PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7525610-0 1994 High resolution analysis of cell cycle-correlated vimentin expression in asynchronously grown, TPA-treated MPC-11 cells by the novel flow cytometric multiparameter BrdU-Hoechst/PI and immunolabeling technique. Tetradecanoylphorbol Acetate 95-98 vimentin Mus musculus 50-58 7896891-5 1995 However, vimentin expression was markedly delayed in okadaic acid-treated relative to TPA-treated cells. Tetradecanoylphorbol Acetate 86-89 vimentin Mus musculus 9-17 7525610-5 1994 There is also evidence that cells located in G1 or G2/M phase at the beginning of TPA treatment finally expressed low levels of vimentin. Tetradecanoylphorbol Acetate 82-85 vimentin Mus musculus 128-136 7525610-6 1994 On the contrary, cells located in S phase at TPA exposure showed high vimentin levels after treatment. Tetradecanoylphorbol Acetate 45-48 vimentin Mus musculus 70-78 1563479-7 1992 The pattern of vimentin mRNA accumulation in synchronized cultures after short-term TPA treatment strongly suggests that the cell cycle-dependent pattern of vimentin expression is caused, at least in part, by different levels of vimentin mRNA accumulated in the cells. Tetradecanoylphorbol Acetate 84-87 vimentin Mus musculus 157-165 1563479-0 1992 Cell cycle-dependent vimentin expression in elutriator-synchronized, TPA-treated MPC-11 mouse plasmacytoma cells. Tetradecanoylphorbol Acetate 69-72 vimentin Mus musculus 21-29 1563479-3 1992 A 6-h TPA treatment of G1-phase-enriched cultures induced both a partial G1-phase arrest in the same cycle and a moderate fraction of cells to become vimentin positive. Tetradecanoylphorbol Acetate 6-9 vimentin Mus musculus 150-158 1563479-4 1992 However, nearly all cells of the cultures enriched in S- or in G2/M-phase cells could be arrested by TPA treatment at the earliest in the G1 phase of the second cell cycle and displayed higher fractions of positive cells as well as higher average levels of vimentin. Tetradecanoylphorbol Acetate 101-104 vimentin Mus musculus 257-265 1563479-6 1992 In terms of fractions of vimentin-positive cells as well as of average cellular vimentin content, the differences between the cultures resembled, albeit on a higher level, those between the respective cultures treated with TPA for 6 h. These observations might explain the striking bimodal distribution of individual cellular vimentin content detectable in G1-phase fractions of asynchronous, TPA-treated cultures. Tetradecanoylphorbol Acetate 223-226 vimentin Mus musculus 25-33 1563479-6 1992 In terms of fractions of vimentin-positive cells as well as of average cellular vimentin content, the differences between the cultures resembled, albeit on a higher level, those between the respective cultures treated with TPA for 6 h. These observations might explain the striking bimodal distribution of individual cellular vimentin content detectable in G1-phase fractions of asynchronous, TPA-treated cultures. Tetradecanoylphorbol Acetate 223-226 vimentin Mus musculus 80-88 1563479-6 1992 In terms of fractions of vimentin-positive cells as well as of average cellular vimentin content, the differences between the cultures resembled, albeit on a higher level, those between the respective cultures treated with TPA for 6 h. These observations might explain the striking bimodal distribution of individual cellular vimentin content detectable in G1-phase fractions of asynchronous, TPA-treated cultures. Tetradecanoylphorbol Acetate 223-226 vimentin Mus musculus 80-88 1544377-2 1992 A 48-h exposure of murine plasmacytomas MPC-11 to the phorbol ester TPA reduces their growth and induces vimentin synthesis without affecting the composition of their nuclear lamina. Tetradecanoylphorbol Acetate 68-71 vimentin Mus musculus 105-113 1563479-7 1992 The pattern of vimentin mRNA accumulation in synchronized cultures after short-term TPA treatment strongly suggests that the cell cycle-dependent pattern of vimentin expression is caused, at least in part, by different levels of vimentin mRNA accumulated in the cells. Tetradecanoylphorbol Acetate 84-87 vimentin Mus musculus 157-165 1563479-8 1992 Since proteinaceous mediator(s) are obviously involved in TPA-induced vimentin expression in MPC-11 cells, cell cycle-dependent vimentin expression in these cells may be dependent on cell cycle-dependent regulation of the activity and/or concentration of such mediator(s). Tetradecanoylphorbol Acetate 58-61 vimentin Mus musculus 70-78 1563479-8 1992 Since proteinaceous mediator(s) are obviously involved in TPA-induced vimentin expression in MPC-11 cells, cell cycle-dependent vimentin expression in these cells may be dependent on cell cycle-dependent regulation of the activity and/or concentration of such mediator(s). Tetradecanoylphorbol Acetate 58-61 vimentin Mus musculus 128-136 34422811-7 2021 Results: Overexpression of lncRNA TPA decreased the expression of E-cadherin, and significantly increased the expression of Vimentin, fibronectin and TGF-beta1 (p < 0.01), and increased the migration rate, migration ability and invasion ability of cell group (P < 0.01). Tetradecanoylphorbol Acetate 34-37 vimentin Mus musculus 124-132 2209721-0 1990 Alterations of cell cycle kinetics and vimentin expression in TPA-treated, asynchronous MPC-11 mouse plasmacytoma cells. Tetradecanoylphorbol Acetate 62-65 vimentin Mus musculus 39-47 2209721-3 1990 In the presence of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), cell proliferation ceases and large quantities of the intermediate filament protein vimentin are synthesized and accumulate in most of the cells. Tetradecanoylphorbol Acetate 37-73 vimentin Mus musculus 165-173 2209721-3 1990 In the presence of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), cell proliferation ceases and large quantities of the intermediate filament protein vimentin are synthesized and accumulate in most of the cells. Tetradecanoylphorbol Acetate 75-78 vimentin Mus musculus 165-173 2209721-8 1990 Vimentin accumulation could be detected by flow cytometry as early as 2 h after TPA addition; at this time, the percentage of vimentin-positive cells was highest in G2/M phase. Tetradecanoylphorbol Acetate 80-83 vimentin Mus musculus 0-8 2209721-9 1990 Prolonged TPA treatment induced vimentin accumulation in cells of all cell cycle phases. Tetradecanoylphorbol Acetate 10-13 vimentin Mus musculus 32-40 2209721-11 1990 The fraction of cells which displayed a higher level of vimentin probably represents those G1-phase cells which previously had undergone cell division in the presence of TPA. Tetradecanoylphorbol Acetate 170-173 vimentin Mus musculus 56-64 2209721-12 1990 Our data indicate that TPA-induced vimentin synthesis is regulated in a cell cycle-dependent manner and is maximally induced in cells which have passed a putative cell cycle restriction point in G1 phase. Tetradecanoylphorbol Acetate 23-26 vimentin Mus musculus 35-43 9351190-3 1997 Additionally, in these cells which are usually devoid of significant amounts of cytoplasmic intermediate filament (cIF) proteins, synthesis and accumulation of the cIF protein vimentin was rapidly induced by TPA treatment and almost all cells became vimentin-positive. Tetradecanoylphorbol Acetate 208-211 vimentin Mus musculus 176-184 3519221-3 1986 The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration. Tetradecanoylphorbol Acetate 12-15 vimentin Mus musculus 62-70 3519221-3 1986 The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration. Tetradecanoylphorbol Acetate 12-15 vimentin Mus musculus 143-151 3519221-3 1986 The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration. Tetradecanoylphorbol Acetate 12-15 vimentin Mus musculus 143-151 3519221-3 1986 The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration. Tetradecanoylphorbol Acetate 200-203 vimentin Mus musculus 143-151 3519221-3 1986 The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration. Tetradecanoylphorbol Acetate 200-203 vimentin Mus musculus 143-151 3519221-3 1986 The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration. Tetradecanoylphorbol Acetate 200-203 vimentin Mus musculus 143-151 3519221-3 1986 The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration. Tetradecanoylphorbol Acetate 200-203 vimentin Mus musculus 143-151 3519221-3 1986 The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration. Tetradecanoylphorbol Acetate 200-203 vimentin Mus musculus 143-151 3519221-3 1986 The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration. Tetradecanoylphorbol Acetate 200-203 vimentin Mus musculus 143-151 3519221-6 1986 The fact that only poly(A) +RNA from TPA-treated MPC-11 cells was able to direct vimentin synthesis in vitro suggests that in MPC-11 cells vimentin production is regulated at the transcriptional level. Tetradecanoylphorbol Acetate 37-40 vimentin Mus musculus 81-89 3519221-6 1986 The fact that only poly(A) +RNA from TPA-treated MPC-11 cells was able to direct vimentin synthesis in vitro suggests that in MPC-11 cells vimentin production is regulated at the transcriptional level. Tetradecanoylphorbol Acetate 37-40 vimentin Mus musculus 139-147 2907482-0 1988 Induction of vimentin synthesis in a murine myeloma cell line by TPA is strongly dependent on the composition of the cell culture medium. Tetradecanoylphorbol Acetate 65-68 vimentin Mus musculus 13-21 2907482-1 1988 MPC-11 mouse plasmacytoma cells virtually lacking intermediate filament (IF) proteins can be induced to synthesize and accumulate the IF protein vimentin by treatment with the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 206-242 vimentin Mus musculus 145-153 2907482-1 1988 MPC-11 mouse plasmacytoma cells virtually lacking intermediate filament (IF) proteins can be induced to synthesize and accumulate the IF protein vimentin by treatment with the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 244-247 vimentin Mus musculus 145-153 2907482-3 1988 Vimentin synthesis could be elicited by a TPA concentration as low as 10(-9) M in cells grown in HB-102 serum-free medium. Tetradecanoylphorbol Acetate 42-45 vimentin Mus musculus 0-8 2907482-5 1988 After 50 generations of culture in the presence of FCS, induction of vimentin synthesis was barely detectable even at a TPA concentration of 10(-6) M. Addition of FCS to cells grown in serum-free medium partially suppressed vimentin induction by TPA. Tetradecanoylphorbol Acetate 120-123 vimentin Mus musculus 69-77 2907482-5 1988 After 50 generations of culture in the presence of FCS, induction of vimentin synthesis was barely detectable even at a TPA concentration of 10(-6) M. Addition of FCS to cells grown in serum-free medium partially suppressed vimentin induction by TPA. Tetradecanoylphorbol Acetate 246-249 vimentin Mus musculus 69-77 2907482-5 1988 After 50 generations of culture in the presence of FCS, induction of vimentin synthesis was barely detectable even at a TPA concentration of 10(-6) M. Addition of FCS to cells grown in serum-free medium partially suppressed vimentin induction by TPA. Tetradecanoylphorbol Acetate 246-249 vimentin Mus musculus 224-232 2907482-6 1988 This suppression seems to be due, at least in part, to nondialyzable, heat-sensitive components of FCS, since the dialyzable fraction even enhanced vimentin induction by TPA. Tetradecanoylphorbol Acetate 170-173 vimentin Mus musculus 148-156 2907482-7 1988 When cells grown in the presence of FCS were transferred back to serum-free medium, their ability to synthesize vimentin in response to TPA treatment was readily restored. Tetradecanoylphorbol Acetate 136-139 vimentin Mus musculus 112-120 2907482-8 1988 The individual components of serum-free medium which proved to support vimentin induction by TPA were insulin and the unsaturated fatty acids oleic acid and linoleic acid. Tetradecanoylphorbol Acetate 93-96 vimentin Mus musculus 71-79 10978519-0 2000 Similar effects of electroporational stress and treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on vimentin expression in mouse plasmacytoma cells. Tetradecanoylphorbol Acetate 81-117 vimentin Mus musculus 121-129 9351190-3 1997 Additionally, in these cells which are usually devoid of significant amounts of cytoplasmic intermediate filament (cIF) proteins, synthesis and accumulation of the cIF protein vimentin was rapidly induced by TPA treatment and almost all cells became vimentin-positive. Tetradecanoylphorbol Acetate 208-211 vimentin Mus musculus 250-258 9351190-6 1997 We suggest that in MPC-11 cells undergoing apoptosis in response to TPA treatment vimentin as well as lamin B are degraded, leading to a rearrangement and eventual loss of their respective filament networks. Tetradecanoylphorbol Acetate 68-71 vimentin Mus musculus 82-90