PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8413220-4 1993 The region downstream of -363 is critical for basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and contains at least three enhancer-like regions. Tetradecanoylphorbol Acetate 56-81 interleukin 2 receptor subunit beta Homo sapiens 92-102 8413220-8 1993 We conclude that this Ets binding site plays a key role in regulating basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and may also contribute to tissue-specific expression of the IL-2R beta gene. Tetradecanoylphorbol Acetate 80-105 interleukin 2 receptor subunit beta Homo sapiens 116-126 8413220-8 1993 We conclude that this Ets binding site plays a key role in regulating basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and may also contribute to tissue-specific expression of the IL-2R beta gene. Tetradecanoylphorbol Acetate 80-105 interleukin 2 receptor subunit beta Homo sapiens 206-216 1333455-3 1992 Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself. Tetradecanoylphorbol Acetate 36-61 interleukin 2 receptor subunit beta Homo sapiens 100-113 1309491-2 1992 STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 186-217 interleukin 2 receptor subunit beta Homo sapiens 72-85 1309491-2 1992 STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 219-222 interleukin 2 receptor subunit beta Homo sapiens 72-85 2469910-4 1989 Treatment of the TsF2 producing hybridoma with phorbol myristate acetate (PMA) causes an increase in the level of IL-2 receptor expression in this hybridoma and enhances the effects of IL-2 on the biosynthesis of TsF2. Tetradecanoylphorbol Acetate 47-72 interleukin 2 receptor subunit beta Homo sapiens 114-127 1733630-5 1992 The IL-2R beta chain is constitutively expressed on freshly isolated thymocytes; this expression can be increased in thymocytes activated with Con A in combination with IL-2 or tetradecanoylphorbol 13-acetate (TPA). Tetradecanoylphorbol Acetate 210-213 interleukin 2 receptor subunit beta Homo sapiens 4-14 1733630-7 1992 The accumulation of IL-2R-beta-specific mRNA is observed in freshly isolated thymocytes and it is increased in thymocytes cultured with rIL-2 alone, with Con A, and further enhanced by the addition of rIL-2 in combination with Con A or with TPA. Tetradecanoylphorbol Acetate 241-244 interleukin 2 receptor subunit beta Homo sapiens 20-25 2121373-1 1990 In this study, we investigated the biological effects of N-m-KRTLR using as an in vitro model the induction of the IL-2 receptor and IL-2 secretion by Jurkat cells in response to stimulation with 12-O tetradecanoylphorbol-13-acetate (TPA) plus phytohemagglutinin (PHA) and TPA plus OKT3 mAb. Tetradecanoylphorbol Acetate 196-232 interleukin 2 receptor subunit beta Homo sapiens 115-128 2121373-2 1990 N-m-KRTLR significantly suppressed induction of the IL-2 receptor on the surface of the Jurkat cells by TPA plus either PHA or OKT3 mAb. Tetradecanoylphorbol Acetate 104-107 interleukin 2 receptor subunit beta Homo sapiens 52-65 2145219-9 1990 Addition of PMA induces both p70/75 and p50/55 IL2 receptor upregulation, as well as IL2-dependent proliferation. Tetradecanoylphorbol Acetate 12-15 interleukin 2 receptor subunit beta Homo sapiens 29-35 1588792-5 1992 We found that PMA induced the expression of both IL-2R alpha and IL-2R beta chains, as well as IL-2 production by T-ALL cells. Tetradecanoylphorbol Acetate 14-17 interleukin 2 receptor subunit beta Homo sapiens 65-75 2469910-4 1989 Treatment of the TsF2 producing hybridoma with phorbol myristate acetate (PMA) causes an increase in the level of IL-2 receptor expression in this hybridoma and enhances the effects of IL-2 on the biosynthesis of TsF2. Tetradecanoylphorbol Acetate 74-77 interleukin 2 receptor subunit beta Homo sapiens 114-127 3106473-4 1987 In T cells, the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) induced IL 2-R expression and proliferation associated with cytosol-to-membrane PKC translocation. Tetradecanoylphorbol Acetate 30-67 interleukin 2 receptor subunit beta Homo sapiens 82-88 3106473-4 1987 In T cells, the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) induced IL 2-R expression and proliferation associated with cytosol-to-membrane PKC translocation. Tetradecanoylphorbol Acetate 69-72 interleukin 2 receptor subunit beta Homo sapiens 82-88 3106473-5 1987 A dose of TPA (1 to 4 ng/ml) that induced about 50% of the maximal activation of PKC in the enzymatic assay also induced half-maximal effects on cell proliferation, IL 2-R expression, and PKC redistribution in intact T cells. Tetradecanoylphorbol Acetate 10-13 interleukin 2 receptor subunit beta Homo sapiens 165-171 3920341-10 1985 TPA induced a low level of IL-2 receptor expression in monocyte-depleted T cells, without inducing IL-2 secretion. Tetradecanoylphorbol Acetate 0-3 interleukin 2 receptor subunit beta Homo sapiens 27-40 2941417-6 1986 These results also provide direct evidence that the in vivo phosphorylation of the IL-2 receptor stimulated by TPA is catalyzed by protein kinase C. The sites phosphorylated in the HLA antigens in vitro by protein kinase C or in vivo after TPA stimulation were also localized to the carboxyl-terminal cytoplasmic domain of the heavy chain by limited proteolysis. Tetradecanoylphorbol Acetate 111-114 interleukin 2 receptor subunit beta Homo sapiens 83-96 2941417-6 1986 These results also provide direct evidence that the in vivo phosphorylation of the IL-2 receptor stimulated by TPA is catalyzed by protein kinase C. The sites phosphorylated in the HLA antigens in vitro by protein kinase C or in vivo after TPA stimulation were also localized to the carboxyl-terminal cytoplasmic domain of the heavy chain by limited proteolysis. Tetradecanoylphorbol Acetate 240-243 interleukin 2 receptor subunit beta Homo sapiens 83-96 3082877-2 1986 The recombinant IL-2 receptor in these cells was rapidly phosphorylated in response to phorbol myristate acetate (PMA), but its phosphorylation could not be detected in the absence of PMA or upon addition of human IL-2. Tetradecanoylphorbol Acetate 87-112 interleukin 2 receptor subunit beta Homo sapiens 16-29 3082877-2 1986 The recombinant IL-2 receptor in these cells was rapidly phosphorylated in response to phorbol myristate acetate (PMA), but its phosphorylation could not be detected in the absence of PMA or upon addition of human IL-2. Tetradecanoylphorbol Acetate 114-117 interleukin 2 receptor subunit beta Homo sapiens 16-29 3082877-2 1986 The recombinant IL-2 receptor in these cells was rapidly phosphorylated in response to phorbol myristate acetate (PMA), but its phosphorylation could not be detected in the absence of PMA or upon addition of human IL-2. Tetradecanoylphorbol Acetate 184-187 interleukin 2 receptor subunit beta Homo sapiens 16-29 3929255-6 1985 4 beta-Phorbol 12-myristate 13-acetate (PMA) also stimulates IL-2 receptor mRNA and protein expression by T cells. Tetradecanoylphorbol Acetate 0-38 interleukin 2 receptor subunit beta Homo sapiens 61-74 3929255-6 1985 4 beta-Phorbol 12-myristate 13-acetate (PMA) also stimulates IL-2 receptor mRNA and protein expression by T cells. Tetradecanoylphorbol Acetate 40-43 interleukin 2 receptor subunit beta Homo sapiens 61-74 6441115-10 1984 Murine thymocytes incubated with PMA for 30 min or with ConA for 4 hr (mitogen-pulsed T-cells) failed to bind the anti-IL-2 receptor antibody AMT-13 and to absorb IL-2 activity present in semipurified IL-2 preparations, but they proliferated vigorously in response to the same IL-2 preparations. Tetradecanoylphorbol Acetate 33-36 interleukin 2 receptor subunit beta Homo sapiens 119-132 9199305-2 1997 Although IL-2Rbeta is constitutively expressed by lymphocytes, its expression can be further induced by a number of stimuli, including phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 135-166 interleukin 2 receptor subunit beta Homo sapiens 9-18 9199305-2 1997 Although IL-2Rbeta is constitutively expressed by lymphocytes, its expression can be further induced by a number of stimuli, including phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 168-171 interleukin 2 receptor subunit beta Homo sapiens 9-18 8206753-4 1994 In T cells stimulated with purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) addition of DM to the cultures resulted in a 60% reduction in IL-2R alpha and a 30% reduction in IL-2R beta membrane expression compared to T cells cultured in the absence of DM (p < 0.01). Tetradecanoylphorbol Acetate 107-110 interleukin 2 receptor subunit beta Homo sapiens 209-219