PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3413110-0 1988 Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. Tetradecanoylphorbol Acetate 76-107 amphiregulin Homo sapiens 0-12 21533382-1 1997 Amphiregulin (AR), a new member of the EGF family of ligand, is a glycoprotein containing a 78 or 84 amino acid core polypeptide that was originally purified from the conditioned medium of the breast carcinoma cell line MCF-7 after treatment with phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 247-278 amphiregulin Homo sapiens 0-12 29662625-10 2018 Phorbol 12-myristate 13-acetate (PMA), similarly to cisplatin, mediated AREG shedding and membrane fading of surface ADAM17. Tetradecanoylphorbol Acetate 0-31 amphiregulin Homo sapiens 72-76 29662625-10 2018 Phorbol 12-myristate 13-acetate (PMA), similarly to cisplatin, mediated AREG shedding and membrane fading of surface ADAM17. Tetradecanoylphorbol Acetate 33-36 amphiregulin Homo sapiens 72-76 22643241-3 2012 Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed. Tetradecanoylphorbol Acetate 31-62 amphiregulin Homo sapiens 286-298 22643241-3 2012 Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed. Tetradecanoylphorbol Acetate 64-67 amphiregulin Homo sapiens 286-298 9870716-1 1998 Calphostin C, a secondary metabolite of the fungus Cladosporium cladosporioides, is generally used as a specific inhibitor of protein kinase C. It is known that 12-O-tetradecanoyl-13-phorbol acetate (TPA), a protein kinase C activator, induces expression of mRNA for amphiregulin (AR), a member of EGF-related polypeptides, in mammalian epithelial cells. Tetradecanoylphorbol Acetate 200-203 amphiregulin Homo sapiens 267-279 9870716-1 1998 Calphostin C, a secondary metabolite of the fungus Cladosporium cladosporioides, is generally used as a specific inhibitor of protein kinase C. It is known that 12-O-tetradecanoyl-13-phorbol acetate (TPA), a protein kinase C activator, induces expression of mRNA for amphiregulin (AR), a member of EGF-related polypeptides, in mammalian epithelial cells. Tetradecanoylphorbol Acetate 200-203 amphiregulin Homo sapiens 281-283 21533382-1 1997 Amphiregulin (AR), a new member of the EGF family of ligand, is a glycoprotein containing a 78 or 84 amino acid core polypeptide that was originally purified from the conditioned medium of the breast carcinoma cell line MCF-7 after treatment with phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 247-278 amphiregulin Homo sapiens 14-16 8952699-0 1996 Characterization of a novel amphiregulin-related molecule in 12-O-tetradecanoylphorbol-13-acetate-treated breast cancer cells. Tetradecanoylphorbol Acetate 61-97 amphiregulin Homo sapiens 28-40 8952699-1 1996 Amphiregulin (AR) can be induced at the mRNA level by 17-beta-estradiol (E2) or the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 113-149 amphiregulin Homo sapiens 0-12 8952699-1 1996 Amphiregulin (AR) can be induced at the mRNA level by 17-beta-estradiol (E2) or the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 113-149 amphiregulin Homo sapiens 14-16 8952699-1 1996 Amphiregulin (AR) can be induced at the mRNA level by 17-beta-estradiol (E2) or the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 151-154 amphiregulin Homo sapiens 0-12 8952699-1 1996 Amphiregulin (AR) can be induced at the mRNA level by 17-beta-estradiol (E2) or the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 151-154 amphiregulin Homo sapiens 14-16 8952699-2 1996 This study compares the effects of TPA and E2 on the regulation of processing of AR isoforms and on subcellular localization in human MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 35-38 amphiregulin Homo sapiens 81-83 8952699-4 1996 AR isoforms of 28, 18, and 10 kDa and an additional species of approximately 55-60 kDa were detected in the cellular conditioned media after TPA stimulation. Tetradecanoylphorbol Acetate 141-144 amphiregulin Homo sapiens 0-2 8952699-9 1996 These data suggest that TPA activation of PKC may be involved in post-translational modifications of AR, such as glycosylation, and in alteration of its subcellular routing to predominantly a secretory pathway. Tetradecanoylphorbol Acetate 24-27 amphiregulin Homo sapiens 101-103 1857220-0 1991 Purification of amphiregulin from serum-free conditioned medium of 12-O-tetradecanoylphorbol 13-acetate-treated cell lines. Tetradecanoylphorbol Acetate 67-103 amphiregulin Homo sapiens 16-28 7649107-3 1995 In the current report we established the mechanisms of the PKC-activating phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) and the steroid hormone E2 on the induction of AR expression in human breast carcinoma cell lines. Tetradecanoylphorbol Acetate 104-140 amphiregulin Homo sapiens 194-196 7649107-3 1995 In the current report we established the mechanisms of the PKC-activating phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) and the steroid hormone E2 on the induction of AR expression in human breast carcinoma cell lines. Tetradecanoylphorbol Acetate 142-145 amphiregulin Homo sapiens 194-196 7649107-4 1995 TPA (100 nM) and E2 (1 nM) induce AR messenger RNA (mRNA) expression by 6- to 8-fold and 3- to 6-fold, respectively, in a time- and dose-dependent manner. Tetradecanoylphorbol Acetate 0-3 amphiregulin Homo sapiens 34-36 7649107-5 1995 In addition, immunoreactive AR protein is induced by both TPA and E2 by 6- to 8-fold and 2- to 4-fold, respectively. Tetradecanoylphorbol Acetate 58-61 amphiregulin Homo sapiens 28-30 7649107-6 1995 The PKC-modulating drugs, bryostatin and H-7, and antiestrogens (ICI 164,384 and 4-hydroxytamoxifen) interfere with AR induction by TPA and estrogen, respectively. Tetradecanoylphorbol Acetate 132-135 amphiregulin Homo sapiens 116-118 7649107-7 1995 The effects of TPA and E2 on the induction of AR mRNA were both closely associated with enhanced transcription of the AR gene. Tetradecanoylphorbol Acetate 15-18 amphiregulin Homo sapiens 46-48 7649107-7 1995 The effects of TPA and E2 on the induction of AR mRNA were both closely associated with enhanced transcription of the AR gene. Tetradecanoylphorbol Acetate 15-18 amphiregulin Homo sapiens 118-120 7649107-8 1995 However, TPA had an additional effect at the posttranscriptional level by stabilizing the AR mRNA. Tetradecanoylphorbol Acetate 9-12 amphiregulin Homo sapiens 90-92 7649107-9 1995 The protein synthesis inhibitor, cycloheximide, prevented AR induction by TPA, suggesting that a component of the TPA induction of AR is indirect and dependent upon protein synthesis. Tetradecanoylphorbol Acetate 74-77 amphiregulin Homo sapiens 58-60 7649107-9 1995 The protein synthesis inhibitor, cycloheximide, prevented AR induction by TPA, suggesting that a component of the TPA induction of AR is indirect and dependent upon protein synthesis. Tetradecanoylphorbol Acetate 74-77 amphiregulin Homo sapiens 131-133 7649107-9 1995 The protein synthesis inhibitor, cycloheximide, prevented AR induction by TPA, suggesting that a component of the TPA induction of AR is indirect and dependent upon protein synthesis. Tetradecanoylphorbol Acetate 114-117 amphiregulin Homo sapiens 58-60 7649107-9 1995 The protein synthesis inhibitor, cycloheximide, prevented AR induction by TPA, suggesting that a component of the TPA induction of AR is indirect and dependent upon protein synthesis. Tetradecanoylphorbol Acetate 114-117 amphiregulin Homo sapiens 131-133 7649107-11 1995 The results presented herein thus demonstrate that TPA and E2 are able to stimulate AR gene transcription by two separate mechanisms. Tetradecanoylphorbol Acetate 51-54 amphiregulin Homo sapiens 84-86