PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20726989-10 2010 Upon stimulation with phorbol myristate acetate plus ionomycin, splenocytes from alpha-GalCer-treated mice produced significantly more cytokines [including IFN-gamma, tumour necrosis factor-alpha, IL-4 and IL-10] than those from untreated mice. Tetradecanoylphorbol Acetate 22-47 interleukin 4 Mus musculus 197-201 24403255-2 2013 Because heretofore the role of IL-4 in DMBA/TPA (9,10-dimethyl-1,2-benz-anthracene/12-O-tetradecanoylphorbol-13-acetate) two-stage carcinogenesis was not studied, we performed such experiments using either IL-4(-/-) or IL-4Ralpha(-/-) mice. Tetradecanoylphorbol Acetate 44-47 interleukin 4 Mus musculus 31-35 24403255-9 2013 Taken together, our results indicate that the course of DMBA/TPA- and MCA-induced carcinogenesis is affected differently by IL-4 versus IL-13-mediated inflammatory cascades. Tetradecanoylphorbol Acetate 61-64 interleukin 4 Mus musculus 124-128 23643258-4 2013 Moreover, IFN-gamma, IL-4, IL-9 and IL-17 secreted by gammadeltaT cells were detected by means of intracellular cytokine staining after stimulation with PMA plus ionomycin. Tetradecanoylphorbol Acetate 153-156 interleukin 4 Mus musculus 21-25 24322293-10 2014 Furthermore, intracellular cytokine staining revealed that expression of IL-4 and IL-17 were significantly enhanced in both the NK and NKT cells of infected mice after phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation (P < 0.05). Tetradecanoylphorbol Acetate 168-199 interleukin 4 Mus musculus 73-77 24322293-10 2014 Furthermore, intracellular cytokine staining revealed that expression of IL-4 and IL-17 were significantly enhanced in both the NK and NKT cells of infected mice after phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation (P < 0.05). Tetradecanoylphorbol Acetate 201-204 interleukin 4 Mus musculus 73-77 22920671-2 2012 We found that brazilin inhibited the mRNA and protein expression of interleukin (IL)-4 and IL-5 induced by phorbol myristate acetate (PMA) and cAMP in EL-4 T cells in a dose-dependent manner. Tetradecanoylphorbol Acetate 107-132 interleukin 4 Mus musculus 68-86 22920671-2 2012 We found that brazilin inhibited the mRNA and protein expression of interleukin (IL)-4 and IL-5 induced by phorbol myristate acetate (PMA) and cAMP in EL-4 T cells in a dose-dependent manner. Tetradecanoylphorbol Acetate 134-137 interleukin 4 Mus musculus 68-86 22733205-4 2012 We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells. Tetradecanoylphorbol Acetate 49-74 interleukin 4 Mus musculus 99-112 22733205-4 2012 We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells. Tetradecanoylphorbol Acetate 49-74 interleukin 4 Mus musculus 114-118 22733205-4 2012 We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells. Tetradecanoylphorbol Acetate 76-79 interleukin 4 Mus musculus 99-112 22733205-4 2012 We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells. Tetradecanoylphorbol Acetate 76-79 interleukin 4 Mus musculus 114-118 17430547-6 2007 Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size. Tetradecanoylphorbol Acetate 11-36 interleukin 4 Mus musculus 106-110 19881301-3 2009 In this study, we showed that 7,8,4"-trihydroxyflavone (T-412) significantly decreased IL-4 production both in phorbol 12-myristate 13-acetate (PMA) and ionomycin (PI)-activated EL-4 T cells and concanavalin A (ConA)-activated murine CD4(+) T cells in a dose- and time-dependent manner. Tetradecanoylphorbol Acetate 111-142 interleukin 4 Mus musculus 87-91 19338776-7 2009 Runx3 inhibited IL-4 production in EL-4 T cells stimulated with PMA/ionomycin. Tetradecanoylphorbol Acetate 64-67 interleukin 4 Mus musculus 16-20 17430547-6 2007 Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size. Tetradecanoylphorbol Acetate 38-41 interleukin 4 Mus musculus 106-110 15755660-5 2005 In particular, ceramide derivatives with a lauroyl group showed strong inhibitory activities on IL-4 production in both phorbol 12-myristate 13-acetate (PMA)-activated EL4 T cells and antigen-primed cells, suggesting that they can be used as compounds for the development of anti-allergic agents. Tetradecanoylphorbol Acetate 120-151 interleukin 4 Mus musculus 96-100 15755660-5 2005 In particular, ceramide derivatives with a lauroyl group showed strong inhibitory activities on IL-4 production in both phorbol 12-myristate 13-acetate (PMA)-activated EL4 T cells and antigen-primed cells, suggesting that they can be used as compounds for the development of anti-allergic agents. Tetradecanoylphorbol Acetate 153-156 interleukin 4 Mus musculus 96-100 15580810-4 2004 Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice. Tetradecanoylphorbol Acetate 0-25 interleukin 4 Mus musculus 165-178 15580810-4 2004 Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice. Tetradecanoylphorbol Acetate 0-25 interleukin 4 Mus musculus 180-184 15580810-4 2004 Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice. Tetradecanoylphorbol Acetate 27-30 interleukin 4 Mus musculus 165-178 15580810-4 2004 Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice. Tetradecanoylphorbol Acetate 27-30 interleukin 4 Mus musculus 180-184 8877730-5 1996 Murine wt p53 derived from pSG5p53cD strongly repressed the IL-2 and IL-4 promoters in both cell lines induced by the phorbol ester TPA and the Ca2+ ionophore ionomycin but not, however, in uninduced cells. Tetradecanoylphorbol Acetate 132-135 interleukin 4 Mus musculus 69-73 12709020-7 2003 Activation of T lymphocytes by phorbol 12-myristate 13-acetate/ionomycin resulted in markedly enhanced binding activities to the NF-AT site, which significantly increased upon addition of BPA or NP, as demonstrated by the electrophoretic mobility shift assay, indicating that the transcription factor NF-AT was involved in the enhancing effect of BPA and NP on IL-4 production. Tetradecanoylphorbol Acetate 31-62 interleukin 4 Mus musculus 361-365 9768762-2 1998 In contrast, IL-4 and IL-5 production by mast cells stimulated in vitro with PMA, ionomycin, or IgE cross-linking are unaffected. Tetradecanoylphorbol Acetate 77-80 interleukin 4 Mus musculus 13-17 9645418-2 1998 When the peripheral mononuclear cells were stimulated with phorbol myristate acetate and ionomycin in the presence of monensin, which blocks the secretion of cytokines, the positive rates for the cytoplasmic IL-2 and IFN-gamma were lower and those for the cytoplasmic IL-4 and IL-10 were higher in SLE than in normal subjects. Tetradecanoylphorbol Acetate 59-84 interleukin 4 Mus musculus 268-272 8947596-6 1996 However, the T cells of B10 mice produced high levels of IL-2 and IL-4 when stimulated by phorbol myristate acetate (PMA) and Ca2+ ionophore, proving the existence of a functionally intact signal transduction pathway downstream of protein kinase C (PKC). Tetradecanoylphorbol Acetate 90-115 interleukin 4 Mus musculus 66-70 8947596-6 1996 However, the T cells of B10 mice produced high levels of IL-2 and IL-4 when stimulated by phorbol myristate acetate (PMA) and Ca2+ ionophore, proving the existence of a functionally intact signal transduction pathway downstream of protein kinase C (PKC). Tetradecanoylphorbol Acetate 117-120 interleukin 4 Mus musculus 66-70 15126071-7 2004 Activation of T cells by phorbol-12-myristate-13-acetate (PMA) resulted in markedly enhanced binding activities to the NF-AT site, which significantly increased upon addition of OP, indicating that the transcription factor NF-AT was involved in the enhancing effect of OP on IL-4 production. Tetradecanoylphorbol Acetate 25-56 interleukin 4 Mus musculus 275-279 15126071-7 2004 Activation of T cells by phorbol-12-myristate-13-acetate (PMA) resulted in markedly enhanced binding activities to the NF-AT site, which significantly increased upon addition of OP, indicating that the transcription factor NF-AT was involved in the enhancing effect of OP on IL-4 production. Tetradecanoylphorbol Acetate 58-61 interleukin 4 Mus musculus 275-279 1831130-1 1991 Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens. Tetradecanoylphorbol Acetate 89-120 interleukin 4 Mus musculus 211-214 1740102-5 1992 We report here that the 150 bp region upstream of the first initiation site of RNA transcribed from the murine germ-line C gamma 1 gene, contains promoter and enhancer elements responsible for basal level transcription and inducibility by anti-Ig phorbol myristate acetate (PMA) and for synergy of these inducers with IL-4 in a surface IgM+ B cell line, L10A6.2 and a surface IgG2a+ B cell line, A20.3. Tetradecanoylphorbol Acetate 247-272 interleukin 4 Mus musculus 318-322 1389229-7 1992 By contrast, the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) prolonged survival of FDC-P1 cells on its own and potentiated the response to IFN-gamma or IL-4, although the combination of stimuli did not support long-term growth. Tetradecanoylphorbol Acetate 44-75 interleukin 4 Mus musculus 173-177 1389229-7 1992 By contrast, the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) prolonged survival of FDC-P1 cells on its own and potentiated the response to IFN-gamma or IL-4, although the combination of stimuli did not support long-term growth. Tetradecanoylphorbol Acetate 77-80 interleukin 4 Mus musculus 173-177 1531644-3 1992 In contrast, in the presence of phorbol myristate acetate (PMA), the expression of IFN-gamma was decreased whereas the IL-4 message was dramatically enhanced. Tetradecanoylphorbol Acetate 32-57 interleukin 4 Mus musculus 119-123 1531644-3 1992 In contrast, in the presence of phorbol myristate acetate (PMA), the expression of IFN-gamma was decreased whereas the IL-4 message was dramatically enhanced. Tetradecanoylphorbol Acetate 59-62 interleukin 4 Mus musculus 119-123 1680700-6 1991 When concanavalin A (Con A)-activated spleen cells were restimulated with Con A and phorbol 12-myristate 13-acetate (PMA), higher levels of IL2, IL4 and IL5 mRNA were induced, as detected both by increased frequencies of positive cells, and by more mRNA per cell. Tetradecanoylphorbol Acetate 84-115 interleukin 4 Mus musculus 145-148 8547036-5 1995 In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production. Tetradecanoylphorbol Acetate 32-63 interleukin 4 Mus musculus 102-106 8547036-5 1995 In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production. Tetradecanoylphorbol Acetate 65-68 interleukin 4 Mus musculus 102-106 8547036-5 1995 In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production. Tetradecanoylphorbol Acetate 65-68 interleukin 4 Mus musculus 213-217 8547036-5 1995 In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production. Tetradecanoylphorbol Acetate 65-68 interleukin 4 Mus musculus 213-217 8415766-2 1993 We have identified two DNA segments that are necessary for full phorbol 12-myristate 13-acetate (PMA)-induced activity of the IL-4 promoter region in the thymoma cell line EL4. Tetradecanoylphorbol Acetate 64-95 interleukin 4 Mus musculus 126-130 8415766-2 1993 We have identified two DNA segments that are necessary for full phorbol 12-myristate 13-acetate (PMA)-induced activity of the IL-4 promoter region in the thymoma cell line EL4. Tetradecanoylphorbol Acetate 97-100 interleukin 4 Mus musculus 126-130 1560050-1 1992 EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R). Tetradecanoylphorbol Acetate 139-142 interleukin 4 Mus musculus 193-206 1560050-1 1992 EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R). Tetradecanoylphorbol Acetate 139-142 interleukin 4 Mus musculus 208-212 1531455-6 1992 After addition of TPA, however, there was an age-related decrease in IL-4 production. Tetradecanoylphorbol Acetate 18-21 interleukin 4 Mus musculus 69-73 1591384-6 1992 Furthermore, interleukin-4 fully inhibited the DNA fragmentation induced by the protein kinase-C activator 12-O-tetradecanoylphorbol-13-acetate, but was ineffective against apoptosis induced by the calcium ionophore A23187. Tetradecanoylphorbol Acetate 107-143 interleukin 4 Mus musculus 13-26 1831130-1 1991 Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens. Tetradecanoylphorbol Acetate 122-125 interleukin 4 Mus musculus 211-214 2116475-6 1990 Organ cultured 14-day-old fetal thymocytes treated with IL-4 during 12 days responded vigorously to IL-2 alone and to IL-4 + PMA + ionomycin. Tetradecanoylphorbol Acetate 125-128 interleukin 4 Mus musculus 56-60 2118480-3 1990 Pretreatment of murine bone marrow-derived macrophages (BMM) with 10 U/ml murine IL-4 for 48 hr was found to enhance the respiratory burst following subsequent stimulation with phorbol myristate acetate (PMA) (10(-6) M) or zymosan (1 mg/ml). Tetradecanoylphorbol Acetate 177-202 interleukin 4 Mus musculus 81-85 2118480-3 1990 Pretreatment of murine bone marrow-derived macrophages (BMM) with 10 U/ml murine IL-4 for 48 hr was found to enhance the respiratory burst following subsequent stimulation with phorbol myristate acetate (PMA) (10(-6) M) or zymosan (1 mg/ml). Tetradecanoylphorbol Acetate 204-207 interleukin 4 Mus musculus 81-85 3257239-2 1988 It was found that these thymocytes proliferated extensively when cultured in the presence of IL-4 + phorbol myristate acetate without apparent differentiation to Lyt-2+ or L3T4+ cells. Tetradecanoylphorbol Acetate 100-125 interleukin 4 Mus musculus 93-97 3257564-5 1988 Approximately 1 of 10 fetal thymocytes at day 14 of gestation expressed mRNA for IL-4 after their stimulation by phorbol 12-myristate 13-acetate and ionomycin. Tetradecanoylphorbol Acetate 113-144 interleukin 4 Mus musculus 81-85 3121729-15 1987 mRNA analysis of adult L3T4-/Lyt-2- thymocytes stimulated with A23187 and phorbol myristate acetate confirms that mRNA for both IL-4 and IFN-gamma is induced in adult L3T4-/Lyt-2- thymocytes. Tetradecanoylphorbol Acetate 74-99 interleukin 4 Mus musculus 128-132 3875657-1 1985 BSF-1 was partially purified from serum-free culture supernatants of cells of the EL-4 thymoma line, which had been induced 48 hr earlier with 4 beta-phorbol-12 beta-myristate-12 alpha-acetate (PMA). Tetradecanoylphorbol Acetate 194-197 interleukin 4 Mus musculus 0-5 31390749-8 2019 This carnosine antioxidant activity was accompanied by the attenuation of the PMA-induced Akt phosphorylation, the down-regulation of TNF-alpha and IL-6 mRNAs, and the up-regulation of the expression of the anti-inflammatory mediators IL-4, IL-10, and TGF-beta1. Tetradecanoylphorbol Acetate 78-81 interleukin 4 Mus musculus 235-239 26319521-5 2015 At the same time, the results showed that infected mouse splenic NK cells expressed increased levels of CD25 and CD69 and produced more IL-2, IL-4, and IL-17 and less IFN-gamma after stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 200-203 interleukin 4 Mus musculus 142-146 27123161-6 2016 In addition, Apo-9"-fucoxanthinone inhibited the expression of interleukin-4, interferon-gamma and tumor necrosis factor-alpha by phorbol 12-myristate 13-acetate and ionomycin-stimulated lymphocytes. Tetradecanoylphorbol Acetate 130-161 interleukin 4 Mus musculus 63-76