PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12787062-5 2003 TH gene transcription rate increased from four- to eight-fold in control cells after treatment with either 50 mM KCl or TPA. Tetradecanoylphorbol Acetate 120-123 tyrosine hydroxylase Rattus norvegicus 0-2 2881980-1 1987 Incubation of rat pheochromocytoma PC12 cells with 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA), an activator of Ca2+/phospholipid-dependent protein kinase (protein kinase C), or forskolin, an activator of adenylate cyclase, is associated with increased activity and enhanced phosphorylation of tyrosine hydroxylase. Tetradecanoylphorbol Acetate 102-105 tyrosine hydroxylase Rattus norvegicus 306-326 2881980-11 1987 However, in cells treated with either PMA or forskolin, there is an increase in the phosphorylation of only one of these peptides derived from tyrosine hydroxylase. Tetradecanoylphorbol Acetate 38-41 tyrosine hydroxylase Rattus norvegicus 143-163 2881980-14 1987 These results indicate that tyrosine hydroxylase is activated and phosphorylated on different sites in PC12 cells exposed to PMA and forskolin and that phosphorylation of either of these sites is associated with activation of tyrosine hydroxylase. Tetradecanoylphorbol Acetate 125-128 tyrosine hydroxylase Rattus norvegicus 28-48 2881980-14 1987 These results indicate that tyrosine hydroxylase is activated and phosphorylated on different sites in PC12 cells exposed to PMA and forskolin and that phosphorylation of either of these sites is associated with activation of tyrosine hydroxylase. Tetradecanoylphorbol Acetate 125-128 tyrosine hydroxylase Rattus norvegicus 226-246 12787062-8 2003 Stimulation of TH gene promoter activity, which was observed in control cell lines treated with either 50 mm KCl or TPA was also dramatically inhibited in the c-Fos-deficient cells. Tetradecanoylphorbol Acetate 116-119 tyrosine hydroxylase Rattus norvegicus 15-17 11438978-2 2001 The TPA-responsive element plays an important role in the trans-synaptically-induced transcription of the TH gene in the AM, whereas it does not appear to be involved in the SCG (Trocme et al. Tetradecanoylphorbol Acetate 4-7 tyrosine hydroxylase Rattus norvegicus 106-108 11238722-1 2001 Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA). Tetradecanoylphorbol Acetate 155-158 tyrosine hydroxylase Rattus norvegicus 22-24 11238722-2 2001 Mutagenesis of either the cAMP responsive element (CRE) or the activator protein-1 element (AP1) within the TH gene proximal promoter leads to a dramatic inhibition of the TPA response. Tetradecanoylphorbol Acetate 172-175 tyrosine hydroxylase Rattus norvegicus 108-110 11238722-3 2001 The TH CRE and TH AP1 sites are also independently responsive to TPA in minimal promoter constructs. Tetradecanoylphorbol Acetate 65-68 tyrosine hydroxylase Rattus norvegicus 4-6 11238722-5 2001 In CREB-deficient cells, the response of the full TH gene proximal promoter or the independent response of the TH CRE by itself to TPA is inhibited. Tetradecanoylphorbol Acetate 131-134 tyrosine hydroxylase Rattus norvegicus 111-113 11238722-6 2001 The TPA-inducibility of TH mRNA is also blocked in CREB-deficient cells. Tetradecanoylphorbol Acetate 4-7 tyrosine hydroxylase Rattus norvegicus 24-26 11238722-7 2001 Expression of the PKA inhibitor protein, PKI, also inhibits the independent response of the TH CRE to TPA. Tetradecanoylphorbol Acetate 102-105 tyrosine hydroxylase Rattus norvegicus 92-94 11238722-8 2001 Our results support the hypothesis that TPA stimulates the TH gene promoter via signaling pathways that activate either the TH AP1 or TH CRE sites. Tetradecanoylphorbol Acetate 40-43 tyrosine hydroxylase Rattus norvegicus 59-61 11238722-8 2001 Our results support the hypothesis that TPA stimulates the TH gene promoter via signaling pathways that activate either the TH AP1 or TH CRE sites. Tetradecanoylphorbol Acetate 40-43 tyrosine hydroxylase Rattus norvegicus 124-126 11238722-8 2001 Our results support the hypothesis that TPA stimulates the TH gene promoter via signaling pathways that activate either the TH AP1 or TH CRE sites. Tetradecanoylphorbol Acetate 40-43 tyrosine hydroxylase Rattus norvegicus 124-126 9885948-4 1998 Treatment of transfected cells with 0.1 microM 12-O-tetradecanoylphorbol 13-acetate (TPA) elicited a 5-6-fold increase in TH gene proximal promoter activity. Tetradecanoylphorbol Acetate 47-83 tyrosine hydroxylase Rattus norvegicus 122-124 9885948-4 1998 Treatment of transfected cells with 0.1 microM 12-O-tetradecanoylphorbol 13-acetate (TPA) elicited a 5-6-fold increase in TH gene proximal promoter activity. Tetradecanoylphorbol Acetate 85-88 tyrosine hydroxylase Rattus norvegicus 122-124 9885948-5 1998 Mutagenesis of the THCRE2 sequence diminished TPA-responsiveness of the TH gene promoter by approximately 50%. Tetradecanoylphorbol Acetate 46-49 tyrosine hydroxylase Rattus norvegicus 19-21 9885948-6 1998 Minimal promoter constructs driven by a single copy of the region of the TH gene that encodes the THCRE2 (from -117 to -59) were also responsive to TPA. Tetradecanoylphorbol Acetate 148-151 tyrosine hydroxylase Rattus norvegicus 73-75 11238722-1 2001 Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA). Tetradecanoylphorbol Acetate 117-153 tyrosine hydroxylase Rattus norvegicus 0-20 11238722-1 2001 Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA). Tetradecanoylphorbol Acetate 117-153 tyrosine hydroxylase Rattus norvegicus 22-24 11238722-1 2001 Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA). Tetradecanoylphorbol Acetate 155-158 tyrosine hydroxylase Rattus norvegicus 0-20 1383560-0 1992 AP-1 complex and c-fos transcription are involved in TPA provoked and trans-synaptic inductions of the tyrosine hydroxylase gene: insights into long-term regulatory mechanisms. Tetradecanoylphorbol Acetate 53-56 tyrosine hydroxylase Rattus norvegicus 103-123 1383560-1 1992 We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis. Tetradecanoylphorbol Acetate 49-52 tyrosine hydroxylase Rattus norvegicus 143-163 1383560-1 1992 We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis. Tetradecanoylphorbol Acetate 49-52 tyrosine hydroxylase Rattus norvegicus 165-167 1383560-8 1992 Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA. Tetradecanoylphorbol Acetate 147-150 tyrosine hydroxylase Rattus norvegicus 47-49 1383560-8 1992 Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA. Tetradecanoylphorbol Acetate 147-150 tyrosine hydroxylase Rattus norvegicus 70-72 1383560-8 1992 Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA. Tetradecanoylphorbol Acetate 147-150 tyrosine hydroxylase Rattus norvegicus 70-72 1383560-8 1992 Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA. Tetradecanoylphorbol Acetate 239-242 tyrosine hydroxylase Rattus norvegicus 47-49 1383560-8 1992 Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA. Tetradecanoylphorbol Acetate 239-242 tyrosine hydroxylase Rattus norvegicus 70-72 1383560-8 1992 Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA. Tetradecanoylphorbol Acetate 239-242 tyrosine hydroxylase Rattus norvegicus 70-72