PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12602901-9 2003 The GHRH antagonist JV-1-38 suppressed the T47D cell growth in vitro stimulated by PKC activator (phorbol-12-myristate-13-acetate). Tetradecanoylphorbol Acetate 98-129 growth hormone releasing hormone Homo sapiens 4-8 2463192-6 1988 In contrast TPA when combined with maximally effective concentrations of either GHRH, forskolin or IBMX caused additional release of growth hormone, suggesting that the TPA-induced secretion involved a cyclic AMP-independent process. Tetradecanoylphorbol Acetate 169-172 growth hormone releasing hormone Homo sapiens 80-84 2463192-8 1988 That TPA induced stimulation of basal and GHRH-stimulated cyclic AMP levels measured in the presence of IBMX suggests an action affecting cyclic AMP synthesis. Tetradecanoylphorbol Acetate 5-8 growth hormone releasing hormone Homo sapiens 42-46 2463192-10 1988 The two actions of TPA, one on secretion and one on cyclic AMP metabolism, may result from activation of some common event possibly involving protein kinase C. Our results suggest that GHRH and TPA activate independent pathways regulating growth hormone secretion. Tetradecanoylphorbol Acetate 19-22 growth hormone releasing hormone Homo sapiens 185-189 2876983-3 1986 Activators of protein kinase C such as teleocidin and 4 beta-phorbol 12-myristate 13-acetate (PMA) double the cyclic AMP accumulation induced by GRF, with no apparent effect on GRF potency; an inactive 4-alpha-PMA has no such action in cultured anterior pituitary cells. Tetradecanoylphorbol Acetate 54-92 growth hormone releasing hormone Homo sapiens 145-148 2876983-3 1986 Activators of protein kinase C such as teleocidin and 4 beta-phorbol 12-myristate 13-acetate (PMA) double the cyclic AMP accumulation induced by GRF, with no apparent effect on GRF potency; an inactive 4-alpha-PMA has no such action in cultured anterior pituitary cells. Tetradecanoylphorbol Acetate 94-97 growth hormone releasing hormone Homo sapiens 145-148 2876983-5 1986 PMA, phorbol 12,13-dibutyrate, and teleocidin ED50 values for potentiating GRF activity are similar to those obtained for direct protein kinase C activation. Tetradecanoylphorbol Acetate 0-3 growth hormone releasing hormone Homo sapiens 75-78 8875488-8 1996 Tumors in which GHRH had no significant effect nevertheless responded to TPA. Tetradecanoylphorbol Acetate 73-76 growth hormone releasing hormone Homo sapiens 16-20 9710361-8 1998 This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min. Tetradecanoylphorbol Acetate 97-100 growth hormone releasing hormone Homo sapiens 216-219 9710361-8 1998 This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min. Tetradecanoylphorbol Acetate 97-100 growth hormone releasing hormone Homo sapiens 386-389 9710361-8 1998 This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min. Tetradecanoylphorbol Acetate 243-246 growth hormone releasing hormone Homo sapiens 216-219 9710361-8 1998 This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min. Tetradecanoylphorbol Acetate 243-246 growth hormone releasing hormone Homo sapiens 216-219 9710361-10 1998 Furthermore, the GRF-induced increase in cFos mRNA level by GRF and TPA did not appear to be participated straightforward in the GH gene expression, suggesting that cFos alone is insufficient to the activation. Tetradecanoylphorbol Acetate 68-71 growth hormone releasing hormone Homo sapiens 17-20 12840904-0 1999 TPA enhances growth hormone (GH) secretion effect of GH-releasing hormone (GHRH) by human gsp-positive pituitary somatotrophinomas. Tetradecanoylphorbol Acetate 0-3 growth hormone releasing hormone Homo sapiens 53-73 12840904-0 1999 TPA enhances growth hormone (GH) secretion effect of GH-releasing hormone (GHRH) by human gsp-positive pituitary somatotrophinomas. Tetradecanoylphorbol Acetate 0-3 growth hormone releasing hormone Homo sapiens 75-79 12840904-5 1999 Moreover, phorbol ester, 1, 2-tetradecanoylphorbol-13-acetate (TPA), enhanced stimulation of lated the GH secretion effect exerted by GHRH in gsp-positive somatotrophinomas, whereas this effect was not observed in gsp-negative tumors. Tetradecanoylphorbol Acetate 63-66 growth hormone releasing hormone Homo sapiens 134-138 7544679-5 1995 The PKC activator TPA amplifies the response of mast cells to human GRF, shifting the dose-response curve to the left. Tetradecanoylphorbol Acetate 18-21 growth hormone releasing hormone Homo sapiens 68-71