PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14634065-3	2004	Although these are detectable even without stimulation, immunoglobulin (Ig)E receptor cross-linking is able to enhance only TNF-alpha production, but phorbol 12-myristate 13-acetate additionally promotes IL-1beta and IL-8.	Tetradecanoylphorbol Acetate	150-181	interleukin 1 beta	Homo sapiens	204-212	
12510792-7	2002	In addition, Dodutang potently inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated human mast cells.	Tetradecanoylphorbol Acetate	125-156	interleukin 1 beta	Homo sapiens	99-121	
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	Tetradecanoylphorbol Acetate	39-70	interleukin 1 beta	Homo sapiens	153-175	
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	Tetradecanoylphorbol Acetate	72-75	interleukin 1 beta	Homo sapiens	153-175	
12769672-8	2003	This technique was used to monitor the transcription patterns of mRNA encoding TNF-alpha, IL-1beta, and Interferon-gamma in human cell lines or primary PBMC treated with inducers such as PMA, ionomycin, and endotoxin.	Tetradecanoylphorbol Acetate	187-190	interleukin 1 beta	Homo sapiens	90-98	
12576215-6	2003	When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	166-197	interleukin 1 beta	Homo sapiens	82-104	
12117969-4	2002	Vascular endothelial growth factor (VEGF), a direct inducer of angiogenesis, and interleukin-1beta (IL-1beta), a potentiator of VEGF, were detected within 12 and 6 h, respectively, in supernatants from phorbol 12-myristate 13-acetate-differentiated human THP-1 macrophages exposed to live B. henselae.	Tetradecanoylphorbol Acetate	202-233	interleukin 1 beta	Homo sapiens	81-98	
12117969-4	2002	Vascular endothelial growth factor (VEGF), a direct inducer of angiogenesis, and interleukin-1beta (IL-1beta), a potentiator of VEGF, were detected within 12 and 6 h, respectively, in supernatants from phorbol 12-myristate 13-acetate-differentiated human THP-1 macrophages exposed to live B. henselae.	Tetradecanoylphorbol Acetate	202-233	interleukin 1 beta	Homo sapiens	100-108	
11779159-4	2002	K562 cells treated with a combination of Lf and PMA showed a synergistic induction in the level of IL-1beta mRNA over treatment with PMA alone.	Tetradecanoylphorbol Acetate	48-51	interleukin 1 beta	Homo sapiens	99-107	
11446745-2	2001	IL-1beta up-regulation is not dependent on PKC but the PKC activator PMA induces low levels of GM-CSF production and acts synergistically with IL-1beta to further increase GM-CSF.	Tetradecanoylphorbol Acetate	69-72	interleukin 1 beta	Homo sapiens	0-8	
11404058-4	2001	Interferon-gamma, phorbol myristate acetate and interleukin-6 all stimulated C9 mRNA expression but the inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, as well as the anaphylatoxin C5a and the bacterial lipopolysaccharide, were ineffective.	Tetradecanoylphorbol Acetate	18-43	interleukin 1 beta	Homo sapiens	156-174	
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Tetradecanoylphorbol Acetate	89-92	interleukin 1 beta	Homo sapiens	62-70	
10924071-4	2000	In addition, we examined whether PMA affects interleukin-1beta (IL-1beta) stimulation of COX-2 and PGE(2) production.	Tetradecanoylphorbol Acetate	33-36	interleukin 1 beta	Homo sapiens	64-72	
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	331-356	interleukin 1 beta	Homo sapiens	83-91	
10092052-4	1999	The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta.	Tetradecanoylphorbol Acetate	114-145	interleukin 1 beta	Homo sapiens	28-36	
10092052-4	1999	The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta.	Tetradecanoylphorbol Acetate	147-150	interleukin 1 beta	Homo sapiens	28-36	
10092052-4	1999	The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta.	Tetradecanoylphorbol Acetate	162-165	interleukin 1 beta	Homo sapiens	28-36	
9920928-2	1999	The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation.	Tetradecanoylphorbol Acetate	67-98	interleukin 1 beta	Homo sapiens	134-142	
9920928-2	1999	The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 beta	Homo sapiens	134-142	
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	95-120	interleukin 1 beta	Homo sapiens	362-371	
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	122-125	interleukin 1 beta	Homo sapiens	362-371	
10527453-7	1999	However, despite the ability of phorbol myristate acetate (PMA) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells, PLD activity was not affected by IL-1beta.	Tetradecanoylphorbol Acetate	59-62	interleukin 1 beta	Homo sapiens	191-199	
9293391-9	1997	TPA increased RNA expression of the TNF-alpha, IL-1 alpha, IL-1 beta, IL-8 and TGF-beta 1.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	59-68	
9877448-3	1998	However, IL-1beta mRNA was not expressed unless the cells had been treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	80-105	interleukin 1 beta	Homo sapiens	9-17	
9877448-3	1998	However, IL-1beta mRNA was not expressed unless the cells had been treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	107-110	interleukin 1 beta	Homo sapiens	9-17	
9877448-4	1998	Both IL-1alpha and IL-1beta were detected in the GCM after the cells had been cultured with PMA, suggesting that IL-1 elaboration required PMA treatment.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 beta	Homo sapiens	19-27	
9877448-4	1998	Both IL-1alpha and IL-1beta were detected in the GCM after the cells had been cultured with PMA, suggesting that IL-1 elaboration required PMA treatment.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 beta	Homo sapiens	5-9	
9877448-8	1998	On the other hand, both the expression and secretion of IL-1beta required treatment with PMA.	Tetradecanoylphorbol Acetate	89-92	interleukin 1 beta	Homo sapiens	56-64	
9584910-4	1998	Furthermore, when the cells were treated simultaneously with a known protein kinase C (PKC) activator, phorbol 12-myristate-13-acetate (PMA) and TNFalpha in the presence of triclosan (0.5 microg/ml), the agent reduced the production of IL-1beta.	Tetradecanoylphorbol Acetate	103-134	interleukin 1 beta	Homo sapiens	236-244	
9596483-6	1998	Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 beta	Homo sapiens	0-17	
9596483-6	1998	Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 beta	Homo sapiens	19-27	
9408252-7	1997	Production of both IL-6 and IL-8 was stimulated in a concentration-dependent fashion by interleukin-1beta (0.1-10 ng/ml), tumor necrosis factor-alpha (1-100 ng/ml), and bacterial lipopolysaccharide (0.1-10 microg/ml), and also by 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	237-268	interleukin 1 beta	Homo sapiens	88-105	
9298128-1	1997	The in vitro growth of human hair follicles is inhibited by interleukin (IL)-1 beta and phorbol esters, such as phorbol-myristate-acetate (PMA), but enhanced by insulin-like growth factor (IGF)-I.	Tetradecanoylphorbol Acetate	139-142	interleukin 1 beta	Homo sapiens	60-83	
9218566-2	1997	PMA alone induced the production of low levels of IL-1beta in THP-1 cells, whereas dexamethasone alone had no effect.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	50-58	
9218566-6	1997	Using an oligonucleotide probe corresponding to an NF-kappaB DNA-binding motif of the IL-1beta gene promoter in gel electrophoresis mobility shift assays, we demonstrated that PMA-induced NF-kappaB activation was greatly potentiated by dexamethasone.	Tetradecanoylphorbol Acetate	176-179	interleukin 1 beta	Homo sapiens	86-94	
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	39-75	interleukin 1 beta	Homo sapiens	155-163	
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	Tetradecanoylphorbol Acetate	240-265	interleukin 1 beta	Homo sapiens	4-13	
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	Tetradecanoylphorbol Acetate	267-270	interleukin 1 beta	Homo sapiens	4-13	
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Homo sapiens	117-134	
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Homo sapiens	136-144	
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Homo sapiens	264-272	
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	39-75	interleukin 1 beta	Homo sapiens	252-260	
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	39-75	interleukin 1 beta	Homo sapiens	252-260	
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 beta	Homo sapiens	155-163	
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 beta	Homo sapiens	252-260	
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 beta	Homo sapiens	252-260	
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	35-38	interleukin 1 beta	Homo sapiens	83-91	
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	35-38	interleukin 1 beta	Homo sapiens	179-187	
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	145-148	interleukin 1 beta	Homo sapiens	83-91	
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	145-148	interleukin 1 beta	Homo sapiens	179-187	
8973628-6	1996	Hypoxia had an overall inhibitory effect on cytokine release except for PMA-induced IL-1 beta release, and hypoxia/reoxygenation had a significant up-regulating effect except for a further inhibition of fMLP-induced release of TNF-alpha.	Tetradecanoylphorbol Acetate	72-75	interleukin 1 beta	Homo sapiens	84-93	
9010683-6	1996	Treatment of THP-1 cells with PMA and LPS caused the highest production of both IL-1 beta and IL-6 (> 5ng/ml).	Tetradecanoylphorbol Acetate	30-33	interleukin 1 beta	Homo sapiens	80-89	
8782659-6	1996	Similarly, growth inhibition and aromatase stimulation in response to TPA were both further enhanced by IL-1beta treatment.	Tetradecanoylphorbol Acetate	70-73	interleukin 1 beta	Homo sapiens	104-112	
8843226-0	1996	Decreased phorbol myristate acetate-induced release of tumor necrosis factor-alpha and interleukin-1 beta from peripheral blood monocytes of patients chronically infected with hepatitis C virus.	Tetradecanoylphorbol Acetate	10-35	interleukin 1 beta	Homo sapiens	87-105	
8615653-0	1996	Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21).	Tetradecanoylphorbol Acetate	56-59	interleukin 1 beta	Homo sapiens	28-32	
8826848-3	1996	Tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) increased in several, but not all, cell lines the production of urokinase-type plasminogen activator (uPA), tissue-type PA (tPA) and plasminogen activator inhibitor type 1 (PAI-1) as analysed by zymography, enzyme immunoassays and Northern analysis.	Tetradecanoylphorbol Acetate	200-203	interleukin 1 beta	Homo sapiens	45-63	
8826848-3	1996	Tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) increased in several, but not all, cell lines the production of urokinase-type plasminogen activator (uPA), tissue-type PA (tPA) and plasminogen activator inhibitor type 1 (PAI-1) as analysed by zymography, enzyme immunoassays and Northern analysis.	Tetradecanoylphorbol Acetate	200-203	interleukin 1 beta	Homo sapiens	65-74	
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	123-141	
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	143-152	
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	178-187	
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	interleukin 1 beta	Homo sapiens	37-41	
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	interleukin 1 beta	Homo sapiens	339-343	
8612684-5	1996	Phorbol ester (PMA), a PKC activator, induced stromelysin gene expression, an effect enhanced by the addition of IL-1 beta.	Tetradecanoylphorbol Acetate	15-18	interleukin 1 beta	Homo sapiens	113-122	
8702428-3	1996	In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes.	Tetradecanoylphorbol Acetate	84-109	interleukin 1 beta	Homo sapiens	61-70	
8702428-3	1996	In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes.	Tetradecanoylphorbol Acetate	111-114	interleukin 1 beta	Homo sapiens	61-70	
7544757-0	1995	Downregulation of phorbol 12-myristate 13-acetate-induced tumor necrosis factor-alpha and interleukin-1 beta production and gene expression in human monocytic cells by human alpha-fetoprotein.	Tetradecanoylphorbol Acetate	18-49	interleukin 1 beta	Homo sapiens	90-108	
7594450-1	1995	An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1 beta inducibility following treatment with LPS, PMA, or TNF-alpha.	Tetradecanoylphorbol Acetate	206-209	interleukin 1 beta	Homo sapiens	77-86	
7594450-1	1995	An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1 beta inducibility following treatment with LPS, PMA, or TNF-alpha.	Tetradecanoylphorbol Acetate	206-209	interleukin 1 beta	Homo sapiens	153-162	
7576691-6	1995	Furthermore, treatment of REC monolayers with TNF-alpha or IL-1 beta significantly increased adhesion of PMA-stimulated eosinophils (P < 0.01).	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Homo sapiens	59-68	
7552526-9	1995	IL-1 beta suppressed production of uPA and tPA in both types of SMCs.	Tetradecanoylphorbol Acetate	43-46	interleukin 1 beta	Homo sapiens	0-9	
7544757-4	1995	Our results showed that U937 cells secreted TNF-alpha and IL-1 beta in response to either phorbyl 12-myristate 13-acetate (PMA) or IFN-gamma + LPS.	Tetradecanoylphorbol Acetate	123-126	interleukin 1 beta	Homo sapiens	58-67	
7544757-5	1995	In contrast, AFP significantly suppressed PMA-induced TNF-alpha and IL-1 beta production by U937 cells in a time and dose dependent fashion.	Tetradecanoylphorbol Acetate	42-45	interleukin 1 beta	Homo sapiens	68-77	
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Tetradecanoylphorbol Acetate	71-102	interleukin 1 beta	Homo sapiens	209-218	
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 beta	Homo sapiens	194-212	
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 beta	Homo sapiens	214-223	
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Tetradecanoylphorbol Acetate	104-107	interleukin 1 beta	Homo sapiens	209-218	
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Tetradecanoylphorbol Acetate	196-221	interleukin 1 beta	Homo sapiens	0-18	
7853198-6	1995	Stimulation of cell-associated IL-1 alpha production by IL-1 beta or lipopolysaccharide was also inhibited by pretreatment with the PKC activator TPA, aplysiatoxin or teleocidin.	Tetradecanoylphorbol Acetate	146-149	interleukin 1 beta	Homo sapiens	56-65	
7853198-8	1995	The present work indicates that the production of cell-associated IL-1 alpha stimulated by TNF-alpha, IL-1 beta or lipopolysaccharide is inhibited by treatment with TPA, aplysiatoxin or teleocidin.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 beta	Homo sapiens	102-111	
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Tetradecanoylphorbol Acetate	223-226	interleukin 1 beta	Homo sapiens	0-18	
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Tetradecanoylphorbol Acetate	94-97	interleukin 1 beta	Homo sapiens	0-18	
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Tetradecanoylphorbol Acetate	94-97	interleukin 1 beta	Homo sapiens	20-29	
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Tetradecanoylphorbol Acetate	94-97	interleukin 1 beta	Homo sapiens	132-141	
7774103-4	1995	By contrast, PMA-induced production of IL-1 beta was impaired in RA patients and was preceded by the disregulated expression of c-Fos and c-Jun proteins when compared with healthy donors.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 beta	Homo sapiens	39-48	
8112326-3	1994	Culture of Mono Mac 6 cells for 24 h with phorbol 12-myristate 13-acetate, bacterial lipopolysaccharide and the cytokines interleukin-1 beta and tumour necrosis factor-alpha enhanced mRNA abundance, with the strongest effect (tenfold) being observed with the lipopolysaccharide.	Tetradecanoylphorbol Acetate	42-73	interleukin 1 beta	Homo sapiens	122-173	
7512570-7	1994	A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol.	Tetradecanoylphorbol Acetate	45-76	interleukin 1 beta	Homo sapiens	168-177	
8134164-5	1993	When treated with 12-o-tetradecanoylphorbol 13-acetate, KP-1 cells became tightly adherent, showed the enhanced reactivity for alpha-naphtyl butyrate esterase, and produced several monokines such as IL-1 beta, tumor necrosis factor-alpha, and macrophage colony-stimulating factor.	Tetradecanoylphorbol Acetate	18-54	interleukin 1 beta	Homo sapiens	199-237	
8186319-6	1994	Treatment with TPA for 48 h induced expression of IL-1 beta mRNA, an effect that was enhanced two fold by LPS.	Tetradecanoylphorbol Acetate	15-18	interleukin 1 beta	Homo sapiens	50-59	
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	19-50	interleukin 1 beta	Homo sapiens	94-103	
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	52-55	interleukin 1 beta	Homo sapiens	94-103	
8256116-8	1993	Similar data were obtained with cells transfected with a reporter plasmid containing the PMA-responsive element (containing a putative AP-1 binding site) of the IL-1 beta gene.	Tetradecanoylphorbol Acetate	89-92	interleukin 1 beta	Homo sapiens	161-170	
8413264-2	1993	Treatment of the transfected cells with various combinations of the inducers lipopolysaccharide, phorbol myristate acetate, and dibutyryl cyclic AMP upregulated the IL-1 beta promoter.	Tetradecanoylphorbol Acetate	97-122	interleukin 1 beta	Homo sapiens	165-174	
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Tetradecanoylphorbol Acetate	156-159	interleukin 1 beta	Homo sapiens	168-186	
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	interleukin 1 beta	Homo sapiens	259-282	
8360592-5	1993	While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed.	Tetradecanoylphorbol Acetate	6-31	interleukin 1 beta	Homo sapiens	40-49	
8500546-4	1993	Heat shock protein 70 gene was initially down regulated and was induced only after 48 h. The well-differentiated malignant keratinocyte cell line differed in that the c-fos, GADD, SPR1, and IL1-beta genes had several-fold higher induction, but involucrin mRNA was undetectable and fibronectin mRNA was only minimally induced after TPA stimulation.	Tetradecanoylphorbol Acetate	331-334	interleukin 1 beta	Homo sapiens	190-198	
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Tetradecanoylphorbol Acetate	156-159	interleukin 1 beta	Homo sapiens	187-196	
8454038-1	1993	The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated.	Tetradecanoylphorbol Acetate	125-128	interleukin 1 beta	Homo sapiens	58-76	
8454038-1	1993	The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated.	Tetradecanoylphorbol Acetate	125-128	interleukin 1 beta	Homo sapiens	78-87	
8436909-5	1993	PMA-treated, but not untreated cells, displayed an additional peptide derived from interleukin 1 beta.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	83-101	
8427707-0	1993	Regulation of interleukin-1ra, interleukin-1 alpha, and interleukin-1 beta production by human alveolar macrophages with phorbol myristate acetate, lipopolysaccharide, and interleukin-4.	Tetradecanoylphorbol Acetate	121-146	interleukin 1 beta	Homo sapiens	56-74	
8441379-7	1993	When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity.	Tetradecanoylphorbol Acetate	95-120	interleukin 1 beta	Homo sapiens	56-68	
8441379-7	1993	When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity.	Tetradecanoylphorbol Acetate	95-120	interleukin 1 beta	Homo sapiens	174-186	
1627264-6	1992	Preincubation by IL-1 beta enhanced the effect of a secondary challenge with phorbol 12-myristate 13-acetate or formyl-Met-Leu-Phe by 30-40%.	Tetradecanoylphorbol Acetate	77-108	interleukin 1 beta	Homo sapiens	17-26	
1421015-8	1992	Recombinant IL-1 beta induced a very low level of TNF alpha production in PMA-treated cells.	Tetradecanoylphorbol Acetate	74-77	interleukin 1 beta	Homo sapiens	12-21	
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	79-104	interleukin 1 beta	Homo sapiens	150-168	
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	79-104	interleukin 1 beta	Homo sapiens	170-179	
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	106-109	interleukin 1 beta	Homo sapiens	150-168	
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	106-109	interleukin 1 beta	Homo sapiens	170-179	
8457632-6	1993	Challenge with PMA induced low levels of IL-1 beta production with a relatively large percentage released.	Tetradecanoylphorbol Acetate	15-18	interleukin 1 beta	Homo sapiens	41-50	
8512018-7	1993	After treatment with PMA and LPS, IL-1 alpha was detected in the culture fluid from two other lines and IL-1 beta in the medium from three lines.	Tetradecanoylphorbol Acetate	21-24	interleukin 1 beta	Homo sapiens	104-113	
1292632-3	1992	After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels.	Tetradecanoylphorbol Acetate	23-48	interleukin 1 beta	Homo sapiens	105-123	
1292632-3	1992	After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels.	Tetradecanoylphorbol Acetate	23-48	interleukin 1 beta	Homo sapiens	125-134	
1384479-5	1992	The tumor promoter, tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the stimulatory effect of IL-1 alpha and IL-1 beta on the production of HGF.	Tetradecanoylphorbol Acetate	53-56	interleukin 1 beta	Homo sapiens	117-126	
1533323-8	1992	However, this phenomenon was not specific for LPS; 1 microgram/mL IL-1ra inhibited IL-1 beta synthesized in response to human recombinant IL-2 by 44% (P less than .001), toxic shock syndrome toxin-1 by 26% (P less than .05), and phorbol 12-myristate 13-acetate by 76% (P less than .001).	Tetradecanoylphorbol Acetate	229-260	interleukin 1 beta	Homo sapiens	83-92	
1797949-1	1991	A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors.	Tetradecanoylphorbol Acetate	58-83	interleukin 1 beta	Homo sapiens	182-200	
1371135-2	1992	After treatment with phorbol ester (PMA) or TNF-alpha, a 20- to 40-fold increase in the level of IL-1 beta mRNA was observed in the HIV-infected PLB-IIIB as compared with the parental PLB-985 cells.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	97-106	
1661292-2	1991	Peripheral monocytes and myelomonocytic cell lines could be stimulated by LPS or phorbol myristate acetate (PMA) to express IL-1 mRNA.	Tetradecanoylphorbol Acetate	81-106	interleukin 1 beta	Homo sapiens	124-128	
1661292-2	1991	Peripheral monocytes and myelomonocytic cell lines could be stimulated by LPS or phorbol myristate acetate (PMA) to express IL-1 mRNA.	Tetradecanoylphorbol Acetate	108-111	interleukin 1 beta	Homo sapiens	124-128	
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Tetradecanoylphorbol Acetate	87-90	interleukin 1 beta	Homo sapiens	189-198	
1661797-4	1991	Treatment with purified human monocyte interleukin-1 beta, partially purified lapine, synovial IL-1 or phorbol myristate acetate strongly induced the synthesis of all these enzymes.	Tetradecanoylphorbol Acetate	103-128	interleukin 1 beta	Homo sapiens	39-57	
1661739-10	1991	Together with the results obtained with phorbol myristate acetate, these data suggest that protein kinase C may play a role in the upregulation of IL-1 beta expression in normal skin fibroblasts.	Tetradecanoylphorbol Acetate	40-65	interleukin 1 beta	Homo sapiens	147-156	
1768743-3	1991	However, treatment of these cells with phorbol myristate acetate (PMA) resulted in the expression of IL-1 beta mRNA.	Tetradecanoylphorbol Acetate	39-64	interleukin 1 beta	Homo sapiens	101-110	
1768743-3	1991	However, treatment of these cells with phorbol myristate acetate (PMA) resulted in the expression of IL-1 beta mRNA.	Tetradecanoylphorbol Acetate	66-69	interleukin 1 beta	Homo sapiens	101-110	
1545152-5	1992	PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	100-109	
1797949-1	1991	A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors.	Tetradecanoylphorbol Acetate	85-88	interleukin 1 beta	Homo sapiens	182-200	
1713637-6	1991	In contrast, IL-1 beta, TNF, and TPA equally stimulated increased levels of M-CSF, GM-CSF, IL-1 beta and IL-6 RNAs.	Tetradecanoylphorbol Acetate	33-36	interleukin 1 beta	Homo sapiens	91-100	
1646841-2	1991	Both protein kinase C-activating phorbol esters, e.g., PMA, and LPS induce IL-1 beta expression in these cells.	Tetradecanoylphorbol Acetate	55-58	interleukin 1 beta	Homo sapiens	75-84	
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	15-52	interleukin 1 beta	Homo sapiens	112-130	
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	15-52	interleukin 1 beta	Homo sapiens	132-141	
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	54-57	interleukin 1 beta	Homo sapiens	112-130	
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	54-57	interleukin 1 beta	Homo sapiens	132-141	
2040654-2	1991	Here we investigated the effect of treatment with both TPA and 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) on LPS-induced IL-1 beta production in U937 cells.	Tetradecanoylphorbol Acetate	55-58	interleukin 1 beta	Homo sapiens	124-133	
2040654-4	1991	Combined treatment with TPA and 1,25(OH)2D3 for 72 h followed by incubation with LPS for 24 h caused synergistic induction of both IL-1 beta release and mRNA expression.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Homo sapiens	131-140	
1903479-4	1991	In human lung fibroblasts and in human umbilical vein endothelial cells, LIF was constitutively expressed and its accumulation was increased in a time-dependent manner following treatment with the phorbol ester TPA and in the presence of the two immediate response cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1-beta.	Tetradecanoylphorbol Acetate	211-214	interleukin 1 beta	Homo sapiens	313-336	
1904515-8	1991	Further investigations on the regulation of cytokine production and release by TPA-differentiated U937 cells revealed that TNF-alpha and IL-1 beta synthesis was not influenced by exogenously added rhTNF-alpha or PGE2, whereas rh gamma-IFN specifically enhanced the IL-1 beta production.	Tetradecanoylphorbol Acetate	79-82	interleukin 1 beta	Homo sapiens	137-146	
1698820-3	1990	After exposure to LPS (10 micrograms/ml) and 12-O-tetradecanoylphorbol-13-acetate (TPA, 100 nM) for 12 h, these HIV-1-infected monoblasts accumulated 8-15-fold greater levels of IL-1 beta RNA as compared with their HIV-1-uninfected counterparts that were similarly stimulated.	Tetradecanoylphorbol Acetate	45-81	interleukin 1 beta	Homo sapiens	178-187	
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	94-119	interleukin 1 beta	Homo sapiens	174-183	
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	94-119	interleukin 1 beta	Homo sapiens	220-229	
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	121-124	interleukin 1 beta	Homo sapiens	174-183	
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	121-124	interleukin 1 beta	Homo sapiens	220-229	
2175219-7	1990	PKC inhibitor, H7, also blocked effectively the PMA plus dbcAMP induced IL-1 beta production, while the protein kinase A (PKA) inhibitor, HA1004, had no effect, suggesting that PKA activation is not involved in the mechanism of action of cAMP in this case.	Tetradecanoylphorbol Acetate	48-51	interleukin 1 beta	Homo sapiens	72-81	
1698820-3	1990	After exposure to LPS (10 micrograms/ml) and 12-O-tetradecanoylphorbol-13-acetate (TPA, 100 nM) for 12 h, these HIV-1-infected monoblasts accumulated 8-15-fold greater levels of IL-1 beta RNA as compared with their HIV-1-uninfected counterparts that were similarly stimulated.	Tetradecanoylphorbol Acetate	83-86	interleukin 1 beta	Homo sapiens	178-187	
1698820-6	1990	Time-course experiments showed that the maximal levels of IL-1 beta RNA occurred at 12 and 24 h after LPS and TPA stimulation of the HIV-1-infected and uninfected U937 cells, respectively.	Tetradecanoylphorbol Acetate	110-113	interleukin 1 beta	Homo sapiens	58-67	
1698820-7	1990	Studies of stability of RNA using actinomycin D showed that IL-1 beta RNA was equally stable in infected and uninfected U937 cells after their stimulation with TPA and LPS.	Tetradecanoylphorbol Acetate	160-163	interleukin 1 beta	Homo sapiens	60-69	
2511200-5	1989	Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone.	Tetradecanoylphorbol Acetate	19-44	interleukin 1 beta	Homo sapiens	184-193	
34578957-0	2021	Kaempferol Blocks the Skin Fibroblastic Interleukin 1beta Expression and Cytotoxicity Induced by 12-O-tetradecanoylphorbol-13-acetate by Suppressing c-Jun N-terminal Kinase.	Tetradecanoylphorbol Acetate	97-133	interleukin 1 beta	Homo sapiens	40-57	
35140721-6	2022	Moreover, the 3D culture system was more suitable for the observation of neutrophil extracellular traps (NETs) stimulated by the classical stimulation phorbol ester (PMA), and other damage associated molecular patterns (DAMPs) such as Lipopolysaccharide (LPS)/ATP, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) than the 2D culture system.	Tetradecanoylphorbol Acetate	166-169	interleukin 1 beta	Homo sapiens	265-283	
2143761-1	1990	Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells.	Tetradecanoylphorbol Acetate	30-61	interleukin 1 beta	Homo sapiens	99-118	
2143761-1	1990	Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells.	Tetradecanoylphorbol Acetate	30-61	interleukin 1 beta	Homo sapiens	174-183	
2143761-1	1990	Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells.	Tetradecanoylphorbol Acetate	30-61	interleukin 1 beta	Homo sapiens	114-118	
2511200-5	1989	Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone.	Tetradecanoylphorbol Acetate	46-49	interleukin 1 beta	Homo sapiens	184-193	
2511200-5	1989	Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone.	Tetradecanoylphorbol Acetate	233-236	interleukin 1 beta	Homo sapiens	184-193	
2511200-13	1989	The present findings thus suggest: 1) that TPA induces LPS responsiveness in U937 cells via de novo synthesis of Gi2; 2) that the LPS response (enhanced IL-1 production) is linked to a pertussis toxin-sensitive G protein which we identified as Gi2; and 3) that LPS leads to phosphorylation of Gi2.	Tetradecanoylphorbol Acetate	43-46	interleukin 1 beta	Homo sapiens	153-157	
2787167-4	1989	Addition of TPA to serum-starved U937 cells induced the expression of the interleukin 1 beta (IL-1 beta) gene.	Tetradecanoylphorbol Acetate	12-15	interleukin 1 beta	Homo sapiens	74-92	
2500449-5	1989	Tumor necrosis factor alpha (TNF alpha) and activators of protein kinase C including 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin induced the accumulation of IL-1 beta mRNA in human fibroblasts (WI-38).	Tetradecanoylphorbol Acetate	85-121	interleukin 1 beta	Homo sapiens	171-180	
2500449-5	1989	Tumor necrosis factor alpha (TNF alpha) and activators of protein kinase C including 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin induced the accumulation of IL-1 beta mRNA in human fibroblasts (WI-38).	Tetradecanoylphorbol Acetate	123-126	interleukin 1 beta	Homo sapiens	171-180	
2500449-8	1989	Stability of IL-1 beta mRNA in fibroblasts exposed to TPA was more than fourfold greater than after fibroblasts were exposed to either TNF alpha or cycloheximide.	Tetradecanoylphorbol Acetate	54-57	interleukin 1 beta	Homo sapiens	13-22	
2801310-3	1989	In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS.	Tetradecanoylphorbol Acetate	57-88	interleukin 1 beta	Homo sapiens	155-164	
2801310-3	1989	In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS.	Tetradecanoylphorbol Acetate	90-93	interleukin 1 beta	Homo sapiens	155-164	
2787167-6	1989	Higher concentrations of TPA, which partially or totally depleted protein kinase C levels in the cells (10(-9)-2 X 10(-5) M), had an inhibitory effect on IL-1 beta mRNA expression.	Tetradecanoylphorbol Acetate	25-28	interleukin 1 beta	Homo sapiens	154-163	
2787167-4	1989	Addition of TPA to serum-starved U937 cells induced the expression of the interleukin 1 beta (IL-1 beta) gene.	Tetradecanoylphorbol Acetate	12-15	interleukin 1 beta	Homo sapiens	94-103	
3263853-1	1988	The acute monocytic leukemia cell line THP-1 secretes predominantly IL-1 beta after treatment with bacterial lipopolysaccharide and tumour promoting phorbol ester (PMA).	Tetradecanoylphorbol Acetate	164-167	interleukin 1 beta	Homo sapiens	68-77	
2496956-3	1989	We used the phorbol ester/lipopolysaccharide (PMA + LPS) co-induction of IL-1 mRNA and CD13 expression in U937 cells to demonstrate the specificity of the technique.	Tetradecanoylphorbol Acetate	46-49	interleukin 1 beta	Homo sapiens	73-77	
3311846-4	1987	Decrease in antigen-positive cells is delayed in LPS/TNF versus IL-1-alpha, beta/TPA-induced antigen expression (LPS vs. IL-1-beta: 60% vs. 5% at 24 h).	Tetradecanoylphorbol Acetate	81-84	interleukin 1 beta	Homo sapiens	121-130	
2838419-5	1988	However, exposure of monocytes to recombinant IL 1 alpha or IL 1 beta resulted in enhanced generation of superoxide response following stimulation with PMA.	Tetradecanoylphorbol Acetate	152-155	interleukin 1 beta	Homo sapiens	60-69	
3137260-6	1988	(90,000), which co-migrated with purified plasma factor B. Incubation of U-937 cells with the immunostimulants PMA, LPS, IFN-gamma, and IL-1 resulted in a dose-dependent augmentation of factor B production.	Tetradecanoylphorbol Acetate	111-114	interleukin 1 beta	Homo sapiens	136-140	
29531138-4	2018	In vitro analysis indicated that HMGB1, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-1beta (IL-1beta) were secreted in response to tumor necrosis factor-alpha (TNF-alpha) stimuli in human gingival epithelial cells (HGECs) and human monocytic leukemia cells (THP-1) treated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	308-333	interleukin 1 beta	Homo sapiens	122-130	
30320338-5	2018	Among them, Anatase-type TiO2 particles with a primary diameter of 50 nm (A50) were reported to induce interleukin (IL)-1beta production and secretion effectively in phorbol 12-myristate 13-acetate-treated human monocytic leukemia THP-1 cells (THP-1 macrophages).	Tetradecanoylphorbol Acetate	166-197	interleukin 1 beta	Homo sapiens	103-125	
3023484-1	1986	The tumor co-promotor TPA is believed to enhance a wide variety of cellular processes by interacting with protein kinase C. Interleukin (IL 1) is a family of highly active molecules which augments the host response to infection.	Tetradecanoylphorbol Acetate	22-25	interleukin 1 beta	Homo sapiens	137-141	
3023484-4	1986	Superoxide anion production by eosinophils stimulated with standard doses of the stimulant phorbol myristic acetate (TPA) (1 microgram/ml) was augmented approximately 20% by preincubation with IL 1.	Tetradecanoylphorbol Acetate	117-120	interleukin 1 beta	Homo sapiens	193-197	
3023484-6	1986	At suboptimal doses of TPA, there was a dose-dependent inhibition of superoxide anion production in the presence of IL 1.	Tetradecanoylphorbol Acetate	23-26	interleukin 1 beta	Homo sapiens	116-120	
3023484-8	1986	When IL 1 was added to eosinophils stimulated by TPA in the presence of calcium ionophore, there was a dose-dependent increase in superoxide anion production.	Tetradecanoylphorbol Acetate	49-52	interleukin 1 beta	Homo sapiens	5-9	
3023484-14	1986	IL 1 may also modify the response of eosinophils to other stimuli such as ionophore and TPA.	Tetradecanoylphorbol Acetate	88-91	interleukin 1 beta	Homo sapiens	0-4	
29531138-4	2018	In vitro analysis indicated that HMGB1, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-1beta (IL-1beta) were secreted in response to tumor necrosis factor-alpha (TNF-alpha) stimuli in human gingival epithelial cells (HGECs) and human monocytic leukemia cells (THP-1) treated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	308-333	interleukin 1 beta	Homo sapiens	103-120	
28276734-5	2017	In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	149-174	interleukin 1 beta	Homo sapiens	114-136	
29207123-5	2018	The present study demonstrated that NLRP3 inflammasome and IL-1beta were activated in PMA-induced macrophages in a time-dependent manner, whereas berberine significantly inhibited their expression in a dose-dependent manner in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	86-89	interleukin 1 beta	Homo sapiens	59-67	
28276734-5	2017	In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	176-179	interleukin 1 beta	Homo sapiens	114-136	
27777559-5	2016	Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	116-119	interleukin 1 beta	Homo sapiens	94-102	
27871911-5	2017	In addition, we also showed that theaflavin-3,3"-digallate inhibited the expression of tumor necrosis factor alpha, interleukin -1 beta, and interleukin 6 in phorbol myristate acetate -primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	158-183	interleukin 1 beta	Homo sapiens	116-135	
27777559-9	2016	Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion.	Tetradecanoylphorbol Acetate	31-34	interleukin 1 beta	Homo sapiens	140-148	
26718326-5	2016	We noted that the purified nonameric peptide (AIGIDP) attenuated the phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced histamine release and the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in human mast cells (HMC-1 cells).	Tetradecanoylphorbol Acetate	69-100	interleukin 1 beta	Homo sapiens	264-286	
27104574-3	2016	Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed.	Tetradecanoylphorbol Acetate	116-119	interleukin 1 beta	Homo sapiens	62-70	
27105502-8	2016	The in vitro study showed that MALT1 inhibitors decreased production of IL-1beta/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	90-115	interleukin 1 beta	Homo sapiens	72-80	
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	146-171	interleukin 1 beta	Homo sapiens	120-132	
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	173-176	interleukin 1 beta	Homo sapiens	120-132	
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Tetradecanoylphorbol Acetate	9-12	interleukin 1 beta	Homo sapiens	186-194	
25022544-7	2014	To determine the role of PKC activation in the effects of DPP-4 inhibitors, cells were treated with PMA- which blocked the effect of DPP-4 inhibitors on NLRP3 and IL-1beta as well as TLR4 and GLP-1R.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 beta	Homo sapiens	163-171	
20851349-6	2010	The activity correlated well with processing of prointerleukin-1beta and prointerleukin-18 in phorbol 12-myristate 13-acetate (PMA)-stimulated cells.	Tetradecanoylphorbol Acetate	94-125	interleukin 1 beta	Homo sapiens	48-68	
22480848-4	2012	They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Homo sapiens	82-90	
22480848-4	2012	They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Homo sapiens	185-193	
21807015-4	2011	Our results showed that among the tested molecules, all sensitizers specifically prevent the production of PMA/LPS-induced COX-2 metabolites (PGE(2,) TxB(2) and PGD(2)), eugenol and cinnamaldehyde inhibiting also the production of IL-1beta and TNF-alpha.	Tetradecanoylphorbol Acetate	107-110	interleukin 1 beta	Homo sapiens	231-239	
21804018-4	2011	Moreover, PMA-induced IL-1beta production was significantly reduced in the presence of TLR2, TLR4, and CD11b Abs.	Tetradecanoylphorbol Acetate	10-13	interleukin 1 beta	Homo sapiens	22-30	
21804018-5	2011	Rottlerin, a PKCdelta-specific inhibitor, significantly reduced PMA-induced IL-1beta production as well as CD11b, TLR2 expression, and IRAK1-JNK activation.	Tetradecanoylphorbol Acetate	64-67	interleukin 1 beta	Homo sapiens	76-84	
24996056-2	2014	Here, we confirmed that IL-32theta, a new isoform of IL-32, decreased the phorbol 12-myristate 13-acetate (PMA)-induced IL-1beta expression in THP-1 human myelomonocyte.	Tetradecanoylphorbol Acetate	74-105	interleukin 1 beta	Homo sapiens	120-128	
24996056-2	2014	Here, we confirmed that IL-32theta, a new isoform of IL-32, decreased the phorbol 12-myristate 13-acetate (PMA)-induced IL-1beta expression in THP-1 human myelomonocyte.	Tetradecanoylphorbol Acetate	107-110	interleukin 1 beta	Homo sapiens	120-128	
21804018-8	2011	IRAK1/4 inhibitors, their small interfering RNAs, and JNK inhibitor also attenuated PMA-induced IL-1beta production.	Tetradecanoylphorbol Acetate	84-87	interleukin 1 beta	Homo sapiens	96-104	
20851349-6	2010	The activity correlated well with processing of prointerleukin-1beta and prointerleukin-18 in phorbol 12-myristate 13-acetate (PMA)-stimulated cells.	Tetradecanoylphorbol Acetate	127-130	interleukin 1 beta	Homo sapiens	48-68	
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	106-137	interleukin 1 beta	Homo sapiens	84-92	
17681786-3	2007	In this study, we demonstrated that various inflammatory agents, including lipopolysaccharide, 12-o-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid and ceramide, were able to induce IL-1beta and TNF-alpha productions in human lung epithelial cells (A-549), fibroblasts (HFL1), and lymphoma cells (U-937).	Tetradecanoylphorbol Acetate	95-131	interleukin 1 beta	Homo sapiens	199-207	
19776509-3	2009	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta.	Tetradecanoylphorbol Acetate	18-49	interleukin 1 beta	Homo sapiens	162-170	
19776509-3	2009	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta.	Tetradecanoylphorbol Acetate	51-54	interleukin 1 beta	Homo sapiens	162-170	
19776509-5	2009	In cells in which PMA-dependent PKC was down-regulated, PMA failed to induce the formation of NFkappaB DNA-protein complex and reduced the release of PMA-induced PGE(2), whereas IL-1beta stimulated the formation of COX-2-NFkappaB DNA-protein complex and PGE(2) release.	Tetradecanoylphorbol Acetate	18-21	interleukin 1 beta	Homo sapiens	178-186	
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	139-142	interleukin 1 beta	Homo sapiens	84-92	
16888805-4	2007	Here, we show that IL-1beta and TPA stimulated TNFalpha gene transcription in hepatoma cells mediated by a composite TPA-responsive element/cAMP response element.	Tetradecanoylphorbol Acetate	117-120	interleukin 1 beta	Homo sapiens	19-27	
17178924-6	2007	IL-1beta-, FBS-, or PMA-induced stabilization of B1 receptor mRNA was inhibited by the addition of the protein kinase C inhibitor 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride (GF-109203x), which also diminished the Bmax under FBS or PMA treatment.	Tetradecanoylphorbol Acetate	20-23	interleukin 1 beta	Homo sapiens	0-8	
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	153-156	interleukin 1 beta	Homo sapiens	233-241	
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	interleukin 1 beta	Homo sapiens	141-149	
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	interleukin 1 beta	Homo sapiens	233-241	
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Tetradecanoylphorbol Acetate	18-49	interleukin 1 beta	Homo sapiens	174-196	
16632868-3	2006	Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis.	Tetradecanoylphorbol Acetate	82-113	interleukin 1 beta	Homo sapiens	0-22	
16632868-3	2006	Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis.	Tetradecanoylphorbol Acetate	115-118	interleukin 1 beta	Homo sapiens	0-22	
16026998-2	2005	In the cells activated by the protein kinase C specific phorbol ester (phorbol 12-myristate 13-acetate) and Ca(2+) ionophore (A23187) both adenosine and the subtype-specific receptor agonists, CPA (A1), CGS 21680 (A2A) and IB-MECA (A3) induced a concentration-dependent inhibition of IL-1beta release.	Tetradecanoylphorbol Acetate	71-102	interleukin 1 beta	Homo sapiens	284-292	
16600024-8	2006	Phorbol myristate acetate-stimulated oxidative burst and IL-8 release by IL-1beta, lipopolysaccharide and GM-CSF in whole blood from mild but not severe asthmatics were inhibited after prednisolone.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 beta	Homo sapiens	73-81	
15135313-2	2004	In this study, we demonstrate that resveratrol enhanced TNF-alpha, IL-12 and IL-1beta production from LPS activated phorbol myristate acetate (PMA) differentiated THP-1 human macrophages.	Tetradecanoylphorbol Acetate	116-141	interleukin 1 beta	Homo sapiens	77-85	
15705185-6	2005	The effects of IL-1beta, which were reproduced by incubation of PTC with PMA (6.25-100 nmol/L), were blocked by H7 but not by BIM-1.	Tetradecanoylphorbol Acetate	73-76	interleukin 1 beta	Homo sapiens	15-23