PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29207123-5 2018 The present study demonstrated that NLRP3 inflammasome and IL-1beta were activated in PMA-induced macrophages in a time-dependent manner, whereas berberine significantly inhibited their expression in a dose-dependent manner in PMA-induced macrophages. Tetradecanoylphorbol Acetate 86-89 interleukin 1 beta Homo sapiens 59-67 29531138-4 2018 In vitro analysis indicated that HMGB1, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-1beta (IL-1beta) were secreted in response to tumor necrosis factor-alpha (TNF-alpha) stimuli in human gingival epithelial cells (HGECs) and human monocytic leukemia cells (THP-1) treated with phorbol myristate acetate. Tetradecanoylphorbol Acetate 308-333 interleukin 1 beta Homo sapiens 103-120 30320338-5 2018 Among them, Anatase-type TiO2 particles with a primary diameter of 50 nm (A50) were reported to induce interleukin (IL)-1beta production and secretion effectively in phorbol 12-myristate 13-acetate-treated human monocytic leukemia THP-1 cells (THP-1 macrophages). Tetradecanoylphorbol Acetate 166-197 interleukin 1 beta Homo sapiens 103-125 29531138-4 2018 In vitro analysis indicated that HMGB1, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-1beta (IL-1beta) were secreted in response to tumor necrosis factor-alpha (TNF-alpha) stimuli in human gingival epithelial cells (HGECs) and human monocytic leukemia cells (THP-1) treated with phorbol myristate acetate. Tetradecanoylphorbol Acetate 308-333 interleukin 1 beta Homo sapiens 122-130 27871911-5 2017 In addition, we also showed that theaflavin-3,3"-digallate inhibited the expression of tumor necrosis factor alpha, interleukin -1 beta, and interleukin 6 in phorbol myristate acetate -primed U937 and RAW 264.7 cells. Tetradecanoylphorbol Acetate 158-183 interleukin 1 beta Homo sapiens 116-135 28276734-5 2017 In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells. Tetradecanoylphorbol Acetate 149-174 interleukin 1 beta Homo sapiens 114-136 28276734-5 2017 In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells. Tetradecanoylphorbol Acetate 176-179 interleukin 1 beta Homo sapiens 114-136 27105502-8 2016 The in vitro study showed that MALT1 inhibitors decreased production of IL-1beta/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome. Tetradecanoylphorbol Acetate 90-115 interleukin 1 beta Homo sapiens 72-80 27777559-5 2016 Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages. Tetradecanoylphorbol Acetate 116-119 interleukin 1 beta Homo sapiens 94-102 27777559-9 2016 Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion. Tetradecanoylphorbol Acetate 31-34 interleukin 1 beta Homo sapiens 140-148 26718326-5 2016 We noted that the purified nonameric peptide (AIGIDP) attenuated the phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced histamine release and the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in human mast cells (HMC-1 cells). Tetradecanoylphorbol Acetate 69-100 interleukin 1 beta Homo sapiens 264-286 27104574-3 2016 Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed. Tetradecanoylphorbol Acetate 116-119 interleukin 1 beta Homo sapiens 62-70 25022544-7 2014 To determine the role of PKC activation in the effects of DPP-4 inhibitors, cells were treated with PMA- which blocked the effect of DPP-4 inhibitors on NLRP3 and IL-1beta as well as TLR4 and GLP-1R. Tetradecanoylphorbol Acetate 100-103 interleukin 1 beta Homo sapiens 163-171 25559824-11 2015 Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression. Tetradecanoylphorbol Acetate 9-12 interleukin 1 beta Homo sapiens 186-194 25677765-10 2015 Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome. Tetradecanoylphorbol Acetate 146-171 interleukin 1 beta Homo sapiens 120-132 25677765-10 2015 Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome. Tetradecanoylphorbol Acetate 173-176 interleukin 1 beta Homo sapiens 120-132 17094021-5 2007 DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 106-137 interleukin 1 beta Homo sapiens 84-92 21807015-4 2011 Our results showed that among the tested molecules, all sensitizers specifically prevent the production of PMA/LPS-induced COX-2 metabolites (PGE(2,) TxB(2) and PGD(2)), eugenol and cinnamaldehyde inhibiting also the production of IL-1beta and TNF-alpha. Tetradecanoylphorbol Acetate 107-110 interleukin 1 beta Homo sapiens 231-239 21804018-4 2011 Moreover, PMA-induced IL-1beta production was significantly reduced in the presence of TLR2, TLR4, and CD11b Abs. Tetradecanoylphorbol Acetate 10-13 interleukin 1 beta Homo sapiens 22-30 21804018-5 2011 Rottlerin, a PKCdelta-specific inhibitor, significantly reduced PMA-induced IL-1beta production as well as CD11b, TLR2 expression, and IRAK1-JNK activation. Tetradecanoylphorbol Acetate 64-67 interleukin 1 beta Homo sapiens 76-84 20851349-6 2010 The activity correlated well with processing of prointerleukin-1beta and prointerleukin-18 in phorbol 12-myristate 13-acetate (PMA)-stimulated cells. Tetradecanoylphorbol Acetate 94-125 interleukin 1 beta Homo sapiens 48-68 20851349-6 2010 The activity correlated well with processing of prointerleukin-1beta and prointerleukin-18 in phorbol 12-myristate 13-acetate (PMA)-stimulated cells. Tetradecanoylphorbol Acetate 127-130 interleukin 1 beta Homo sapiens 48-68 19776509-3 2009 The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta. Tetradecanoylphorbol Acetate 18-49 interleukin 1 beta Homo sapiens 162-170 19776509-3 2009 The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta. Tetradecanoylphorbol Acetate 51-54 interleukin 1 beta Homo sapiens 162-170 19776509-5 2009 In cells in which PMA-dependent PKC was down-regulated, PMA failed to induce the formation of NFkappaB DNA-protein complex and reduced the release of PMA-induced PGE(2), whereas IL-1beta stimulated the formation of COX-2-NFkappaB DNA-protein complex and PGE(2) release. Tetradecanoylphorbol Acetate 18-21 interleukin 1 beta Homo sapiens 178-186 24996056-2 2014 Here, we confirmed that IL-32theta, a new isoform of IL-32, decreased the phorbol 12-myristate 13-acetate (PMA)-induced IL-1beta expression in THP-1 human myelomonocyte. Tetradecanoylphorbol Acetate 74-105 interleukin 1 beta Homo sapiens 120-128 24996056-2 2014 Here, we confirmed that IL-32theta, a new isoform of IL-32, decreased the phorbol 12-myristate 13-acetate (PMA)-induced IL-1beta expression in THP-1 human myelomonocyte. Tetradecanoylphorbol Acetate 107-110 interleukin 1 beta Homo sapiens 120-128 22480848-4 2012 They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively. Tetradecanoylphorbol Acetate 24-27 interleukin 1 beta Homo sapiens 82-90 22480848-4 2012 They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively. Tetradecanoylphorbol Acetate 24-27 interleukin 1 beta Homo sapiens 185-193 21804018-8 2011 IRAK1/4 inhibitors, their small interfering RNAs, and JNK inhibitor also attenuated PMA-induced IL-1beta production. Tetradecanoylphorbol Acetate 84-87 interleukin 1 beta Homo sapiens 96-104 17681786-3 2007 In this study, we demonstrated that various inflammatory agents, including lipopolysaccharide, 12-o-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid and ceramide, were able to induce IL-1beta and TNF-alpha productions in human lung epithelial cells (A-549), fibroblasts (HFL1), and lymphoma cells (U-937). Tetradecanoylphorbol Acetate 95-131 interleukin 1 beta Homo sapiens 199-207 17094021-5 2007 DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 139-142 interleukin 1 beta Homo sapiens 84-92 17178924-6 2007 IL-1beta-, FBS-, or PMA-induced stabilization of B1 receptor mRNA was inhibited by the addition of the protein kinase C inhibitor 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride (GF-109203x), which also diminished the Bmax under FBS or PMA treatment. Tetradecanoylphorbol Acetate 20-23 interleukin 1 beta Homo sapiens 0-8 17079162-4 2007 Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells. Tetradecanoylphorbol Acetate 18-49 interleukin 1 beta Homo sapiens 174-196 16888805-4 2007 Here, we show that IL-1beta and TPA stimulated TNFalpha gene transcription in hepatoma cells mediated by a composite TPA-responsive element/cAMP response element. Tetradecanoylphorbol Acetate 117-120 interleukin 1 beta Homo sapiens 19-27 16888805-6 2007 Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression. Tetradecanoylphorbol Acetate 153-156 interleukin 1 beta Homo sapiens 233-241 16888805-6 2007 Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression. Tetradecanoylphorbol Acetate 246-249 interleukin 1 beta Homo sapiens 141-149 16888805-6 2007 Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression. Tetradecanoylphorbol Acetate 246-249 interleukin 1 beta Homo sapiens 233-241 15705185-6 2005 The effects of IL-1beta, which were reproduced by incubation of PTC with PMA (6.25-100 nmol/L), were blocked by H7 but not by BIM-1. Tetradecanoylphorbol Acetate 73-76 interleukin 1 beta Homo sapiens 15-23 16632868-3 2006 Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis. Tetradecanoylphorbol Acetate 82-113 interleukin 1 beta Homo sapiens 0-22 16632868-3 2006 Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis. Tetradecanoylphorbol Acetate 115-118 interleukin 1 beta Homo sapiens 0-22 16600024-8 2006 Phorbol myristate acetate-stimulated oxidative burst and IL-8 release by IL-1beta, lipopolysaccharide and GM-CSF in whole blood from mild but not severe asthmatics were inhibited after prednisolone. Tetradecanoylphorbol Acetate 0-25 interleukin 1 beta Homo sapiens 73-81 16026998-2 2005 In the cells activated by the protein kinase C specific phorbol ester (phorbol 12-myristate 13-acetate) and Ca(2+) ionophore (A23187) both adenosine and the subtype-specific receptor agonists, CPA (A1), CGS 21680 (A2A) and IB-MECA (A3) induced a concentration-dependent inhibition of IL-1beta release. Tetradecanoylphorbol Acetate 71-102 interleukin 1 beta Homo sapiens 284-292 11779159-4 2002 K562 cells treated with a combination of Lf and PMA showed a synergistic induction in the level of IL-1beta mRNA over treatment with PMA alone. Tetradecanoylphorbol Acetate 48-51 interleukin 1 beta Homo sapiens 99-107 12769672-8 2003 This technique was used to monitor the transcription patterns of mRNA encoding TNF-alpha, IL-1beta, and Interferon-gamma in human cell lines or primary PBMC treated with inducers such as PMA, ionomycin, and endotoxin. Tetradecanoylphorbol Acetate 187-190 interleukin 1 beta Homo sapiens 90-98 12510792-7 2002 In addition, Dodutang potently inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated human mast cells. Tetradecanoylphorbol Acetate 125-156 interleukin 1 beta Homo sapiens 99-121 12117969-4 2002 Vascular endothelial growth factor (VEGF), a direct inducer of angiogenesis, and interleukin-1beta (IL-1beta), a potentiator of VEGF, were detected within 12 and 6 h, respectively, in supernatants from phorbol 12-myristate 13-acetate-differentiated human THP-1 macrophages exposed to live B. henselae. Tetradecanoylphorbol Acetate 202-233 interleukin 1 beta Homo sapiens 81-98 12117969-4 2002 Vascular endothelial growth factor (VEGF), a direct inducer of angiogenesis, and interleukin-1beta (IL-1beta), a potentiator of VEGF, were detected within 12 and 6 h, respectively, in supernatants from phorbol 12-myristate 13-acetate-differentiated human THP-1 macrophages exposed to live B. henselae. Tetradecanoylphorbol Acetate 202-233 interleukin 1 beta Homo sapiens 100-108 15135313-2 2004 In this study, we demonstrate that resveratrol enhanced TNF-alpha, IL-12 and IL-1beta production from LPS activated phorbol myristate acetate (PMA) differentiated THP-1 human macrophages. Tetradecanoylphorbol Acetate 116-141 interleukin 1 beta Homo sapiens 77-85 14634065-3 2004 Although these are detectable even without stimulation, immunoglobulin (Ig)E receptor cross-linking is able to enhance only TNF-alpha production, but phorbol 12-myristate 13-acetate additionally promotes IL-1beta and IL-8. Tetradecanoylphorbol Acetate 150-181 interleukin 1 beta Homo sapiens 204-212 19180800-4 2003 Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively. Tetradecanoylphorbol Acetate 39-70 interleukin 1 beta Homo sapiens 153-175 19180800-4 2003 Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively. Tetradecanoylphorbol Acetate 72-75 interleukin 1 beta Homo sapiens 153-175 12576215-6 2003 When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 166-197 interleukin 1 beta Homo sapiens 82-104 11404058-4 2001 Interferon-gamma, phorbol myristate acetate and interleukin-6 all stimulated C9 mRNA expression but the inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, as well as the anaphylatoxin C5a and the bacterial lipopolysaccharide, were ineffective. Tetradecanoylphorbol Acetate 18-43 interleukin 1 beta Homo sapiens 156-174 11292747-8 2001 As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta. Tetradecanoylphorbol Acetate 95-120 interleukin 1 beta Homo sapiens 362-371 11446745-2 2001 IL-1beta up-regulation is not dependent on PKC but the PKC activator PMA induces low levels of GM-CSF production and acts synergistically with IL-1beta to further increase GM-CSF. Tetradecanoylphorbol Acetate 69-72 interleukin 1 beta Homo sapiens 0-8 11292747-8 2001 As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta. Tetradecanoylphorbol Acetate 122-125 interleukin 1 beta Homo sapiens 362-371 10766857-3 2000 We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation. Tetradecanoylphorbol Acetate 331-356 interleukin 1 beta Homo sapiens 83-91 10924071-4 2000 In addition, we examined whether PMA affects interleukin-1beta (IL-1beta) stimulation of COX-2 and PGE(2) production. Tetradecanoylphorbol Acetate 33-36 interleukin 1 beta Homo sapiens 64-72 10527453-7 1999 However, despite the ability of phorbol myristate acetate (PMA) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells, PLD activity was not affected by IL-1beta. Tetradecanoylphorbol Acetate 59-62 interleukin 1 beta Homo sapiens 191-199 9920928-2 1999 The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation. Tetradecanoylphorbol Acetate 67-98 interleukin 1 beta Homo sapiens 134-142 10092052-4 1999 The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta. Tetradecanoylphorbol Acetate 114-145 interleukin 1 beta Homo sapiens 28-36 10092052-4 1999 The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta. Tetradecanoylphorbol Acetate 147-150 interleukin 1 beta Homo sapiens 28-36 10092052-4 1999 The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta. Tetradecanoylphorbol Acetate 162-165 interleukin 1 beta Homo sapiens 28-36 9920928-2 1999 The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation. Tetradecanoylphorbol Acetate 100-103 interleukin 1 beta Homo sapiens 134-142 9218566-2 1997 PMA alone induced the production of low levels of IL-1beta in THP-1 cells, whereas dexamethasone alone had no effect. Tetradecanoylphorbol Acetate 0-3 interleukin 1 beta Homo sapiens 50-58 9877448-3 1998 However, IL-1beta mRNA was not expressed unless the cells had been treated with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 80-105 interleukin 1 beta Homo sapiens 9-17 9877448-3 1998 However, IL-1beta mRNA was not expressed unless the cells had been treated with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 107-110 interleukin 1 beta Homo sapiens 9-17 9877448-4 1998 Both IL-1alpha and IL-1beta were detected in the GCM after the cells had been cultured with PMA, suggesting that IL-1 elaboration required PMA treatment. Tetradecanoylphorbol Acetate 92-95 interleukin 1 beta Homo sapiens 19-27 9877448-4 1998 Both IL-1alpha and IL-1beta were detected in the GCM after the cells had been cultured with PMA, suggesting that IL-1 elaboration required PMA treatment. Tetradecanoylphorbol Acetate 92-95 interleukin 1 beta Homo sapiens 5-9 9877448-8 1998 On the other hand, both the expression and secretion of IL-1beta required treatment with PMA. Tetradecanoylphorbol Acetate 89-92 interleukin 1 beta Homo sapiens 56-64 9596483-6 1998 Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively. Tetradecanoylphorbol Acetate 118-121 interleukin 1 beta Homo sapiens 0-17 9596483-6 1998 Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively. Tetradecanoylphorbol Acetate 118-121 interleukin 1 beta Homo sapiens 19-27 9298128-1 1997 The in vitro growth of human hair follicles is inhibited by interleukin (IL)-1 beta and phorbol esters, such as phorbol-myristate-acetate (PMA), but enhanced by insulin-like growth factor (IGF)-I. Tetradecanoylphorbol Acetate 139-142 interleukin 1 beta Homo sapiens 60-83 9293391-9 1997 TPA increased RNA expression of the TNF-alpha, IL-1 alpha, IL-1 beta, IL-8 and TGF-beta 1. Tetradecanoylphorbol Acetate 0-3 interleukin 1 beta Homo sapiens 59-68 10051376-5 1999 Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner. Tetradecanoylphorbol Acetate 89-92 interleukin 1 beta Homo sapiens 62-70 9584910-4 1998 Furthermore, when the cells were treated simultaneously with a known protein kinase C (PKC) activator, phorbol 12-myristate-13-acetate (PMA) and TNFalpha in the presence of triclosan (0.5 microg/ml), the agent reduced the production of IL-1beta. Tetradecanoylphorbol Acetate 103-134 interleukin 1 beta Homo sapiens 236-244 9408252-7 1997 Production of both IL-6 and IL-8 was stimulated in a concentration-dependent fashion by interleukin-1beta (0.1-10 ng/ml), tumor necrosis factor-alpha (1-100 ng/ml), and bacterial lipopolysaccharide (0.1-10 microg/ml), and also by 100 nM phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 237-268 interleukin 1 beta Homo sapiens 88-105 9218566-6 1997 Using an oligonucleotide probe corresponding to an NF-kappaB DNA-binding motif of the IL-1beta gene promoter in gel electrophoresis mobility shift assays, we demonstrated that PMA-induced NF-kappaB activation was greatly potentiated by dexamethasone. Tetradecanoylphorbol Acetate 176-179 interleukin 1 beta Homo sapiens 86-94 9191470-7 1997 The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway. Tetradecanoylphorbol Acetate 240-265 interleukin 1 beta Homo sapiens 4-13 9191470-7 1997 The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway. Tetradecanoylphorbol Acetate 267-270 interleukin 1 beta Homo sapiens 4-13 9085940-3 1997 Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days. Tetradecanoylphorbol Acetate 39-75 interleukin 1 beta Homo sapiens 155-163 9150350-12 1997 Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta. Tetradecanoylphorbol Acetate 57-60 interleukin 1 beta Homo sapiens 117-134 9150350-12 1997 Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta. Tetradecanoylphorbol Acetate 57-60 interleukin 1 beta Homo sapiens 136-144 9150350-12 1997 Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta. Tetradecanoylphorbol Acetate 57-60 interleukin 1 beta Homo sapiens 264-272 9085940-3 1997 Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days. Tetradecanoylphorbol Acetate 39-75 interleukin 1 beta Homo sapiens 252-260 9085940-3 1997 Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days. Tetradecanoylphorbol Acetate 39-75 interleukin 1 beta Homo sapiens 252-260 9085940-3 1997 Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days. Tetradecanoylphorbol Acetate 77-80 interleukin 1 beta Homo sapiens 155-163 9085940-3 1997 Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days. Tetradecanoylphorbol Acetate 77-80 interleukin 1 beta Homo sapiens 252-260 9085940-3 1997 Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days. Tetradecanoylphorbol Acetate 77-80 interleukin 1 beta Homo sapiens 252-260 9085940-4 1997 Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level. Tetradecanoylphorbol Acetate 35-38 interleukin 1 beta Homo sapiens 83-91 9085940-4 1997 Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level. Tetradecanoylphorbol Acetate 35-38 interleukin 1 beta Homo sapiens 179-187 9085940-4 1997 Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level. Tetradecanoylphorbol Acetate 145-148 interleukin 1 beta Homo sapiens 83-91 9085940-4 1997 Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level. Tetradecanoylphorbol Acetate 145-148 interleukin 1 beta Homo sapiens 179-187 9010683-6 1996 Treatment of THP-1 cells with PMA and LPS caused the highest production of both IL-1 beta and IL-6 (> 5ng/ml). Tetradecanoylphorbol Acetate 30-33 interleukin 1 beta Homo sapiens 80-89 8973628-6 1996 Hypoxia had an overall inhibitory effect on cytokine release except for PMA-induced IL-1 beta release, and hypoxia/reoxygenation had a significant up-regulating effect except for a further inhibition of fMLP-induced release of TNF-alpha. Tetradecanoylphorbol Acetate 72-75 interleukin 1 beta Homo sapiens 84-93 8612684-5 1996 Phorbol ester (PMA), a PKC activator, induced stromelysin gene expression, an effect enhanced by the addition of IL-1 beta. Tetradecanoylphorbol Acetate 15-18 interleukin 1 beta Homo sapiens 113-122 8826848-3 1996 Tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) increased in several, but not all, cell lines the production of urokinase-type plasminogen activator (uPA), tissue-type PA (tPA) and plasminogen activator inhibitor type 1 (PAI-1) as analysed by zymography, enzyme immunoassays and Northern analysis. Tetradecanoylphorbol Acetate 200-203 interleukin 1 beta Homo sapiens 45-63 8826848-3 1996 Tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) increased in several, but not all, cell lines the production of urokinase-type plasminogen activator (uPA), tissue-type PA (tPA) and plasminogen activator inhibitor type 1 (PAI-1) as analysed by zymography, enzyme immunoassays and Northern analysis. Tetradecanoylphorbol Acetate 200-203 interleukin 1 beta Homo sapiens 65-74 8702428-3 1996 In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes. Tetradecanoylphorbol Acetate 84-109 interleukin 1 beta Homo sapiens 61-70 8702428-3 1996 In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes. Tetradecanoylphorbol Acetate 111-114 interleukin 1 beta Homo sapiens 61-70 8843226-0 1996 Decreased phorbol myristate acetate-induced release of tumor necrosis factor-alpha and interleukin-1 beta from peripheral blood monocytes of patients chronically infected with hepatitis C virus. Tetradecanoylphorbol Acetate 10-35 interleukin 1 beta Homo sapiens 87-105 8782659-6 1996 Similarly, growth inhibition and aromatase stimulation in response to TPA were both further enhanced by IL-1beta treatment. Tetradecanoylphorbol Acetate 70-73 interleukin 1 beta Homo sapiens 104-112 8753812-4 1996 The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production. Tetradecanoylphorbol Acetate 36-39 interleukin 1 beta Homo sapiens 123-141 8753812-4 1996 The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production. Tetradecanoylphorbol Acetate 36-39 interleukin 1 beta Homo sapiens 143-152 8753812-4 1996 The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production. Tetradecanoylphorbol Acetate 36-39 interleukin 1 beta Homo sapiens 178-187 8753812-5 1996 It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway. Tetradecanoylphorbol Acetate 131-134 interleukin 1 beta Homo sapiens 37-41 8753812-5 1996 It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway. Tetradecanoylphorbol Acetate 131-134 interleukin 1 beta Homo sapiens 339-343 7594450-1 1995 An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1 beta inducibility following treatment with LPS, PMA, or TNF-alpha. Tetradecanoylphorbol Acetate 206-209 interleukin 1 beta Homo sapiens 77-86 8615653-0 1996 Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21). Tetradecanoylphorbol Acetate 56-59 interleukin 1 beta Homo sapiens 28-32 7594450-1 1995 An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1 beta inducibility following treatment with LPS, PMA, or TNF-alpha. Tetradecanoylphorbol Acetate 206-209 interleukin 1 beta Homo sapiens 153-162 8186319-6 1994 Treatment with TPA for 48 h induced expression of IL-1 beta mRNA, an effect that was enhanced two fold by LPS. Tetradecanoylphorbol Acetate 15-18 interleukin 1 beta Homo sapiens 50-59 7576691-6 1995 Furthermore, treatment of REC monolayers with TNF-alpha or IL-1 beta significantly increased adhesion of PMA-stimulated eosinophils (P < 0.01). Tetradecanoylphorbol Acetate 105-108 interleukin 1 beta Homo sapiens 59-68 7544757-4 1995 Our results showed that U937 cells secreted TNF-alpha and IL-1 beta in response to either phorbyl 12-myristate 13-acetate (PMA) or IFN-gamma + LPS. Tetradecanoylphorbol Acetate 123-126 interleukin 1 beta Homo sapiens 58-67 7544757-5 1995 In contrast, AFP significantly suppressed PMA-induced TNF-alpha and IL-1 beta production by U937 cells in a time and dose dependent fashion. Tetradecanoylphorbol Acetate 42-45 interleukin 1 beta Homo sapiens 68-77 7473001-4 1995 Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts. Tetradecanoylphorbol Acetate 71-102 interleukin 1 beta Homo sapiens 209-218 7473001-4 1995 Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts. Tetradecanoylphorbol Acetate 104-107 interleukin 1 beta Homo sapiens 209-218 7480798-0 1995 Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis. Tetradecanoylphorbol Acetate 196-221 interleukin 1 beta Homo sapiens 0-18 7480798-0 1995 Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis. Tetradecanoylphorbol Acetate 223-226 interleukin 1 beta Homo sapiens 0-18 7480798-2 1995 Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms. Tetradecanoylphorbol Acetate 94-97 interleukin 1 beta Homo sapiens 0-18 7480798-2 1995 Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms. Tetradecanoylphorbol Acetate 94-97 interleukin 1 beta Homo sapiens 20-29 7480798-2 1995 Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms. Tetradecanoylphorbol Acetate 94-97 interleukin 1 beta Homo sapiens 132-141 7512570-7 1994 A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol. Tetradecanoylphorbol Acetate 45-76 interleukin 1 beta Homo sapiens 168-177 7552526-9 1995 IL-1 beta suppressed production of uPA and tPA in both types of SMCs. Tetradecanoylphorbol Acetate 43-46 interleukin 1 beta Homo sapiens 0-9 7544757-0 1995 Downregulation of phorbol 12-myristate 13-acetate-induced tumor necrosis factor-alpha and interleukin-1 beta production and gene expression in human monocytic cells by human alpha-fetoprotein. Tetradecanoylphorbol Acetate 18-49 interleukin 1 beta Homo sapiens 90-108 7482442-6 1995 In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged. Tetradecanoylphorbol Acetate 165-168 interleukin 1 beta Homo sapiens 194-212 7482442-6 1995 In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged. Tetradecanoylphorbol Acetate 165-168 interleukin 1 beta Homo sapiens 214-223 7853198-6 1995 Stimulation of cell-associated IL-1 alpha production by IL-1 beta or lipopolysaccharide was also inhibited by pretreatment with the PKC activator TPA, aplysiatoxin or teleocidin. Tetradecanoylphorbol Acetate 146-149 interleukin 1 beta Homo sapiens 56-65 7853198-8 1995 The present work indicates that the production of cell-associated IL-1 alpha stimulated by TNF-alpha, IL-1 beta or lipopolysaccharide is inhibited by treatment with TPA, aplysiatoxin or teleocidin. Tetradecanoylphorbol Acetate 165-168 interleukin 1 beta Homo sapiens 102-111 7774103-4 1995 By contrast, PMA-induced production of IL-1 beta was impaired in RA patients and was preceded by the disregulated expression of c-Fos and c-Jun proteins when compared with healthy donors. Tetradecanoylphorbol Acetate 13-16 interleukin 1 beta Homo sapiens 39-48 8112326-3 1994 Culture of Mono Mac 6 cells for 24 h with phorbol 12-myristate 13-acetate, bacterial lipopolysaccharide and the cytokines interleukin-1 beta and tumour necrosis factor-alpha enhanced mRNA abundance, with the strongest effect (tenfold) being observed with the lipopolysaccharide. Tetradecanoylphorbol Acetate 42-73 interleukin 1 beta Homo sapiens 122-173 8245177-1 1993 In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels. Tetradecanoylphorbol Acetate 19-50 interleukin 1 beta Homo sapiens 94-103 8256116-8 1993 Similar data were obtained with cells transfected with a reporter plasmid containing the PMA-responsive element (containing a putative AP-1 binding site) of the IL-1 beta gene. Tetradecanoylphorbol Acetate 89-92 interleukin 1 beta Homo sapiens 161-170 8413264-2 1993 Treatment of the transfected cells with various combinations of the inducers lipopolysaccharide, phorbol myristate acetate, and dibutyryl cyclic AMP upregulated the IL-1 beta promoter. Tetradecanoylphorbol Acetate 97-122 interleukin 1 beta Homo sapiens 165-174 8245177-1 1993 In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels. Tetradecanoylphorbol Acetate 52-55 interleukin 1 beta Homo sapiens 94-103 8360592-5 1993 While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed. Tetradecanoylphorbol Acetate 6-31 interleukin 1 beta Homo sapiens 40-49 8134164-5 1993 When treated with 12-o-tetradecanoylphorbol 13-acetate, KP-1 cells became tightly adherent, showed the enhanced reactivity for alpha-naphtyl butyrate esterase, and produced several monokines such as IL-1 beta, tumor necrosis factor-alpha, and macrophage colony-stimulating factor. Tetradecanoylphorbol Acetate 18-54 interleukin 1 beta Homo sapiens 199-237 8386622-2 1993 We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60). Tetradecanoylphorbol Acetate 156-159 interleukin 1 beta Homo sapiens 168-186 8500546-4 1993 Heat shock protein 70 gene was initially down regulated and was induced only after 48 h. The well-differentiated malignant keratinocyte cell line differed in that the c-fos, GADD, SPR1, and IL1-beta genes had several-fold higher induction, but involucrin mRNA was undetectable and fibronectin mRNA was only minimally induced after TPA stimulation. Tetradecanoylphorbol Acetate 331-334 interleukin 1 beta Homo sapiens 190-198 8394087-3 1993 Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8. Tetradecanoylphorbol Acetate 21-52 interleukin 1 beta Homo sapiens 259-282 8386622-2 1993 We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60). Tetradecanoylphorbol Acetate 156-159 interleukin 1 beta Homo sapiens 187-196 8441379-7 1993 When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity. Tetradecanoylphorbol Acetate 95-120 interleukin 1 beta Homo sapiens 56-68 8436909-5 1993 PMA-treated, but not untreated cells, displayed an additional peptide derived from interleukin 1 beta. Tetradecanoylphorbol Acetate 0-3 interleukin 1 beta Homo sapiens 83-101 8454038-1 1993 The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated. Tetradecanoylphorbol Acetate 125-128 interleukin 1 beta Homo sapiens 58-76 8454038-1 1993 The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated. Tetradecanoylphorbol Acetate 125-128 interleukin 1 beta Homo sapiens 78-87 8427707-0 1993 Regulation of interleukin-1ra, interleukin-1 alpha, and interleukin-1 beta production by human alveolar macrophages with phorbol myristate acetate, lipopolysaccharide, and interleukin-4. Tetradecanoylphorbol Acetate 121-146 interleukin 1 beta Homo sapiens 56-74 8457632-1 1993 Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro. Tetradecanoylphorbol Acetate 79-104 interleukin 1 beta Homo sapiens 150-168 8457632-1 1993 Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro. Tetradecanoylphorbol Acetate 79-104 interleukin 1 beta Homo sapiens 170-179 8457632-1 1993 Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro. Tetradecanoylphorbol Acetate 106-109 interleukin 1 beta Homo sapiens 150-168 8457632-1 1993 Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro. Tetradecanoylphorbol Acetate 106-109 interleukin 1 beta Homo sapiens 170-179 8457632-6 1993 Challenge with PMA induced low levels of IL-1 beta production with a relatively large percentage released. Tetradecanoylphorbol Acetate 15-18 interleukin 1 beta Homo sapiens 41-50 8512018-7 1993 After treatment with PMA and LPS, IL-1 alpha was detected in the culture fluid from two other lines and IL-1 beta in the medium from three lines. Tetradecanoylphorbol Acetate 21-24 interleukin 1 beta Homo sapiens 104-113 8441379-7 1993 When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity. Tetradecanoylphorbol Acetate 95-120 interleukin 1 beta Homo sapiens 174-186 1421015-8 1992 Recombinant IL-1 beta induced a very low level of TNF alpha production in PMA-treated cells. Tetradecanoylphorbol Acetate 74-77 interleukin 1 beta Homo sapiens 12-21 1292632-3 1992 After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels. Tetradecanoylphorbol Acetate 23-48 interleukin 1 beta Homo sapiens 105-123 1292632-3 1992 After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels. Tetradecanoylphorbol Acetate 23-48 interleukin 1 beta Homo sapiens 125-134 1384479-5 1992 The tumor promoter, tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the stimulatory effect of IL-1 alpha and IL-1 beta on the production of HGF. Tetradecanoylphorbol Acetate 53-56 interleukin 1 beta Homo sapiens 117-126 1533323-8 1992 However, this phenomenon was not specific for LPS; 1 microgram/mL IL-1ra inhibited IL-1 beta synthesized in response to human recombinant IL-2 by 44% (P less than .001), toxic shock syndrome toxin-1 by 26% (P less than .05), and phorbol 12-myristate 13-acetate by 76% (P less than .001). Tetradecanoylphorbol Acetate 229-260 interleukin 1 beta Homo sapiens 83-92 1627264-6 1992 Preincubation by IL-1 beta enhanced the effect of a secondary challenge with phorbol 12-myristate 13-acetate or formyl-Met-Leu-Phe by 30-40%. Tetradecanoylphorbol Acetate 77-108 interleukin 1 beta Homo sapiens 17-26 1371135-2 1992 After treatment with phorbol ester (PMA) or TNF-alpha, a 20- to 40-fold increase in the level of IL-1 beta mRNA was observed in the HIV-infected PLB-IIIB as compared with the parental PLB-985 cells. Tetradecanoylphorbol Acetate 36-39 interleukin 1 beta Homo sapiens 97-106 1545152-5 1992 PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein. Tetradecanoylphorbol Acetate 0-3 interleukin 1 beta Homo sapiens 100-109 1904515-8 1991 Further investigations on the regulation of cytokine production and release by TPA-differentiated U937 cells revealed that TNF-alpha and IL-1 beta synthesis was not influenced by exogenously added rhTNF-alpha or PGE2, whereas rh gamma-IFN specifically enhanced the IL-1 beta production. Tetradecanoylphorbol Acetate 79-82 interleukin 1 beta Homo sapiens 137-146 1646841-2 1991 Both protein kinase C-activating phorbol esters, e.g., PMA, and LPS induce IL-1 beta expression in these cells. Tetradecanoylphorbol Acetate 55-58 interleukin 1 beta Homo sapiens 75-84 2040654-1 1991 Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937. Tetradecanoylphorbol Acetate 15-52 interleukin 1 beta Homo sapiens 112-130 2040654-1 1991 Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937. Tetradecanoylphorbol Acetate 15-52 interleukin 1 beta Homo sapiens 132-141 2040654-1 1991 Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937. Tetradecanoylphorbol Acetate 54-57 interleukin 1 beta Homo sapiens 112-130 2040654-1 1991 Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937. Tetradecanoylphorbol Acetate 54-57 interleukin 1 beta Homo sapiens 132-141 2040654-2 1991 Here we investigated the effect of treatment with both TPA and 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) on LPS-induced IL-1 beta production in U937 cells. Tetradecanoylphorbol Acetate 55-58 interleukin 1 beta Homo sapiens 124-133 2040654-4 1991 Combined treatment with TPA and 1,25(OH)2D3 for 72 h followed by incubation with LPS for 24 h caused synergistic induction of both IL-1 beta release and mRNA expression. Tetradecanoylphorbol Acetate 24-27 interleukin 1 beta Homo sapiens 131-140 1661292-2 1991 Peripheral monocytes and myelomonocytic cell lines could be stimulated by LPS or phorbol myristate acetate (PMA) to express IL-1 mRNA. Tetradecanoylphorbol Acetate 81-106 interleukin 1 beta Homo sapiens 124-128 1661292-2 1991 Peripheral monocytes and myelomonocytic cell lines could be stimulated by LPS or phorbol myristate acetate (PMA) to express IL-1 mRNA. Tetradecanoylphorbol Acetate 108-111 interleukin 1 beta Homo sapiens 124-128 1661292-3 1991 Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone. Tetradecanoylphorbol Acetate 87-90 interleukin 1 beta Homo sapiens 189-198 1661797-4 1991 Treatment with purified human monocyte interleukin-1 beta, partially purified lapine, synovial IL-1 or phorbol myristate acetate strongly induced the synthesis of all these enzymes. Tetradecanoylphorbol Acetate 103-128 interleukin 1 beta Homo sapiens 39-57 1661739-10 1991 Together with the results obtained with phorbol myristate acetate, these data suggest that protein kinase C may play a role in the upregulation of IL-1 beta expression in normal skin fibroblasts. Tetradecanoylphorbol Acetate 40-65 interleukin 1 beta Homo sapiens 147-156 1797949-1 1991 A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors. Tetradecanoylphorbol Acetate 58-83 interleukin 1 beta Homo sapiens 182-200 1797949-1 1991 A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors. Tetradecanoylphorbol Acetate 85-88 interleukin 1 beta Homo sapiens 182-200 1768743-3 1991 However, treatment of these cells with phorbol myristate acetate (PMA) resulted in the expression of IL-1 beta mRNA. Tetradecanoylphorbol Acetate 39-64 interleukin 1 beta Homo sapiens 101-110 1768743-3 1991 However, treatment of these cells with phorbol myristate acetate (PMA) resulted in the expression of IL-1 beta mRNA. Tetradecanoylphorbol Acetate 66-69 interleukin 1 beta Homo sapiens 101-110 1903479-4 1991 In human lung fibroblasts and in human umbilical vein endothelial cells, LIF was constitutively expressed and its accumulation was increased in a time-dependent manner following treatment with the phorbol ester TPA and in the presence of the two immediate response cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1-beta. Tetradecanoylphorbol Acetate 211-214 interleukin 1 beta Homo sapiens 313-336 1713637-6 1991 In contrast, IL-1 beta, TNF, and TPA equally stimulated increased levels of M-CSF, GM-CSF, IL-1 beta and IL-6 RNAs. Tetradecanoylphorbol Acetate 33-36 interleukin 1 beta Homo sapiens 91-100 2175219-3 1990 In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines. Tetradecanoylphorbol Acetate 94-119 interleukin 1 beta Homo sapiens 174-183 2175219-3 1990 In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines. Tetradecanoylphorbol Acetate 94-119 interleukin 1 beta Homo sapiens 220-229 2175219-3 1990 In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines. Tetradecanoylphorbol Acetate 121-124 interleukin 1 beta Homo sapiens 174-183 2143761-1 1990 Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells. Tetradecanoylphorbol Acetate 30-61 interleukin 1 beta Homo sapiens 99-118 2175219-3 1990 In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines. Tetradecanoylphorbol Acetate 121-124 interleukin 1 beta Homo sapiens 220-229 2175219-7 1990 PKC inhibitor, H7, also blocked effectively the PMA plus dbcAMP induced IL-1 beta production, while the protein kinase A (PKA) inhibitor, HA1004, had no effect, suggesting that PKA activation is not involved in the mechanism of action of cAMP in this case. Tetradecanoylphorbol Acetate 48-51 interleukin 1 beta Homo sapiens 72-81 1698820-3 1990 After exposure to LPS (10 micrograms/ml) and 12-O-tetradecanoylphorbol-13-acetate (TPA, 100 nM) for 12 h, these HIV-1-infected monoblasts accumulated 8-15-fold greater levels of IL-1 beta RNA as compared with their HIV-1-uninfected counterparts that were similarly stimulated. Tetradecanoylphorbol Acetate 45-81 interleukin 1 beta Homo sapiens 178-187 1698820-3 1990 After exposure to LPS (10 micrograms/ml) and 12-O-tetradecanoylphorbol-13-acetate (TPA, 100 nM) for 12 h, these HIV-1-infected monoblasts accumulated 8-15-fold greater levels of IL-1 beta RNA as compared with their HIV-1-uninfected counterparts that were similarly stimulated. Tetradecanoylphorbol Acetate 83-86 interleukin 1 beta Homo sapiens 178-187 1698820-6 1990 Time-course experiments showed that the maximal levels of IL-1 beta RNA occurred at 12 and 24 h after LPS and TPA stimulation of the HIV-1-infected and uninfected U937 cells, respectively. Tetradecanoylphorbol Acetate 110-113 interleukin 1 beta Homo sapiens 58-67 1698820-7 1990 Studies of stability of RNA using actinomycin D showed that IL-1 beta RNA was equally stable in infected and uninfected U937 cells after their stimulation with TPA and LPS. Tetradecanoylphorbol Acetate 160-163 interleukin 1 beta Homo sapiens 60-69 2143761-1 1990 Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells. Tetradecanoylphorbol Acetate 30-61 interleukin 1 beta Homo sapiens 174-183 2143761-1 1990 Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells. Tetradecanoylphorbol Acetate 30-61 interleukin 1 beta Homo sapiens 114-118 34578957-0 2021 Kaempferol Blocks the Skin Fibroblastic Interleukin 1beta Expression and Cytotoxicity Induced by 12-O-tetradecanoylphorbol-13-acetate by Suppressing c-Jun N-terminal Kinase. Tetradecanoylphorbol Acetate 97-133 interleukin 1 beta Homo sapiens 40-57 35140721-6 2022 Moreover, the 3D culture system was more suitable for the observation of neutrophil extracellular traps (NETs) stimulated by the classical stimulation phorbol ester (PMA), and other damage associated molecular patterns (DAMPs) such as Lipopolysaccharide (LPS)/ATP, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) than the 2D culture system. Tetradecanoylphorbol Acetate 166-169 interleukin 1 beta Homo sapiens 265-283 2801310-3 1989 In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS. Tetradecanoylphorbol Acetate 57-88 interleukin 1 beta Homo sapiens 155-164 2511200-5 1989 Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone. Tetradecanoylphorbol Acetate 19-44 interleukin 1 beta Homo sapiens 184-193 2511200-5 1989 Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone. Tetradecanoylphorbol Acetate 46-49 interleukin 1 beta Homo sapiens 184-193 2511200-5 1989 Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone. Tetradecanoylphorbol Acetate 233-236 interleukin 1 beta Homo sapiens 184-193 2511200-13 1989 The present findings thus suggest: 1) that TPA induces LPS responsiveness in U937 cells via de novo synthesis of Gi2; 2) that the LPS response (enhanced IL-1 production) is linked to a pertussis toxin-sensitive G protein which we identified as Gi2; and 3) that LPS leads to phosphorylation of Gi2. Tetradecanoylphorbol Acetate 43-46 interleukin 1 beta Homo sapiens 153-157 2801310-3 1989 In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS. Tetradecanoylphorbol Acetate 90-93 interleukin 1 beta Homo sapiens 155-164 2787167-4 1989 Addition of TPA to serum-starved U937 cells induced the expression of the interleukin 1 beta (IL-1 beta) gene. Tetradecanoylphorbol Acetate 12-15 interleukin 1 beta Homo sapiens 74-92 2500449-5 1989 Tumor necrosis factor alpha (TNF alpha) and activators of protein kinase C including 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin induced the accumulation of IL-1 beta mRNA in human fibroblasts (WI-38). Tetradecanoylphorbol Acetate 85-121 interleukin 1 beta Homo sapiens 171-180 2500449-5 1989 Tumor necrosis factor alpha (TNF alpha) and activators of protein kinase C including 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin induced the accumulation of IL-1 beta mRNA in human fibroblasts (WI-38). Tetradecanoylphorbol Acetate 123-126 interleukin 1 beta Homo sapiens 171-180 2500449-8 1989 Stability of IL-1 beta mRNA in fibroblasts exposed to TPA was more than fourfold greater than after fibroblasts were exposed to either TNF alpha or cycloheximide. Tetradecanoylphorbol Acetate 54-57 interleukin 1 beta Homo sapiens 13-22 2787167-6 1989 Higher concentrations of TPA, which partially or totally depleted protein kinase C levels in the cells (10(-9)-2 X 10(-5) M), had an inhibitory effect on IL-1 beta mRNA expression. Tetradecanoylphorbol Acetate 25-28 interleukin 1 beta Homo sapiens 154-163 2787167-4 1989 Addition of TPA to serum-starved U937 cells induced the expression of the interleukin 1 beta (IL-1 beta) gene. Tetradecanoylphorbol Acetate 12-15 interleukin 1 beta Homo sapiens 94-103 2496956-3 1989 We used the phorbol ester/lipopolysaccharide (PMA + LPS) co-induction of IL-1 mRNA and CD13 expression in U937 cells to demonstrate the specificity of the technique. Tetradecanoylphorbol Acetate 46-49 interleukin 1 beta Homo sapiens 73-77 3311846-4 1987 Decrease in antigen-positive cells is delayed in LPS/TNF versus IL-1-alpha, beta/TPA-induced antigen expression (LPS vs. IL-1-beta: 60% vs. 5% at 24 h). Tetradecanoylphorbol Acetate 81-84 interleukin 1 beta Homo sapiens 121-130 3263853-1 1988 The acute monocytic leukemia cell line THP-1 secretes predominantly IL-1 beta after treatment with bacterial lipopolysaccharide and tumour promoting phorbol ester (PMA). Tetradecanoylphorbol Acetate 164-167 interleukin 1 beta Homo sapiens 68-77 3137260-6 1988 (90,000), which co-migrated with purified plasma factor B. Incubation of U-937 cells with the immunostimulants PMA, LPS, IFN-gamma, and IL-1 resulted in a dose-dependent augmentation of factor B production. Tetradecanoylphorbol Acetate 111-114 interleukin 1 beta Homo sapiens 136-140 2838419-5 1988 However, exposure of monocytes to recombinant IL 1 alpha or IL 1 beta resulted in enhanced generation of superoxide response following stimulation with PMA. Tetradecanoylphorbol Acetate 152-155 interleukin 1 beta Homo sapiens 60-69 3023484-1 1986 The tumor co-promotor TPA is believed to enhance a wide variety of cellular processes by interacting with protein kinase C. Interleukin (IL 1) is a family of highly active molecules which augments the host response to infection. Tetradecanoylphorbol Acetate 22-25 interleukin 1 beta Homo sapiens 137-141 3023484-4 1986 Superoxide anion production by eosinophils stimulated with standard doses of the stimulant phorbol myristic acetate (TPA) (1 microgram/ml) was augmented approximately 20% by preincubation with IL 1. Tetradecanoylphorbol Acetate 117-120 interleukin 1 beta Homo sapiens 193-197 3023484-6 1986 At suboptimal doses of TPA, there was a dose-dependent inhibition of superoxide anion production in the presence of IL 1. Tetradecanoylphorbol Acetate 23-26 interleukin 1 beta Homo sapiens 116-120 3023484-8 1986 When IL 1 was added to eosinophils stimulated by TPA in the presence of calcium ionophore, there was a dose-dependent increase in superoxide anion production. Tetradecanoylphorbol Acetate 49-52 interleukin 1 beta Homo sapiens 5-9 3023484-14 1986 IL 1 may also modify the response of eosinophils to other stimuli such as ionophore and TPA. Tetradecanoylphorbol Acetate 88-91 interleukin 1 beta Homo sapiens 0-4