PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8241020-2	1993	By Northern analysis, preproGRP mRNA was stimulated by 4 beta-phorbol 12-myristate 13 alpha-acetate (PMA) in a concentration- and time-dependent manner in these cells.	Tetradecanoylphorbol Acetate	101-104	gastrin releasing peptide	Homo sapiens	22-31	
10542109-4	1999	Further, we demonstrate that gastrin-releasing peptide, which activates a Gq-coupled GRP receptor, isoproterenol, which activates a Gs-coupled beta-adrenergic receptor, calcium ionophores, and phorbol 12-myristate 13-acetate, a stimulator of protein kinase C, can mediate increases in luciferase expression in the presence of forskolin but not in its absence.	Tetradecanoylphorbol Acetate	193-224	gastrin releasing peptide	Homo sapiens	29-54	
8241020-3	1993	In cell line NCI-H209, the addition of 10(-6) M PMA increased a 0.9-kb mRNA after 8 h. An inactive phorbol ester, 4 alpha-PMA, had little effect on preproGRP mRNA.	Tetradecanoylphorbol Acetate	48-51	gastrin releasing peptide	Homo sapiens	148-157	
2849413-4	1988	Pretreatment with phorbol 12-myristate 13-acetate (PMA) for 20 min inhibited the ability of [Tyr4]bombesin to induce phosphatidylinositol (PtdIns) turnover and to increase intracellular free Ca2+ ([Ca2+]i).	Tetradecanoylphorbol Acetate	18-49	gastrin releasing peptide	Homo sapiens	98-106	
1321770-4	1992	Pretreatment of MCF-7 cells with TPA caused attenuation of both these BN-induced responses.	Tetradecanoylphorbol Acetate	33-36	gastrin releasing peptide	Homo sapiens	70-72	
1321770-6	1992	Furthermore, putative down-regulation of PKC by prolonged TPA pretreatment also reversed the inhibitory action of TPA and enhanced BN-induced phosphoinositide hydrolysis.	Tetradecanoylphorbol Acetate	58-61	gastrin releasing peptide	Homo sapiens	131-133	
1321770-7	1992	TPA also inhibited BN-induced increases in cytosolic Ca2+ concentration ([Ca2+]i) and caused a dose-dependent inhibition of epidermal growth factor (EGF) binding in MCF-7 cells.	Tetradecanoylphorbol Acetate	0-3	gastrin releasing peptide	Homo sapiens	19-21	
2849413-4	1988	Pretreatment with phorbol 12-myristate 13-acetate (PMA) for 20 min inhibited the ability of [Tyr4]bombesin to induce phosphatidylinositol (PtdIns) turnover and to increase intracellular free Ca2+ ([Ca2+]i).	Tetradecanoylphorbol Acetate	51-54	gastrin releasing peptide	Homo sapiens	98-106	
2849413-5	1988	Pretreatment with PMA for 48 h attenuated the ability of subsequently added PMA to decrease the response to [Tyr4]bombesin.	Tetradecanoylphorbol Acetate	18-21	gastrin releasing peptide	Homo sapiens	114-122	
2849413-5	1988	Pretreatment with PMA for 48 h attenuated the ability of subsequently added PMA to decrease the response to [Tyr4]bombesin.	Tetradecanoylphorbol Acetate	76-79	gastrin releasing peptide	Homo sapiens	114-122	
3558493-5	1987	Pretreatment of cells with phorbol-12, 13-dibutyrate (PDBu) for 24 h depleted cellular protein kinase C activity and inhibited the ability of TPA to induce these effects suggesting a direct involvement of protein kinase C. Similarly the bombesin stimulation of 32Pi into PC and of [3H]choline and [3H]phosphocholine release was inhibited by PDBu pretreatment.	Tetradecanoylphorbol Acetate	142-145	gastrin releasing peptide	Homo sapiens	237-245