PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18171992-9 2007 Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner. Tetradecanoylphorbol Acetate 92-95 erb-b2 receptor tyrosine kinase 2 Mus musculus 207-212 18171992-9 2007 Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner. Tetradecanoylphorbol Acetate 92-95 erb-b2 receptor tyrosine kinase 2 Mus musculus 313-318 21594311-7 1996 Furthermore, azatyrosine inhibited activation of the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element in response to stimulation by oncogenic c-ErbB-2. Tetradecanoylphorbol Acetate 91-94 erb-b2 receptor tyrosine kinase 2 Mus musculus 153-161 9309155-5 1997 Furthermore, azatyrosine inhibited activation of the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element in response to stimulation by oncogenic c-ErbB-2. Tetradecanoylphorbol Acetate 53-89 erb-b2 receptor tyrosine kinase 2 Mus musculus 153-161 9309155-5 1997 Furthermore, azatyrosine inhibited activation of the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element in response to stimulation by oncogenic c-ErbB-2. Tetradecanoylphorbol Acetate 91-94 erb-b2 receptor tyrosine kinase 2 Mus musculus 153-161 9136987-8 1997 In mouse epidermis following multiple treatments with 12-O-tetradecanoylphorbol-13-acetate (TPA), the phosphotyrosine content of erbB2 was significantly elevated in a dose-dependent manner. Tetradecanoylphorbol Acetate 54-90 erb-b2 receptor tyrosine kinase 2 Mus musculus 129-134 9136987-8 1997 In mouse epidermis following multiple treatments with 12-O-tetradecanoylphorbol-13-acetate (TPA), the phosphotyrosine content of erbB2 was significantly elevated in a dose-dependent manner. Tetradecanoylphorbol Acetate 92-95 erb-b2 receptor tyrosine kinase 2 Mus musculus 129-134 9136987-9 1997 Concomittantly, erbB2:EGFr heterodimer formation and c-src kinase activity were also elevated in TPA-treated epidermis. Tetradecanoylphorbol Acetate 97-100 erb-b2 receptor tyrosine kinase 2 Mus musculus 16-21 1706346-6 1991 Prolonged pretreatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) also prevented the induction of immediate early growth factor-regulated genes in response to neu activation. Tetradecanoylphorbol Acetate 28-65 erb-b2 receptor tyrosine kinase 2 Mus musculus 165-168 21594311-7 1996 Furthermore, azatyrosine inhibited activation of the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element in response to stimulation by oncogenic c-ErbB-2. Tetradecanoylphorbol Acetate 53-89 erb-b2 receptor tyrosine kinase 2 Mus musculus 153-161 1677566-0 1991 Transactivation of the TPA-responsive element by the oncogenic C-erbB-2 protein is partly mediated by protein kinase C. The mutant c-erbB-2 gene encoding a protein with Glu instead of Val-659 in the transmembrane domain is able to transform NIH3T3 cells, while the wild type c-erbB-2 unless overexpressed does not. Tetradecanoylphorbol Acetate 23-26 erb-b2 receptor tyrosine kinase 2 Mus musculus 63-71 1677566-0 1991 Transactivation of the TPA-responsive element by the oncogenic C-erbB-2 protein is partly mediated by protein kinase C. The mutant c-erbB-2 gene encoding a protein with Glu instead of Val-659 in the transmembrane domain is able to transform NIH3T3 cells, while the wild type c-erbB-2 unless overexpressed does not. Tetradecanoylphorbol Acetate 23-26 erb-b2 receptor tyrosine kinase 2 Mus musculus 131-139 1677566-0 1991 Transactivation of the TPA-responsive element by the oncogenic C-erbB-2 protein is partly mediated by protein kinase C. The mutant c-erbB-2 gene encoding a protein with Glu instead of Val-659 in the transmembrane domain is able to transform NIH3T3 cells, while the wild type c-erbB-2 unless overexpressed does not. Tetradecanoylphorbol Acetate 23-26 erb-b2 receptor tyrosine kinase 2 Mus musculus 275-283 1677566-2 1991 Transient expression of this active c-erbB-2 stimulated the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, serum response element, and cyclic AMP response element. Tetradecanoylphorbol Acetate 60-96 erb-b2 receptor tyrosine kinase 2 Mus musculus 36-44 1677566-2 1991 Transient expression of this active c-erbB-2 stimulated the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, serum response element, and cyclic AMP response element. Tetradecanoylphorbol Acetate 98-101 erb-b2 receptor tyrosine kinase 2 Mus musculus 36-44 7642554-2 1995 Within minutes of phorbol 12-myristate 13-acetate treatment, epidermal growth factor receptor and HER2 tyrosine phosphorylation was decreased, while platelet-derived growth factor receptor and insulin receptor autophosphorylation was upregulated. Tetradecanoylphorbol Acetate 18-49 erb-b2 receptor tyrosine kinase 2 Mus musculus 98-102 1677566-3 1991 Particularly, stimulation of the TPA response element by active c-erbB-2 was prominent. Tetradecanoylphorbol Acetate 33-36 erb-b2 receptor tyrosine kinase 2 Mus musculus 64-72 1677566-5 1991 Transactivation of the TPA response element was also observed in a cell line that stably expresses active c-erbB-2. Tetradecanoylphorbol Acetate 23-26 erb-b2 receptor tyrosine kinase 2 Mus musculus 106-114 1677566-6 1991 The active c-erbB-2-induced transactivation of the TPA response element was partially prevented either by down-regulation of protein kinase C or by the protein kinase C inhibitor H7. Tetradecanoylphorbol Acetate 51-54 erb-b2 receptor tyrosine kinase 2 Mus musculus 11-19 1706346-6 1991 Prolonged pretreatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) also prevented the induction of immediate early growth factor-regulated genes in response to neu activation. Tetradecanoylphorbol Acetate 67-70 erb-b2 receptor tyrosine kinase 2 Mus musculus 165-168 20682802-5 2010 GW2974 effectively inhibited skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in wild-type and BK5.erbB2 mice, although a more marked effect was seen in BK5.erbB2 mice. Tetradecanoylphorbol Acetate 53-89 erb-b2 receptor tyrosine kinase 2 Mus musculus 111-116 20682802-7 2010 GW2974 inhibited 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperproliferation, which correlated with reduced activation of both the EGFR and erbB2. Tetradecanoylphorbol Acetate 17-53 erb-b2 receptor tyrosine kinase 2 Mus musculus 154-159 27931797-5 2017 Compared with control littermates, Erbb2del mice remained free of papillomas for a longer time and had significantly reduced tumor burden after application of the 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate multistage chemical carcinogenesis protocol. Tetradecanoylphorbol Acetate 194-230 erb-b2 receptor tyrosine kinase 2 Mus musculus 35-40 27931797-6 2017 Furthermore, tumor cell proliferation was substantially reduced in Erbb2del mice, and loss of ERBB2 also decreased keratinocyte proliferation after 12-O-tetradecanoylphorbol-13-acetate application. Tetradecanoylphorbol Acetate 148-184 erb-b2 receptor tyrosine kinase 2 Mus musculus 94-99