PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7888303-5 1994 PKC activation by phorbol ester TPA increased the effect of EGF alone as well as the oxysterol potentiating effect, whereas PKC down-regulation strongly decreased both of these effects, showing that both are dependent on PKC activity. Tetradecanoylphorbol Acetate 32-35 epidermal growth factor like 1 Rattus norvegicus 60-63 8602120-7 1996 However, a ligand for protein kinase C (PKC), phorbol 12-myristate 13-acetate, was effective in augmenting the action of intrauterine EGF, or forskolin, for initiation of implantation. Tetradecanoylphorbol Acetate 46-77 epidermal growth factor like 1 Rattus norvegicus 134-137 8095029-3 1993 Overnight pretreatment of hepatocytes with TPA, which is known to downregulate protein kinase C, abolished the TPA and reduced the EGF-mediated inhibition of PEPCK gene expression. Tetradecanoylphorbol Acetate 43-46 epidermal growth factor like 1 Rattus norvegicus 131-134 1735341-7 1992 Moreover, the tumor promoter, tetradecanoylphorbol acetate (TPA), down-regulates the EGF receptor. Tetradecanoylphorbol Acetate 30-58 epidermal growth factor like 1 Rattus norvegicus 85-88 1585373-11 1992 In contrast, PMA pretreatment, which depletes PKC, significantly attenuated the latter effect of EGF, suggesting that downregulation by PKC of EGF-induced increases in 45Ca and 210Pb efflux. Tetradecanoylphorbol Acetate 13-16 epidermal growth factor like 1 Rattus norvegicus 97-100 1585373-11 1992 In contrast, PMA pretreatment, which depletes PKC, significantly attenuated the latter effect of EGF, suggesting that downregulation by PKC of EGF-induced increases in 45Ca and 210Pb efflux. Tetradecanoylphorbol Acetate 13-16 epidermal growth factor like 1 Rattus norvegicus 143-146 1735341-7 1992 Moreover, the tumor promoter, tetradecanoylphorbol acetate (TPA), down-regulates the EGF receptor. Tetradecanoylphorbol Acetate 60-63 epidermal growth factor like 1 Rattus norvegicus 85-88 2323487-4 1990 Chronic exposure of GH3 cells to TPA, which strongly down-regulates protein kinase C activity, completely inhibited acute TPA stimulation of transient expression of a transfected PRL promoter construct ((-187)PRL-CAT), but did not inhibit EGF stimulation of either accumulation of endogenous PRL mRNA or of expression of (-187)PRL-CAT. Tetradecanoylphorbol Acetate 33-36 epidermal growth factor like 1 Rattus norvegicus 239-242 2170389-5 1990 Addition of the protein kinase C inhibitor staurosporine or down-regulation of protein kinase C by prolonged incubation with phorbol 12-myristate 13-acetate partially reduced the effects of angiotensin II and alpha-thrombin and completely blunted the phorbol 12-myristate 13-acetate-induced stimulation of Na+/K+/Cl- cotransport but did not affect EGF-induced stimulation. Tetradecanoylphorbol Acetate 125-156 epidermal growth factor like 1 Rattus norvegicus 348-351 2154379-2 1990 The rate of amiloride-sensitive Na(+)-dependent recovery from cytoplasmic-acid-loading was found to be increased in cells treated with epidermal growth factor (EGF), 8-(4-chlorophenylthio)adenosine 3",5"-monophosphate (ClPhScAMP) or phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 233-264 epidermal growth factor like 1 Rattus norvegicus 135-158 2154379-2 1990 The rate of amiloride-sensitive Na(+)-dependent recovery from cytoplasmic-acid-loading was found to be increased in cells treated with epidermal growth factor (EGF), 8-(4-chlorophenylthio)adenosine 3",5"-monophosphate (ClPhScAMP) or phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 233-264 epidermal growth factor like 1 Rattus norvegicus 160-163 2154379-2 1990 The rate of amiloride-sensitive Na(+)-dependent recovery from cytoplasmic-acid-loading was found to be increased in cells treated with epidermal growth factor (EGF), 8-(4-chlorophenylthio)adenosine 3",5"-monophosphate (ClPhScAMP) or phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 266-269 epidermal growth factor like 1 Rattus norvegicus 135-158 2154379-2 1990 The rate of amiloride-sensitive Na(+)-dependent recovery from cytoplasmic-acid-loading was found to be increased in cells treated with epidermal growth factor (EGF), 8-(4-chlorophenylthio)adenosine 3",5"-monophosphate (ClPhScAMP) or phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 266-269 epidermal growth factor like 1 Rattus norvegicus 160-163 1903108-11 1991 While the inactive phorbol ester 4 alpha-phorbol 12,13-didecanoate did not modulate the hepatic actions of EGF, activation of protein kinase C by 4 beta-phorbol 12-myristate 13-acetate (70 nM) abolished the ability of EGF to stimulate gluconeogenesis, tricarboxylic acid cycle activity and metabolic flux through the 2-oxoglutarate dehydrogenase complex. Tetradecanoylphorbol Acetate 148-184 epidermal growth factor like 1 Rattus norvegicus 218-221 2174429-9 1990 The duplication of these actions by TPA suggests that protein kinase C is a mediator of EGF action in hepatocytes. Tetradecanoylphorbol Acetate 36-39 epidermal growth factor like 1 Rattus norvegicus 88-91 2769792-2 1989 : Oncogene 1:263-270, 1987) mRNAs in secondary cultures of rat neocortical astrocytes was much greater in response to tetradecanoyl phorbol acetate (TPA) than in response to either epidermal growth factor (EGF) or fibroblast growth factor (FGF). Tetradecanoylphorbol Acetate 149-152 epidermal growth factor like 1 Rattus norvegicus 206-209 2790804-0 1989 Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in reduction of epidermal growth factor binding by rat hepatocytes. Tetradecanoylphorbol Acetate 61-97 epidermal growth factor like 1 Rattus norvegicus 114-137 2544397-7 1989 Cotreatment of a saturating dose of EGF with phorbol myristate acetate (PMA) or GnRH resulted in additive increases in both tPA enzyme activity and mRNA levels. Tetradecanoylphorbol Acetate 45-70 epidermal growth factor like 1 Rattus norvegicus 36-39 2544397-7 1989 Cotreatment of a saturating dose of EGF with phorbol myristate acetate (PMA) or GnRH resulted in additive increases in both tPA enzyme activity and mRNA levels. Tetradecanoylphorbol Acetate 72-75 epidermal growth factor like 1 Rattus norvegicus 36-39 2544397-8 1989 In addition, pretreatment with PMA desensitized the cells to subsequent treatment with PMA or GnRH, but did not diminish EGF-induced tPA mRNA, suggesting that EGF acts through a pathway independent of protein kinase-C. Also, extracellular cAMP levels did not increase with EGF treatment in the presence or absence of a phosphodiesterase inhibitor, suggesting the lack of involvement of the protein kinase-A pathway. Tetradecanoylphorbol Acetate 31-34 epidermal growth factor like 1 Rattus norvegicus 159-162 2544397-8 1989 In addition, pretreatment with PMA desensitized the cells to subsequent treatment with PMA or GnRH, but did not diminish EGF-induced tPA mRNA, suggesting that EGF acts through a pathway independent of protein kinase-C. Also, extracellular cAMP levels did not increase with EGF treatment in the presence or absence of a phosphodiesterase inhibitor, suggesting the lack of involvement of the protein kinase-A pathway. Tetradecanoylphorbol Acetate 31-34 epidermal growth factor like 1 Rattus norvegicus 159-162 2544397-8 1989 In addition, pretreatment with PMA desensitized the cells to subsequent treatment with PMA or GnRH, but did not diminish EGF-induced tPA mRNA, suggesting that EGF acts through a pathway independent of protein kinase-C. Also, extracellular cAMP levels did not increase with EGF treatment in the presence or absence of a phosphodiesterase inhibitor, suggesting the lack of involvement of the protein kinase-A pathway. Tetradecanoylphorbol Acetate 87-90 epidermal growth factor like 1 Rattus norvegicus 159-162 2544397-8 1989 In addition, pretreatment with PMA desensitized the cells to subsequent treatment with PMA or GnRH, but did not diminish EGF-induced tPA mRNA, suggesting that EGF acts through a pathway independent of protein kinase-C. Also, extracellular cAMP levels did not increase with EGF treatment in the presence or absence of a phosphodiesterase inhibitor, suggesting the lack of involvement of the protein kinase-A pathway. Tetradecanoylphorbol Acetate 87-90 epidermal growth factor like 1 Rattus norvegicus 159-162 2769792-6 1989 In contrast, when either EGF or FGF was presented to astrocytes in combination with maximally inducing levels of TPA, the resulting levels of accumulation of TIS mRNAs were at least as great as the sum of the levels induced by the individual mitogens. Tetradecanoylphorbol Acetate 113-116 epidermal growth factor like 1 Rattus norvegicus 25-28 2544106-9 1989 Incubation with phorbol myristate acetate decreased 125I-EGF binding in a concentration-dependent manner. Tetradecanoylphorbol Acetate 16-41 epidermal growth factor like 1 Rattus norvegicus 57-60 2546062-9 1989 Both 8-CPT-cAMP and EGF were also equally effective in causing a rapid and transient induction of c-fos and c-myc protooncogene mRNA levels when added to growth-arrested H4IIE cells while A23187, N-(Bu)2-cAMP, and 4 beta-phorbol 12-myristate 13-acetate were significantly less effective. Tetradecanoylphorbol Acetate 216-252 epidermal growth factor like 1 Rattus norvegicus 20-23 6328483-3 1984 The intracellular levels of this RNA product were increased 2.5- to 5-fold by exposure of the cells to epidermal growth factor (EGF) and 2- to 3-fold by exposure of the cells to a potent phorbol ester, phorbol 12-myristate 13-acetate, apparently due to regulation at the level of gene transcription. Tetradecanoylphorbol Acetate 202-233 epidermal growth factor like 1 Rattus norvegicus 103-138 3499217-1 1987 Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine. Tetradecanoylphorbol Acetate 5-41 epidermal growth factor like 1 Rattus norvegicus 121-144 3499217-1 1987 Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine. Tetradecanoylphorbol Acetate 5-41 epidermal growth factor like 1 Rattus norvegicus 146-149 3499217-1 1987 Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine. Tetradecanoylphorbol Acetate 43-46 epidermal growth factor like 1 Rattus norvegicus 121-144 3499217-1 1987 Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine. Tetradecanoylphorbol Acetate 43-46 epidermal growth factor like 1 Rattus norvegicus 146-149 3499217-5 1987 The binding of EGF was transiently down-regulated by TPA, then restored to control values 6 h later, whereas the binding of this factor was significantly increased at both the 12th and 24th h after PB addition. Tetradecanoylphorbol Acetate 53-56 epidermal growth factor like 1 Rattus norvegicus 15-18 2458349-8 1988 When cells were incubated continuously with TRH, there was a recovery of 125I-EGF binding after 24 h. Incubation with the protein kinase C activating phorbol ester TPA caused an immediate (less than 10 min) profound (greater than 85%) decrease in 125I-EGF binding followed by partial recovery at 24 h. Maximally effective doses of TRH and TPA decreased EGF receptor affinity with half-times of 3 min. Tetradecanoylphorbol Acetate 164-167 epidermal growth factor like 1 Rattus norvegicus 78-81 2458349-8 1988 When cells were incubated continuously with TRH, there was a recovery of 125I-EGF binding after 24 h. Incubation with the protein kinase C activating phorbol ester TPA caused an immediate (less than 10 min) profound (greater than 85%) decrease in 125I-EGF binding followed by partial recovery at 24 h. Maximally effective doses of TRH and TPA decreased EGF receptor affinity with half-times of 3 min. Tetradecanoylphorbol Acetate 164-167 epidermal growth factor like 1 Rattus norvegicus 252-255 2458349-8 1988 When cells were incubated continuously with TRH, there was a recovery of 125I-EGF binding after 24 h. Incubation with the protein kinase C activating phorbol ester TPA caused an immediate (less than 10 min) profound (greater than 85%) decrease in 125I-EGF binding followed by partial recovery at 24 h. Maximally effective doses of TRH and TPA decreased EGF receptor affinity with half-times of 3 min. Tetradecanoylphorbol Acetate 164-167 epidermal growth factor like 1 Rattus norvegicus 252-255 2458349-8 1988 When cells were incubated continuously with TRH, there was a recovery of 125I-EGF binding after 24 h. Incubation with the protein kinase C activating phorbol ester TPA caused an immediate (less than 10 min) profound (greater than 85%) decrease in 125I-EGF binding followed by partial recovery at 24 h. Maximally effective doses of TRH and TPA decreased EGF receptor affinity with half-times of 3 min. Tetradecanoylphorbol Acetate 339-342 epidermal growth factor like 1 Rattus norvegicus 78-81 2458349-10 1988 GH4C1 cells were incubated with 500 nM TPA for 24 h in order to down-regulate protein kinase C. Protein kinase C depletion was confirmed by immunoblots and the effects of TRH and TPA on 125I-EGF binding were tested. Tetradecanoylphorbol Acetate 39-42 epidermal growth factor like 1 Rattus norvegicus 191-194 6970201-5 1980 Tetradecanoyl-phorbol-acetate (TPA), a potent tumor promoter, blocks the EGF-induced increase in adhesion rate of PC-12 cells, but does not alter the NGF-induced increase in adhesion rate. Tetradecanoylphorbol Acetate 0-29 epidermal growth factor like 1 Rattus norvegicus 73-76 6970201-10 1980 TPA blocks the decrease in the number of short microvilli in EGF-treated cells, but not in NGF-treated cells. Tetradecanoylphorbol Acetate 0-3 epidermal growth factor like 1 Rattus norvegicus 61-64 6970201-5 1980 Tetradecanoyl-phorbol-acetate (TPA), a potent tumor promoter, blocks the EGF-induced increase in adhesion rate of PC-12 cells, but does not alter the NGF-induced increase in adhesion rate. Tetradecanoylphorbol Acetate 31-34 epidermal growth factor like 1 Rattus norvegicus 73-76 6970201-6 1980 TPA shifts the EGF bindings curve to the right for PC-12 cells, but does not alter maximal EGF binding at saturating concentrations of EGF. Tetradecanoylphorbol Acetate 0-3 epidermal growth factor like 1 Rattus norvegicus 15-18 6169058-4 1980 These biological effects of TPA, insulin and EGF appeared to resemble each other, and subsequent hormone binding studies showed that TPA inhibited 125I-EGF binding to its membrane receptors without affecting 125I-insulin binding. Tetradecanoylphorbol Acetate 133-136 epidermal growth factor like 1 Rattus norvegicus 152-155 6169058-5 1980 Scatchard analysis of TPA effect on EGF binding indicated that TPA altered the affinity of the membrane receptors for EGF without changing the total number of available receptors per cell. Tetradecanoylphorbol Acetate 22-25 epidermal growth factor like 1 Rattus norvegicus 36-39 6169058-5 1980 Scatchard analysis of TPA effect on EGF binding indicated that TPA altered the affinity of the membrane receptors for EGF without changing the total number of available receptors per cell. Tetradecanoylphorbol Acetate 22-25 epidermal growth factor like 1 Rattus norvegicus 118-121 6169058-5 1980 Scatchard analysis of TPA effect on EGF binding indicated that TPA altered the affinity of the membrane receptors for EGF without changing the total number of available receptors per cell. Tetradecanoylphorbol Acetate 63-66 epidermal growth factor like 1 Rattus norvegicus 36-39 6169058-5 1980 Scatchard analysis of TPA effect on EGF binding indicated that TPA altered the affinity of the membrane receptors for EGF without changing the total number of available receptors per cell. Tetradecanoylphorbol Acetate 63-66 epidermal growth factor like 1 Rattus norvegicus 118-121