PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2699432-0	1989	Receptor downregulation and DNA synthesis are modulated by EGF and TPA in cells expressing an EGFR/neu chimera.	Tetradecanoylphorbol Acetate	67-70	epidermal growth factor receptor	Rattus norvegicus	94-98	
15048868-6	2004	In addition, inhibition of conventional and novel PKC isoforms by chronic (24 h) exposure to phorbol 12-myristate 13-acetate (PMA) inhibited AVP-induced activation of ERK and p70S6 kinase as well as EGF-R phosphorylation.	Tetradecanoylphorbol Acetate	93-124	epidermal growth factor receptor	Rattus norvegicus	199-204	
15048868-6	2004	In addition, inhibition of conventional and novel PKC isoforms by chronic (24 h) exposure to phorbol 12-myristate 13-acetate (PMA) inhibited AVP-induced activation of ERK and p70S6 kinase as well as EGF-R phosphorylation.	Tetradecanoylphorbol Acetate	126-129	epidermal growth factor receptor	Rattus norvegicus	199-204	
9722539-6	1998	UTP, ionomycin, and phorbol ester (phorbol 12-myristate 13-acetate) increased MAP kinase activity and also promoted the tyrosine phosphorylation of RAFTK, the epidermal growth factor (EGF) receptor, SHC, and p120(cbl).	Tetradecanoylphorbol Acetate	35-66	epidermal growth factor receptor	Rattus norvegicus	159-197	
9722539-9	1998	The similar effects of UTP, ionomycin, and phorbol 12-myristate 13-acetate (PMA) on these signaling proteins demonstrate that the two signaling molecules from phosphatidylinositol 4,5-bisphosphate hydrolysis ([Ca2+]i, from inositol 1,4,5-trisphosphate production, and diacylglycerol) can individually initiate the activation of MAP kinase in an EGF receptor-dependent manner.	Tetradecanoylphorbol Acetate	43-74	epidermal growth factor receptor	Rattus norvegicus	345-357	
9722539-9	1998	The similar effects of UTP, ionomycin, and phorbol 12-myristate 13-acetate (PMA) on these signaling proteins demonstrate that the two signaling molecules from phosphatidylinositol 4,5-bisphosphate hydrolysis ([Ca2+]i, from inositol 1,4,5-trisphosphate production, and diacylglycerol) can individually initiate the activation of MAP kinase in an EGF receptor-dependent manner.	Tetradecanoylphorbol Acetate	76-79	epidermal growth factor receptor	Rattus norvegicus	345-357	
2288880-8	1990	Since the phorbol ester 12-O-tetradecanoylphorbol-13-acetate also decreases 125I-EGF binding and increases EGF receptor biosynthesis in GP6ac cells, we tested the effect of RA in cells depleted of protein kinase C by prolonged treatment (18 h) with 10 microM 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	24-60	epidermal growth factor receptor	Rattus norvegicus	107-119	
2786455-7	1989	TPA also increased epidermal growth factor receptor mRNA in GP6ac cells but the effect was less prolonged; maximal levels were seen at 4 h after TPA exposure and returned to control levels by 12 h. TPA increased TGF-alpha mRNA in GP6ac cells, in part, by increasing transcription of the TGF-alpha gene as measured by run-on transcription rates in isolated nuclei.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor receptor	Rattus norvegicus	19-51	
2790804-7	1989	These results demonstrate that phenobarbital, like TPA and other tumor promoters, can modulate the EGF receptor system but suggest that it does so without directly competing with EGF for binding to its receptor or by activating protein kinase C.	Tetradecanoylphorbol Acetate	51-54	epidermal growth factor receptor	Rattus norvegicus	99-111	
2699432-8	1989	These results show that the chimeric EGFR/neu receptor undergoes typical downregulation upon ligand binding and TPA pretreatment and is capable of transducing an EGF-induced mitogenic signal.	Tetradecanoylphorbol Acetate	112-115	epidermal growth factor receptor	Rattus norvegicus	37-41