PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21878491-6 2011 Mutating these two serine residues into alanine residues abrogates PMA-induced redistribution of SH2B1beta out of focal adhesions, decreases SH2B1beta cycling into and out of focal adhesions in control and GH-stimulated cells, and increases the size of focal adhesions. Tetradecanoylphorbol Acetate 67-70 growth hormone 1 Homo sapiens 206-208 10644756-7 2000 The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs. Tetradecanoylphorbol Acetate 113-150 growth hormone 1 Homo sapiens 33-35 10644756-7 2000 The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs. Tetradecanoylphorbol Acetate 152-155 growth hormone 1 Homo sapiens 33-35 10644756-7 2000 The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs. Tetradecanoylphorbol Acetate 185-188 growth hormone 1 Homo sapiens 33-35 9710361-8 1998 This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min. Tetradecanoylphorbol Acetate 97-100 growth hormone 1 Homo sapiens 262-264 12845746-2 2000 12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH). Tetradecanoylphorbol Acetate 0-37 growth hormone 1 Homo sapiens 64-66 12845746-2 2000 12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH). Tetradecanoylphorbol Acetate 0-37 growth hormone 1 Homo sapiens 118-120 12845746-2 2000 12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH). Tetradecanoylphorbol Acetate 39-42 growth hormone 1 Homo sapiens 64-66 12845746-2 2000 12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH). Tetradecanoylphorbol Acetate 39-42 growth hormone 1 Homo sapiens 118-120 12840904-0 1999 TPA enhances growth hormone (GH) secretion effect of GH-releasing hormone (GHRH) by human gsp-positive pituitary somatotrophinomas. Tetradecanoylphorbol Acetate 0-3 growth hormone 1 Homo sapiens 13-27 12840904-0 1999 TPA enhances growth hormone (GH) secretion effect of GH-releasing hormone (GHRH) by human gsp-positive pituitary somatotrophinomas. Tetradecanoylphorbol Acetate 0-3 growth hormone 1 Homo sapiens 29-31 12840904-5 1999 Moreover, phorbol ester, 1, 2-tetradecanoylphorbol-13-acetate (TPA), enhanced stimulation of lated the GH secretion effect exerted by GHRH in gsp-positive somatotrophinomas, whereas this effect was not observed in gsp-negative tumors. Tetradecanoylphorbol Acetate 63-66 growth hormone 1 Homo sapiens 103-105 8875488-6 1996 RESULTS: TPA consistently stimulated GH secretion by cultured somatotrophinoma cells. Tetradecanoylphorbol Acetate 9-12 growth hormone 1 Homo sapiens 37-39 19215372-16 1990 Intracellular accumulation of Ca(2+) by the ionophore A23187 and protein kinase C stimulation by the phorbol ester 12-O- tetradecanoyl phorbol acetate (TPA), strongly stimulated GH and prolactin release. Tetradecanoylphorbol Acetate 115-150 growth hormone 1 Homo sapiens 178-180 8048538-6 1994 The mRNAs and cellular growth hormone protein generated from the chimeric TKGH(SP-B2.0) and TKGH(SP-B.837) genes were each inhibited by approximately 50% by TPA and TNF-alpha. Tetradecanoylphorbol Acetate 157-160 growth hormone 1 Homo sapiens 23-37 8391998-5 1993 The peptide (100 microM) also inhibited LH and GH exocytosis stimulated by phorbol myristate acetate plus cAMP by more than 45% and 80%, respectively. Tetradecanoylphorbol Acetate 75-100 growth hormone 1 Homo sapiens 47-49 8246449-9 1993 Although GH mRNA transcript was markedly changed by dexamethasone and phorbol 12-myristate 13-acetate in vitro, Pit-1 mRNA transcripts were not changed significantly by these secretagogues. Tetradecanoylphorbol Acetate 70-101 growth hormone 1 Homo sapiens 9-11 19215372-16 1990 Intracellular accumulation of Ca(2+) by the ionophore A23187 and protein kinase C stimulation by the phorbol ester 12-O- tetradecanoyl phorbol acetate (TPA), strongly stimulated GH and prolactin release. Tetradecanoylphorbol Acetate 152-155 growth hormone 1 Homo sapiens 178-180 2546831-0 1989 Effects of pretreatment with tetradecanoyl phorbol acetate on regulation of growth hormone and prolactin secretion from ovine anterior pituitary cells. Tetradecanoylphorbol Acetate 29-58 growth hormone 1 Homo sapiens 76-90 2546831-1 1989 Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells. Tetradecanoylphorbol Acetate 0-29 growth hormone 1 Homo sapiens 47-61 2546831-1 1989 Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells. Tetradecanoylphorbol Acetate 0-29 growth hormone 1 Homo sapiens 63-65 2546831-1 1989 Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells. Tetradecanoylphorbol Acetate 31-34 growth hormone 1 Homo sapiens 47-61 2546831-1 1989 Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells. Tetradecanoylphorbol Acetate 31-34 growth hormone 1 Homo sapiens 63-65 2546831-2 1989 Pretreatment of the cells with TPA abolishes this effect, presumably due to down-regulation of protein kinase C. Such pretreatment did not alter effects of thyrotropin-releasing hormone or dopamine on prolactin secretion, suggesting no involvement of protein kinase C. Pretreatment with TPA attenuated actions of GH-releasing hormone on GH release (but not actions on cyclic AMP levels), possibly due to depletion of cellular stores of GH. Tetradecanoylphorbol Acetate 31-34 growth hormone 1 Homo sapiens 313-315 2463192-1 1988 Growth hormone-releasing hormone (GHRH) and the phorbol ester tetradecanoylphorbol acetate (TPA) each stimulated a rapid and extensive (up to 15-fold) increase in the secretion of growth hormone from cultured ovine anterior pituitary cells. Tetradecanoylphorbol Acetate 92-95 growth hormone 1 Homo sapiens 180-194 2463192-6 1988 In contrast TPA when combined with maximally effective concentrations of either GHRH, forskolin or IBMX caused additional release of growth hormone, suggesting that the TPA-induced secretion involved a cyclic AMP-independent process. Tetradecanoylphorbol Acetate 12-15 growth hormone 1 Homo sapiens 133-147 2463192-6 1988 In contrast TPA when combined with maximally effective concentrations of either GHRH, forskolin or IBMX caused additional release of growth hormone, suggesting that the TPA-induced secretion involved a cyclic AMP-independent process. Tetradecanoylphorbol Acetate 169-172 growth hormone 1 Homo sapiens 133-147 2463192-10 1988 The two actions of TPA, one on secretion and one on cyclic AMP metabolism, may result from activation of some common event possibly involving protein kinase C. Our results suggest that GHRH and TPA activate independent pathways regulating growth hormone secretion. Tetradecanoylphorbol Acetate 19-22 growth hormone 1 Homo sapiens 239-253 2463192-10 1988 The two actions of TPA, one on secretion and one on cyclic AMP metabolism, may result from activation of some common event possibly involving protein kinase C. Our results suggest that GHRH and TPA activate independent pathways regulating growth hormone secretion. Tetradecanoylphorbol Acetate 194-197 growth hormone 1 Homo sapiens 239-253 3124825-2 1988 Human growth hormone (hGH) and rat IL-2 stimulated Nb2-cell proliferation to approximately the same degree, and the actions of both mitogens were potentiated by phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 194-197 growth hormone 1 Homo sapiens 6-20