PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27731361-9 2016 Our results therefore imply that physiological activation of ADAM17 does not rely on its relocalisation, but that PMA-induced PKC activity drastically dysregulates the localisation of ADAM17. Tetradecanoylphorbol Acetate 114-117 ADAM metallopeptidase domain 17 Homo sapiens 184-190 27599715-2 2016 We here report that stimulation of lung epithelial A549 tumor cells with phorbol-12-myristate-13-acetate (PMA) leads to the downregulation of the surface expressed mature form of ADAM17 without affecting ADAM10 expression. Tetradecanoylphorbol Acetate 73-104 ADAM metallopeptidase domain 17 Homo sapiens 179-185 27599715-2 2016 We here report that stimulation of lung epithelial A549 tumor cells with phorbol-12-myristate-13-acetate (PMA) leads to the downregulation of the surface expressed mature form of ADAM17 without affecting ADAM10 expression. Tetradecanoylphorbol Acetate 106-109 ADAM metallopeptidase domain 17 Homo sapiens 179-185 31796994-6 2020 Notably, treatment of cells with ionomycin, a calcium ionophore and a known activator of ADAM10, or with phorbol 12-myristate 13-acetate, an activator of ADAM17, dramatically increases the release of soluble PD-L1 to the media. Tetradecanoylphorbol Acetate 105-136 ADAM metallopeptidase domain 17 Homo sapiens 154-160 29662625-10 2018 Phorbol 12-myristate 13-acetate (PMA), similarly to cisplatin, mediated AREG shedding and membrane fading of surface ADAM17. Tetradecanoylphorbol Acetate 0-31 ADAM metallopeptidase domain 17 Homo sapiens 117-123 29662625-10 2018 Phorbol 12-myristate 13-acetate (PMA), similarly to cisplatin, mediated AREG shedding and membrane fading of surface ADAM17. Tetradecanoylphorbol Acetate 33-36 ADAM metallopeptidase domain 17 Homo sapiens 117-123 28666872-2 2017 Tumor necrosis factor-alpha converting enzyme (TACE) is known to be responsible for phorbol myristate acetate (PMA)-induced shedding of various membrane proteins. Tetradecanoylphorbol Acetate 84-109 ADAM metallopeptidase domain 17 Homo sapiens 0-45 28666872-2 2017 Tumor necrosis factor-alpha converting enzyme (TACE) is known to be responsible for phorbol myristate acetate (PMA)-induced shedding of various membrane proteins. Tetradecanoylphorbol Acetate 84-109 ADAM metallopeptidase domain 17 Homo sapiens 47-51 28666872-2 2017 Tumor necrosis factor-alpha converting enzyme (TACE) is known to be responsible for phorbol myristate acetate (PMA)-induced shedding of various membrane proteins. Tetradecanoylphorbol Acetate 111-114 ADAM metallopeptidase domain 17 Homo sapiens 0-45 28666872-2 2017 Tumor necrosis factor-alpha converting enzyme (TACE) is known to be responsible for phorbol myristate acetate (PMA)-induced shedding of various membrane proteins. Tetradecanoylphorbol Acetate 111-114 ADAM metallopeptidase domain 17 Homo sapiens 47-51 23470260-7 2013 Stimulation with the ADAM17 agonist chemokine phorbol myristate acetate increased migration and invasion of GSCs, which was counteracted by ADAM17 knockdown. Tetradecanoylphorbol Acetate 46-71 ADAM metallopeptidase domain 17 Homo sapiens 21-27 25301262-6 2015 EGFR and AKT phosphorylation was enhanced by stimulation with the ADAM17 agonist chemokine phorbol myristate acetate. Tetradecanoylphorbol Acetate 91-116 ADAM metallopeptidase domain 17 Homo sapiens 66-72 24337742-5 2014 ADAM17 was found to be expressed on NK cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcgammaRIIIA/CD16A and CD62L, a specific substrate of ADAM17. Tetradecanoylphorbol Acetate 67-70 ADAM metallopeptidase domain 17 Homo sapiens 0-6 24337742-5 2014 ADAM17 was found to be expressed on NK cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcgammaRIIIA/CD16A and CD62L, a specific substrate of ADAM17. Tetradecanoylphorbol Acetate 67-70 ADAM metallopeptidase domain 17 Homo sapiens 174-180 23470260-7 2013 Stimulation with the ADAM17 agonist chemokine phorbol myristate acetate increased migration and invasion of GSCs, which was counteracted by ADAM17 knockdown. Tetradecanoylphorbol Acetate 46-71 ADAM metallopeptidase domain 17 Homo sapiens 140-146 17942404-3 2007 In the present study we present new evidence that a disintegrin and metalloproteinase-17 (ADAM17) is responsible for phorbol 12-myristate 13-acetate-induced release of TMEFF2-ECD using small interfering RNA to ablate ADAM17 expression or by inhibiting enzymatic activity. Tetradecanoylphorbol Acetate 117-148 ADAM metallopeptidase domain 17 Homo sapiens 90-96 21386996-5 2011 In agreement with previous studies, we demonstrated that PMA triggers a rapid ADAM17-mediated release of HB-EGF. Tetradecanoylphorbol Acetate 57-60 ADAM metallopeptidase domain 17 Homo sapiens 78-84 20331435-4 2010 By using PMA and the phosphatase inhibitors cantharidin and calyculin A, we could selectively activate PKC or p38 MAPK respectively to promote TACE-dependent shedding of L-selectin. Tetradecanoylphorbol Acetate 9-12 ADAM metallopeptidase domain 17 Homo sapiens 143-147 20861614-8 2010 Epithelial cells with increased levels of TACE shed more soluble TNFR2 into culture media and even more after TACE activation by phorbol-12-myristate-13-acetate stimulation. Tetradecanoylphorbol Acetate 129-160 ADAM metallopeptidase domain 17 Homo sapiens 42-46 20861614-8 2010 Epithelial cells with increased levels of TACE shed more soluble TNFR2 into culture media and even more after TACE activation by phorbol-12-myristate-13-acetate stimulation. Tetradecanoylphorbol Acetate 129-160 ADAM metallopeptidase domain 17 Homo sapiens 110-114 23702712-10 2013 KB-R7785 and ADAM17 depletion significantly blocked TNF-alpha shedding by TPA. Tetradecanoylphorbol Acetate 74-77 ADAM metallopeptidase domain 17 Homo sapiens 13-19 18487372-6 2008 HCECs were incubated with and without activators (IgE-activated mast cell supernates, phorbol myristate acetate [PMA; to activate TACE], TNFalpha, and IFNgamma [to upregulate TNFR1]) for 24 hours. Tetradecanoylphorbol Acetate 86-111 ADAM metallopeptidase domain 17 Homo sapiens 130-134 17942404-3 2007 In the present study we present new evidence that a disintegrin and metalloproteinase-17 (ADAM17) is responsible for phorbol 12-myristate 13-acetate-induced release of TMEFF2-ECD using small interfering RNA to ablate ADAM17 expression or by inhibiting enzymatic activity. Tetradecanoylphorbol Acetate 117-148 ADAM metallopeptidase domain 17 Homo sapiens 217-223 12941954-9 2003 We identified tumor necrosis factor alpha-converting enzyme (TACE or ADAM17) as the protease that mediates the PMA-induced release. Tetradecanoylphorbol Acetate 111-114 ADAM metallopeptidase domain 17 Homo sapiens 61-65 17155946-4 2007 Phorbol-12-myristate 13-acetate (PMA)-stimulated EPCR shedding is reduced by approximately 50% in HEK293 cells transfected with human EPCR cDNA and by 60% in human umbilical vein endothelial cells after transfection of TACE small interfering RNA (siRNA) into these cells. Tetradecanoylphorbol Acetate 33-36 ADAM metallopeptidase domain 17 Homo sapiens 219-223 17155946-4 2007 Phorbol-12-myristate 13-acetate (PMA)-stimulated EPCR shedding is reduced by approximately 50% in HEK293 cells transfected with human EPCR cDNA and by 60% in human umbilical vein endothelial cells after transfection of TACE small interfering RNA (siRNA) into these cells. Tetradecanoylphorbol Acetate 0-31 ADAM metallopeptidase domain 17 Homo sapiens 219-223 16183650-4 2005 The apoptotic effect of phorbol 12-myristate 13-acetate in LNCaP cells was impaired by inhibition or depletion of tumor necrosis factor alpha-converting enzyme, the enzyme responsible for tumor necrosis factor alpha (TNFalpha) shedding. Tetradecanoylphorbol Acetate 24-55 ADAM metallopeptidase domain 17 Homo sapiens 114-159 15066986-6 2004 Cotransfection of TACE in EC-2 cells enhanced phorbol myristate acetate-induced but not constitutive shedding of epiregulin and had no effect on betacellulin (BTC) processing. Tetradecanoylphorbol Acetate 46-71 ADAM metallopeptidase domain 17 Homo sapiens 18-22 14625290-4 2004 Stimulation of transfected cells with phorbol 12-myristate 13-acetate (PMA) induced metalloproteinase-mediated release of c-Kit ectodomain, which increased further upon TACE overexpression. Tetradecanoylphorbol Acetate 38-69 ADAM metallopeptidase domain 17 Homo sapiens 169-173 14625290-4 2004 Stimulation of transfected cells with phorbol 12-myristate 13-acetate (PMA) induced metalloproteinase-mediated release of c-Kit ectodomain, which increased further upon TACE overexpression. Tetradecanoylphorbol Acetate 71-74 ADAM metallopeptidase domain 17 Homo sapiens 169-173 12941954-9 2003 We identified tumor necrosis factor alpha-converting enzyme (TACE or ADAM17) as the protease that mediates the PMA-induced release. Tetradecanoylphorbol Acetate 111-114 ADAM metallopeptidase domain 17 Homo sapiens 69-75 12901873-5 2003 However, stimulation of cells with phorbol-12-myristate-13-acetate (PMA) increased peptide cleavage in a TACE-dependent manner. Tetradecanoylphorbol Acetate 35-66 ADAM metallopeptidase domain 17 Homo sapiens 105-109 12901873-5 2003 However, stimulation of cells with phorbol-12-myristate-13-acetate (PMA) increased peptide cleavage in a TACE-dependent manner. Tetradecanoylphorbol Acetate 68-71 ADAM metallopeptidase domain 17 Homo sapiens 105-109 10818238-3 2000 Differentiation of U937 and HPM cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the H1 receptor expression and rather suppressed the H2 receptor, resulting in up-regulation of the histamine-induced expression and secretion of TNF-alpha, modulated via TACE. Tetradecanoylphorbol Acetate 43-79 ADAM metallopeptidase domain 17 Homo sapiens 266-270 12621058-6 2003 This protein, which we named SPRACT, is derived through alternative translation of the TACE-coding sequence and is, similarly to TACE, phosphorylated in response to growth factor and phorbol 12-myristate 13-acetate stimulation. Tetradecanoylphorbol Acetate 183-214 ADAM metallopeptidase domain 17 Homo sapiens 87-91 12621058-6 2003 This protein, which we named SPRACT, is derived through alternative translation of the TACE-coding sequence and is, similarly to TACE, phosphorylated in response to growth factor and phorbol 12-myristate 13-acetate stimulation. Tetradecanoylphorbol Acetate 183-214 ADAM metallopeptidase domain 17 Homo sapiens 129-133 12972643-4 2003 To examine this hypothesis, we stimulated NCI-H292 cells with phorbol 12-myristate 13-acetate (PMA, an activator of TACE) and pathophysiologic stimuli [lipopolysaccharide (LPS) and supernatant from the Gram-negative bacterium Pseudomonas aeruginosa (PA sup)]. Tetradecanoylphorbol Acetate 95-98 ADAM metallopeptidase domain 17 Homo sapiens 116-120 12755693-4 2003 This maturation is negatively influenced by the phorbol ester phorbol-12-myristate-13-acetate (PMA), which decreases the cellular amount of the mature form of TACE in PMA-treated HEK293 and SH-SY5Y cells. Tetradecanoylphorbol Acetate 62-93 ADAM metallopeptidase domain 17 Homo sapiens 159-163 12755693-4 2003 This maturation is negatively influenced by the phorbol ester phorbol-12-myristate-13-acetate (PMA), which decreases the cellular amount of the mature form of TACE in PMA-treated HEK293 and SH-SY5Y cells. Tetradecanoylphorbol Acetate 95-98 ADAM metallopeptidase domain 17 Homo sapiens 159-163 12755693-4 2003 This maturation is negatively influenced by the phorbol ester phorbol-12-myristate-13-acetate (PMA), which decreases the cellular amount of the mature form of TACE in PMA-treated HEK293 and SH-SY5Y cells. Tetradecanoylphorbol Acetate 167-170 ADAM metallopeptidase domain 17 Homo sapiens 159-163 12755693-8 2003 Moreover, the PMA dependent decrease of the mature enzyme form is specific for TACE, as the amount of mature ADAM10 was unaffected in PMA-treated HEK293 and SH-SY5Y cells. Tetradecanoylphorbol Acetate 14-17 ADAM metallopeptidase domain 17 Homo sapiens 79-83 11495925-6 2001 We show that the cleavage of fractalkine can be markedly enhanced by stimulating cells with phorbol 12-myristate 13-acetate (PMA), and we identify tumor necrosis factor-alpha converting enzyme (TACE; ADAM17) as the protease responsible for this PMA-induced fractalkine release. Tetradecanoylphorbol Acetate 245-248 ADAM metallopeptidase domain 17 Homo sapiens 147-192 11495925-6 2001 We show that the cleavage of fractalkine can be markedly enhanced by stimulating cells with phorbol 12-myristate 13-acetate (PMA), and we identify tumor necrosis factor-alpha converting enzyme (TACE; ADAM17) as the protease responsible for this PMA-induced fractalkine release. Tetradecanoylphorbol Acetate 245-248 ADAM metallopeptidase domain 17 Homo sapiens 194-198 11495925-6 2001 We show that the cleavage of fractalkine can be markedly enhanced by stimulating cells with phorbol 12-myristate 13-acetate (PMA), and we identify tumor necrosis factor-alpha converting enzyme (TACE; ADAM17) as the protease responsible for this PMA-induced fractalkine release. Tetradecanoylphorbol Acetate 245-248 ADAM metallopeptidase domain 17 Homo sapiens 200-206 11156944-4 2001 However, it is not fully understood how PMA activates TACE and induces ectodomain shedding. Tetradecanoylphorbol Acetate 40-43 ADAM metallopeptidase domain 17 Homo sapiens 54-58 11156944-7 2001 Exogenous H2O2 mimicked PMA-induced enhancement of ectodomain shedding, and H2O2-induced shedding was blocked by TAPI, a TACE inhibitor. Tetradecanoylphorbol Acetate 24-27 ADAM metallopeptidase domain 17 Homo sapiens 121-125 10799546-5 2000 Phorbol 12-myristate 13-acetate (PMA), a potent inducer of shedding, decreased cell-surface staining for TACE. Tetradecanoylphorbol Acetate 0-31 ADAM metallopeptidase domain 17 Homo sapiens 105-109 10799546-5 2000 Phorbol 12-myristate 13-acetate (PMA), a potent inducer of shedding, decreased cell-surface staining for TACE. Tetradecanoylphorbol Acetate 33-36 ADAM metallopeptidase domain 17 Homo sapiens 105-109 10799546-6 2000 Surface biotinylation experiments confirmed and extended this observation; PMA decreased the half-life of surface-biotinylated TACE without increasing the turnover of total cell-surface proteins. Tetradecanoylphorbol Acetate 75-78 ADAM metallopeptidase domain 17 Homo sapiens 127-131 10799546-9 2000 Surprisingly, a metalloprotease inhibitor prevented the PMA-induced turnover of TACE. Tetradecanoylphorbol Acetate 56-59 ADAM metallopeptidase domain 17 Homo sapiens 80-84 10818238-3 2000 Differentiation of U937 and HPM cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the H1 receptor expression and rather suppressed the H2 receptor, resulting in up-regulation of the histamine-induced expression and secretion of TNF-alpha, modulated via TACE. Tetradecanoylphorbol Acetate 81-84 ADAM metallopeptidase domain 17 Homo sapiens 266-270 12749772-2 2000 The down-modulation induced upon cellular activation with PMA is due to proteolytic shedding mediated by a cysteine metalloprotease, presumably the TNF-alpha converting enzyme (TALE), and is susceptible to inhibitors of the hydroxamate class. Tetradecanoylphorbol Acetate 58-61 ADAM metallopeptidase domain 17 Homo sapiens 148-175 12749772-2 2000 The down-modulation induced upon cellular activation with PMA is due to proteolytic shedding mediated by a cysteine metalloprotease, presumably the TNF-alpha converting enzyme (TALE), and is susceptible to inhibitors of the hydroxamate class. Tetradecanoylphorbol Acetate 58-61 ADAM metallopeptidase domain 17 Homo sapiens 177-181