PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11033016-3 2000 In vitro stimulation of IFN-gamma production required incubation of splenocytes with PMA and ionomycin in the presence of the protein transport inhibitor brefeldin A for 6 h. Three stimulation protocols for IL-4 and IL-10 production were evaluated. Tetradecanoylphorbol Acetate 85-88 interferon gamma Rattus norvegicus 24-33 7564571-2 1995 To elucidate this, we investigated the capacity of AM from young (16-week-old) and aged (100-week-old) rats to become primed with recombinant rat interferon-gamma (IFN-gamma) for increased phorbol myristate acetate (PMA)-elicited O2- production, utilizing an MCLA-dependent chemiluminescent assay. Tetradecanoylphorbol Acetate 189-214 interferon gamma Rattus norvegicus 146-162 7558122-8 1995 When splenocytes were stimulated with Con A for 4 days in the presence of IL-4, and restimulated with PMA and ionomycin, IFN-gamma secretion was greatly suppressed. Tetradecanoylphorbol Acetate 102-105 interferon gamma Rattus norvegicus 121-130 7564571-2 1995 To elucidate this, we investigated the capacity of AM from young (16-week-old) and aged (100-week-old) rats to become primed with recombinant rat interferon-gamma (IFN-gamma) for increased phorbol myristate acetate (PMA)-elicited O2- production, utilizing an MCLA-dependent chemiluminescent assay. Tetradecanoylphorbol Acetate 189-214 interferon gamma Rattus norvegicus 164-173 1526661-2 1992 Macrophage activation was accomplished by exposing inflammatory rat peritoneal macrophages to 10 units of IFN gamma for 72 h. IFN gamma treatment caused a four to fivefold increase in phorbol myristate acetate (PMA)-triggered H2O2 production, but Fc receptor phagocytic function was unaltered. Tetradecanoylphorbol Acetate 184-209 interferon gamma Rattus norvegicus 106-115 7945348-2 1994 Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after treatment with recombinant interferon-gamma (rIFN-gamma) resulted in the increased production of NO in the medium. Tetradecanoylphorbol Acetate 58-89 interferon gamma Rattus norvegicus 147-157 7945348-2 1994 Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after treatment with recombinant interferon-gamma (rIFN-gamma) resulted in the increased production of NO in the medium. Tetradecanoylphorbol Acetate 91-94 interferon gamma Rattus norvegicus 147-157 8135804-2 1994 Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in the increased accumulation of nitrite in the medium. Tetradecanoylphorbol Acetate 58-89 interferon gamma Rattus norvegicus 149-159 8135804-2 1994 Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in the increased accumulation of nitrite in the medium. Tetradecanoylphorbol Acetate 91-94 interferon gamma Rattus norvegicus 149-159 8406581-6 1993 Cells cultured with Con A for 4 days, washed, and restimulated with PMA + ionomycin were unable to express detectable levels of IL-4 and IL-5 mRNA, but produced high levels of IFN-gamma mRNA. Tetradecanoylphorbol Acetate 68-71 interferon gamma Rattus norvegicus 176-185 7527831-14 1994 The phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) also stimulated nitric oxide production by macrophages and endothelial cells from endotoxin-treated rats, although not as effectively as LPS and IFN-gamma. Tetradecanoylphorbol Acetate 57-60 interferon gamma Rattus norvegicus 207-216 8495968-5 1993 IFN-gamma production by phytohaemagglutinin (PHA)- or ionomycin and phorbol myristate acetate (PMA)-stimulated splenocytes or purified splenic T cells from animals immunized with antigen and ricin was substantially reduced as compared with animals which were given saline or antigen alone (P < 0.001 Student"s t-test). Tetradecanoylphorbol Acetate 68-93 interferon gamma Rattus norvegicus 0-9 8495968-5 1993 IFN-gamma production by phytohaemagglutinin (PHA)- or ionomycin and phorbol myristate acetate (PMA)-stimulated splenocytes or purified splenic T cells from animals immunized with antigen and ricin was substantially reduced as compared with animals which were given saline or antigen alone (P < 0.001 Student"s t-test). Tetradecanoylphorbol Acetate 95-98 interferon gamma Rattus norvegicus 0-9 8469926-7 1993 The rIFN-gamma-activated macrophages displayed enhanced O2-consumption after stimulation with phorbol myristate acetate and heat-killed Listeria compared with macrophages from normal mice. Tetradecanoylphorbol Acetate 94-119 interferon gamma Rattus norvegicus 4-14 1526661-2 1992 Macrophage activation was accomplished by exposing inflammatory rat peritoneal macrophages to 10 units of IFN gamma for 72 h. IFN gamma treatment caused a four to fivefold increase in phorbol myristate acetate (PMA)-triggered H2O2 production, but Fc receptor phagocytic function was unaltered. Tetradecanoylphorbol Acetate 211-214 interferon gamma Rattus norvegicus 126-135 1526661-2 1992 Macrophage activation was accomplished by exposing inflammatory rat peritoneal macrophages to 10 units of IFN gamma for 72 h. IFN gamma treatment caused a four to fivefold increase in phorbol myristate acetate (PMA)-triggered H2O2 production, but Fc receptor phagocytic function was unaltered. Tetradecanoylphorbol Acetate 184-209 interferon gamma Rattus norvegicus 126-135 1526661-2 1992 Macrophage activation was accomplished by exposing inflammatory rat peritoneal macrophages to 10 units of IFN gamma for 72 h. IFN gamma treatment caused a four to fivefold increase in phorbol myristate acetate (PMA)-triggered H2O2 production, but Fc receptor phagocytic function was unaltered. Tetradecanoylphorbol Acetate 211-214 interferon gamma Rattus norvegicus 106-115 34619426-8 2021 RESULTS: Stimulations of whole blood and spleen samples with phorbol 12-myristate 13-acetate/ionomycin (PMA/I) at post-injury day 1 were associated with significant decreases in IFN-gamma-positive cells/million in injured animals. Tetradecanoylphorbol Acetate 61-92 interferon gamma Rattus norvegicus 178-187 1531944-5 1992 In vitro stimulation of T cells with concanavalin A or calcium ionophore and phorbol myristate acetate (PMA) for 1-4 hr caused a marked (7- to 12-fold) increase in lymphocyte adhesion to unstimulated and IFN-gamma- or LPS-treated EC. Tetradecanoylphorbol Acetate 77-102 interferon gamma Rattus norvegicus 204-213 1531944-5 1992 In vitro stimulation of T cells with concanavalin A or calcium ionophore and phorbol myristate acetate (PMA) for 1-4 hr caused a marked (7- to 12-fold) increase in lymphocyte adhesion to unstimulated and IFN-gamma- or LPS-treated EC. Tetradecanoylphorbol Acetate 104-107 interferon gamma Rattus norvegicus 204-213 1663531-3 1991 Both rIFN-beta ser and rIFN-gamma increased phorbol myristate acetate-stimulated superoxide anion generation by AM in a dose-dependent fashion. Tetradecanoylphorbol Acetate 44-69 interferon gamma Rattus norvegicus 23-33 34619426-8 2021 RESULTS: Stimulations of whole blood and spleen samples with phorbol 12-myristate 13-acetate/ionomycin (PMA/I) at post-injury day 1 were associated with significant decreases in IFN-gamma-positive cells/million in injured animals. Tetradecanoylphorbol Acetate 104-107 interferon gamma Rattus norvegicus 178-187 2957433-11 1987 Checking the state of activation of rIFN-gamma-activated macrophages on the basis of two commonly used criteria for macrophage activation showed that rIFN-gamma-activated macrophages inhibited the intracellular replication of Toxoplasma gondii and displayed enhanced O2 consumption and H2O2 release after stimulation with phorbol myristate acetate compared with macrophages from normal CBA and C57BL/10 mice. Tetradecanoylphorbol Acetate 322-347 interferon gamma Rattus norvegicus 36-46 2957433-11 1987 Checking the state of activation of rIFN-gamma-activated macrophages on the basis of two commonly used criteria for macrophage activation showed that rIFN-gamma-activated macrophages inhibited the intracellular replication of Toxoplasma gondii and displayed enhanced O2 consumption and H2O2 release after stimulation with phorbol myristate acetate compared with macrophages from normal CBA and C57BL/10 mice. Tetradecanoylphorbol Acetate 322-347 interferon gamma Rattus norvegicus 150-160 3108018-4 1987 Exposure to rIFN-gamma led to an enhanced chemiluminescence (CL) signal in the presence of luminol and a variety of respiratory burst stimuli, such as zymosan, phorbol 12-myristate 13-acetate or IgG-sensitized sheep erythrocytes (EA). Tetradecanoylphorbol Acetate 160-191 interferon gamma Rattus norvegicus 12-22 2985706-2 1985 The stimulatory effect of rIFN-gamma on HLA-DR antigen expression was suppressed by the addition of the phorbol ester TPA or its analog PDBu to the culture medium. Tetradecanoylphorbol Acetate 118-121 interferon gamma Rattus norvegicus 26-36 26268522-9 2015 CD4+CD25+ enriched PBL stimulated with PMA/Ionomycin in the presence of rIFNgamma were rather resistant to the effect of rIFNgamma, in contrast to CD4+CD25- enriched PBL which showed increasing total Treg with Helios+ Treg switching from IFNgamma- to IFNgamma+ and increasing Helios-IFNgamma+ Treg. Tetradecanoylphorbol Acetate 39-42 interferon gamma Rattus norvegicus 72-81 2440910-6 1987 H2O2 release in the range seen in sarcoid patients could be induced in PMA-triggered AM from normals by rIFN gamma in a time- (t1/2 approximately 1 d) and dose-dependent fashion (threefold increase, EC50 5 antiviral U/ml) and by rIFN alpha A and rIFN beta at higher concentrations, but not by 1,25-dihydroxyvitamin D3. Tetradecanoylphorbol Acetate 71-74 interferon gamma Rattus norvegicus 104-114 16156895-6 2005 However, if NOX was activated (by PMA or BzATP) in the presence of iNOS (induced by LPS and interferon-gamma) then substantial delayed neuronal death occurred over 48 hours, which was prevented by inhibitors of iNOS (1400W), NOX (apocynin) or a peroxynitrite decomposer (FeTPPS). Tetradecanoylphorbol Acetate 34-37 interferon gamma Rattus norvegicus 92-108