PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11884403-4	2002	Phorbol myristate acetate induced a dramatic increase of both IL-6R shedding (i.e. the production of sIL-6R) and IL-6 release in osteoblast cultures, but the cell surface expression of gp130 remained unchanged.	Tetradecanoylphorbol Acetate	0-25	interleukin 6 receptor	Homo sapiens	62-67	
11884403-7	2002	Protein kinase C inhibitors blocked phorbol myristate acetate-induced and spontaneous shedding of IL-6R resulting in the absence of sIL-6R in the culture medium, which in turn also prevented the activation of gp130.	Tetradecanoylphorbol Acetate	36-61	interleukin 6 receptor	Homo sapiens	98-103	
11485567-4	2001	Here we provide evidence that PMA-induced IL-6Ralpha shedding is controlled by a metalloproteinase and by protein kinase C (PKC) isoenzymes that do not require Ca(2+) for their activation.	Tetradecanoylphorbol Acetate	30-33	interleukin 6 receptor	Homo sapiens	42-52	
11485567-8	2001	In addition, by using rottlerin, a specific inhibitor of PKC-delta, we demonstrate that PKC-delta is involved in the PMA-induced shedding of IL-6Ralpha.	Tetradecanoylphorbol Acetate	117-120	interleukin 6 receptor	Homo sapiens	141-151	
11485567-9	2001	With the use of UO126, a specific inhibitor of the mitogen-activated protein kinase (MAPK) pathway, we show that the PMA-induced IL-6Ralpha shedding is mediated in part by the MAPK pathway.	Tetradecanoylphorbol Acetate	117-120	interleukin 6 receptor	Homo sapiens	129-139	
11485567-11	2001	Taken together, these results suggest that the PMA-induced shedding of IL-6Ralpha is mediated by a PKC isoenzyme network.	Tetradecanoylphorbol Acetate	47-50	interleukin 6 receptor	Homo sapiens	71-81	
8440709-8	1993	Whereas treatment of HepG2 cells with PMA led to an increase in the formation of gp80.gp130.IL-6 complexes determined by cross-linking, no corresponding increase in high affinity binding sites was found.	Tetradecanoylphorbol Acetate	38-41	interleukin 6 receptor	Homo sapiens	81-85	
10613356-1	1999	It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells.	Tetradecanoylphorbol Acetate	34-65	interleukin 6 receptor	Homo sapiens	194-204	
7594530-8	1995	To determine whether TAPI would prevent shedding under more physiologic conditions, we demonstrated that TAPI was able to prevent unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes.	Tetradecanoylphorbol Acetate	147-150	interleukin 6 receptor	Homo sapiens	216-221	
10613356-1	1999	It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells.	Tetradecanoylphorbol Acetate	67-70	interleukin 6 receptor	Homo sapiens	194-204	
10406952-6	1999	IL-6RDeltaIg was shed as effectively as wild-type IL-6R from transfected COS-7 cells upon 4beta-phorbol 12-myristate 13-acetate (PMA) treatment, whereas nonstimulated shedding of IL-6RDeltaIg was not observed.	Tetradecanoylphorbol Acetate	90-127	interleukin 6 receptor	Homo sapiens	0-5	
10406952-6	1999	IL-6RDeltaIg was shed as effectively as wild-type IL-6R from transfected COS-7 cells upon 4beta-phorbol 12-myristate 13-acetate (PMA) treatment, whereas nonstimulated shedding of IL-6RDeltaIg was not observed.	Tetradecanoylphorbol Acetate	129-132	interleukin 6 receptor	Homo sapiens	0-5	
9674743-6	1998	In addition, phorbol 12-myristate 13-acetate (PMA) stimulated a loss of IL-6R from the cell surface, with a corresponding increase in the concentration of sIL-6R in the supernatant.	Tetradecanoylphorbol Acetate	13-44	interleukin 6 receptor	Homo sapiens	72-77	
9674743-6	1998	In addition, phorbol 12-myristate 13-acetate (PMA) stimulated a loss of IL-6R from the cell surface, with a corresponding increase in the concentration of sIL-6R in the supernatant.	Tetradecanoylphorbol Acetate	46-49	interleukin 6 receptor	Homo sapiens	72-77	
1290964-3	1992	We found that GM-CSFR beta-subunit mRNA was expressed constitutively in CMK cells and was transiently down-regulated by TPA and IL-6, while the expression of IL-6R mRNA was increased by TPA in association with the differentiation of megakaryocytes.	Tetradecanoylphorbol Acetate	186-189	interleukin 6 receptor	Homo sapiens	158-163	
8436181-3	1993	Shedding of the gp80 protein was strongly induced by 4 beta-phorbol-12-myristate-13-acetate, indicating that the process was regulated by protein kinase C (PKC).	Tetradecanoylphorbol Acetate	53-91	interleukin 6 receptor	Homo sapiens	16-20	
1337986-3	1992	Our data show a definite downregulation of IL-6R and gp130 expression by TPA in U266 and BMNH at both mRNA and cell surface protein levels.	Tetradecanoylphorbol Acetate	73-76	interleukin 6 receptor	Homo sapiens	43-48	
1337986-4	1992	In U937 TPA inhibits only the IL-6R expression, without affecting that of gp130.	Tetradecanoylphorbol Acetate	8-11	interleukin 6 receptor	Homo sapiens	30-35