PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3677084-1 1987 Topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating the reactive oxygen species superoxide and hydrogen peroxide. Tetradecanoylphorbol Acetate 42-78 xanthine dehydrogenase Mus musculus 151-167 2473135-0 1989 Conversion of xanthine dehydrogenase to xanthine oxidase occurs during keratinocyte differentiation: modulation by 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 115-151 xanthine dehydrogenase Mus musculus 14-36 2473135-0 1989 Conversion of xanthine dehydrogenase to xanthine oxidase occurs during keratinocyte differentiation: modulation by 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 115-151 xanthine dehydrogenase Mus musculus 40-56 2473135-5 1989 Total XD + XO and XO specific activities in each subpopulation derived from TPA-treated mice were approximately twice the values measured in their control counterparts. Tetradecanoylphorbol Acetate 76-79 xanthine dehydrogenase Mus musculus 6-8 2473135-9 1989 Furthermore, the increases in XO activity measured in epidermal homogenates after TPA treatment are due to TPA-dependent increases in 1) the relative proportions of keratinocytes undergoing differentiation, 2) tissue XD content, and 3) increased conversion of XD to XO. Tetradecanoylphorbol Acetate 82-85 xanthine dehydrogenase Mus musculus 217-219 2473135-9 1989 Furthermore, the increases in XO activity measured in epidermal homogenates after TPA treatment are due to TPA-dependent increases in 1) the relative proportions of keratinocytes undergoing differentiation, 2) tissue XD content, and 3) increased conversion of XD to XO. Tetradecanoylphorbol Acetate 82-85 xanthine dehydrogenase Mus musculus 260-262 2473135-9 1989 Furthermore, the increases in XO activity measured in epidermal homogenates after TPA treatment are due to TPA-dependent increases in 1) the relative proportions of keratinocytes undergoing differentiation, 2) tissue XD content, and 3) increased conversion of XD to XO. Tetradecanoylphorbol Acetate 107-110 xanthine dehydrogenase Mus musculus 217-219 2473135-9 1989 Furthermore, the increases in XO activity measured in epidermal homogenates after TPA treatment are due to TPA-dependent increases in 1) the relative proportions of keratinocytes undergoing differentiation, 2) tissue XD content, and 3) increased conversion of XD to XO. Tetradecanoylphorbol Acetate 107-110 xanthine dehydrogenase Mus musculus 260-262 2845222-7 1988 The relevance of oxidant production to the tumor promotion process is suggested by the ability of exogenous xanthine/xanthine oxidase, a superoxide anion-generating system, to induce ornithine decarboxylase, a characteristic of TPA-treated cells. Tetradecanoylphorbol Acetate 228-231 xanthine dehydrogenase Mus musculus 117-133 3677084-2 1987 The antiinflammatory steroid fluocinolone acetonide, an inhibitor of TPA-induced hyperplasia, as well as the multiple stages of tumor promotion as defined in SENCAR mice (Stages I and II), inhibited the TPA-dependent elevation of epidermal XO activity. Tetradecanoylphorbol Acetate 203-206 xanthine dehydrogenase Mus musculus 240-242 3677084-6 1987 Multiple treatments with TPA or ethyl phenylpropiolate resulted in a sustained elevation of XO activity which peaked at five treatments and then declined. Tetradecanoylphorbol Acetate 25-28 xanthine dehydrogenase Mus musculus 92-94 3677084-9 1987 These results suggest that the TPA-dependent elevation of epidermal XO activity is associated with the hyperplasia induced by the agent, and is a consequence of the hyperplasia rather than the cause of it. Tetradecanoylphorbol Acetate 31-34 xanthine dehydrogenase Mus musculus 68-70 8055654-0 1994 Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NIH3T3 cells. Tetradecanoylphorbol Acetate 75-106 xanthine dehydrogenase Mus musculus 33-63 8055654-1 1994 Treatment of NIH3T3 cells with the tumor promoter phorbol-12-myristate-13-acetate (PMA) results within 30 min in a 1.8-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating reactive oxygen species such as superoxide and hydrogen peroxide. Tetradecanoylphorbol Acetate 50-81 xanthine dehydrogenase Mus musculus 137-153 8055654-1 1994 Treatment of NIH3T3 cells with the tumor promoter phorbol-12-myristate-13-acetate (PMA) results within 30 min in a 1.8-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating reactive oxygen species such as superoxide and hydrogen peroxide. Tetradecanoylphorbol Acetate 50-81 xanthine dehydrogenase Mus musculus 155-157 8055654-1 1994 Treatment of NIH3T3 cells with the tumor promoter phorbol-12-myristate-13-acetate (PMA) results within 30 min in a 1.8-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating reactive oxygen species such as superoxide and hydrogen peroxide. Tetradecanoylphorbol Acetate 83-86 xanthine dehydrogenase Mus musculus 137-153 8055654-1 1994 Treatment of NIH3T3 cells with the tumor promoter phorbol-12-myristate-13-acetate (PMA) results within 30 min in a 1.8-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating reactive oxygen species such as superoxide and hydrogen peroxide. Tetradecanoylphorbol Acetate 83-86 xanthine dehydrogenase Mus musculus 155-157 8055654-2 1994 Simultaneous administration of 2 and 10 microM curcumin with 100 ng/ml PMA inhibits PMA-induced increases in XO activity measured 30 min later by 22.7% and 36.5%, respectively. Tetradecanoylphorbol Acetate 71-74 xanthine dehydrogenase Mus musculus 109-111 8055654-2 1994 Simultaneous administration of 2 and 10 microM curcumin with 100 ng/ml PMA inhibits PMA-induced increases in XO activity measured 30 min later by 22.7% and 36.5%, respectively. Tetradecanoylphorbol Acetate 84-87 xanthine dehydrogenase Mus musculus 109-111 8055654-5 1994 Based on these findings, induction of XO activity is deemed to be one of the major causative elements in PMA-mediated tumor promotion, and the major inhibitory mechanism of curcumin on PMA-induced increases in XD/XO enzyme activities is through direct inactivation at the protein level. Tetradecanoylphorbol Acetate 105-108 xanthine dehydrogenase Mus musculus 38-40 3677084-1 1987 Topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating the reactive oxygen species superoxide and hydrogen peroxide. Tetradecanoylphorbol Acetate 42-78 xanthine dehydrogenase Mus musculus 169-171 3677084-1 1987 Topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating the reactive oxygen species superoxide and hydrogen peroxide. Tetradecanoylphorbol Acetate 80-83 xanthine dehydrogenase Mus musculus 151-167 3677084-1 1987 Topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating the reactive oxygen species superoxide and hydrogen peroxide. Tetradecanoylphorbol Acetate 80-83 xanthine dehydrogenase Mus musculus 169-171 3469021-0 1987 12-O-tetradecanoylphorbol-13-acetate-dependent induction of xanthine dehydrogenase and conversion to xanthine oxidase in murine epidermis. Tetradecanoylphorbol Acetate 0-36 xanthine dehydrogenase Mus musculus 60-82 3469021-0 1987 12-O-tetradecanoylphorbol-13-acetate-dependent induction of xanthine dehydrogenase and conversion to xanthine oxidase in murine epidermis. Tetradecanoylphorbol Acetate 0-36 xanthine dehydrogenase Mus musculus 101-117 19861506-8 2011 Elevated activities of myeloperoxidase, xanthine oxidase and skin edema formation in TPA-treated mice were also lowered by NDGA indicating a restrained inflammatory response. Tetradecanoylphorbol Acetate 85-88 xanthine dehydrogenase Mus musculus 40-56