PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11809863-9	2002	The induction of Egr-1 in rat neonatal ventricular myocytes with phorbol-12-myristate-13-acetate or in HeLa S3 cells by regulated expression of Egr-1 in a tetracycline-responsive promoter, suppressed expression from the beta(1)-AR promoter.	Tetradecanoylphorbol Acetate	65-96	early growth response 1	Rattus norvegicus	17-22	
10842166-5	2000	Treatment of PC12 cells with phorbol ester (2 micrometer 12-O-tetradecanoylphorbol-13-acetate (TPA)) gives rise to a new Egr1-containing complex.	Tetradecanoylphorbol Acetate	57-93	early growth response 1	Rattus norvegicus	121-125	
10842166-5	2000	Treatment of PC12 cells with phorbol ester (2 micrometer 12-O-tetradecanoylphorbol-13-acetate (TPA)) gives rise to a new Egr1-containing complex.	Tetradecanoylphorbol Acetate	95-98	early growth response 1	Rattus norvegicus	121-125	
10842166-6	2000	TPA treatment reduces the steady-state levels of the Sp1 protein and leads to the appearance of immunoreactive Egr1 protein within 30-60 min.	Tetradecanoylphorbol Acetate	0-3	early growth response 1	Rattus norvegicus	111-115	
10842166-9	2000	An oligonucleotide encompassing the AP-1/E-box sequence of the rat TH promoter competes in electrophoretic mobility shift assays for binding of nuclear extracts from control and TPA-treated cells to an oligonucleotide containing the Sp1/Egr1 element, indicating that these two enhancers may interact.	Tetradecanoylphorbol Acetate	178-181	early growth response 1	Rattus norvegicus	237-241	
10693946-3	2000	Significant increases in the levels of c-fos, c-jun, and egr-1 but not NGFIB mRNA were observed in PC12 cells exposed to lead or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	129-160	early growth response 1	Rattus norvegicus	57-62	
9892016-8	1999	We conclude that PMA-induced stimulation of LHbeta gene expression is achieved, at least in part, by induction of Egr-1 expression.	Tetradecanoylphorbol Acetate	17-20	early growth response 1	Rattus norvegicus	114-119	
8035171-6	1994	An analysis of the effects of IL-1 and TPA on immediate early gene expression indicated that IL-1 preferentially induced c-jun gene expression, whereas TPA greatly increased c-fos and zif/268 gene expression.	Tetradecanoylphorbol Acetate	152-155	early growth response 1	Rattus norvegicus	184-191	
7504706-10	1993	The protein kinase C activator phorbol 12-myristate 13-acetate also induced Egr-1.	Tetradecanoylphorbol Acetate	31-62	early growth response 1	Rattus norvegicus	76-81	
8483478-0	1993	Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	124-155	early growth response 1	Rattus norvegicus	45-50	
8483478-8	1993	We have also established that the regulatory region of NGFIA that mediates NGF induction also mediates the induction by serum and phorbol 12-myristate 13-acetate, suggesting that multiple signal transduction pathways must converge on these sequences to regulate the expression of this gene.	Tetradecanoylphorbol Acetate	130-161	early growth response 1	Rattus norvegicus	55-60	
29905975-4	2018	Stimulation of immortalized rat cardiomyocytes (H9c2) with phorbol 12-myristate 13-acetate (PMA) resulted in up-regulation of Egr-1 and subsequently of Grk2 mRNA expression, with maximum Grk2 expression (p = 0.008) 5 hr after PMA stimulation and being abolished by actinomycin D, indicating a transcriptional mechanism.	Tetradecanoylphorbol Acetate	59-90	early growth response 1	Rattus norvegicus	126-131	
12670703-1	2003	Several treatments which regulate tyrosine hydroxylase (TH) transcription, such as stress in vivo, or 12-O-tetradecanoylphorbol-13-acetate (TPA) in cell culture, induce both Egr1 and AP1 factors.	Tetradecanoylphorbol Acetate	102-138	early growth response 1	Rattus norvegicus	174-178	
12670703-1	2003	Several treatments which regulate tyrosine hydroxylase (TH) transcription, such as stress in vivo, or 12-O-tetradecanoylphorbol-13-acetate (TPA) in cell culture, induce both Egr1 and AP1 factors.	Tetradecanoylphorbol Acetate	140-143	early growth response 1	Rattus norvegicus	174-178	
1330491-10	1992	c-fos mRNA was induced by treatment with 50 ng/ml tetradecanoyl phorbol acetate or by 40 ng/ml forskolin, while induction of Egr-1 mRNA was stimulated by treatment with tetradecanoyl phorbol acetate, but not forskolin.	Tetradecanoylphorbol Acetate	169-198	early growth response 1	Rattus norvegicus	125-130	
1374838-7	1992	The effect of the DHPs was stereospecific; (+)Bay K 8644, a Ca2+ antagonist, inhibited PMA-induced increases in c-fos and NGFI-A mRNAs.	Tetradecanoylphorbol Acetate	87-90	early growth response 1	Rattus norvegicus	122-128	
1899867-4	1991	Stimulation with arginine vasopressin, epidermal growth factor, or phorbol myristate acetate increased [3H]thymidine incorporation and mRNA levels of the immediate-early response genes c-fos and Egr-1.	Tetradecanoylphorbol Acetate	67-92	early growth response 1	Rattus norvegicus	195-200