5 1987 Pretreatment of cells with phorbol-12, 13-dibutyrate (PDBu) for 24 h depleted cellular protein kinase C activity and inhibited the ability of TPA to induce these effects suggesting a direct involvement of protein kinase C. Similarly the bombesin stimulation of 32Pi into PC and of [3H]choline and [3H]phosphocholine release was inhibited by PDBu pretreatment. Tetradecanoylphorbol Acetate 142-145 gastrin releasing peptide Homo sapiens 237-245