PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8943722-7	1996	However, IL-1 beta, IL-2 and TNF-alpha mRNA levels of lymph node cells from CD4- mice could be upregulated by phorbol myristate acetate in vitro.	Tetradecanoylphorbol Acetate	110-135	interleukin 1 beta	Mus musculus	9-18	
8632179-7	1996	Relative to IL-1 beta, the greater increases in PGE2 production and cyclooxygenase activity caused by TPA correlated with a greater induction of PGHS-2 mRNA.	Tetradecanoylphorbol Acetate	102-105	interleukin 1 beta	Mus musculus	12-21	
30556022-7	2018	Increased brain levels of IL-1beta, IL-6, and TNF-alpha in the LPS-induced mice were reduced by TPA treatment.	Tetradecanoylphorbol Acetate	96-99	interleukin 1 beta	Mus musculus	26-34	
31361289-6	2019	Furthermore, in a tetradecanoylphorbolacetate (TPA)-treated mouse model, AA and IA could effectively attenuate mouse ear edema and pathological damage and reduced levels of cytokines including iNOS, COX-2, TNF-alpha, and IL-1beta.	Tetradecanoylphorbol Acetate	47-50	interleukin 1 beta	Mus musculus	221-229	
30466979-6	2018	The anti-inflammatory mechanism was explored by measuring the protein and mRNA levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in the ear of the TPA-treated mice.	Tetradecanoylphorbol Acetate	180-183	interleukin 1 beta	Mus musculus	130-152	
30455947-12	2018	The aqueous fraction decreased the levels of inflammatory markers interleukin-6, nitric oxide, and matrix metalloproteinase 9 in the mouse mammary SCp2 cells, and the level of interleukin-1beta produced by phorbol-12-myristate-13-acetate-activated THP-1 human monocytic cells.	Tetradecanoylphorbol Acetate	206-237	interleukin 1 beta	Mus musculus	176-193	
30498366-7	2018	This inhibitory effect was associated with the inhibition of TPA-induced upregulation of proinflammatory cytokines IL-1beta, TNF-alpha, and COX-2.	Tetradecanoylphorbol Acetate	61-64	interleukin 1 beta	Mus musculus	115-123	
23566359-9	2013	Pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) were also reduced significantly in a dose dependent manner in all the TPA treated groups as compared to control.	Tetradecanoylphorbol Acetate	128-131	interleukin 1 beta	Mus musculus	28-36	
29458014-4	2018	Subsequently l-theanine ameliorated TPA-induced erythema, vascular permeability increase, epidermal and dermal hyperplasia, neutrophil infiltration and activation via downregulating the expression of PECAM-1 (a platelet endothelial adhesion molecule-1) in blood vessels and the production of pro-inflammatory cytokines IL-1beta, TNF-alpha, and mediator cyclooxygenase-2 (COX-2), which is mainly expressed in neutrophils.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Mus musculus	319-327	
27680589-5	2016	Compound 4 pretreatment resulted in markedly suppression of TPA-induced IL-1beta, IL-6, TNF-alpha, and COX-2, respectively.	Tetradecanoylphorbol Acetate	60-63	interleukin 1 beta	Mus musculus	72-80	
27170516-6	2016	Furthermore, sacran significantly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema and mRNA expression levels of cyclooxygenase (COX)-2 as well as pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	Tetradecanoylphorbol Acetate	45-81	interleukin 1 beta	Mus musculus	246-268	
27170516-6	2016	Furthermore, sacran significantly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema and mRNA expression levels of cyclooxygenase (COX)-2 as well as pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	Tetradecanoylphorbol Acetate	83-86	interleukin 1 beta	Mus musculus	246-268	
25753147-5	2016	Notably, a short-term DMBA/TPA challenge, modeling the initial stages of chemical skin carcinogenesis treatment, elicited an enhanced inflammation in p38delta-null skin compared with skin of wild-type mice, as assessed by measuring the expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-17, and TNFalpha.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 beta	Mus musculus	288-296	
26651527-5	2015	This inhibitory effect was associated with inhibition on TPA-induced up-regulation of pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Mus musculus	113-121	
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	143-146	interleukin 1 beta	Mus musculus	155-172	
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	143-146	interleukin 1 beta	Mus musculus	174-182	
26626250-12	2015	The optimized cream showed no phase separation after 30 min centrifugation at 825 g. In the TPA-induced inflammation model, the resin formulation significantly reduced ear thickness and interleukin-1 beta levels in mouse ear tissue.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 beta	Mus musculus	186-204	
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	interleukin 1 beta	Mus musculus	322-330	
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	interleukin 1 beta	Mus musculus	384-392	
23888334-3	2013	A2 also showed a stronger inhibitory effect than curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in NF-kappaB activation and IL-1beta expression as well as in aldose reductase activity.	Tetradecanoylphorbol Acetate	61-97	interleukin 1 beta	Mus musculus	150-158	
23888334-5	2013	In vivo studies indicated that A2 was more potent than curcumin for inhibiting TPA-induced ear edema and TPA-induced increases in IL-1beta.	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Mus musculus	130-138	
23339930-6	2013	The changes 8 h after TPA treatment probably reflected transcriptional regulation, and the genes were divided into three groups, up-regulated (IL-6, MCP-1, HO-1 and SOCS3), unregulated (IL-1beta, TNF-alpha and IL-10) and down-regulated (RANTES) genes.	Tetradecanoylphorbol Acetate	22-25	interleukin 1 beta	Mus musculus	186-194	
23339930-7	2013	TPA-induced gene expression of cytokines, except for RANTES, peaked at 8 h and significantly declined in the late phase in control mice, while the expression of IL-1beta and TNF-alpha did not decline in the late phase in the diabetic mice.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Mus musculus	161-169	
16890203-4	2006	The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT.	Tetradecanoylphorbol Acetate	91-94	interleukin 1 beta	Mus musculus	61-69	
20731354-4	2010	Topical application of TPA to ears of CD-1 mice induced inflammation accompanied with substantial increase in TNF-alpha, IL-1beta, IL-6, LTB4, and PGE2 levels and an elevation in intercellular adhesion molecule-1 (ICAM-1) gene expressions in ear skin tissues.	Tetradecanoylphorbol Acetate	23-26	interleukin 1 beta	Mus musculus	121-129	
18164693-5	2008	Topical application on mice ears of Tat-SOD also suppressed TPA-induced expression of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 as well as cyclooxygenase-2 (COX-2) and production of PGE(2).	Tetradecanoylphorbol Acetate	60-63	interleukin 1 beta	Mus musculus	131-139	
22511759-5	2012	Despite these data, the levels of the transcripts that encode the proinflammatory cytokines IL-1beta and TNF-alpha were reduced in phorbol 12-myristate 13-acetate-treated MCs developed from RasGRP4-null mice.	Tetradecanoylphorbol Acetate	131-162	interleukin 1 beta	Mus musculus	92-100	
18174358-7	2008	However, phorbol 12-myristate 13-acetate-induced inflammation was only partially inhibited by GR-TR, which efficiently repressed IL-1beta and MMP-3 genes while weakly repressing IL-6 and TNF-alpha.	Tetradecanoylphorbol Acetate	9-40	interleukin 1 beta	Mus musculus	129-137	
16890203-4	2006	The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT.	Tetradecanoylphorbol Acetate	136-139	interleukin 1 beta	Mus musculus	61-69	
16890203-6	2006	The number of infiltrating inflammatory cells and the IL-1beta expressing cells was obviously reduced in TPA-treated Tg EC-SOD in comparison with TPA-treated WT.	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Mus musculus	54-62	
16890203-7	2006	The result suggests that EC-SOD might play an important role in the suppression of TPA-induced cutaneous inflammation and epidermal hyperplasia by regulating the expression of IL-1alpha and IL-1beta, although the mechanisms remain to be elucidated.	Tetradecanoylphorbol Acetate	83-86	interleukin 1 beta	Mus musculus	190-198	
16404705-5	2006	A single topical application of TPA to ears of CD-1 mice induced a time- and dose-dependent increase in edema as well as formation of proinflammatory cytokine proteins interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in mouse ears.	Tetradecanoylphorbol Acetate	32-35	interleukin 1 beta	Mus musculus	168-185	
16404705-5	2006	A single topical application of TPA to ears of CD-1 mice induced a time- and dose-dependent increase in edema as well as formation of proinflammatory cytokine proteins interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in mouse ears.	Tetradecanoylphorbol Acetate	32-35	interleukin 1 beta	Mus musculus	187-195	
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	109-140	interleukin 1 beta	Mus musculus	4-21	
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	109-140	interleukin 1 beta	Mus musculus	23-31	
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	142-145	interleukin 1 beta	Mus musculus	4-21	
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	142-145	interleukin 1 beta	Mus musculus	23-31	
11743653-3	2002	Judging from the expression of various inflammatory cytokine genes in TNF+/+ and TNF-/- mice, the residual tumor promoting activity of TPA in TNF-/- mice may be dependent on expression of IL-1alpha and IL-1beta genes.	Tetradecanoylphorbol Acetate	135-138	interleukin 1 beta	Mus musculus	202-210	
10960082-3	2000	Astrocyte cultures stimulated with IL-1beta or the phorbol ester, PMA significantly increased PGE(2) secretion.	Tetradecanoylphorbol Acetate	66-69	interleukin 1 beta	Mus musculus	35-43	
10493498-6	1999	A single application of TPA and okadaic acid increased IL-1alpha and IL-1beta gene expression in TNF-/- mice.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Mus musculus	69-77	
15270842-7	2004	Phorbol myristate acetate (PMA)-stimulated superoxide production by zymosan-induced peritoneal neutrophils and the levels of zymosan-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta in peritoneal exudate fluids were also reduced in the diabetic mice.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 beta	Mus musculus	180-202	
15270842-7	2004	Phorbol myristate acetate (PMA)-stimulated superoxide production by zymosan-induced peritoneal neutrophils and the levels of zymosan-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta in peritoneal exudate fluids were also reduced in the diabetic mice.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 beta	Mus musculus	180-202	
11125308-4	2000	However, following stimulation with lipopolysaccharide or phorbol myristate acetate/calcium ionophore, peritoneal cells from H2(b) mice synthesised significantly more IL-1 beta, TNF-alpha, TNFR and IFN-gamma protein and IFN-gamma mRNA than cells from congenic H2(k) or H2(d) mice.	Tetradecanoylphorbol Acetate	58-83	interleukin 1 beta	Mus musculus	167-176