PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10495787-4	1997	Ribonuclease protection assay revealed the expression of ECE-1 and -2 in cultured GEN, and the expression was increased approximately 2.5- and approximately 1.8-fold, respectively, by treatment with 10(-7) M 12-O-tetradecanocyl-phorbol-13-acetate (TPA) for 4 hours.	Tetradecanoylphorbol Acetate	248-251	endothelin converting enzyme 1	Homo sapiens	57-69	
10495787-5	1997	These increases in ECE-1 and -2 expression with TPA were inhibited by cotreatment with calphostin C (10(-7) M).	Tetradecanoylphorbol Acetate	48-51	endothelin converting enzyme 1	Homo sapiens	19-31	
10495787-6	1997	In contrast, 24-h treatment with 10(-7) M TPA significantly decreased the expression of ECE-1 and -2, indicating that the expression was tightly regulated by protein kinase C (PKC)-dependent mechanism(s).	Tetradecanoylphorbol Acetate	42-45	endothelin converting enzyme 1	Homo sapiens	88-100	
10495787-7	1997	Actinomycin D (1 microgram/mL) abolished the TPA-induced increase of ECE-1 and -2 mRNA, whereas TPA treatment did not affect the mRNA stability of ECE-1 and -2, thus suggesting that TPA-induced increases of ECE-1 and -2 mRNA resulted from the transcriptional activation of ECE-1 and -2, gene, rather than from the increase of mRNA stability.	Tetradecanoylphorbol Acetate	45-48	endothelin converting enzyme 1	Homo sapiens	69-81	
16741047-7	2006	Serum withdrawal from the incubation medium as well as addition of carbachol or PMA for 24 hrs also led to a significant reduction of the levels of ECE-1 protein in NB7 cells.	Tetradecanoylphorbol Acetate	80-83	endothelin converting enzyme 1	Homo sapiens	148-153	
20558134-7	2010	The stimulation of cells by PMA (1 microM, 6 h) significantly increased the ECE-1 activity (0.28+/-0.02; n=3) compared to the control (0.07+/-0.02; n=3).	Tetradecanoylphorbol Acetate	28-31	endothelin converting enzyme 1	Homo sapiens	76-81	
20558134-9	2010	Treatment with PMA also increased the activity of ECE-1 in the media (0.18+/-0.01; n=3) compared to control (0.08+/-0.01; n=3).	Tetradecanoylphorbol Acetate	15-18	endothelin converting enzyme 1	Homo sapiens	50-55