PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7816604-3 1994 We show that TPA has a direct stimulatory action on the promoter and further that this is mediated by the AP-1 transcription factor. Tetradecanoylphorbol Acetate 13-16 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 106-110 16116958-6 2005 58+/-1 626.57) and the expression of IL-5 mRNA (0.8300+/-0.0294) in T lymphocytes stimulated with PMA were significantly higher than these in blank control (20888.47 +/- 1103.56 and 0.3050 +/- 0.0208, respectively, P< 0.01), while the indexes (23219.83 +/- 1024.86 and 0.3425 +/- 0.0171 respectively) of T lymphocytes stimulated with PMA and AP-1 decoy ODNs were significantly inhibited, as compared with group B (P< 0.01). Tetradecanoylphorbol Acetate 98-101 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 345-349 12433930-8 2003 We demonstrated that c-Fos, c-Jun, and JunD are involved in TPA inhibitory effect due to their ability to bind TRE-ALAS, evidenced by supershift analysis and their capacity to repress promoter activity in transfection assays. Tetradecanoylphorbol Acetate 60-63 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 39-43 12082101-3 2002 In the present study, we found that the exposure of myeloblastic leukemia ML-1 cells to UV light (UVC) caused a significant increase in junD mRNA expression within 5 min that persisted for a period of 3 h. The activation of protein kinase C (PKC) with 12-O-tetradecaoylphorbol-13-acetate (TPA) also induced increases in junD expression similar to those of UV irradiation. Tetradecanoylphorbol Acetate 289-292 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 136-140 12082101-4 2002 In addition, UV irradiation- and TPA-induced increases in junD expression were completely abolished by GF-109203X, a PKC-specific inhibitor. Tetradecanoylphorbol Acetate 33-36 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 58-62 12082101-8 2002 The overexpression of MEK1 enhanced substantially junD expression in response to UV or TPA. Tetradecanoylphorbol Acetate 87-90 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 50-54 12082101-9 2002 In contrast, the suppression of Erk activation with PD98059, a specific inhibitor of MEK1, inhibited UV- and TPA-induced junD mRNA expression, UV-induced increases in caspase-3 activities, and cell death. Tetradecanoylphorbol Acetate 109-112 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 121-125 10454570-5 1999 The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer. Tetradecanoylphorbol Acetate 260-263 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 202-206 10454570-5 1999 The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer. Tetradecanoylphorbol Acetate 381-384 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 202-206 9602173-3 1998 We report here that the human junD promoter is repressed by serum and TPA. Tetradecanoylphorbol Acetate 70-73 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 30-34 9602173-6 1998 We found that c-Fos, a bZip protein known to be induced by serum and TPA, is sufficient to antagonize the JunD function. Tetradecanoylphorbol Acetate 69-72 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 106-110 9218873-8 1997 This TRE bound TPA induced specific nuclear complexes in vitro containing junD, c-jun, c-fos, and fra2 but not cAMP-responsive element binding/activating transcription factor family proteins. Tetradecanoylphorbol Acetate 15-18 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 74-78 9156339-7 1997 Further studies showed that inhibition of TPA-induced endothelial cell morphogenesis by oxLDL is correlated with suppression of the protein kinase C (PKC) and ETS1/AP1 activities. Tetradecanoylphorbol Acetate 42-45 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 164-167 9156339-8 1997 The results indicated that the inhibition of endothelial cell morphogenesis by oxLDL is probably mediated through inhibition of the TPA-activated PKC pathway and its subsequent suppression of the ETS1/AP1 activity. Tetradecanoylphorbol Acetate 132-135 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 201-204 1445621-0 1992 Role of activator protein-1 and methylation function in 12-O-tetradecanoylphorbol-13-acetate--mediated inhibition of differentiation of Friend erythroleukemia cells. Tetradecanoylphorbol Acetate 56-92 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 8-27 8253775-7 1993 The rapidity and the protein synthesis-independent nature of TPA-induced T-AP1 activation suggests that this complex is involved in the earliest stages of T-cell activation. Tetradecanoylphorbol Acetate 61-64 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 75-78 1445622-0 1992 12-O-tetradecanoylphorbol-13-acetate--induced levels of AP-1 proteins: a 46-kDa protein immunoprecipitated by anti-fra-1 and induced in promotion-resistant but not promotion-sensitive JB6 cells. Tetradecanoylphorbol Acetate 0-36 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 56-60 1445622-4 1992 In this investigation, steady-state levels of AP-1 protein components were measured by immunoprecipitating proteins from 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated P+ and P- cells to discern what may limit the AP-1 response. Tetradecanoylphorbol Acetate 121-157 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 46-50 1445622-4 1992 In this investigation, steady-state levels of AP-1 protein components were measured by immunoprecipitating proteins from 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated P+ and P- cells to discern what may limit the AP-1 response. Tetradecanoylphorbol Acetate 159-162 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 46-50 1445622-4 1992 In this investigation, steady-state levels of AP-1 protein components were measured by immunoprecipitating proteins from 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated P+ and P- cells to discern what may limit the AP-1 response. Tetradecanoylphorbol Acetate 159-162 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 218-222 20188714-8 2010 Furthermore, glycitein suppresses PMA-induced phosphorylation of three types of MAP kinases, which are upstream signaling molecules in MMP gene expressions and NF-kappaB and AP-1 activities in glioma cells. Tetradecanoylphorbol Acetate 34-37 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 174-178 31893611-8 2020 Taken together, our findings indicated that ML attenuated the TPA-stimulated invasion and migration of MCF-7 cells by suppressing the phosphorylation of ERK and its downstream factors, AP-1 and STAT3. Tetradecanoylphorbol Acetate 62-65 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 185-189 20053986-2 2010 To bind to its target AP-1/12-O-tetradecanoylphorbol-13-acetate-responsive element or cAMP-responsive element DNA sequences in gene promoters and exert its transcriptional part, c-Fos must heterodimerize with other bZip proteins, its best studied partners being the Jun proteins (c-Jun, JunB, and JunD). Tetradecanoylphorbol Acetate 27-63 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 297-301