PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26222138-7 2015 In addition, PMA-inducible secretion of monocyte chemotactic protein 1 (MCP-1) was significantly high in NRF2-silenced U937. Tetradecanoylphorbol Acetate 13-16 C-C motif chemokine ligand 2 Homo sapiens 40-70 26222138-7 2015 In addition, PMA-inducible secretion of monocyte chemotactic protein 1 (MCP-1) was significantly high in NRF2-silenced U937. Tetradecanoylphorbol Acetate 13-16 C-C motif chemokine ligand 2 Homo sapiens 72-77 11502881-3 2001 In this study, we investigated the effect of Wog on phorbol ester (PMA)-induced MCP-1 expression in human umbilical vein endothelial cells (ECs). Tetradecanoylphorbol Acetate 67-70 C-C motif chemokine ligand 2 Homo sapiens 80-85 21224075-5 2011 12-O-tetradecanoylphorbol-13-acetate stimulated skin fibroblasts, secreting high levels of monocyte chemotactic protein-1, and neutralization of this chemokine eliminated almost completely the fibroblast-induced chemotaxis of macrophages. Tetradecanoylphorbol Acetate 0-36 C-C motif chemokine ligand 2 Homo sapiens 91-121 19766691-0 2010 Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity. Tetradecanoylphorbol Acetate 18-43 C-C motif chemokine ligand 2 Homo sapiens 58-63 19766691-0 2010 Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity. Tetradecanoylphorbol Acetate 45-48 C-C motif chemokine ligand 2 Homo sapiens 58-63 19766691-3 2010 We found that curcumin, a natural biologically active compound extracted from rhizomes of Curcuma species, significantly inhibited the PMA-induced increase in MCP-1 expression and secretion. Tetradecanoylphorbol Acetate 135-138 C-C motif chemokine ligand 2 Homo sapiens 159-164 12787135-5 2003 E2 inhibited constitutive and 12-O-tetradecanoylphorbol-13-acetate-induced MCP-1 secretion, mRNA expression, and promoter activity in keratinocytes, and these effects of E2 were counteracted by estrogen receptor antagonist ICI 182 780. Tetradecanoylphorbol Acetate 30-66 C-C motif chemokine ligand 2 Homo sapiens 75-80 12787135-6 2003 GC-rich Sp1 element and activator protein 1 (AP-1) element on MCP-1 promoter were required for constitutive and 12-O-tetradecanoylphorbol-13-acetate-induced transcription, respectively, and involved in transrepression by E2. Tetradecanoylphorbol Acetate 112-148 C-C motif chemokine ligand 2 Homo sapiens 62-67 12499080-2 2003 MEM significantly inhibited PMA-induced secretions of IL-8 and MCP-1 proteins in a dose-dependent manner. Tetradecanoylphorbol Acetate 28-31 C-C motif chemokine ligand 2 Homo sapiens 63-68 12499080-4 2003 In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes. Tetradecanoylphorbol Acetate 110-113 C-C motif chemokine ligand 2 Homo sapiens 145-150 12499080-4 2003 In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes. Tetradecanoylphorbol Acetate 110-113 C-C motif chemokine ligand 2 Homo sapiens 191-196 19048368-5 2009 Activation of intracellular cyclic adenosine monophosphate or protein kinase C with forskolin and phorbol 12-myristate 13-acetate, respectively, was able to completely abolish the MCP-1-induced migration. Tetradecanoylphorbol Acetate 98-129 C-C motif chemokine ligand 2 Homo sapiens 180-185 17379255-3 2007 EGCG markedly inhibited the phorbol 12-myristate 13-acetate (PMA)-induced MCP-1 mRNA and protein levels in a dose-dependent manner. Tetradecanoylphorbol Acetate 28-59 C-C motif chemokine ligand 2 Homo sapiens 74-79 17379255-3 2007 EGCG markedly inhibited the phorbol 12-myristate 13-acetate (PMA)-induced MCP-1 mRNA and protein levels in a dose-dependent manner. Tetradecanoylphorbol Acetate 61-64 C-C motif chemokine ligand 2 Homo sapiens 74-79 16376386-0 2006 Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells. Tetradecanoylphorbol Acetate 19-22 C-C motif chemokine ligand 2 Homo sapiens 40-45 11502881-8 2001 Furthermore, the PMA-induced extracellular signal-regulated kinase 1/2 and c-Jun amino-terminal kinase activities that contributed to AP-1 activity and MCP-1 gene induction were obviously attenuated after pretreating ECs with Wog. Tetradecanoylphorbol Acetate 17-20 C-C motif chemokine ligand 2 Homo sapiens 152-157 9388261-8 1997 The binding of (p65)2 and/or c-Rel/p65 to the A2 probe was also detected from 12-o-tetradecanoylphorbol 13-acetate-stimulated HeLa, HOS, and A172 cells in which expression of MCP-1 mRNA was elevated. Tetradecanoylphorbol Acetate 78-114 C-C motif chemokine ligand 2 Homo sapiens 175-180 11287779-6 2001 The stimulating effect of high glucose on MCP-1 expression in HMC was mimicked by activation of protein kinase C (PKC) with the phorbol ester PMA (20 nM). Tetradecanoylphorbol Acetate 142-145 C-C motif chemokine ligand 2 Homo sapiens 42-47 10683319-3 2000 Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines. Tetradecanoylphorbol Acetate 0-29 C-C motif chemokine ligand 2 Homo sapiens 68-73 10683319-3 2000 Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines. Tetradecanoylphorbol Acetate 31-34 C-C motif chemokine ligand 2 Homo sapiens 68-73 9609459-4 1998 Semiquantitative PCR showed that phorbol myristate acetate (100 nM) increased the ratio of PCR products for MCP-1 to housekeeping gene glyceraldehyde-3-phosphate dehydrogenase on densitometric results at 24 h by 2.7-fold, which was prevented by calphostin C (200 nM) pretreatment. Tetradecanoylphorbol Acetate 33-58 C-C motif chemokine ligand 2 Homo sapiens 108-113 10475624-4 1999 Stimulation of HL-60 and MONO-MAC-6 with lipopolysaccharide (LPS), and stimulation of ML-2 and MUTZ-3 with 12-tetradecanoyl phorbol 13-acetate (TPA) dramatically increased the MCP-1 level in the culture medium. Tetradecanoylphorbol Acetate 107-142 C-C motif chemokine ligand 2 Homo sapiens 176-181 10475624-5 1999 The highest amount of MCP-1 (> 80 ng/ml within 24 h) was achieved by TPA stimulation of MUTZ-3 cells. Tetradecanoylphorbol Acetate 72-75 C-C motif chemokine ligand 2 Homo sapiens 22-27 10051376-5 1999 Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner. Tetradecanoylphorbol Acetate 89-92 C-C motif chemokine ligand 2 Homo sapiens 55-60 9740146-10 1998 TPA (10 nmol/L) also stimulated the production of IL-6 and IL-8 by these cells, but inhibited that of monocyte chemoattractant protein-1. Tetradecanoylphorbol Acetate 0-3 C-C motif chemokine ligand 2 Homo sapiens 102-136 8587246-7 1995 Furthermore, PMA induced an increase in MCP-1 mRNA levels, whereas dibutyryl cyclic AMP and forskolin had minimal effects. Tetradecanoylphorbol Acetate 13-16 C-C motif chemokine ligand 2 Homo sapiens 40-45 7891669-2 1994 The expression of MCP-1 gene can be induced by lipopolysaccharides (LPS), phorbol esters (TPA) and several cytokines. Tetradecanoylphorbol Acetate 90-93 C-C motif chemokine ligand 2 Homo sapiens 18-23 7644539-0 1995 The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Tetradecanoylphorbol Acetate 30-66 C-C motif chemokine ligand 2 Homo sapiens 123-153 7891669-4 1994 We tested whether the two putative TPA-responsive elements (TREs) and one kappa B enhancer-like region found in the MCP-1 promoter region, are involved in this regulation of MCP-1 gene expression. Tetradecanoylphorbol Acetate 35-38 C-C motif chemokine ligand 2 Homo sapiens 174-179 7891669-5 1994 The 5" untranslated region of MCP-1 gene was linked to chloramphenicol acetyl transferase (CAT) reporter gene and transfected into human glioblastoma cells in which endogenous MCP gene expression was found to be stimulated by TPA and tumor necrosis factor-alpha (TNF-alpha). Tetradecanoylphorbol Acetate 226-229 C-C motif chemokine ligand 2 Homo sapiens 30-35 7891669-6 1994 The 128 bp 5"-flanking region containing one TRE was adequate for basal promoter activity but the presence of both TREs in the MCP-1 promoter region were needed to give TPA responsive enhancement (2.5 fold) of expression of the marker gene. Tetradecanoylphorbol Acetate 169-172 C-C motif chemokine ligand 2 Homo sapiens 127-132 1365641-12 1992 In contrast, retinoic acid strongly increased phorbol myristate acetate-induced MCP-1 expression and potentiated the effects of IL-1 and LPS. Tetradecanoylphorbol Acetate 46-71 C-C motif chemokine ligand 2 Homo sapiens 80-85 8484776-3 1993 The TPA-induced monocyte chemotactic protein-1 expression was abolished by treating the cells with both staurosporine and genistein; however, only a portion of the LPS-induced expression was inhibited by staurosporine/genistein. Tetradecanoylphorbol Acetate 4-7 C-C motif chemokine ligand 2 Homo sapiens 16-46