PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12646569-4 2003 Protein kinase activators (cAMP, forskolin, or phorbol-12-myristate-13-acetate) markedly increased GSTA4-4 targeting to mitochondria, whereas kinase inhibitors caused its retention in the cytosol. Tetradecanoylphorbol Acetate 47-78 glutathione S-transferase, alpha 4 Mus musculus 99-106 20966433-6 2010 We used quantitative polymerase chain reaction, western blotting, and immunohistochemistry to verify induction of Gsta4 in mouse epidermis following TPA treatment and biochemical assays to associate Gsta4 activity with tumor promotion susceptibility. Tetradecanoylphorbol Acetate 149-152 glutathione S-transferase, alpha 4 Mus musculus 114-119 20966433-10 2010 Gsta4 maps to Psl1.2 and was highly induced (mRNA and protein) in the epidermis of resistant C57BL/6 mice compared with that of sensitive DBA/2 mice following treatment with TPA. Tetradecanoylphorbol Acetate 174-177 glutathione S-transferase, alpha 4 Mus musculus 0-5 20966433-11 2010 Gsta4 activity levels were also higher in the epidermis of C57BL/6 mice following treatment with TPA. Tetradecanoylphorbol Acetate 97-100 glutathione S-transferase, alpha 4 Mus musculus 0-5 20966433-12 2010 Gsta4-deficient mice (C57BL/6.Gsta4(-/-) mice) were more sensitive to TPA skin tumor promotion (0.8 tumors per mouse vs 0.4 tumors per mouse in wild-type controls; difference = 0.4 tumors per mouse; 95% confidence interval = 0.1 to 0.7, P = .007). Tetradecanoylphorbol Acetate 70-73 glutathione S-transferase, alpha 4 Mus musculus 0-5 16044405-9 2005 Three genes, Gsta4, Nmes1 (MGC58382), and Serpinb2, located within promotion susceptibility loci Psl1 (chr 9), Psl2 (chr 2), and Psl3 (chr 1), respectively, were identified in this analysis as potential candidates for modifiers of susceptibility to skin tumor promotion by TPA. Tetradecanoylphorbol Acetate 273-276 glutathione S-transferase, alpha 4 Mus musculus 13-18