PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2896538-3 1987 In this system we have found that the cells release GH in response to low concentrations of TPA: the EC50 was 0.23 +/- 0.05 nM (n = 6) and the maximal concentration was 5 nM. Tetradecanoylphorbol Acetate 92-95 gonadotropin releasing hormone receptor Rattus norvegicus 52-54 8206322-6 1994 A significant dose-dependent increase in tPA activity was observed in the GH-treated cells. Tetradecanoylphorbol Acetate 41-44 gonadotropin releasing hormone receptor Rattus norvegicus 74-76 8206322-7 1994 This effect was exerted at the mRNA level and the use of cycloheximide, a protein synthesis inhibitor, suggested that GH did not require any other intermediary protein for inducing tPA-mRNA. Tetradecanoylphorbol Acetate 181-184 gonadotropin releasing hormone receptor Rattus norvegicus 118-120 2896538-4 1987 However, the maximal TPA-induced GH release was only 34 +/- 5% (n = 7) of the GH released by maximal growth hormone releasing factor (GRF) suggesting TPA releases a subpool of stored GH. Tetradecanoylphorbol Acetate 21-24 gonadotropin releasing hormone receptor Rattus norvegicus 33-35 2896538-5 1987 Both somatostatin and insulin-like growth factor I inhibit GH release stimulated by TPA to the same extent as that stimulated by GRF, showing that the normal inhibitory control mechanism of release is not altered. Tetradecanoylphorbol Acetate 84-87 gonadotropin releasing hormone receptor Rattus norvegicus 59-61 2896538-6 1987 Incubation in a low calcium medium that totally blocks GRF-stimulated GH release also inhibits TPA-stimulated GH release. Tetradecanoylphorbol Acetate 95-98 gonadotropin releasing hormone receptor Rattus norvegicus 70-72 2896538-7 1987 The calcium channel blockers nifedipine and diltiazem both partly inhibit GRF- and TPA-stimulated GH release, showing some component of the calcium necessary for GH release arises from influx across the cell membrane. Tetradecanoylphorbol Acetate 83-86 gonadotropin releasing hormone receptor Rattus norvegicus 98-100 2981678-1 1985 The mechanism(s) of action of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on rat (r) GH release was studied in primary rat pituitary cell cultures. Tetradecanoylphorbol Acetate 69-72 gonadotropin releasing hormone receptor Rattus norvegicus 85-87 2981678-0 1985 12-O-tetradecanoyl phorbol-13-acetate stimulates rat growth hormone (GH) release through different pathways from that of human pancreatic GH-releasing factor. Tetradecanoylphorbol Acetate 0-37 gonadotropin releasing hormone receptor Rattus norvegicus 53-67 2981678-0 1985 12-O-tetradecanoyl phorbol-13-acetate stimulates rat growth hormone (GH) release through different pathways from that of human pancreatic GH-releasing factor. Tetradecanoylphorbol Acetate 0-37 gonadotropin releasing hormone receptor Rattus norvegicus 69-71 2981678-1 1985 The mechanism(s) of action of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on rat (r) GH release was studied in primary rat pituitary cell cultures. Tetradecanoylphorbol Acetate 30-67 gonadotropin releasing hormone receptor Rattus norvegicus 85-87 6149663-2 1984 12-O-tetradecanoyl phorbol-13-acetate (TPA), the most potent phorbol ester, stimulated GH accumulation in the cultured medium in a dose-dependent manner. Tetradecanoylphorbol Acetate 0-37 gonadotropin releasing hormone receptor Rattus norvegicus 87-89 6149663-2 1984 12-O-tetradecanoyl phorbol-13-acetate (TPA), the most potent phorbol ester, stimulated GH accumulation in the cultured medium in a dose-dependent manner. Tetradecanoylphorbol Acetate 39-42 gonadotropin releasing hormone receptor Rattus norvegicus 87-89 6149663-4 1984 A time course study indicated that TPA mainly stimulates release of GH. Tetradecanoylphorbol Acetate 35-38 gonadotropin releasing hormone receptor Rattus norvegicus 68-70 6149663-5 1984 The maximal stimulation of GH release by TPA (100 ng/ml) was 3-4-fold over control. Tetradecanoylphorbol Acetate 41-44 gonadotropin releasing hormone receptor Rattus norvegicus 27-29 6149663-7 1984 TPA-stimulated GH release was not affected by the presence of indomethacin, an inhibitor of prostaglandin (PG) synthesis, indicating that PG is not involved in the process of TPA-stimulated GH release. Tetradecanoylphorbol Acetate 0-3 gonadotropin releasing hormone receptor Rattus norvegicus 15-17 6149663-8 1984 Co++, a competitive antagonist of Ca++, at 2.0 mM completely suppressed the GH release induced by TPA, and this inhibition was partially reversed by the addition of 2.0 mM Ca++. Tetradecanoylphorbol Acetate 98-101 gonadotropin releasing hormone receptor Rattus norvegicus 76-78 6149663-9 1984 Verapamil, a Ca++ channel blocker, reduced TPA-stimulated GH release, and trifluoperazine, an inhibitor of Ca-calmodulin formation, had a similar effect. Tetradecanoylphorbol Acetate 43-46 gonadotropin releasing hormone receptor Rattus norvegicus 58-60 6149663-10 1984 Somatostatin (SRIF) also inhibited the GH release by TPA. Tetradecanoylphorbol Acetate 53-56 gonadotropin releasing hormone receptor Rattus norvegicus 39-41 6149663-11 1984 These observations are compatible with the idea that Ca++ may be involved in the process of TPA-stimulated GH release. Tetradecanoylphorbol Acetate 92-95 gonadotropin releasing hormone receptor Rattus norvegicus 107-109